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Andrew V. Kossenkov
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Journal Articles

Abstract 3582: PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding

LIfeng Tian, Xuanmao Jiao, Chenguang Wang, Adam Ertel, Raymond Soccio, Eric R. Chen, Balázs Győrffy, Gabriele Di Sante, Zhijiu Zhong, Sankar Addya, Peter A. McCue, Andrew V. Kossenkov, Joanna Achinger-Kawecka, Susan Clark, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3582.
https://doi.org/10.1158/1538-7445.AM2024-3582
Published: 22 March 2024
View articletitled, Abstract 3582: PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding
Journal Articles

Abstract PR011: TXNRD1 drives innate immune response in senescent cells to promote tumor immune surveillance and age-associated inflammation

Xue Hao, Bo Zhao, Martina Towers, Liping Liao, Hsin Yao Tang, Aaron Havas, Andrew V. Kossenkov, Shelley Berger, Peter D. Adams, David W. Speicher, Rugang Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): PR011.
https://doi.org/10.1158/1538-7445.AGCA22-PR011
Published: 15 January 2023
View articletitled, Abstract PR011: TXNRD1 drives innate immune response in senescent cells to promote tumor immune surveillance and age-associated inflammation
Journal Articles

Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers

Joseph A. Zundell, Takeshi Fukumoto, Jianhuang Lin, Nail Fatkhudinov, Timothy Nacarelli, Andrew V. Kossenkov, Qin Liu, Joel Cassel, Chih-Chi Andrew Hu, Shuai Wu, Rugang Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5325–5335.
https://doi.org/10.1158/0008-5472.CAN-21-1545
Published: 15 October 2021
View articletitled, Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers
Open the PDF for Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers in another window
Includes: Supplementary data
Journal Articles

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Jianglan Liu, Vito W. Rebecca, Andrew V. Kossenkov, Thomas Connelly, Qin Liu, Alexis Gutierrez, Min Xiao, Ling Li, Gao Zhang, Anastasia Samarkina, Delaine Zayasbazan, Jie Zhang, Chaoran Cheng, Zhi Wei, Gretchen M. Alicea, Mizuho Fukunaga-Kalabis, Clemens Krepler, Pedro Aza-Blanc, Chih-Cheng Yang, Bela Delvadia, Cynthia Tong, Ye Huang, Maya Delvadia, Alice S. Morias, Katrin Sproesser, Patricia Brafford, Joshua X. Wang, Marilda Beqiri, Rajasekharan Somasundaram, Adina Vultur, Denitsa M. Hristova, Lawrence W. Wu, Yiling Lu, Gordon B. Mills, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Ravi K. Amaravadi, Lawrence N. Kwong, Dennie T. Frederick, Genevieve M. Boland, Joseph M. Salvino, David W. Speicher, Keith T. Flaherty, Ze'ev A. Ronai, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5230–5241.
https://doi.org/10.1158/0008-5472.CAN-20-1496
Published: 15 October 2021
View articletitled, Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Open the PDF for Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance in another window
Includes: Supplementary data
Journal Articles

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Katelyn D. Miller, Katherine Pniewski, Caroline E. Perry, Sara B. Papp, Joshua D. Shaffer, Jesse N. Velasco-Silva, Jessica C. Casciano, Tomas M. Aramburu, Yellamelli V.V. Srikanth, Joel Cassel, Emmanuel Skordalakes, Andrew V. Kossenkov, Joseph M. Salvino, Zachary T. Schug
Journal: Cancer Research
Cancer Res (2021) 81 (5): 1252–1264.
https://doi.org/10.1158/0008-5472.CAN-20-1847
Published: 01 March 2021
View articletitled, Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth
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Includes: Supplementary data
Journal Articles

Abstract PS17-58: Pparg1 induces an EGF-EphA2 receptor tyrosine kinase module to promote ErbB2- mammary adenocarcinoma in mice

Richard G Pestell, Xuanmao Jiao, Andrew V Kossenkov, Adam Ertel, Wei Tong, Zhao Zhang, Peter A McCue
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-58.
https://doi.org/10.1158/1538-7445.SABCS20-PS17-58
Published: 15 February 2021
View articletitled, Abstract PS17-58: Pparg1 induces an EGF-EphA2 receptor tyrosine kinase module to promote ErbB2- mammary adenocarcinoma in mice
Journal Articles

A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors

Thibaut Barnoud, Jessica C. Leung, Julia I-Ju Leu, Subhasree Basu, Adi Narayana Reddy Poli, Joshua L.D. Parris, Alexandra Indeglia, Tetyana Martynyuk, Madeline Good, Keerthana Gnanapradeepan, Emilio Sanseviero, Rebecca Moeller, Hsin-Yao Tang, Joel Cassel, Andrew V. Kossenkov, Qin Liu, David W. Speicher, Dmitry I. Gabrilovich, Joseph M. Salvino, Donna L. George, Maureen E. Murphy
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5270–5281.
https://doi.org/10.1158/0008-5472.CAN-20-0397
Published: 02 December 2020
View articletitled, A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors
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Includes: Supplementary data
Journal Articles

A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers

Jacquelyn Powers, Emilia M. Pinto, Thibaut Barnoud, Jessica C. Leung, Tetyana Martynyuk, Andrew V. Kossenkov, Aaron H. Philips, Heena Desai, Ryan Hausler, Gregory Kelly, Anh N. Le, Marilyn M. Li, Suzanne P. MacFarland, Louise C. Pyle, Kristin Zelley, Katherine L. Nathanson, Susan M. Domchek, Thomas P. Slavin, Jeffrey N. Weitzel, Jill E. Stopfer, Judy E. Garber, Vijai Joseph, Kenneth Offit, Jill S. Dolinsky, Stephanie Gutierrez, Kelly McGoldrick, Fergus J. Couch, Brooke Levin, Morris C. Edelman, Carolyn Fein Levy, Sheri L. Spunt, Richard W. Kriwacki, Gerard P. Zambetti, Raul C. Ribeiro, Maureen E. Murphy, Kara N. Maxwell
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3732–3744.
https://doi.org/10.1158/0008-5472.CAN-20-1390
Published: 02 September 2020
View articletitled, A Rare TP53 Mutation Predominant in Ashkenazi Jews Confers Risk of Multiple Cancers
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Includes: Supplementary data
Journal Articles

Abstract 1457: Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits

Jagadish C. ghosh, Jae Ho Seo, Ekta Agarwal, Yuan Wang, Andrew V. Kossenkov, Hsin-Yao Tang, David W. Speicher, Dario C. Altieri
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1457.
https://doi.org/10.1158/1538-7445.AM2020-1457
Published: 15 August 2020
View articletitled, Abstract 1457: Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits
Journal Articles

MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Jae Ho Seo, Young Chan Chae, Andrew V. Kossenkov, Yu Geon Lee, Hsin-Yao Tang, Ekta Agarwal, Dmitry I. Gabrilovich, Lucia R. Languino, David W. Speicher, Prashanth K. Shastrula, Alessandra Maria Storaci, Stefano Ferrero, Gabriella Gaudioso, Manuela Caroli, Davide Tosi, Massimo Giroda, Valentina Vaira, Vito W. Rebecca, Meenhard Herlyn, Min Xiao, Dylan Fingerman, Alessandra Martorella, Emmanuel Skordalakes, Dario C. Altieri
Journal: Cancer Research
Cancer Res (2019) 79 (24): 6215–6226.
https://doi.org/10.1158/0008-5472.CAN-19-1982
Published: 13 December 2019
View articletitled, MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
Open the PDF for MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology

Xuanmao Jiao, Omar Nawab, Tejal Patel, Andrew V. Kossenkov, Niels Halama, Dirk Jaeger, Richard G. Pestell
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (19): 4801–4807.
https://doi.org/10.1158/0008-5472.CAN-19-1167
Published: 01 October 2019
View articletitled, Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology
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Journal Articles

N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance

Takeshi Fukumoto, Hengrui Zhu, Timothy Nacarelli, Sergey Karakashev, Nail Fatkhutdinov, Shuai Wu, Pingyu Liu, Andrew V. Kossenkov, Louise C. Showe, Stephanie Jean, Lin Zhang, Rugang Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2812–2820.
https://doi.org/10.1158/0008-5472.CAN-18-3592
Published: 03 June 2019
View articletitled, N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT

Andrew V. Kossenkov, Rehman Qureshi, Noor B. Dawany, Jayamanna Wickramasinghe, Qin Liu, R. Sonali Majumdar, Celia Chang, Sandy Widura, Trisha Kumar, Wen-Hwai Horng, Eric Konnisto, Gerard Criner, Jun-Chieh J. Tsay, Harvey Pass, Sai Yendamuri, Anil Vachani, Thomas Bauer, Brian Nam, William N. Rom, Michael K. Showe, Louise C. Showe
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (1): 263–273.
https://doi.org/10.1158/0008-5472.CAN-18-2032
Published: 02 January 2019
View articletitled, A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT
Open the PDF for A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT in another window
Includes: Supplementary data
Journal Articles

Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements

Jae Ho Seo, Ekta Agarwal, Kelly G. Bryant, M. Cecilia Caino, Eui Tae Kim, Andrew V. Kossenkov, Hsin-Yao Tang, Lucia R. Languino, Dmitry I. Gabrilovich, Andrew R. Cohen, David W. Speicher, Dario C. Altieri
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (15): 4215–4228.
https://doi.org/10.1158/0008-5472.CAN-18-0595
Published: 31 July 2018
View articletitled, Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements
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Includes: Supplementary data
Journal Articles

Abstract 2381: Loss of S6K2 perturbs redox balance and fatty acid metabolism, leading to oxidative cell death

Hsin-Yi Chen, Minu Samanta, Patricia Reyes-Uribe, Andrew V. Kossenkov, Xiangfan Yin, Yiling Lu, Mark Axelrod, Michael J. Weber, Qin Liu, Gordon B. Mills, Jessie Villanueva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2381.
https://doi.org/10.1158/1538-7445.AM2018-2381
Published: 01 July 2018
View articletitled, Abstract 2381: Loss of S6K2 perturbs redox balance and fatty acid metabolism, leading to oxidative cell death
Journal Articles

BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer

Yuhki Yokoyama, Hengrui Zhu, Jeong Heon Lee, Andrew V. Kossenkov, Sherry Y. Wu, Jayamanna M. Wickramasinghe, Xiangfan Yin, Katherine C. Palozola, Alessandro Gardini, Louise C. Showe, Kenneth S. Zaret, Qin Liu, David Speicher, Jose R. Conejo-Garcia, James E. Bradner, Zhiguo Zhang, Anil K. Sood, Tamas Ordog, Benjamin G. Bitler, Rugang Zhang
Journal: Cancer Research
Cancer Res (2016) 76 (21): 6320–6330.
https://doi.org/10.1158/0008-5472.CAN-16-0854
Published: 31 October 2016
View articletitled, BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer
Open the PDF for BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors

Anna Budina-Kolomets, Marie R. Webster, Julia I-Ju Leu, Matthew Jennis, Clemens Krepler, Anastasia Guerrini, Andrew V. Kossenkov, Wei Xu, Giorgos Karakousis, Lynn Schuchter, Ravi K. Amaravadi, Hong Wu, Xiangfan Yin, Qin Liu, Yiling Lu, Gordon B. Mills, Xiaowei Xu, Donna L. George, Ashani T. Weeraratna, Maureen E. Murphy
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2720–2730.
https://doi.org/10.1158/0008-5472.CAN-15-2137
Published: 01 May 2016
View articletitled, HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Open the PDF for HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

Marie R. Webster, Mai Xu, Kathryn Kinzler, Amanpreet Kaur, Jessica Appleton, Michael P. O'Connell, Katie Marchbank, Alexander Valiga, Vanessa Dang, Michela Perego, Gao Zhang, Ana Slipicevic, Frederick Keeney, Elin Lehrmann, William Wood, III, Kevin Becker, Andrew V. Kossenkov, Meenhard Herlyn, Maureen Murphy, Ashani T. Weeraratna
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): B27.
https://doi.org/10.1158/1538-7445.MEL2014-B27
Published: 16 July 2015
View articletitled, Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites
Journal Articles

Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer

Alessia Lopergolo, Michele Tavecchio, Sofia Lisanti, Jagadish C. Ghosh, Takehiko Dohi, Alice Faversani, Valentina Vaira, Silvano Bosari, Nobuhiko Tanigawa, Domenico Delia, Andrew V. Kossenkov, Louise C. Showe, Dario C. Altieri
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3251–3259.
https://doi.org/10.1158/0008-5472.CAN-11-4035
Published: 01 July 2012
View articletitled, Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer
Open the PDF for Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer in another window
Includes: Supplementary data
Journal Articles

Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program

Dmitri G. Negorev, Olga V. Vladimirova, Andrew V. Kossenkov, Elena V. Nikonova, Renee M. Demarest, Anthony J. Capobianco, Michael K. Showe, Frank J. Rauscher, III, Louise C. Showe, Gerd G. Maul
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9991–10001.
https://doi.org/10.1158/0008-5472.CAN-10-1483
Published: 06 December 2010
View articletitled, Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program
Open the PDF for Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program in another window
Includes: Supplementary data