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Andrew M. Lowy
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Journal Articles

Abstract LB282: Overcoming chemotherapy resistance in pancreatic cancer: The impact of novel RAS inhibitors and tumor microenvironment modulation

Free
Kevin C. Gulay, Jay Patel, Rithika Medari, Alexei Martsinkovskiy, Timothy Pham, Tatiana Hurtado De Mendoza, Andrew M. Lowy, Hervé Tiriac
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB282.
https://doi.org/10.1158/1538-7445.AM2025-LB282
Published: 25 April 2025
View articletitled, Abstract LB282: Overcoming chemotherapy resistance in pancreatic cancer: The impact of novel RAS inhibitors and tumor microenvironment modulation
Journal Articles

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Open Access
Bharti Garg, Sohini Khan, Asimina S. Courelli, Ponmathi Panneerpandian, Deepa Sheik Pran Babu, Evangeline S. Mose, Kevin Christian Montecillo Gulay, Shweta Sharma, Divya Sood, Alexander T. Wenzel, Alexei Martsinkovskiy, Nirakar Rajbhandari, Jay Patel, Dawn Jaquish, Edgar Esparza, Katelin Jaque, Neetu Aggarwal, Guillem Lambies, Anthony D’Ippolito, Kathryn Austgen, Brian Johnston, David A. Orlando, Gun Ho Jang, Steven Gallinger, Elliot Goodfellow, Pnina Brodt, Cosimo Commisso, Pablo Tamayo, Jill P. Mesirov, Hervé Tiriac, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1049–1063.
https://doi.org/10.1158/0008-5472.CAN-24-0744
Published: 14 March 2025
View articletitled, MICAL2 Promotes Pancreatic Cancer Growth and Metastasis
Open the PDF for MICAL2 Promotes Pancreatic Cancer Growth and Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract A052: Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy

Free
Bharti Garg, Evangeline Mose, Edgar Esparaza, Jay Patel, Rithika Medari, Alexei Martsinkovskiy, Carrie Bishop, Gissele Gonzalez, Adam Engler, Parag Katira, Herve Tiriac, Andrew M Lowy
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A052.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A052
Published: 15 September 2024
View articletitled, Abstract A052: Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy
Journal Articles

Abstract 2979: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to create a fibronectin-rich extracellular matrix niche and promote tumor initiation

Free
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I. Wettersten, Alejandro Campos, Tami Von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G. Childers, Andrew M. Lowy, Sara M. Weis, David A. Cheresh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2979.
https://doi.org/10.1158/1538-7445.AM2024-2979
Published: 22 March 2024
View articletitled, Abstract 2979: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to create a fibronectin-rich extracellular matrix niche and promote tumor initiation
Journal Articles

Abstract B026: αvβ5 Integrin serves as a tumor-specific marker for immunosuppressive regulatory T cells in pancreatic cancer

Free
Yuki Kunisada, Kodai Suzuki, Norio Miyamura, Shingo Eikawa, Tatiana Hurtado de Mendoza, Evangeline S. Mose, Caisheng Lu, Yukihito Kuroda, Erkki Ruoslahti, Andrew M. Lowy, Kazuki N. Sugahara
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B026.
https://doi.org/10.1158/1538-7445.PANCA2023-B026
Published: 16 January 2024
View articletitled, Abstract B026: αvβ5 Integrin serves as a tumor-specific marker for immunosuppressive regulatory T cells in pancreatic cancer
Journal Articles

Abstract A039: Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+ T cell dependent mechanism

Free
Bharti Garg, EvanGeline Mose, Edgar Esparza, Jay Patel, Sarah Sass, Alexei Martsinkovskiy, Dawn Jacquish, Herve Tiriac, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A039.
https://doi.org/10.1158/1538-7445.PANCA2023-A039
Published: 16 January 2024
View articletitled, Abstract A039: Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+ T cell dependent mechanism
Journal Articles

Abstract B059: A novel pancreatic cancer mouse model with human immunity

Free
Norio Miyamura, Kodai Suzuki, Richard A. Friedman, Aristidis Floratos, Yuki Kunisada, Kazuya Masuda, Andrew M. Lowy, Moriya Tsuji, Kazuki N. Sugahara
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B059.
https://doi.org/10.1158/1538-7445.PANCA2023-B059
Published: 16 January 2024
View articletitled, Abstract B059: A novel pancreatic cancer mouse model with human immunity
Journal Articles

Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma

Open Access
Kevin Christian Montecillo Gulay, Xinlian Zhang, Vasiliki Pantazopoulou, Jay Patel, Edgar Esparza, Deepa Sheik Pran Babu, Satoshi Ogawa, Jonathan Weitz, Isabella Ng, Evangeline S. Mose, Minya Pu, Dannielle D. Engle, Andrew M. Lowy, Hervé Tiriac
Journal: Cancer Research
Cancer Res (2023) 83 (18): 3001–3012.
https://doi.org/10.1158/0008-5472.CAN-23-1313
Published: 15 September 2023
View articletitled, Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma
Open the PDF for Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma

Open Access
Deepak Rohila, In Hwan Park, Timothy V. Pham, Jonathan Weitz, Tatiana Hurtado de Mendoza, Suresh Madheswaran, Mehreen Ishfaq, Cooper Beaman, Elisabette Tapia, Siming Sun, Jay Patel, Pablo Tamayo, Andrew M. Lowy, Shweta Joshi
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2675–2689.
https://doi.org/10.1158/0008-5472.CAN-22-3645
Published: 15 August 2023
View articletitled, Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma
Open the PDF for Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1328: Building a 3D co-culture model for metastatic pancreatic ductal cancer using Curiochips microphysiological system

Free
Sumin Kim, Yeongmin Choi, Jihye Baek, Bharti Garg, Jan Pencik, Andrew M. Lowy, Herve Tiriac, Sanghee Yoo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1328.
https://doi.org/10.1158/1538-7445.AM2023-1328
Published: 04 April 2023
View articletitled, Abstract 1328: Building a 3D co-culture model for metastatic pancreatic ductal cancer using Curiochips microphysiological system
Journal Articles

Abstract C021: Targeted delivery of neoantigens to pancreatic cancer to enable immunotherapy

Free
Siming Sun, Jay Patel, Alexis Wascher, Evangeline S. Mose, Dawn Jaquish, Spencer Brightman, Stephen Schoenberger, Andrew M. Lowy, Tatiana Hurtado de Mendoza
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C021.
https://doi.org/10.1158/1538-7445.PANCA22-C021
Published: 15 November 2022
View articletitled, Abstract C021: Targeted delivery of neoantigens to pancreatic cancer to enable immunotherapy
Journal Articles

Abstract A029: A randomized study of two Strategies of remote Genetic Education, Risk Assessment, and Testing (GENERATE) for family members of patients with pancreatic cancer

Free
Nicolette J. Rodriguez, C. Sloane Furniss, Matthew B. Yurgelun, Chinedu Ukaegbu, Pamela E. Constantinou, Ileana Fortes, Alyson Caruso, Alison N. Schwartz, Jill E. Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H. Nelson, Sydney Okumura, Alicia Y. Zhou, Tara B. Coffin, Hajime Uno, Miki Horiguchi, Allyson J. Ocean, Florencia McAllister, Andrew M. Lowy, Scott M. Lippman, Alison P. Klein, Lisa Madlensky, Gloria M. Petersen, Judy E. Garber, Michael G. Goggins, Anirban Maitra, Sapna Syngal
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A029.
https://doi.org/10.1158/1538-7445.PANCA22-A029
Published: 15 November 2022
View articletitled, Abstract A029: A randomized study of two Strategies of remote Genetic Education, Risk Assessment, and Testing (GENERATE) for family members of patients with pancreatic cancer
Journal Articles

Abstract A072: Strategies to improve KRAS G12D inhibitor (MRTX1133) therapy in pancreatic ductal adenocarcinoma

Free
Kevin Christian M. Gulay, Edgar Esparza, Xinlian Zhang, Evangeline S. Mose, Jonathan Weitz, Minya Pu, Karen Messer, Andrew M. Lowy, Herve Tiriac
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A072.
https://doi.org/10.1158/1538-7445.PANCA22-A072
Published: 15 November 2022
View articletitled, Abstract A072: Strategies to improve KRAS G12D inhibitor (MRTX1133) therapy in pancreatic ductal adenocarcinoma
Journal Articles

Abstract B017: MICAL2 promotes pancreatic cancer growth and metastasis independent of MRTF-A signaling

Free
Sohini Khan, Shweta Sharma, Divya Sood, Bharti Garg, Dawn Jaquish, Evangeline Mose, Edgar Esparza, Herve Tiriac, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B017.
https://doi.org/10.1158/1538-7445.PANCA22-B017
Published: 15 November 2022
View articletitled, Abstract B017: MICAL2 promotes pancreatic cancer growth and metastasis independent of MRTF-A signaling
Journal Articles

Abstract 385: iRGD mediated delivery of neoantigens to enable immunotherapy in integrin b5-rich tumors

Free
Tatiana Hurtado de Mendoza, Evangeline S. Mose, Gregory P. Botta, Gary B. Braun, Venkata R. Kotamraju, Randall P. French, Kodai Suzuki, Norio Miyamura, Siming Sun, Jay Patel, Tambet Teesalu, Erkki Ruoslahti, Kazuki N. Sugahara, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 385.
https://doi.org/10.1158/1538-7445.AM2022-385
Published: 15 June 2022
View articletitled, Abstract 385: iRGD mediated delivery of neoantigens to enable immunotherapy in integrin b5-rich tumors
Journal Articles

Abstract PO-013: Comparison of novel healthcare delivery models on the uptake of genetic education and testing in families with a history of pancreatic cancer: The GENetic Education, Risk Assessment and TEsting (GENERATE) study

Free
Nicolette J. Rodriguez, Constance S. Furniss, Matthew B. Yurgelun, Chinedu Ukaegbu, Pamela E. Constantinou, Alison N. Schwartz, Jill Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott Nelson, Sydney Okumura, Sherman Law, Alicia Y. Zhou, Tara B. Coffin, Hajime Uno, Allyson Ocean, Florencia McAllister, Andrew M. Lowy, Scott M. Lippman, Alison P. Klein, Lisa Madlensky, Gloria M. Petersen, Judy E. Garber, Michael G. Goggins, Anirban Maitra, Sapna Syngal
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-013.
https://doi.org/10.1158/1538-7445.PANCA21-PO-013
Published: 15 November 2021
View articletitled, Abstract PO-013: Comparison of novel healthcare delivery models on the uptake of genetic education and testing in families with a history of pancreatic cancer: The GENetic Education, Risk Assessment and TEsting (GENERATE) study
Journal Articles

Abstract PO-036: Defining the role of chromatin remodelers in pancreatic cancer

Free
Lesley Paige Ferguson, Jovylyn Gatchalian, Nikki Lytle, Nirakar Rajbhandari, Matthew McDermott, Kendall Chambers, Sara Brin Rosenthal, Christian Schuerch, Inti Zlobec, Marten Wartenberg, Eva Diamantis, José A. Galván, Sonia Albini, Lorenzo Puri, Benoit Bruneau, Andrew M. Lowy, Diana Hargreaves, Tannishtha Reya
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-036.
https://doi.org/10.1158/1538-7445.PANCA20-PO-036
Published: 13 November 2020
View articletitled, Abstract PO-036: Defining the role of chromatin remodelers in pancreatic cancer
Journal Articles

Abstract A07: Mst1r inhibition with LY2801653 increases survival in mice bearing aggressive pancreatic adenocarcinoma organoid model

Free
Betzaira G. Childers, Divya Sood, Dawn Jaquish, Andrew M. Lowy
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A07.
https://doi.org/10.1158/1538-7445.PANCA19-A07
Published: 13 December 2019
View articletitled, Abstract A07: Mst1r inhibition with LY2801653 increases survival in mice bearing aggressive pancreatic adenocarcinoma organoid model
Journal Articles

Abstract 118: GPR68, a proton-sensing GPCR that mediates interaction of pancreatic cancer associated fibroblasts and cancer cells, is a potential therapeutic target for pancreatic cancer

Free
Shu Z. Wiley, Krishna Sriram, Cristina Salmeron-Salvador, Hiroshi Nishihara, Randall French, Andrew M. Lowy, Paul A. Insel
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 118.
https://doi.org/10.1158/1538-7445.AM2019-118
Published: 01 July 2019
View articletitled, Abstract 118: GPR68, a proton-sensing GPCR that mediates interaction of pancreatic cancer associated fibroblasts and cancer cells, is a potential therapeutic target for pancreatic cancer
Journal Articles

Abstract 5076: Pancreatic ductal adenocarcinoma associated stellate cells promote a pro-metastatic microenvironment in the liver

Free
John David Konda, Masakazu Hashimoto, Jian Zhang, Maria Celia Fernandez, Ni Wang, Stephanie Perrino, Laura Montermini, Janusz Rak, Jean-Sebastien Pelletier, Andrew M. Lowy, Pnina Brodt
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5076.
https://doi.org/10.1158/1538-7445.AM2018-5076
Published: 01 July 2018
View articletitled, Abstract 5076: Pancreatic ductal adenocarcinoma associated stellate cells promote a pro-metastatic microenvironment in the liver