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Andrew Lam
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Journal Articles

Abstract C002: CKLF attracts CCR4-expressing CD4+ cells to foster immune repression and tumor aggressiveness in MYCN-driven neuroblastoma

Free
Xiaodan Qin, Hui Feng, Andrew Lam, Xu Zhang, Satyaki Sengupta, Bryan Iorgulescu, Sanjukta Das, Zhenwei Zhou, Tao Zuo, Grace Meara, Madison Rager, Alexander Floru, Hongru Ni, Chinyere Kemet, Divya Veerapaneni, Daniel Kashy, Liang Lin, Kenneth Lloyd, Lauren Kwok, Kaylee Smith, Raghavendar Nagaraju, Rob Meijers, Craig Ceol, Ching-Ti Liu, Sanda Alexandrescu, Catherine J. Wu, Derin Keskin, Rani George
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): C002.
https://doi.org/10.1158/1538-7445.TUMBODY-C002
Published: 17 November 2024
View articletitled, Abstract C002: CKLF attracts CCR4-expressing CD4+ cells to foster immune repression and tumor aggressiveness in MYCN-driven neuroblastoma
Journal Articles

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Available to Purchase
Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, Rindert Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Thomas Look, Guoliang Qing, M. Celeste Simon, Hui Feng
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4417–4430.
https://doi.org/10.1158/0008-5472.CAN-20-2153
Published: 01 September 2021
View articletitled, Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma
Open the PDF for Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5627: Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition

Free
Gretchen M. Argast, Belinda Cancilla, Fiore Cattaruzza, Pete Yeung, Erwan le Scolan, Rose Harris, Reyhaneh Lahmy, Alayne Brunner, Min Wang, Gilbert O'Young, Earth Light Lowe, Fumiko Axelrod, Jorge Monteon, Jennifer Elechko, Andrew Lam, MingHong Xie, Austin Gurney, John Lewicki, Ann Kapoun
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5627.
https://doi.org/10.1158/1538-7445.AM2018-5627
Published: 01 July 2018
View articletitled, Abstract 5627: Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition
Journal Articles

Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth

Free
Gretchen M. Argast, Belinda Cancilla, Fiore Cattaruzza, Pete Yeung, Reyhaneh Lahmy, Erwan Le Scolan, Rose Harris, Alayne Brunner, Min Wang, Fumiko Axelrod, Jorge Monteon, Jennifer Elechko, Andrew Lam, MingHong Xie, Earth Light Lowe, Gilbert O'Young, Austin Gurney, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3826.
https://doi.org/10.1158/1538-7445.AM2018-3826
Published: 01 July 2018
View articletitled, Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth
Journal Articles

Abstract 2726: In vitro functional activity of OMP-336B11, a GITRL-Fc fusion protein, on primary human immune cells

Free
Ivan H. Chan, Ming-Hong Xie, Andrew Lam, Fumiko T. Axelrod, Jennifer Elechko, Angie I. Park, Austin Gurney
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2726.
https://doi.org/10.1158/1538-7445.AM2018-2726
Published: 01 July 2018
View articletitled, Abstract 2726: In vitro functional activity of OMP-336B11, a GITRL-Fc fusion protein, on primary human immune cells
Journal Articles

Abstract 2003: Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory

Free
Angie Inkyung Park, Minu Srivastava, Erin Mayes, Hyun-Bae Jie, Rui Yun, Christopher Murriel, Ming-hong Xie, Andrew Lam, May Ji, Fumiko Axelrod, Jorge Monteon, John Lewicki, Tim Hoey, Austin Gurney
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2003.
https://doi.org/10.1158/1538-7445.AM2017-2003
Published: 01 July 2017
View articletitled, Abstract 2003: Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory
Journal Articles

Abstract 2612: Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity

Free
Minu K. Srivastava, Rui Yun, Erin Mayes, Janice Yu, Hyun-Bae Jie, Fumiko Axelrod, Ming-Hong Xie, Jorge Monteon, Andrew Lam, May Ji, Yuwang Liu, John Lewicki, Tim Hoey, Austin Gurney, Angie Inkyung Park
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2612.
https://doi.org/10.1158/1538-7445.AM2017-2612
Published: 01 July 2017
View articletitled, Abstract 2612: Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity
Journal Articles

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Free
Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M. Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M. Kapoun, John Lewicki, Timothy Hoey, Austin Gurney
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (3): 713–723.
https://doi.org/10.1158/0008-5472.CAN-15-0561
Published: 31 January 2016
View articletitled, Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Open the PDF for Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types in another window
Includes: Supplementary data
Journal Articles

SX-007, a small molecule TGF-β receptor I kinase inhibitor, prolongs animal survival in the syngeneic SMA560 glioma model

Free
Thomas-Toan Tran, Jing Ying Ma, Irene Kerr, Lisa Janssen, Ann Kapoun, Andrew Lam, Glenn McEnroe, Barry Hart, Jonathan Axon, Alison Murphy, Andrew A. Protter, Linda S. Higgins, Darren H. Wong
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1419.
Published: 01 May 2005
View articletitled, SX-007, a small molecule TGF-β receptor I kinase inhibitor, prolongs animal survival in the syngeneic SMA560 glioma model