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Andrew J. Aguirre
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Journal Articles

Abstract LB281: Mechanisms of resistance to the RAS(ON) multi-selective inhibitor daraxonrasib (RMC-6236) in RAS mutant PDAC and potential resolution with RAS(ON) combination therapies

Free
Sumit Kar, Yongxian Zhuang, Ethan Ahler, Lick P. Lai, Alexander Starodub, Alexander Spira, Salman R. Punekar, Ignacio Garrido-Laguna, Wungki Park, David S. Hong, Anirban Maitra, David Sommerhalder, Minal Barve, Meredith Pelster, Harika Gundlapalli, Vidya Seshadri, Shurui Cai, Mark Labrecque, Wan-Ying Hsieh, Sean Bredeson, Jim Evans, Brett Garrick, Yevgeniy Gindin, Cristina Blaj, Marie Menard, Lingyan Jiang, Elsa Quintana, Matthew Holderfield, Aparna Hegde, Jingjing Jiang, Zeena Salman, W Clay Gustafson, Jacqueline A. Smith, Brian Wolpin, Ida Aronchik, Kevin K. Lin, Andrew J. Aguirre, Mallika Singh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB281.
https://doi.org/10.1158/1538-7445.AM2025-LB281
Published: 25 April 2025
View articletitled, Abstract LB281: Mechanisms of resistance to the RAS(ON) multi-selective inhibitor daraxonrasib (RMC-6236) in RAS mutant PDAC and potential resolution with RAS(ON) combination therapies
Journal Articles

Abstract 5998: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

Free
Amber N. Habowski, Hardik Patel, Caitlin Tsang, Luce St. Surin, Dennis Plenker, Fatim M. Kouassi, Raditya Utama, James Rouse, Deepthi Budagavi, Grainne M. O'Kane, Stephanie Ramotar, Anna Dodd, Julie Wilson, Kenneth H. Yu, Faiyaz Notta, Robert C. Grant, Steven Gallinger, Eileen M. O'Reilly, Kimberly Perez, Andrew J. Aguirre, Brian M. Wolpin, Dan A. Laheru, Daniel A. King, Elizabeth M. Jaffee, Jennifer J. Knox, David A. Tuveson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5998.
https://doi.org/10.1158/1538-7445.AM2025-5998
Published: 21 April 2025
View articletitled, Abstract 5998: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC
Journal Articles

Abstract 1254: Neural-like progenitor pancreatic cancer cells are enriched in residual disease following neoadjuvant chemoradiotherapy and acquire invasive and stem-like features through inflammatory reprogramming

Free
Dennis Gong, Jimmy A. Guo, Jennifer Su, Sueda Cetinkaya, Peter Wang, Ashley Lam, Carina Shiau, Laleh Abbassi, Seema Chugh, Andrew J. Aguirre, William L. Hwang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1254.
https://doi.org/10.1158/1538-7445.AM2025-1254
Published: 21 April 2025
View articletitled, Abstract 1254: Neural-like progenitor pancreatic cancer cells are enriched in residual disease following neoadjuvant chemoradiotherapy and acquire invasive and stem-like features through inflammatory reprogramming
Journal Articles

Abstract 5926: Determining classical-basal transcriptional subtypes of pancreatic ductal adenocarcinoma using circulating tumor DNA epigenomic profiling

Free
Karl Semaan, Marc Eid, Damien Vasseur, Gunsagar S. Gulati, Ji-Heui Seo, Alexander Jordan, Andressa Dias Costa, John Canniff, Leigh Culnane, Elizabeth Andrews, Emma C. Coleman, Noa Phillips, Brad Fortunato, Hunter Savignano, Rashad Nawfal, Razane El Hajj Chehade, Talal El Zarif, Ze Zhang, Paulo Cordeiro, Antoine Hollebecque, Antoine Italiano, Brandon M. Huffman, James M. Cleary, Jonathan Nowak, Jacob E. Berchuck, Toni K. Choueiri, Kimberly Perez, Andrew J. Aguirre, Sylvan C. Baca, Brian M. Wolpin, Matthew L. Freedman, Harshabad Singh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5926.
https://doi.org/10.1158/1538-7445.AM2025-5926
Published: 21 April 2025
View articletitled, Abstract 5926: Determining classical-basal transcriptional subtypes of pancreatic ductal adenocarcinoma using circulating tumor DNA epigenomic profiling
Journal Articles

Abstract 2930: Intrinsic payload resistance governs responses to datopotamab deruxtecan, a TROP2 antibody drug conjugate, in pancreatic cancer model systems

Free
Panot Sainamthip, Kazuki Takahashi, Jiajia Chen, Junning Wang, Julien Dilly, Seema Chugh, David Lui, Andrew J. Aguirre, Harshabad Singh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2930.
https://doi.org/10.1158/1538-7445.AM2025-2930
Published: 21 April 2025
View articletitled, Abstract 2930: Intrinsic payload resistance governs responses to datopotamab deruxtecan, a TROP2 antibody drug conjugate, in pancreatic cancer model systems
Journal Articles

Abstract 5507: Mechanisms of resistance to RAS-GTP inhibition in pancreatic cancer

Free
Joshua H. Choe, Julien Dilly, Eejung Kim, Lick P. Lai, Nicole Sindoni, Fan Yi Kong, Dennis Gong, Jaclyn Varga-Wiles, Brendan Parent, Junning Wang, Kyle Seamon, Jennifer A. Chan, Clint A. Stalnecker, Channing J. Der, William L. Hwang, Brian M. Wolpin, David Wildes, Joseph D. Mancias, Lewis C. Cantley, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5507.
https://doi.org/10.1158/1538-7445.AM2025-5507
Published: 21 April 2025
View articletitled, Abstract 5507: Mechanisms of resistance to RAS-GTP inhibition in pancreatic cancer
Journal Articles

Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer

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Andrew J. Aguirre, Ben Z. Stanger, Anirban Maitra
Journal: Cancer Research
Cancer Res (2024) 84 (18): 2950–2953.
https://doi.org/10.1158/0008-5472.CAN-24-1926
Published: 16 September 2024
View articletitled, Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer
Open the PDF for Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer in another window
Journal Articles

Abstract PR-21: Temporal stability and chemotherapy responsiveness of classical and basal transcriptional subtypes of pancreatic cancer

Free
Harshabad Singh, Joanne Xiu, Kevin Kapner, Chen Yuan, Raja R Narayan, Matthew Oberley, Alex Farrell, Rishi Surana, Brandon M Huffmann, Kimberly J Perez, James M Cleary, Alexander C Jordan, Andressa Dias Costa, Hannah L Williams, Srivatsan Raghavan, Benjamin Weinberg, Michael J Pishvaian, Rachna T Shroff, Sanjay Goel, Stephanie K Dougan, Jonathan Nowak, David Spetzler, George Sledge, Brian M Wolpin, Andrew J Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-21.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-21
Published: 15 September 2024
View articletitled, Abstract PR-21: Temporal stability and chemotherapy responsiveness of classical and basal transcriptional subtypes of pancreatic cancer
Journal Articles

Abstract C024: Quantitative mass spectrometry-based multi-omic profiling to overcome drug resistance in pancreatic cancer post KRAS G12D inhibition

Free
Qijia Yu, Nicole Sindoni, Huan Zhang, Ziyue Li, Joao A. Paulo, Andrew J. Aguirre, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C024.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C024
Published: 15 September 2024
View articletitled, Abstract C024: Quantitative mass spectrometry-based multi-omic profiling to overcome drug resistance in pancreatic cancer post KRAS G12D inhibition
Journal Articles

Abstract PR-07: Discovery and therapeutic potential of novel cryptic peptides in pancreatic cancer

Free
Zackery A Ely, Zachary J Kulstad, Gurcan Gunaydin, Sudarsana Addepalli, Eva K Verzani, Jennifer G Abelin, Marta Casarrubios, Karl R Clauser, Xilin Wang, Isabelle Lippincott, Cedric Louvet, Tom Schmitt, Miles Agus, Kevin S Kapner, Connor J Hennessey, James Cleary, Sine R Hadrup, Susan Klaeger, Jennifer Su, Alex M Jaeger, Brian M Wolpin, Srivatsan Raghavan, Eric Smith, Philip D Greenberg, Andrew J Aguirre, Steven A Carr, Tyler Jacks, William A Freed-Pastor
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-07.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-07
Published: 15 September 2024
View articletitled, Abstract PR-07: Discovery and therapeutic potential of novel cryptic peptides in pancreatic cancer
Journal Articles

Abstract PR-17: Genomic and transcriptomic characterization of pancreatic cancer patients on the PASS-01 trial

Free
Grainne M O'Kane, Gunho Jang, Trevor J Pugh, Julie Wilson, Stephanie Ramotar, Daniel A King, Dan Laheru, Ken H Yu, Kimberly J Perez, Amber Habowski, Erica S Tsang, Robert C Grant, Andrew J Aguirre, Raymond W-J Jang, Craig E Devoe, Eileen M O'Reilly, Anna Dodd, Brian M Wolpin, Xiang Y Ye, Elizabeth M Jaffee, David Tuveson, Steven Gallinger, Jennifer J Knox, Faiyaz Notta
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-17.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-17
Published: 15 September 2024
View articletitled, Abstract PR-17: Genomic and transcriptomic characterization of pancreatic cancer patients on the PASS-01 trial
Journal Articles

Abstract A001: An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer

Free
Rishi Surana, Hui Zheng, Junning Wang, Micaela Morgado, Lauren K Brais, Kirsten L Bryant, Ashwin Somasundaram, Colin D Weekes, Bruno Bockorny, Mary Linton B Peters, Andrea J Bullock, Jessica A Zerillo, Ahmed A Rattani, Hanna K Sanoff, Jeffrey W Clark, Aparna R Parikh, Matthew B Yurgelun, Anuj Patel, Robert J Mayer, James M Cleary, Peter C Enzinger, Douglas A Rubinson, Nadine J McCleary, Andrea C Enzinger, Sarah E Slater, Kimmie Ng, Thomas A Abrams, Leah Biller, Srivatsan Raghavan, Joseph D Mancias, Jonathan O Nowak, Andrew J Aguirre, Channing J Der, Brian M Wolpin, Kimberley Perez
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A001.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A001
Published: 15 September 2024
View articletitled, Abstract A001: An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer
Journal Articles

Abstract PR-04: Phase 2 Trial Testing The PARP Inhibitor Niraparib In Patients With Advanced Pancreatic Cancer with Pathogenic Variants In BRCA 1, BRCA2, PALB2, ATM and CHEK2

Free
Brandon M. Huffman, Jett Crowdis, Matthew B. Yurgelun, Nora Horick, Yvonne Li, Huy Nguyen, Kalindi Parmar, Bose S. Kochupurakkal, Andrea Enzinger, Marios Giannakis, Nadine McCleary, Kimmie Ng, Anuj K. Patel, Kimberly J. Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Harshabad Singh, Helen Lam, Kaitlyn Ramsey, Elizabeth Andrews, Leigh Culnane, Andrea Bullock, Ahmed Rattani, Jeffrey Clark, Mary Linton Peters, Brian M. Wolpin, Alan D. D'Andrea, Geoffrey I. Shapiro, Andrew J. Aguirre, James M. Cleary
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-04.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-04
Published: 15 September 2024
View articletitled, Abstract PR-04: Phase 2 Trial Testing The PARP Inhibitor Niraparib In Patients With Advanced Pancreatic Cancer with Pathogenic Variants In BRCA 1, BRCA2, PALB2, ATM and CHEK2
Journal Articles

Abstract C032: De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

Free
huan zhang, Qijia yu, Naiara Santana-Codina, Clara Poupault, Claudia Campos, Xingping Qin, Aparna Padhye, Nicole Sindoni, Miljan Kuljanin, Junning Wang, Matthew J. Dorman, Andrew J. Aguirre, Stephanie K. Dougan, Kristopher A. Sarosiek, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C032.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C032
Published: 15 September 2024
View articletitled, Abstract C032: De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
Journal Articles

Abstract LB203: CRISPR anchor screens to identify co-vulnerabilities and drug combinations in DepMap

Free
Jenny Serra-Vinardell, Zoe Posner, Alison Cameron, Yuqi Chen, Negin Karisani, Barbara De Kegel, Joshua M. Dempster, Andrew J. Aguirre, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB203.
https://doi.org/10.1158/1538-7445.AM2024-LB203
Published: 05 April 2024
View articletitled, Abstract LB203: CRISPR anchor screens to identify co-vulnerabilities and drug combinations in DepMap
Journal Articles

Abstract 1933: Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Free
Julien Dilly, Laleh Abbassi, Connor J. Hennessey, Giselle A. Uribe, Brendan Parent, Annan Yang, Kevin S. Kapner, Ziyue Li, Kyle E. Evans, Shatavisha Dasgupta, Megan T. Hoffman, Li Qiang, Felix P. Hambitzer, Seema Chugh, Alex K. Shalek, Stephanie K. Dougan, Brian M. Wolpin, Jonathan A. Nowak, Srivatsan Raghavan, Peter S. Winter, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1933.
https://doi.org/10.1158/1538-7445.AM2024-1933
Published: 22 March 2024
View articletitled, Abstract 1933: Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1927: Resistance to RAS-GTP inhibition in models of pancreatic ductal adenocarcinoma arises downstream of RAS effectors

Free
Urszula N. Wasko, Jingjing Jiang, Yingyun Wang, Lorenzo Tomassoni, Lingyan Jiang, Marie Menard, Alvaro Curiel-Garcia, Tanner C. Dalton, Margo Orlen, Cole Edwards, Clint Stalnecker, Julien Dilly, Stephanie Chang, Stephen A. Sastra, Carmine F. Palermo, Timour Baslan, Sha Tian, Matthew Holderfield, Elsa Quintana, Zhengping Wang, Jacqueline A. Smith, Andrea Califano, David Wildes, Andrew J. Aguirre, Robert H. Vonderheide, Ben Z. Stanger, Scott W. Lowe, Channing J. Der, Mallika Singh, Kenneth P. Olive
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1927.
https://doi.org/10.1158/1538-7445.AM2024-1927
Published: 22 March 2024
View articletitled, Abstract 1927: Resistance to RAS-GTP inhibition in models of pancreatic ductal adenocarcinoma arises downstream of RAS effectors
Journal Articles

Abstract 4588: Combination of MTA-cooperative PRMT5 inhibitor and direct mutant-selective KRAS inhibitors as a novel therapeutic approach for MTAP-deficient pancreatic cancer

Free
Kristina Drizyte-Miller, Wen-Hsuan Chang, Andrew M. Waters, Clint A. Stalnecker, Junning Wang, Andrew J. Aguirre, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4588.
https://doi.org/10.1158/1538-7445.AM2024-4588
Published: 22 March 2024
View articletitled, Abstract 4588: Combination of MTA-cooperative PRMT5 inhibitor and direct mutant-selective KRAS inhibitors as a novel therapeutic approach for MTAP-deficient pancreatic cancer
Journal Articles

Abstract A117: Molecular stratification of therapeutic targets in pancreatic cancer

Free
Dennis Gong, Jimmy A. Guo, Carina Shiau, Ananya D. Jambhale, Steven Wang, Scott Ginebaugh, Patrick Z. Yu, Kevin S. Kapner, Seema Chugh, Laleh Abbassi, Daniel Zhao, Westley W. Wu, Peter Chen, Harshabad Singh, William L. Hwang, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A117.
https://doi.org/10.1158/1538-7445.PANCA2023-A117
Published: 16 January 2024
View articletitled, Abstract A117: Molecular stratification of therapeutic targets in pancreatic cancer
Journal Articles

Abstract B101: Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma

Free
Urszula N. Wasko, Jingjing Jiang, Lorenzo Tomassoni, Yingyun Wang, Bianca Lee, Margo Orlen, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Steven A. Sastra, Carmine F. Palermo, Stephanie Chang, Andrew J. Aguirre, Channing J. Der, Robert H. Vonderheide, Ben Z. Stanger, Andrea Califano, Mallika Singh, Kenneth P. Olive
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B101.
https://doi.org/10.1158/1538-7445.PANCA2023-B101
Published: 16 January 2024
View articletitled, Abstract B101: Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma