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Andres Klein-Szanto
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Journal Articles

Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression

Samuel Flashner, Masataka Shimonosono, Satoshi Takada, Norihiro Matsuura, Yasuto Tomita, Xiao Chen, Alison Taylor, Andres Klein-Szanto, Fatameh Momen-Heravi, J. Alan Diehl, Chao Lu, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3077.
https://doi.org/10.1158/1538-7445.AM2022-3077
Published: 15 June 2022
View articletitled, Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression
Journal Articles

Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development

Robert Agee, Samuel Flashner, Masataka Shimonosono, Andres Klein-Szanto, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3082.
https://doi.org/10.1158/1538-7445.AM2022-3082
Published: 15 June 2022
View articletitled, Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development
Journal Articles

Abstract 816: Cyclin c suppresses pancreatic intraepithelial neoplasm progression and neuroendocrine neoplasm development in a murine Kras model

Kathy Q. Cai, Sara E. Hanley, Andres Klein-Szanto, Kerry S. Campbell, Randy Strich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 816.
https://doi.org/10.1158/1538-7445.AM2022-816
Published: 15 June 2022
View articletitled, Abstract 816: Cyclin c suppresses pancreatic intraepithelial neoplasm progression and neuroendocrine neoplasm development in a murine Kras model
Journal Articles

Abstract 2578: Investigating the role of mutant p53 in esophageal squamous cell carcinoma

Ashley Lento, Apple Long, Veronique Giroux, Qiaosi Tang, Morgan Sammons, Andres Klein-Szanto, Shelly Berger, Anil Rustgi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2578.
https://doi.org/10.1158/1538-7445.AM2017-2578
Published: 01 July 2017
View articletitled, Abstract 2578: Investigating the role of mutant p53 in esophageal squamous cell carcinoma
Journal Articles

Abstract A32: Il-6 initiates a self-sustaining signaling loop to promote nurturing tumor microenvironment

Tatiana A. Karakasheva, Monica Soni, Todd J. Waldron, Eric W. Lin, Philip D. Hicks, Andres Klein-Szanto, Kwok K. Wong, Adam J. Bass, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): A32.
https://doi.org/10.1158/1538-7445.TME16-A32
Published: 28 July 2016
View articletitled, Abstract A32: Il-6 initiates a self-sustaining signaling loop to promote nurturing tumor microenvironment
Journal Articles

Abstract 1254: Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations

Kelly A. Whelan, Hideaki Kinugasa, Koji Tanaka, Satish Srinivasan, Manti Guha, Daret St. Clair, Andres Klein-Szanto, Narayan Avadhani, Alan Diehl, Anil Rustgi, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1254.
https://doi.org/10.1158/1538-7445.AM2015-1254
Published: 01 August 2015
View articletitled, Abstract 1254: Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations
Journal Articles

Abstract 3257: NEDD9 is required for initiation of HER2/Neu-dependent mammary tumor development

Joy L. Little, Eugene Izumchenko, Mahendra K. Singh, Sachiko Seo, Mineo Kurokawa, Brian L. Egleston, Andres Klein-Szanto, Erica A. Golemis
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3257.
https://doi.org/10.1158/1538-7445.AM10-3257
Published: 15 April 2010
View articletitled, Abstract 3257: NEDD9 is required for initiation of HER2/Neu-dependent mammary tumor development
Journal Articles

Abstract 2294: IGF-independent regulation of EMT by insulin-like growth factor binding protein-3 in transformed human esophageal cells

Mitsuteru Natsuizaka, Ross A. Kalman, Shinya Ohashi, Munenori Takaoka, Phyllis Gimotty, Wafik S. El-Deiry, Andres Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2294.
https://doi.org/10.1158/1538-7445.AM10-2294
Published: 15 April 2010
View articletitled, Abstract 2294: IGF-independent regulation of EMT by insulin-like growth factor binding protein-3 in transformed human esophageal cells
Journal Articles

NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

Eugene Izumchenko, Mahendra K. Singh, Olga V. Plotnikova, Nadezhda Tikhmyanova, Joy L. Little, Ilya G. Serebriiskii, Sachiko Seo, Mineo Kurokawa, Brian L. Egleston, Andres Klein-Szanto, Elena N. Pugacheva, Richard R. Hardy, Marina Wolfson, Denise C. Connolly, Erica A. Golemis
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7198–7206.
https://doi.org/10.1158/0008-5472.CAN-09-0795
Published: 14 September 2009
View articletitled, NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development
Open the PDF for NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development in another window
Includes: Supplementary data
Journal Articles

Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma

Yuwaraj Kadariya, Bu Yin, Baiqing Tang, Susan A. Shinton, Eoin P. Quinlivan, Xiang Hua, Andres Klein-Szanto, Tahseen I. Al-Saleem, Craig H. Bassing, Richard R. Hardy, Warren D. Kruger
Journal: Cancer Research
Cancer Res (2009) 69 (14): 5961–5969.
https://doi.org/10.1158/0008-5472.CAN-09-0145
Published: 15 July 2009
View articletitled, Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma
Open the PDF for Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma in another window
Includes: Supplementary data
Journal Articles

Abstract #2087: HEF1/NEDD9/CasL is required for activation of oncogenic signaling pathways in mammary tumor development

Eugene Izumchenko, Olga Plotnikova, Mahendra Singh, Nadezhda Tikhmyanova, Joy Little, Sachiko Seo, Mineo Kurokawa, Brian Egleston, Andres Klein-Szanto, Elena Pugacheva, Randy Hardy, Marina Wolfson, Denise Connolly, Erica Golemis
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2087.
Published: 01 May 2009
View articletitled, Abstract #2087: HEF1/NEDD9/CasL is required for activation of oncogenic signaling pathways in mammary tumor development
Journal Articles

Abstract #706: Evidence for DNA damage checkpoint activation in Barrett\#8217;s esophagus

Urs von Holzen, Tina Chen, Amelie Boquoi, Joel Richter, Gary Falk, Andres Klein-Szanto, Harry Cooper, Samuel Litwin, David Weinberg, Greg Enders
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 706.
Published: 01 May 2009
View articletitled, Abstract #706: Evidence for DNA damage checkpoint activation in Barrett\#8217;s esophagus
Journal Articles

Abstract #2497: The Rac-GEF P-Rex1 is an essential mediator of Rac activation and motility downstream of ErbB receptors in breast cancer cells

Maria Soledad Sosa, Chengfeng Yang, Cynthia Lopez-Haber, Andres Klein-Szanto, Mark Lemmon, J. Silvio Gutkind, Marcelo Kazanietz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2497.
Published: 01 May 2009
View articletitled, Abstract #2497: The Rac-GEF P-Rex1 is an essential mediator of Rac activation and motility downstream of ErbB receptors in breast cancer cells
Journal Articles

The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma

Tanguy Y. Seiwert, Ramasamy Jagadeeswaran, Leonardo Faoro, Varalakshmi Janamanchi, Vidya Nallasura, Mohamed El Dinali, Soheil Yala, Rajani Kanteti, Ezra E.W. Cohen, Mark W. Lingen, Leslie Martin, Soundararajan Krishnaswamy, Andres Klein-Szanto, James G. Christensen, Everett E. Vokes, Ravi Salgia
Journal: Cancer Research
Cancer Res (2009) 69 (7): 3021–3031.
https://doi.org/10.1158/0008-5472.CAN-08-2881
Published: 01 April 2009
View articletitled, The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma
Open the PDF for The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Hypoxia inducible factor-1α regulates cyclooxgenase-2 and prostaglandin E synthase in esophageal cancer.

James Lee, Kazuhiro Noma, Munenori Takaoka, Carmen Michaylira, Doug Stairs, Katharine Grugan, Jiri Kalabis, Daniela Budo, Yasuhiro Shirakawa, Michiyuki Kanai, Andres Klein-Szanto, Meenhard Herlyn, Volker Haase, Yoshio Naomoto, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2049.
Published: 01 May 2008
View articletitled, Hypoxia inducible factor-1α regulates cyclooxgenase-2 and prostaglandin E synthase in esophageal cancer.
Journal Articles

The micrornas mir-373 and mir-520c promote tumor migration, invasion and metastasis

Qihong Huang, Kiranmai Gumireddy, Mariette Schrier, Carlos le Sage, Remco Nagel, Suresh Nair, David Egan, Anping Li, Guanghua Huang, Andres Klein-Szanto, Gimotty Phyllis, Dionyssios Katsaros, George Coukos, Lin Zhang, Ellen Pure, Reuven Agami
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5015.
Published: 01 May 2008
View articletitled, The micrornas mir-373 and mir-520c promote tumor migration, invasion and metastasis
Journal Articles

Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis

Everardo Macias, Yongbaek Kim, Paula L. Miliani de Marval, Andres Klein-Szanto, Marcelo L. Rodriguez-Puebla
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9713–9720.
https://doi.org/10.1158/0008-5472.CAN-07-2119
Published: 17 October 2007
View articletitled, Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis
Open the PDF for Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis in another window
Journal Articles

Mrp4 protects proliferating tissues from nucleotide analog induced damage, and functions in the extrusion of sulfates across the basolateral surface of hepatocytes.

Martin Belinsky, James Gallo, Ping Guo, Kun Lee, Maciej Zamek-Gliszczynski, Ken-ichi Nezasa, Irina Shchaveleva, Elena Kotova, Alex Grinberg, Heiner Westphal, Andres Klein-Szanto, Kim Brouwer, Gary Kruh
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1628.
Published: 01 May 2007
View articletitled, Mrp4 protects proliferating tissues from nucleotide analog induced damage, and functions in the extrusion of sulfates across the basolateral surface of hepatocytes.
Journal Articles

Cdk2 deficiency decrease Ras/Cdk4-dependent malignant progression, but not c-Myc-induced tumorigenesis

Everardo Macias, Yongbaek Kim, Andres Klein-Szanto, Mariano Barbacid, Marcelo Rodriguez-Puebla
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5694.
Published: 01 May 2007
View articletitled, Cdk2 deficiency decrease Ras/Cdk4-dependent malignant progression, but not c-Myc-induced tumorigenesis
Journal Articles

Insulin-like growth factor binding protein-3, induced by hypoxia inducible factor-1α, determines esophageal cancer cell adaptation to the microenvironment

Munenori Takaoka, Seok-Hyun Kim, James Lee, Carmen Michaylira, Doug Stairs, Takaomi Okawa, Claudia Andl, Cameron Johnstone, Ben Rhoades, Andres Klein-Szanto, Wafik El-Deiry, Volker Haase, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 347.
Published: 01 May 2007
View articletitled, Insulin-like growth factor binding protein-3, induced by hypoxia inducible factor-1α, determines esophageal cancer cell adaptation to the microenvironment