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Andrei V. Gudkov
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Journal Articles

Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity

Craig M Brackett, Alyssa R Aldrich, Kellee F Greene, Bojidar Kandar, Jean Veith, Lyudmila G Burdelya, Scott I. Abrams, Andrei V Gudkov
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-04-02.
https://doi.org/10.1158/1538-7445.SABCS21-P4-04-02
Published: 15 February 2022
View articletitled, Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity
Journal Articles

Abstract 4496: Induction of immunogenicity in tumor cells by small molecule drugs that destabilize nucleosomes

Katerina Leonova, Alfiya Safina, Andrei V. Gudkov, Katerina V. Gurova
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4496.
https://doi.org/10.1158/1538-7445.AM2020-4496
Published: 15 August 2020
View articletitled, Abstract 4496: Induction of immunogenicity in tumor cells by small molecule drugs that destabilize nucleosomes
Journal Articles

Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Michelle Haber, Laura Gamble, Lin Xiao, Ruby Pandher, Klaartje Somers, Jayne Murray, Aaminah Khan, Denise Yu, Laura Franshaw, Mark R. Burns, Maria Tsoli, Anahid Ehteda, Anthony Cesare, Aisling O’Connor, Francis Mussai, Carmela de Santo, Paul Cheng, Lioubov Korotchkina, Katerina Gurova, Vanessa Tyrrell, Emily Mould, Loretta Lau, Dong Anh Khuong Quang, Chelsea Mayoh, Greg Arndt, Paulette Barahona, Tim Failes, Jamie Fletcher, Noemi Fuentes- Bolanos, Marie-Emilie Gauthier, Andrew Gifford, Dylan Grebert-Wade, Alvin Kamili, Amit Kumar, Sumanth Nagabushan, Tracey O’Brien, Patrick Strong, Alexandra Sherstyuk, David Thomas, Toby Trahair, Katherine Tucker, Meera Warby, Marie Wong, Jinhan Xie, Kathryn Evans, Richard Lock, Olga B. Chernova, Michelle Henderson, Andrei V Gudkov, Paul Ekert, Mark J. Cowley, Glenn M. Marshall, David S. Ziegler, Murray D. Norris
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA13.
https://doi.org/10.1158/1538-7445.PEDCA19-IA13
Published: 15 July 2020
View articletitled, Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies
Journal Articles

Abstract 1178: Unbiased efficacy-based screening of small molecules highly selective against hematological malignancies revealed inhibitor of NAD synthesis

Lioubov Korotchkina, Sangeeta Joshi, Slavoljub Vujcic, Ilya Toshkov, Mikhail Chernov, Denis Kazyulkin, Katerina Andrianova, Alexander Polinsky, Olga Chernova, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1178.
https://doi.org/10.1158/1538-7445.AM2017-1178
Published: 01 July 2017
View articletitled, Abstract 1178: Unbiased efficacy-based screening of small molecules highly selective against hematological malignancies revealed inhibitor of NAD synthesis
Journal Articles

Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia

Klaartje Somers, Shiloh Middlemiss, Asel Biktasova, Mawar Karsa, Leanna Cheung, Angelika Kosciolek, Kathryn Evans, Chelsea Mayoh, Ursula R. Kees, Lioubov Korotchkina, Olga B. Chernova, Richard B. Lock, Andrei V. Gudkov, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1175.
https://doi.org/10.1158/1538-7445.AM2017-1175
Published: 01 July 2017
View articletitled, Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia
Journal Articles

Abstract 809: A novel woodchuck model of hepatic artery infusion (HAI) with FACT complex targeted drug CBL0137

Minhyung Kim, Leslie I. Curtin, Colin A. Powers, Sandra Sexton, Katerina V. Gurova, Andrei V. Gudkov, Renuka V. Iyer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 809.
https://doi.org/10.1158/1538-7445.AM2017-809
Published: 01 July 2017
View articletitled, Abstract 809: A novel woodchuck model of hepatic artery infusion (HAI) with FACT complex targeted drug CBL0137
Journal Articles

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Minhyung Kim, Nickolay Neznanov, Chandler D. Wilfong, Daria I. Fleyshman, Andrei A. Purmal, Gary Haderski, Patricia Stanhope-Baker, Catherine A. Burkhart, Katerina V. Gurova, Andrei V. Gudkov, Joseph J. Skitzki
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6620–6630.
https://doi.org/10.1158/0008-5472.CAN-15-2764
Published: 14 November 2016
View articletitled, Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas
Open the PDF for Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas in another window
Includes: Supplementary data
Journal Articles

Abstract B23: Selective and rapid killing of mixed lineage leukemia and CALM-AF10 leukemia by SM7, a novel small molecule identified by chemical library screening

Daria Chudakova, Klaartje Somers, Shiloh Middlemiss, Victoria Wen, Alan Kwek, Bing Liu, Molly Clifton, Sukey Pan, Sarah Cruikshank, Marissa Scandlyn, Tim Failes, Wendy Hoang, Ursula Kees, Olga Chernova, Andrei V. Gudkov, Michelle Haber, Murray Norris, Michelle Henderson
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): B23.
https://doi.org/10.1158/1538-7445.PEDCA15-B23
Published: 04 April 2016
View articletitled, Abstract B23: Selective and rapid killing of mixed lineage leukemia and CALM-AF10 leukemia by SM7, a novel small molecule identified by chemical library screening
Journal Articles

Abstract 5492: Functional characterization of human toll-like receptor 5 (TLR5) genetic variants

Andrzej J. Wierzbicki, Araba A. Adjei, Nuttapong Ngamphaiboon, Thanyanan Reungwetwattana, Andrei V. Gudkov, Alex A. Adjei
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5492.
https://doi.org/10.1158/1538-7445.AM2015-5492
Published: 01 August 2015
View articletitled, Abstract 5492: Functional characterization of human toll-like receptor 5 (TLR5) genetic variants
Journal Articles

Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting

Michelle Haber, Jayne Murray, Laura Gamble, Ashleigh Carnegie-Clark, Hannah Webber, Michelle Ruhle, Michelle J. Henderson, Shiloh Middlemass, Daniel Carter, Maria Tsoli, Anahid Ehteda, Sandy Simon, Andre Oberthuer, Matthias Fischer, Katerina Gurova, Catherine Burkhart, Andrei Purmal, Richard B. Lock, David Ziegler, Glenn M. Marshall, Andrei V. Gudkov, Murray D. Norris
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1611.
https://doi.org/10.1158/1538-7445.AM2015-1611
Published: 01 August 2015
View articletitled, Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting
Journal Articles

Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Michelle Haber, Jayne Murray, Ashleigh Carnegie-Clark, Hannah Webber, Glenn M. Marshall, Katerina V. Gurova, Catherine A. Burkhart, Andrei Purmal, Andrei V. Gudkov, Murray D. Norris
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2759.
https://doi.org/10.1158/1538-7445.AM2013-2759
Published: 15 April 2013
View articletitled, Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.
Journal Articles

Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Daniel R. Carter, Belamy B. Cheung, Tao Liu, Carol Au, Murray D. Norris, Michelle Haber, Jayne Murray, Katerina V. Gurova, Andrei V. Gudkov, Glenn M. Marshall
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5043.
https://doi.org/10.1158/1538-7445.AM2013-5043
Published: 15 April 2013
View articletitled, Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.
Journal Articles

Abstract 2959: p53 as a guardian of genomic junk: A novel role for p53 in epigenetic silencing of retroelements

Katerina Leonova, Brittany Lipchick, Leonid Brodsky, Elena Komarova, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2959.
https://doi.org/10.1158/1538-7445.AM2012-2959
Published: 15 April 2012
View articletitled, Abstract 2959: p53 as a guardian of genomic junk: A novel role for p53 in epigenetic silencing of retroelements
Journal Articles

Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State

Min-Hyung Lee, Mathivanan Jothi, Andrei V. Gudkov, Asoke K. Mal
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3921–3931.
https://doi.org/10.1158/0008-5472.CAN-10-3358
Published: 31 May 2011
View articletitled, Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Open the PDF for Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State in another window
Includes: Supplementary data
Journal Articles

Abstract LB-160: Dual application of TLR5 agonist in cancer treatment: A single agent combines supporting care and antitumor activities

Lyudmila Burdelya, Anatoly Gleiberman, Ilya Gitlin, Semra Aygun-Sunar, Youcef Rustum, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-160.
https://doi.org/10.1158/1538-7445.AM2011-LB-160
Published: 15 April 2011
View articletitled, Abstract LB-160: Dual application of TLR5 agonist in cancer treatment: A single agent combines supporting care and antitumor activities
Journal Articles

Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers

Naoyuki G. Saito, Mairead Commane, Kellee F. Greene, Liliya R. Novototskaya, Andrei A. Purmal, Zhou Wang, Katerina V. Gurova, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-166.
https://doi.org/10.1158/1538-7445.AM10-LB-166
Published: 15 April 2010
View articletitled, Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers
Journal Articles

Abstract SY18-02: Targeting transcriptional regulators for simultaneous modulation of p53 and NF-κB in cancer treatment

Katerina Gurova, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): SY18-02.
https://doi.org/10.1158/1538-7445.AM10-SY18-02
Published: 15 April 2010
View articletitled, Abstract SY18-02: Targeting transcriptional regulators for simultaneous modulation of p53 and NF-κB in cancer treatment
Journal Articles

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Catherine A. Burkhart, Fujiko Watt, Jayne Murray, Marina Pajic, Anatoly Prokvolit, Chengyuan Xue, Claudia Flemming, Janice Smith, Andrei Purmal, Nadezhda Isachenko, Pavel G. Komarov, Katerina V. Gurova, Alan C. Sartorelli, Glenn M. Marshall, Murray D. Norris, Andrei V. Gudkov, Michelle Haber
Journal: Cancer Research
Cancer Res (2009) 69 (16): 6573–6580.
https://doi.org/10.1158/0008-5472.CAN-09-1075
Published: 12 August 2009
View articletitled, Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma
Open the PDF for Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

p53 Determines Multidrug Sensitivity of Childhood Neuroblastoma

Chengyuan Xue, Michelle Haber, Claudia Flemming, Glenn M. Marshall, Richard B. Lock, Karen L. MacKenzie, Katerina V. Gurova, Murray D. Norris, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2007) 67 (21): 10351–10360.
https://doi.org/10.1158/0008-5472.CAN-06-4345
Published: 01 November 2007
View articletitled, p53 Determines Multidrug Sensitivity of Childhood Neuroblastoma
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Journal Articles

Inhibition of p53 Response in Tumor Stroma Improves Efficacy of Anticancer Treatment by Increasing Antiangiogenic Effects of Chemotherapy and Radiotherapy in Mice

Lyudmila G. Burdelya, Elena A. Komarova, Jason E. Hill, Timothy Browder, Natalia D. Tararova, Lori Mavrakis, Paul E. DiCorleto, Judah Folkman, Andrei V. Gudkov
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9356–9361.
https://doi.org/10.1158/0008-5472.CAN-06-1223
Published: 03 October 2006
View articletitled, Inhibition of p53 Response in Tumor Stroma Improves Efficacy of Anticancer Treatment by Increasing Antiangiogenic Effects of Chemotherapy and Radiotherapy in Mice
Open the PDF for Inhibition of p53 Response in Tumor Stroma Improves Efficacy of Anticancer Treatment by Increasing Antiangiogenic Effects of Chemotherapy and Radiotherapy in Mice in another window