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Andreas von Deimling
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Journal Articles

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E

Ying Zhang, Stefan Pusch, James Innes, Kastytis Sidlauskas, Matthew Ellis, Joanne Lau, Tedani El-Hassan, Natasha Aley, Francesca Launchbury, Angela Richard-Loendt, Jasper deBoer, Sheng Chen, Lei Wang, Andreas von Deimling, Ningning Li, Sebastian Brandner
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (19): 4994–5007.
https://doi.org/10.1158/0008-5472.CAN-19-0054
Published: 01 October 2019
View article titled, Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E
Open the PDF for Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E in another window
Includes: Supplementary data
Journal Articles

Abstract 3646: (Epi-)genomic homogeneity in radiation-induced glioblastoma with recurrent PDGFRA amplification and loss of CDKN2A/B following primary acute lymphatic leukemia and medulloblastoma

Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Gnana P. Balasubramanian, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Andrey Korshunov, Andreas von Deimling, Olaf Witt, Stefan M. Pfister, David T. Jones
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3646.
https://doi.org/10.1158/1538-7445.AM2019-3646
Published: 01 July 2019
View article titled, Abstract 3646: (Epi-)genomic homogeneity in radiation-induced glioblastoma with recurrent <em>PDGFRA</em> amplification and loss of <em>CDKN2A/B</em> following primary acute lymphatic leukemia and medulloblastoma
Journal Articles

Abstract 2182: Preclincial in vitro and in vivo combination therapies for mutant IDH1R132 tumors with BAY 1436032

Stefan Kaulfuss, Julia Zaman, Anuhar Chaturvedi, Holger Hess-Stumpp, Jennifer Höde, Ricarda Biber, Renan Borowicz, Michael Heuser, Andreas von Deimling, Stefan Pusch
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2182.
https://doi.org/10.1158/1538-7445.AM2019-2182
Published: 01 July 2019
View article titled, Abstract 2182: Preclincial in vitro and in vivo combination therapies for mutant IDH1R132 tumors with BAY 1436032
Journal Articles

Abstract IA11: Pediatric precision oncology programs in Germany and Europe

David T. W. Jones, Barbara C. Worst, Elke Pfaff, Cornelis M. Van Tilburg, Gnana Prakash Balasubramanian, Petra Fiesel, Kristian W. Pajtler, Angelika Freitag, Ruth Witt, Andreas E. Kulozik, Felix Sahm, Andreas von Deimling, Angelika Eggert, Uta Dirksen, Peter Lichter, David Capper, Olaf Witt, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA11.
https://doi.org/10.1158/1538-7445.PEDCA17-IA11
Published: 01 October 2018
View article titled, Abstract IA11: Pediatric precision oncology programs in Germany and Europe
Journal Articles

Abstract 1906: PFKFB4, much more than just a glycolytic gene

Emma L. Phillips, Frederic Bethke, Jörg Balss, Stefan Pusch, Stefan Christen, Martina Schnölzer, Antje Habel, David Capper, Andreas Von Deimling, Sarah-Maria Fendt, Peter Lichter, Violaine Goidts
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1906.
https://doi.org/10.1158/1538-7445.AM2018-1906
Published: 01 July 2018
View article titled, Abstract 1906: <em>PFKFB4</em>, much more than just a glycolytic gene
Journal Articles

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G. Martelotto, Kathleen A. Burke, Thais Basili, Anqi Li, Felipe C. Geyer, Salvatore Piscuoglio, Charlotte K.Y. Ng, Achim A. Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M. Baker, Kimberly S. Cole, Andreas von Deimling, Julie M. Batten, Jonathan D. Marotti, Hwei-Choo Soh, Benjamin L. McCalip, Jonathan Serrano, Raymond S. Lim, Kalliopi P. Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A. John Iafrate, Jorge S. Reis-Filho, Stuart J. Schnitt
Journal: Cancer Research
Cancer Res (2016) 76 (24): 7118–7129.
https://doi.org/10.1158/0008-5472.CAN-16-0298
Published: 15 December 2016
View article titled, <em>IDH2</em> Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity
Open the PDF for <em>IDH2</em> Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity in another window
Includes: Supplementary data
Journal Articles

Abstract 138: Solid papillary carcinoma with reverse polarization are driven by IDH2 and PI3K pathway mutations

Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Salvatore Piscuoglio, Luciano G. Martelotto, Charlotte K Y Ng, Jörg Balss, Gabrielle Baker, Kimberly S. Cole, Andreas von Deimling, Julie M. Batten, Jonathan D. Marotti, Hwei-Choo Soh, Benjamin L. McCalip, Raymond S. Lim, Kalliopi P. Siziopikou, Randi Burke, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, A John Iafrate, Jorge S. Reis-Filho, Stuart J. Schnitt
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 138.
https://doi.org/10.1158/1538-7445.AM2016-138
Published: 15 July 2016
View article titled, Abstract 138: Solid papillary carcinoma with reverse polarization are driven by IDH2 and PI3K pathway mutations
Journal Articles

Abstract 4277: Development and validation of a novel IDH1-mutant astrocyte cell line as a model for high-grade gliomas

Nathaniel D. Robinson, Karin R. Purshouse, Nathan R. Fons, Gregory A. Breuer, Stefan Pusch, Andreas von Deimling, Ranjini K. Sundaram, Ranjit S. Bindra
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4277.
https://doi.org/10.1158/1538-7445.AM2016-4277
Published: 15 July 2016
View article titled, Abstract 4277: Development and validation of a novel IDH1-mutant astrocyte cell line as a model for high-grade gliomas
Journal Articles

Abstract 2645: BAY 1436032: A highly selective, potent and orally available inhibitor of mutant forms of IDH1

Olaf Panknin, Stefan Pusch, Lena Herbst, Stefan Kaulfuss, Katja Zimmermann, Hartmut Rehwinkel, Roland Neuhaus, Sven Ring, Michael Brüning, Claudia Stark, Katja Prelle, Martin Michels, Michael Jeffers, Holger Hess-Stumpp, Karl Ziegelbauer, Michael Brands, Alwin Krämer, Andreas von Deimling
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2645.
https://doi.org/10.1158/1538-7445.AM2016-2645
Published: 15 July 2016
View article titled, Abstract 2645: BAY 1436032: A highly selective, potent and orally available inhibitor of mutant forms of IDH1
Journal Articles

Abstract 2654: GAPVAC-101 phase I trial: First data of an innovative actively personalized peptide vaccination trial in patients with newly diagnosed glioblastoma

Norbert Hilf, Katrin Frenzel, Sabrina Kuttruff-Coqui, Sandra Heesch, Sebastian Kreiter, Arie Admon, Valesca Bukur, Sjoerd van der Burg, Cecile Gouttefangeas, Judith R. Kroep, Marij Schoenmaekers-Welters, Jordi Piro, Berta Ponsati, Hans Skovgaard Poulsen, Ulrik Lassen, Francisco Martinez-Ricarte, Jordi Rodon, Juan Sahuquillo, Monika Stieglbauer, Stefan Stevanovic, Per thor Straten, Marco Skardelly, Ghazaleh Tabatabai, Michael Platten, David Capper, Andreas von Deimling, Valérie Dutoit, Hideho Okada, Christian Ottensmeier, Randi Kristina Feist, Jens Fritsche, Karoline Laske, Peter Lewandrowski, Martin Löwer, Regina Mendryzk, Miriam Meyer, Carsten Reinhardt, Bernhard Rössler, Anna Paruzynski, Nina Pawlowski, Colette Song, Stevermann Lea, Toni Weinschenk, Christoph Huber, Hans-Georg Rammensee, Pierre-Yves Dietrich, Wick Wolfgang, Ugur Sahin, Harpreet Singh-Jasuja
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2654.
https://doi.org/10.1158/1538-7445.AM2016-2654
Published: 15 July 2016
View article titled, Abstract 2654: GAPVAC-101 phase I trial: First data of an innovative actively personalized peptide vaccination trial in patients with newly diagnosed glioblastoma
Journal Articles

Abstract LB-114: The INFORM personalized medicine study for high-risk pediatric cancer patients

Barbara C. Worst, Cornelis M. van Tilburg, Gnana P. Balasubramanian, Petra Fiesel, David Capper, Miream Boudalil, Stephan Wolf, Sabine Schmidt, Melanie Bewerunge-Hudler, Matthias Schick, Angelika Freitag, Ruth Witt, Lenka Taylor, Andreas von Deimling, Matthias Schlesner, Angelika Eggert, Peter Lichter, David TW Jones, Olaf Witt, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-114.
https://doi.org/10.1158/1538-7445.AM2015-LB-114
Published: 01 August 2015
View article titled, Abstract LB-114: The INFORM personalized medicine study for high-risk pediatric cancer patients
Journal Articles

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Hendrik Witt, Martin Sill, Khalida Wani, Steve Mack, David Capper, Stephanie Heim, Pascal Johann, Sally Lambert, Marina Rhyzova, Volker Hovestadt, Theophilos Tzaridis, Kristian Pajtler, Sebastian Bender, Till Milde, Paul A. Northcott, Andreas E. Kulozik, Olaf Witt, Peter Lichter, V Peter Collins, Andreas von Deimling, Marcel Kool, Michael D. Taylor, Martin Hasselblatt, David T. Jones, Andrey Korshunov, Ken Aldape, Stefan Pfister
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3094.
https://doi.org/10.1158/1538-7445.AM2014-3094
Published: 01 October 2014
View article titled, Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups
Journal Articles

Abstract 3093: Unravelling the biology of aggressive and therapy-resistant embryonal tumors with multilayered rosettes (ETMR)

Marcel Kool, Natalie Jäger, Dominik Sturm, David T.W. Jones, Volker Hoverstadt, Ivo Buchhalter, Pascal Johann, Christin Schmidt, Marina Ryzhova, Paul A. Northcott, Pablo Landgraf, Marc Remke, Michael D. Taylor, Martin Hasselblatt, Ulrich Schüller, Annie Huang, Marie-Laure Yaspo, Andreas von Deimling, Roland Eils, Peter Lichter, Andrey Korshunov, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3093.
https://doi.org/10.1158/1538-7445.AM2014-3093
Published: 01 October 2014
View article titled, Abstract 3093: Unravelling the biology of aggressive and therapy-resistant embryonal tumors with multilayered rosettes (ETMR)
Journal Articles

Abstract 1889: Next-generation neuropathology - Improving diagnostic accuracy for brain tumors using DNA methylation array-based molecular profiling

David T. W. Jones, David Capper, Martin Sill, Volker Hovestadt, Leonille Schweizer, Roger Fischer, Matthias Schick, Melanie Bewerunge-Hudler, Axel Benner, David Zagzag, Peter Lichter, Matthias A. Karajannis, Kenneth D. Aldape, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1889.
https://doi.org/10.1158/1538-7445.AM2014-1889
Published: 01 October 2014
View article titled, Abstract 1889: Next-generation neuropathology - Improving diagnostic accuracy for brain tumors using DNA methylation array-based molecular profiling
Journal Articles

GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3

Johannes Fabian, Marco Lodrini, Ina Oehme, Marie C. Schier, Theresa M. Thole, Thomas Hielscher, Annette Kopp-Schneider, Lennart Opitz, David Capper, Andreas von Deimling, Inga Wiegand, Till Milde, Ulrich Mahlknecht, Frank Westermann, Odilia Popanda, Frederik Roels, Barbara Hero, Frank Berthold, Matthias Fischer, Andreas E. Kulozik, Olaf Witt, Hedwig E. Deubzer
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2604–2616.
https://doi.org/10.1158/0008-5472.CAN-13-1904
Published: 30 April 2014
View article titled, <em>GRHL1</em> Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3
Open the PDF for <em>GRHL1</em> Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3 in another window
Includes: Supplementary data
Journal Articles

The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress

Felix Sahm, Iris Oezen, Christiane A. Opitz, Bernhard Radlwimmer, Andreas von Deimling, Tilman Ahrendt, Seray Adams, Helge B. Bode, Gilles J. Guillemin, Wolfgang Wick, Michael Platten
Journal: Cancer Research
Cancer Res (2013) 73 (11): 3225–3234.
https://doi.org/10.1158/0008-5472.CAN-12-3831
Published: 30 May 2013
View article titled, The Endogenous Tryptophan Metabolite and NAD<sup>+</sup> Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress
Open the PDF for The Endogenous Tryptophan Metabolite and NAD<sup>+</sup> Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress in another window
Includes: Supplementary data
Journal Articles

Abstract LB-80: ATRX loss refines the classification of anaplastic glioma and is a favorable prognostic marker.

Benedikt Wiestler, David Capper, Tim Holland-Letz, Andreas von Deimling, Stefan M. Pfister, Michael Platten, Michael Weller, Wolfgang Wick
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-80.
https://doi.org/10.1158/1538-7445.AM2013-LB-80
Published: 15 April 2013
View article titled, Abstract LB-80: ATRX loss refines the classification of anaplastic glioma and is a favorable prognostic marker.
Journal Articles

Abstract 1424: KCNJ2 comprises a marker of poor prognosis and a therapeutic target in non-WNT/non-SHH medulloblastoma

Francesca Valdora, Florian Freier, Claudia Seyler, Nathan Brady, Dominique Kranz, Thomas Hielscher, Sebastian Bender, Paul Northcott, Marcel Kool, David Jones, Hendrik Witt, Marina Ryzhova, Sabrina Pleier, Simona Coco, Gian Paolo Tonini, Axel Benner, Andreas von Deimling, Wolfram Scheurlen, Michael Boutros, Michael Taylor, Hugo Katus, Andreas Kulozik, Peter Lichter, Andrey Korshunov, Edgar Zitron, Stefan Pfister, Marc Remke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1424.
https://doi.org/10.1158/1538-7445.AM2012-1424
Published: 15 April 2012
View article titled, Abstract 1424: KCNJ2 comprises a marker of poor prognosis and a therapeutic target in non-WNT/non-SHH medulloblastoma
Journal Articles

Abstract 1432: The heterogeneous genomic landscape of posterior fossa ependymoma

Hendrik Witt, Stephen C. Mack, Sebastian Bender, Marina Ryzhova, Sill Martin, Ruth Isserlin, David T. W. Jones, Paul A. Northcott, Milde Till, Marc Remke, Axel Benner, Thomas Hielscher, Nalin Gupta, Livia Garcia, William A. Weiss, Kelsey Betrand, Timothy van Meter, Andreas von Deimling, Stefan Rutkowski, Torsten Pietsch, Andreas E. Kulozik, Yoon-Jae Cho, Uri Tabori, Cynthia E. Hawkins, Olaf Witt, Gary D. Bader, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1432.
https://doi.org/10.1158/1538-7445.AM2012-1432
Published: 15 April 2012
View article titled, Abstract 1432: The heterogeneous genomic landscape of posterior fossa ependymoma
Journal Articles

Abstract 3240: The Wnt secretion factor Evi/Wls/Gpr177 promotes glioma tumorigenesis

Iris Augustin, Violaine Goidts, Angelika Bongers, Grainne Kerr, Bernhard Radlwimmer, Christian Hartmann, Christel Herold-Mende, Andreas von Deimling, Guido Reifenberg, Michael Boutros
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3240.
https://doi.org/10.1158/1538-7445.AM2012-3240
Published: 15 April 2012
View article titled, Abstract 3240: The Wnt secretion factor Evi/Wls/Gpr177 promotes glioma tumorigenesis