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André Lechel
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Journal Articles

Abstract 6242: Inhibition of BIRC5/survivin by LQZ-7I inhibits neuroblastoma growth while hemizygosity of BIRC5 does not: implications for therapy of neuroblastoma

Free
Carmen Dorneburg, Celimene Galliger, Voker Rasche, Andre Lechel, Thomas F. Barth, Klaus-Michael Debatin, Christian Beltinger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6242.
https://doi.org/10.1158/1538-7445.AM2023-6242
Published: 04 April 2023
View articletitled, Abstract 6242: Inhibition of BIRC5/survivin by LQZ-7I inhibits neuroblastoma growth while hemizygosity of BIRC5 does not: implications for therapy of neuroblastoma
Journal Articles

RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

Available to Purchase
Frank Arnold, Johann Gout, Heike Wiese, Stephanie E. Weissinger, Elodie Roger, Lukas Perkhofer, Karolin Walter, Jeanette Scheible, Caterina Prelli Bozzo, André Lechel, Thomas J. Ettrich, Ninel Azoitei, Li Hao, Axel Fürstberger, Ewa K. Kaminska, Konstantin M.J. Sparrer, Volker Rasche, Sebastian Wiese, Hans A. Kestler, Peter Möller, Thomas Seufferlein, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1758–1774.
https://doi.org/10.1158/0008-5472.CAN-20-2633
Published: 01 April 2021
View articletitled, RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer
Open the PDF for RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4136: Marked decrease of BIRC5/Survivin by haploinsufficiency does not inhibit neuroblastoma in transgenic mice: Implications for survivin as a therapeutic target in neuroblastoma

Free
Carmen Dorneburg, Volker Rasche, Andre Lechel, Sarah-Fee Katz, Klaus-Michael Debatin, Christian Beltinger
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4136.
https://doi.org/10.1158/1538-7445.AM2018-4136
Published: 01 July 2018
View articletitled, Abstract 4136: Marked decrease of BIRC5/Survivin by haploinsufficiency does not inhibit neuroblastoma in transgenic mice: Implications for survivin as a therapeutic target in neuroblastoma
Journal Articles

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Free
Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, Michaela Ihle, Stephanie Hampp, Dietrich Alexander Ruess, Elisabeth Hessmann, Ronan Russell, André Lechel, Ninel Azoitei, Qiong Lin, Stefan Liebau, Meike Hohwieler, Hanibal Bohnenberger, Marina Lesina, Hana Algül, Laura Gieldon, Evelin Schröck, Jochen Gaedcke, Martin Wagner, Lisa Wiesmüller, Bence Sipos, Thomas Seufferlein, Hans Christian Reinhardt, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5576–5590.
https://doi.org/10.1158/0008-5472.CAN-17-0634
Published: 15 October 2017
View articletitled, ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Open the PDF for ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage in another window
Includes: Supplementary data
Journal Articles

Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway

Free
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, André Lechel, Kevin Mellert, Michael Böhm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss, Adrienne M. Flanagan, Peter Möller, Silke Brüderlein, Thomas F.E. Barth
Journal: Cancer Research
Cancer Res (2015) 75 (18): 3823–3831.
https://doi.org/10.1158/0008-5472.CAN-14-3270
Published: 14 September 2015
View articletitled, Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Open the PDF for Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract 328: Complex oligonucleotide libraries enable high-resolution cytogenetic analysis of human and mouse genomes with fluorescence in situ hybridization (FISH)

Free
Robert A. Ach, N. Alice Yamada, Peter Tsang, Kristina Aleksic, Yvonne Begus-Nahrmann, Alicia Scheffer-Wong, Stephen Laderman, Andre Lechel, K. Lenhard Rudolph, Michael Speicher, Laurakay Bruhn
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 328.
https://doi.org/10.1158/1538-7445.AM10-328
Published: 15 April 2010
View articletitled, Abstract 328: Complex oligonucleotide libraries enable high-resolution cytogenetic analysis of human and mouse genomes with fluorescence in situ hybridization (FISH)
Journal Articles

Abstract #4907: Identification of tumor stem cell markers in TRP53 deleted liver tumors

Free
André Lechel, Sarah-Fee Katz, Daniel Hartmann, Yvonne Begus-Nahrmann, Peter Schirmacher, K. Rudolph
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4907.
Published: 01 May 2009
View articletitled, Abstract #4907: Identification of tumor stem cell markers in TRP53 deleted liver tumors
Journal Articles

Abstract #596: p53 deletion impairs clearance of chromosomal instable stem cells and accelerates epithelial aging in telomere dysfunctional mice

Free
Yvonne Begus-Nahrmann, Andre Lechel, Anna Obenauf, Peter Schirmacher, Michael Speicher, Lenhard Rudolph
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 596.
Published: 01 May 2009
View articletitled, Abstract #596: p53 deletion impairs clearance of chromosomal instable stem cells and accelerates epithelial aging in telomere dysfunctional mice
Journal Articles

Trp53 deletion induces liver carcinoma in mice containing bipotential progenitor cells

Free
Andre Lechel, Yvonne Begus-Nahrmann, Peter Schirmacher, K Rudolph
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2945.
Published: 01 May 2008
View articletitled, Trp53 deletion induces liver carcinoma in mice containing bipotential progenitor cells
Journal Articles

Telomerase gene rescue promotes hepatocarcinogenesis in the context of p53- and telomere-dysfunction by limiting chromosomal instability

Free
Andre Lechel, Henne Holstege, Yvonne Begus, Michael P. Manns, Jos Jonkers, Karl L. Rudolph
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 340–341.
Published: 15 April 2006
View articletitled, Telomerase gene rescue promotes hepatocarcinogenesis in the context of p53- and telomere-dysfunction by limiting chromosomal instability