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Analisa DiFeo
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Journal Articles

Abstract 5173: Heterozygous Ppp2r1a mutations with concurrent loss of Tp53 drive invasive high-grade uterine cancer

Caitlin M. O'Connor, Kelsey Barrie, Kaitlin Zawacki, Ingrid L. Bergin, Gabrielle Hodges Onishi, Analisa DiFeo, Kathleen Cho, Thom Saunders, Goutham Narla
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5173.
https://doi.org/10.1158/1538-7445.AM2025-5173
Published: 21 April 2025
View articletitled, Abstract 5173: Heterozygous Ppp2r1a mutations with concurrent loss of Tp53 drive invasive high-grade uterine cancer
Journal Articles

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Terrance J. Haanen, III, Sophie Boock, Catherine G. Callahan, Irene Peris, Kaitlin P. Zawacki, Brynne Raines, Charles A. Nino, Brian Tran, Alexis Harold, Gabrielle Hodges Onishi, Matthew Hinderman, Amanda Dowdican, Wei Huang, Derek J. Taylor, Sarah E. Taylor, Mark W. Jackson, Analisa DiFeo, Caitlin M. O’Connor, Goutham Narla
Journal: Cancer Research
Cancer Res (2025) 85 (3): 442–461.
https://doi.org/10.1158/0008-5472.CAN-24-1263
Published: 01 February 2025
View articletitled, Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer
Open the PDF for Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2013: Extracellular vesicles transfer miR-181a to confer PARP inhibitor resistance and induce STING degradation in BRCA-mutated triple-negative breast and ovarian cancers cells

Matias A. Bustos, Takamichi Yokoe, Yoshiaki Shoji, Yuta Kobayashi, Shodai Mizuno, Tomohiro Murakami, Sreeja C. Sekhar, Matthew Knarr, Steven A. Vasilev, Analisa DiFeo, Ronny Drapkin, Dave S. Hoon
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2013.
https://doi.org/10.1158/1538-7445.AM2024-2013
Published: 22 March 2024
View articletitled, Abstract 2013: Extracellular vesicles transfer miR-181a to confer PARP inhibitor resistance and induce STING degradation in BRCA-mutated triple-negative breast and ovarian cancers cells
Journal Articles

Abstract 4717: Small molecule modulation of PP2A selectively induces oncogenic cytotoxicity through chronic and irreversible integrated stress response

Rita A. Avelar, Riya Gupta, Grace Carvette, Felipe da Veiga Leprevost, Jose Colina, Jessica Teitel, Goutham Narla, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4717.
https://doi.org/10.1158/1538-7445.AM2024-4717
Published: 22 March 2024
View articletitled, Abstract 4717: Small molecule modulation of PP2A selectively induces oncogenic cytotoxicity through chronic and irreversible integrated stress response
Journal Articles

Abstract 1570: Novel Myc-dependent compound DL78 selectively induces mitotic catastrophe and cell death in high grade serous ovarian cancer

Jessica Teitel, Michele Cusato, Margaret Farah, Agharnan Gandhi, Pil Lee, Andrew White, John Takyi-Williams, Bo Wen, Andre Monterio Da Rocha, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1570.
https://doi.org/10.1158/1538-7445.AM2023-1570
Published: 04 April 2023
View articletitled, Abstract 1570: Novel Myc-dependent compound DL78 selectively induces mitotic catastrophe and cell death in high grade serous ovarian cancer
Journal Articles

Abstract 1679: Unraveling the function of TRAF2 and NCK interacting kinase (TNIK) in high-grade serous ovarian cancer

Noah Puleo, Michele Cusato, Dylan Carvette, Chantelle Husdon, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1679.
https://doi.org/10.1158/1538-7445.AM2023-1679
Published: 04 April 2023
View articletitled, Abstract 1679: Unraveling the function of TRAF2 and NCK interacting kinase (TNIK) in high-grade serous ovarian cancer
Journal Articles

Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma

Caitlin M. O'Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3341.
https://doi.org/10.1158/1538-7445.AM2022-3341
Published: 15 June 2022
View articletitled, Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma
Journal Articles

Abstract 3340: Small molecule mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death

Rita A. Avelar, Amy Armstrong, Goutham Narla, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3340.
https://doi.org/10.1158/1538-7445.AM2022-3340
Published: 15 June 2022
View articletitled, Abstract 3340: Small molecule mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death
Journal Articles

Abstract 4003: Identification of a targeted anti-mitotic agent that degrades Myc and specifically induces cancer cell death

Jessica McAnulty, Michele Dziubinski, Agharnan Gandhi, Margaret Farah, Pil Lee, Andrew D. White, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4003.
https://doi.org/10.1158/1538-7445.AM2022-4003
Published: 15 June 2022
View articletitled, Abstract 4003: Identification of a targeted anti-mitotic agent that degrades Myc and specifically induces cancer cell death
Journal Articles

Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

Caitlin M. O'Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla
Journal: Cancer Research
Cancer Res (2022) 82 (4): 721–733.
https://doi.org/10.1158/0008-5472.CAN-21-1987
Published: 15 February 2022
View articletitled, Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma
Open the PDF for Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 236: Genomic loss in cancers enable discovery of metabolic targets for precision cancer therapy via multiobjective flux analysis and machine learning

Abhinav Achreja, Tao Yu, Anjali Mittal, Srinadh Choppara, Noah Meurs, Olamide Animasahun, Jin Heon Jeon, Aradhana Mohan, Anusha Jayaraman, Reva Kulkarni, Justin Reinhold, Michele Cusato, Analisa Difeo, Xiongbin Lu, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 236.
https://doi.org/10.1158/1538-7445.AM2021-236
Published: 01 July 2021
View articletitled, Abstract 236: Genomic loss in cancers enable discovery of metabolic targets for precision cancer therapy via multiobjective flux analysis and machine learning
Journal Articles

The miR–181a–SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer

Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2021) 81 (8): 2044–2055.
https://doi.org/10.1158/0008-5472.CAN-20-2041
Published: 15 April 2021
View articletitled, The miR–181a–SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer
Open the PDF for The miR–181a–SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO-076: miR-181a initiates and perpetuates ovarian cancer transformation through inhibition of the tumor suppressors RB1 and stimulator of interferon genes (STING)

Matthew Knarr, Rita Avelar, Sreeja Sekhar, Lily Kwiatkowski, Michele Dziubinski, Jessica McAnulty, Stephanie Skala, Stefanie Avril, Ronny Drapkin, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-076.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-076
Published: 03 November 2020
View articletitled, Abstract PO-076: miR-181a initiates and perpetuates ovarian cancer transformation through inhibition of the tumor suppressors RB1 and stimulator of interferon genes (STING)
Journal Articles

Abstract 1831: Mistletoe lectin induces apoptosis in MYC-driven cancers through post-translational downregulation of c-MYC protein

Gabrielle Kennelley, Eric Yuan, Mohammad Shatat, Betsy Gauthier, Peiying Yang, Analisa Difeo, Richard Lee
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1831.
https://doi.org/10.1158/1538-7445.AM2020-1831
Published: 15 August 2020
View articletitled, Abstract 1831: Mistletoe lectin induces apoptosis in MYC-driven cancers through post-translational downregulation of c-MYC protein
Journal Articles

Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer

Stephen Shang, Jiekun Yang, Amir A. Jazaeri, Alexander James Duval, Turan Tufan, Natasha Lopes Fischer, Mouadh Benamar, Fadila Guessous, Inyoung Lee, Robert M. Campbell, Philip J. Ebert, Tarek Abbas, Charles N. Landen, Analisa Difeo, Peter C. Scacheri, Mazhar Adli
Journal: Cancer Research
Cancer Res (2019) 79 (18): 4599–4611.
https://doi.org/10.1158/0008-5472.CAN-19-0215
Published: 13 September 2019
View articletitled, Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer
Open the PDF for Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Sarah E. Taylor, Caitlin M. O'Connor, Zhizhi Wang, Guobo Shen, Haichi Song, Daniel Leonard, Jaya Sangodkar, Corinne LaVasseur, Stefanie Avril, Steven Waggoner, Kristine Zanotti, Amy J. Armstrong, Christa Nagel, Kimberly Resnick, Sareena Singh, Mark W. Jackson, Wenqing Xu, Shozeb Haider, Analisa DiFeo, Goutham Narla
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4242–4257.
https://doi.org/10.1158/0008-5472.CAN-19-0218
Published: 15 August 2019
View articletitled, The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Open the PDF for The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract 3557: miR-181a is a key driver of genomic instability and ovarian cancer tumorigenesis through the regulation of RB1

Matthew Knarr, Lily Kwiatkowski, Anil Nagaraj, Ronny Drapkin, Analisa DiFeo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3557.
https://doi.org/10.1158/1538-7445.AM2019-3557
Published: 01 July 2019
View articletitled, Abstract 3557: miR-181a is a key driver of genomic instability and ovarian cancer tumorigenesis through the regulation of RB1
Journal Articles

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Kimberly McClinch, Rita A. Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B. Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L. Brautigan, Stephen R. Plymate, Cynthia C.T. Sprenger, William K. Oh, Alice C. Levine, Alexander Kirschenbaum, John P. Sfakianos, Rosalie Sears, Analisa DiFeo, Yiannis Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D. Galsky
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2065–2080.
https://doi.org/10.1158/0008-5472.CAN-17-0123
Published: 12 April 2018
View articletitled, Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
Open the PDF for Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3857: Pharmacological reactivation of the tumor suppressor protein phosphatase 2A as a novel approach for the treatment of breast cancer

Caroline C. Farrington, Xiaoyan Wang, Mahnaz Janghorban, Juan Liang, Analisa Difeo, Rosalie Sears, Goutham Narla
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3857.
https://doi.org/10.1158/1538-7445.AM2016-3857
Published: 15 July 2016
View articletitled, Abstract 3857: Pharmacological reactivation of the tumor suppressor protein phosphatase 2A as a novel approach for the treatment of breast cancer
Journal Articles

Abstract LB-151: Positively selected enhancer elements endow tumor cells with metastatic competence

James J. Morrow, Tyler E. Miller, Alina Saiakhova, Michael M. Lizardo, Cynthia F. Bartels, Ian Bayles, Stevephen Hung, Arnulfo Mendoza, Jay T. Myers, Frederick Allen, Analisa DiFeo, Brian P. Rubin, Alex Y. Huang, Paul S. Meltzer, Lee J. Helman, Chand Khanna, Peter C. Scacheri
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-151.
https://doi.org/10.1158/1538-7445.AM2016-LB-151
Published: 15 July 2016
View articletitled, Abstract LB-151: Positively selected enhancer elements endow tumor cells with metastatic competence