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Ana Maria Gonzalez
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Journal Articles

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer

Open Access
Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5572–5581.
https://doi.org/10.1158/0008-5472.CAN-20-3242
Published: 01 November 2021
View articletitled, Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 4970: Oxidative phosphorylation as a target in triple negative breast cancer therapy

Free
Funda Meric-Bernstam, Kurt Evans, Xiaofeng Zheng, Xiaoping Su, Erkan Yuca, Stephen Scott, Argun Akcakanat, Naoto Ueno, Bora Lim, Jennifer Litton, Vicente Valero, Fraser Symmans, Gabriel Hortobagyi, Charles Perou, Debu Tripathy, Guilio Draetta, Joe Marszalek, Ana Maria Gonzalez-Angulo, Stacy Moulder
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4970.
https://doi.org/10.1158/1538-7445.AM2017-4970
Published: 01 July 2017
View articletitled, Abstract 4970: Oxidative phosphorylation as a target in triple negative breast cancer therapy
Journal Articles

Abstract 3204: INCAGN01949: an anti-OX40 agonist antibody with the potential to enhance tumor-specific T-cell responsiveness, while selectively depleting intratumoral regulatory T cells

Free
Ana Maria Gonzalez, Mariana L. Manrique, Ekaterina Breous, David Savitsky, Jeremy Waight, Randi Gombos, Yuqi Liu, Shiwen Lin, Taha Merghoub, Daniel Hirschhorn-Cymerman, Gerd Ritter, Jedd Wolchok, Peggy Scherle, Gregory Hollis, Reid Huber, Marc Van Dijk, Robert Stein, Nicholas S. Wilson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3204.
https://doi.org/10.1158/1538-7445.AM2016-3204
Published: 15 July 2016
View articletitled, Abstract 3204: INCAGN01949: an anti-OX40 agonist antibody with the potential to enhance tumor-specific T-cell responsiveness, while selectively depleting intratumoral regulatory T cells
Journal Articles

Abstract 3220: A novel agonist antibody (INCAGN01876) that targets the costimulatory receptor GITR

Free
Ana Maria Gonzalez, Ekaterina Breous, Mariana L. Manrique, David Savitsky, Jeremy Waight, Randi Gombos, Yuqi Liu, Shiwen Lin, Olivier Leger, Volker Seibert, Takemasa Tsuji, Taha Merghoub, Sadna Budha, Roberta Zappasodi, Gerd Ritter, Jedd Wolchok, Peggy Scherle, Gregory Hollis, Reid Huber, Marc Van Dijk, Robert Stein, Nicholas Wilson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3220.
https://doi.org/10.1158/1538-7445.AM2016-3220
Published: 15 July 2016
View articletitled, Abstract 3220: A novel agonist antibody (INCAGN01876) that targets the costimulatory receptor GITR
Journal Articles

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Free
Russell Hughes, Bin-Zhi Qian, Charlotte Rowan, Munitta Muthana, Ioanna Keklikoglou, Oakley C. Olson, Simon Tazzyman, Sarah Danson, Christina Addison, Mark Clemons, Ana Maria Gonzalez-Angulo, Johanna A. Joyce, Michele De Palma, Jeffrey W. Pollard, Claire E. Lewis
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (17): 3479–3491.
https://doi.org/10.1158/0008-5472.CAN-14-3587
Published: 31 August 2015
View articletitled, Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
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Includes: Supplementary data
Journal Articles

Abstract PD3-6: ConvertHER: Evolution of genomic alterations from primary to metastatic breast cancer

Free
Ana Maria Gonzalez-Angulo, Ana Lluch, Agda K Eterovic, Angel Guerrero, Xiaofeng Zheng, Ramon Perez, Shuying Liu, José I Chacón, Ken Chen, Silvia Antolin, Gordon B Mills, Jaime Ferrer, Octavio Burgues, Begona Bermejo, Elia Munoz, Rosalia Caballero, Eva Carrasco, Eduardo Martinez, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): PD3-6.
https://doi.org/10.1158/1538-7445.SABCS14-PD3-6
Published: 01 May 2015
View articletitled, Abstract PD3-6: ConvertHER: Evolution of genomic alterations from primary to metastatic breast cancer
Journal Articles

Abstract 1186: Patient-derived breast cancer xenografts demonstrate molecular evolution in the phosphatidylinositol 3-kinase pathway upon engraftment

Free
Priscilla F. McAuliffe, Argun Akcakanat, Kurt Evans, Agda Karina Eterovic, Hao Zhao, Ken Chen, Takafumi Sangai, Huiqin Chen, Kim-Anh Do, Ashley M. Holder, Chandeshwar Sharma, William Fraser Symmans, Mihai Gagea, Katherine A. Naff, Aysegul Sahin, Asha S. Multani, Gordon B. Mills, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1186.
https://doi.org/10.1158/1538-7445.AM2014-1186
Published: 01 October 2014
View articletitled, Abstract 1186: Patient-derived breast cancer xenografts demonstrate molecular evolution in the phosphatidylinositol 3-kinase pathway upon engraftment
Journal Articles

Abstract LB-265: Patient-derived xenografts from advanced luminal-type breast cancer: insights into endocrine therapy resistance.

Free
Matthew J. Ellis, Shunqiang Li, Dong Shen, Li Ding, Robert Crowder, Jeiya Shao, Rodrigo Goncalves, Yu Tao, Jingqin Luo, Aleix Prat, Wenbin Liu, Ana Maria Gonzalez-Angulo, Shuying Liu, Joshua F. McMichael, Chris Miller, Dave Larson, Robert S. Fulton, Tom Mooney, Jeremy Hoog, Li Lin, Therese Giuntoli, Caroline Bumb, Crystal Cooper, Rebecca Aft, Robert T. Kitchens, Stephen N. Johnson, Chanpheng Phommaly, Megha Shiyam Kavuri, Katherine DeSchryver, Austin Lin, YiYu Dong, Cynthia X. Ma, Timothy Pluard, Michael Naughton, Ron Bose, Rama Suresh, Reida G. McDowell, Loren Michel, Richard Wilson, Shaomeng Wang, Christopher Maher, Gordon B. Mills, Charles Perou, Elaine R. Mardis
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-265.
https://doi.org/10.1158/1538-7445.AM2013-LB-265
Published: 15 April 2013
View articletitled, Abstract LB-265: Patient-derived xenografts from advanced luminal-type breast cancer: insights into endocrine therapy resistance.
Journal Articles

Abstract LB-65: Towards defining the genetic framework for clinical response to treatment with BYL719, a PI3Kalpha-specific inhibitor.

Free
Jordi Rodon, Dejan Juric, Ana-Maria Gonzalez-Angulo, Johanna Bendell, Jordan Berlin, Douglas Bootle, Kathlene Gravelin, Alan Huang, Adnan Derti, Joseph Lehar, Jens Würthner, Markus Boehm, Eliezer van Allen, Nikhil Wagle, Levi A. Garraway, Roman Yelensky, Philip J. Stephens, Vincent A. Miller, Robert Schlegel, Cornelia Quadt, José Baselga
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-65.
https://doi.org/10.1158/1538-7445.AM2013-LB-65
Published: 15 April 2013
View articletitled, Abstract LB-65: Towards defining the genetic framework for clinical response to treatment with BYL719, a PI3Kalpha-specific inhibitor.
Journal Articles

A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Available to Purchase
Emily M. Fox, Todd W. Miller, Justin M. Balko, Maria G. Kuba, Violeta Sánchez, R. Adam Smith, Shuying Liu, Ana María González-Angulo, Gordon B. Mills, Fei Ye, Yu Shyr, H. Charles Manning, Elizabeth Buck, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2011) 71 (21): 6773–6784.
https://doi.org/10.1158/0008-5472.CAN-11-1295
Published: 30 October 2011
View articletitled, A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Open the PDF for A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers

Free
Ritwik Ghosh, Archana Narasanna, Shizhen Emily Wang, Shuying Liu, Anindita Chakrabarty, Justin M. Balko, Ana María González-Angulo, Gordon B. Mills, Elicia Penuel, John Winslow, Jeff Sperinde, Rajiv Dua, Sailaja Pidaparthi, Ali Mukherjee, Kim Leitzel, Wolfgang J. Kostler, Allan Lipton, Michael Bates, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1871–1882.
https://doi.org/10.1158/0008-5472.CAN-10-1872
Published: 01 March 2011
View articletitled, Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers
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Includes: Supplementary data
Journal Articles

Abstract 2303: The redox-active protein thioredoxin: A modulator of epithelial-mesenchymal transition

Free
Geoffrey A. Bartholomeusz, Ana Maria Gonzalez-Angulo, Veera Baladandayuthapani, Liu Ping, Garth Powis
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2303.
https://doi.org/10.1158/1538-7445.AM10-2303
Published: 15 April 2010
View articletitled, Abstract 2303: The redox-active protein thioredoxin: A modulator of epithelial-mesenchymal transition
Journal Articles

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

Available to Purchase
Bryan T. Hennessy, Ana-Maria Gonzalez-Angulo, Katherine Stemke-Hale, Michael Z. Gilcrease, Savitri Krishnamurthy, Ju-Seog Lee, Jane Fridlyand, Aysegul Sahin, Roshan Agarwal, Corwin Joy, Wenbin Liu, David Stivers, Keith Baggerly, Mark Carey, Ana Lluch, Carlos Monteagudo, Xiaping He, Victor Weigman, Cheng Fan, Juan Palazzo, Gabriel N. Hortobagyi, Laura K. Nolden, Nicholas J. Wang, Vicente Valero, Joe W. Gray, Charles M. Perou, Gordon B. Mills
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4116–4124.
https://doi.org/10.1158/0008-5472.CAN-08-3441
Published: 15 May 2009
View articletitled, Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Open the PDF for Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics in another window
Includes: Supplementary data
Journal Articles

Abstract #3822: PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA- mutant cancers

Free
Krishna Vasudevan, David Barbie, Michael Davies, Rosalia Rabinovsky, Bryan Hennessy, Hsiuyi Tseng, Panisa Pochanard, So Young Kim, Ian Dunn, Anna Schinzel, Chontelle McNear, Jessica Kim, Jesse Boehm, Serena Silver, Yiling Lu, Katherine Stemke-Hale, Bhaskar Dutta, Corwin Joy, Aysegul Sahin, Ana Maria Gonzalez-Angulo, Ana Lluch, Lucia Rameh, Tyler Jacks, David Root, Eric Lander, Gordon Mills, William Hahn, William Sellers, Levi Garraway
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3822.
Published: 01 May 2009
View articletitled, Abstract #3822: PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA- mutant cancers
Journal Articles

An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

Available to Purchase
Katherine Stemke-Hale, Ana Maria Gonzalez-Angulo, Ana Lluch, Richard M. Neve, Wen-Lin Kuo, Michael Davies, Mark Carey, Zhi Hu, Yinghui Guan, Aysegul Sahin, W. Fraser Symmans, Lajos Pusztai, Laura K. Nolden, Hugo Horlings, Katrien Berns, Mien-Chie Hung, Marc J. van de Vijver, Vicente Valero, Joe W. Gray, René Bernards, Gordon B. Mills, Bryan T. Hennessy
Journal: Cancer Research
Cancer Res (2008) 68 (15): 6084–6091.
https://doi.org/10.1158/0008-5472.CAN-07-6854
Published: 01 August 2008
View articletitled, An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
Open the PDF for An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Enhanced Phagemid Particle Gene Transfer in Camptothecin-treated Carcinoma Cells

Available to Purchase
Michael A. Burg, Kristen Jensen-Pergakes, Ana Maria Gonzalez, Prenn Ravey, Andrew Baird, David Larocca
Journal: Cancer Research
Cancer Res (2002) 62 (4): 977–981.
Published: 01 February 2002
View articletitled, Enhanced Phagemid Particle Gene Transfer in Camptothecin-treated Carcinoma Cells
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Journal Articles

Fibroblast Growth Factor 2 Retargeted Adenovirus Has Redirected Cellular Tropism: Evidence for Reduced Toxicity and Enhanced AntitumorActivity in Mice

Available to Purchase
Dan-ling Gu, Ana Maria Gonzalez, Marie A. Printz, John Doukas, Wenbin Ying, Mark D’Andrea, Diana K. Hoganson, David T. Curiel, Joanne T. Douglas, Barbara A. Sosnowski, Andrew Baird, Sharon Lea Aukerman, Glenn F. Pierce
Journal: Cancer Research
Cancer Res (1999) 59 (11): 2608–2614.
Published: 01 June 1999
View articletitled, Fibroblast Growth Factor 2 Retargeted Adenovirus Has Redirected Cellular Tropism: Evidence for Reduced Toxicity and Enhanced AntitumorActivity in Mice
Open the PDF for Fibroblast Growth Factor 2 Retargeted Adenovirus Has Redirected Cellular Tropism: Evidence for Reduced Toxicity and Enhanced AntitumorActivity in Mice in another window