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Journal Articles

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer

Soma Samanta, Suhui Yang, Bikash Debnath, Ding Xue, Yuting Kuang, Kavya Ramkumar, Amy S. Lee, Mats Ljungman, Nouri Neamati
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1883–1895.
https://doi.org/10.1158/0008-5472.CAN-20-1540
Published: 01 April 2021
View article titled, The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer
Open the PDF for The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

Jooske F. van Lidth de Jeude, Claudia N. Spaan, Bartolomeus J. Meijer, Wouter L. Smit, Tanya T.D. Soeratram, Mattheus C.B. Wielenga, B. Florien Westendorp, Amy S. Lee, Sander Meisner, Jacqueline L.M. Vermeulen, Manon E. Wildenberg, Gijs R. van den Brink, Vanesa Muncan, Jarom Heijmans
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6098–6106.
https://doi.org/10.1158/0008-5472.CAN-17-3600
Published: 01 November 2018
View article titled, Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation
Open the PDF for Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation in another window
Includes: Supplementary data
Journal Articles

Abstract SY13-03: GRP78/BiP: Cancer's comrade in crime

Amy S. Lee, Jieli Shen, Daisy Rangel, Chun-Chih Tseng, Yuan Li Tsai, Dat P. Ha, He Zhao, Louis Dubeau
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): SY13-03.
https://doi.org/10.1158/1538-7445.AM2017-SY13-03
Published: 01 July 2017
View article titled, Abstract SY13-03: GRP78/BiP: Cancer's comrade in crime
Journal Articles

Abstract LB-136: The role of ER chaperone GRP94 in endometrial cancer progression

Jieli Shen, Yvonne G. Lin, Louis Dubeau, Amy S. Lee
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-136.
https://doi.org/10.1158/1538-7445.AM2015-LB-136
Published: 01 August 2015
View article titled, Abstract LB-136: The role of ER chaperone GRP94 in endometrial cancer progression
Journal Articles

Abstract SY44-01: Critical role of stress chaperone GRP78/BiP in cancer

Amy S. Lee
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY44-01.
https://doi.org/10.1158/1538-7445.AM2014-SY44-01
Published: 01 October 2014
View article titled, Abstract SY44-01: Critical role of stress chaperone GRP78/BiP in cancer
Journal Articles

Abstract B09: Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis

Wan-Ting Chen, Chun-Chih Tseng, Kyle Pfaffenbach, Gary Kanel, Biquan Luo, Bangyan L. Stiles, Amy S. Lee
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): B09.
https://doi.org/10.1158/1538-7445.FBCR13-B09
Published: 15 May 2014
View article titled, Abstract B09: Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis
Journal Articles

Abstract C61: GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

Wan-Ting Chen, Genyuan Zhu, Kyle Pfaffenbach, Gary Kanel, Bangyan Stiles, Amy S. Lee
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): C61.
https://doi.org/10.1158/1538-7445.FBCR13-C61
Published: 15 May 2014
View article titled, Abstract C61: GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN
Journal Articles

Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.

Kavya Ramkumar, Bikash Debnath, Amy S. Lee, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5678.
https://doi.org/10.1158/1538-7445.AM2013-5678
Published: 15 April 2013
View article titled, Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.
Journal Articles

Abstract A8: Defining specific microRNAs that cooperatively regulate GRP78, an ER chaperone and signaling regulator, in cancer

Sheng-Fang Su, Amy S. Lee, Gangning Liang
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): A8.
https://doi.org/10.1158/1538-7445.NONRNA12-A8
Published: 03 April 2013
View article titled, Abstract A8: Defining specific microRNAs that cooperatively regulate GRP78, an ER chaperone and signaling regulator, in cancer
Journal Articles

Abstract LB-37: Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

Shiuan Wey, Biquan Luo, Min Ni, Hui Zhou, Yong Fu, Deepa Bhojwani, William L. Carroll, Amy S. Lee
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-37.
https://doi.org/10.1158/1538-7445.AM2011-LB-37
Published: 15 April 2011
View article titled, Abstract LB-37: Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling
Journal Articles

Abstract LB-49: The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche

Biquan Luo, Ben S. Lam, Sung Hyung Lee, Shiuan Wey, Hui Zhou, Miao Wang, Si-Yi Chen, Gregor B. Adams, Amy S. Lee
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-49.
https://doi.org/10.1158/1538-7445.AM2011-LB-49
Published: 15 April 2011
View article titled, Abstract LB-49: The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche
Journal Articles

Abstract SY06-01: Critical role of the stress chaperone and cell signaling regulator GRP78 in cancer

Amy S. Lee
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): SY06-01.
https://doi.org/10.1158/1538-7445.AM2011-SY06-01
Published: 15 April 2011
View article titled, Abstract SY06-01: Critical role of the stress chaperone and cell signaling regulator GRP78 in cancer
Journal Articles

A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis

Dezheng Dong, Christopher Stapleton, Biquan Luo, Shigang Xiong, Wei Ye, Yi Zhang, Niyati Jhaveri, Genyuan Zhu, Risheng Ye, Zhi Liu, Kevin W. Bruhn, Noah Craft, Susan Groshen, Florence M. Hofman, Amy S. Lee
Journal: Cancer Research
Cancer Res (2011) 71 (8): 2848–2857.
https://doi.org/10.1158/0008-5472.CAN-10-3151
Published: 13 April 2011
View article titled, A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis
Open the PDF for A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis in another window
Includes: Supplementary data
Journal Articles

The unfolded protein response regulator GRP78 as a novel target of BRCA1 for inhibiting stress-induced apoptosis

Bernadette W.Y. Kwan, Bonnie H.Y. Yeung, Alice S.T. Wong, Qing-Yu He, Amy S. Lee, J. Liu
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1785.
Published: 01 May 2008
View article titled, The unfolded protein response regulator GRP78 as a novel target of BRCA1 for inhibiting stress-induced apoptosis
Journal Articles

Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by novel combination strategies

Dehua Yu, James Macdonald, Guohong Liu, Amy S Lee, Mimi Ly, Ning Ke, Flossie Wong-Staal, Qi-Xiang Li
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5713.
Published: 01 May 2008
View article titled, Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by novel combination strategies
Journal Articles

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

Dezheng Dong, Min Ni, Jianze Li, Shigang Xiong, Wei Ye, Jenilyn J. Virrey, Changhui Mao, Risheng Ye, Miao Wang, Ligaya Pen, Louis Dubeau, Susan Groshen, Florence M. Hofman, Amy S. Lee
Journal: Cancer Research
Cancer Res (2008) 68 (2): 498–505.
https://doi.org/10.1158/0008-5472.CAN-07-2950
Published: 15 January 2008
View article titled, Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development
Open the PDF for Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development in another window
Journal Articles

The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas

Peter Pyrko, Axel H. Schönthal, Florence M. Hofman, Thomas C. Chen, Amy S. Lee
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9809–9816.
https://doi.org/10.1158/0008-5472.CAN-07-0625
Published: 17 October 2007
View article titled, The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas
Open the PDF for The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas in another window
Journal Articles

GRP78/BiP Inhibits Endoplasmic Reticulum BIK and Protects Human Breast Cancer Cells against Estrogen Starvation–Induced Apoptosis

Yong Fu, Jianze Li, Amy S. Lee
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3734–3740.
https://doi.org/10.1158/0008-5472.CAN-06-4594
Published: 17 April 2007
View article titled, GRP78/BiP Inhibits Endoplasmic Reticulum BIK and Protects Human Breast Cancer Cells against Estrogen Starvation–Induced Apoptosis
Open the PDF for GRP78/BiP Inhibits Endoplasmic Reticulum BIK and Protects Human Breast Cancer Cells against Estrogen Starvation–Induced Apoptosis in another window
Journal Articles

GRP78 Induction in Cancer: Therapeutic and Prognostic Implications

Amy S. Lee
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3496–3499.
https://doi.org/10.1158/0008-5472.CAN-07-0325
Published: 17 April 2007
View article titled, GRP78 Induction in Cancer: Therapeutic and Prognostic Implications
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Journal Articles

GRP78 as a Novel Predictor of Responsiveness to Chemotherapy in Breast Cancer

Eunjung Lee, Peter Nichols, Darcy Spicer, Susan Groshen, Mimi C. Yu, Amy S. Lee
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7849–7853.
https://doi.org/10.1158/0008-5472.CAN-06-1660
Published: 15 August 2006
View article titled, GRP78 as a Novel Predictor of Responsiveness to Chemotherapy in Breast Cancer
Open the PDF for GRP78 as a Novel Predictor of Responsiveness to Chemotherapy in Breast Cancer in another window
Includes: Supplementary data