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Amy H. Tang
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Journal Articles

Abstract 2137: Racial disparities in triple-negative breast cancer (TNBC) mortality rates in Hampton Roads Virginia and the effects of SIAH expression on prognosis

Claire B. Piatak, Taylor N. Drake, Ashleigh Hannah, Jonathan Baker, Caroline L. Dasom, Emily L. Breeding, Janet S. Winston, Billur Samli, Rick Jansen, Michael Danso, Richard A. Hoefer, Amy H. Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2137.
https://doi.org/10.1158/1538-7445.AM2024-2137
Published: 22 March 2024
View article titled, Abstract 2137: Racial disparities in triple-negative breast cancer (TNBC) mortality rates in Hampton Roads Virginia and the effects of SIAH expression on prognosis
Journal Articles

Abstract 7664: Early detection of racial disparity and treatment resistance in triple negative breast cancer

Amy H. Tang, Richard A. Hoefer, Mary L. Guye, Billur Samli, Janet S. Winston, Jennifer Koblinski, Valentina Robila, Michael O. Idowu, Rick J. Jansen, Harry D. Bear
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7664.
https://doi.org/10.1158/1538-7445.AM2024-7664
Published: 22 March 2024
View article titled, Abstract 7664: Early detection of racial disparity and treatment resistance in triple negative breast cancer
Journal Articles

Abstract 5531: Early detection of cancer disparity and treatment resistance in TNBC

Amy H. Tang, Richard A. Hoefer, Dasom Lee, Emily L. Breeding, Mary L. Guye, Janet S. Winston, Billur Samli, Jennifer Koblinski, Valentina Robila, Michael O. Idowu, Rick J. Jansen, Harry D. Bear
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5531.
https://doi.org/10.1158/1538-7445.AM2023-5531
Published: 04 April 2023
View article titled, Abstract 5531: Early detection of cancer disparity and treatment resistance in TNBC
Journal Articles

Abstract 5248: The use of reverse phase protein array (RPPA) to identify new tumor vulnerability and actionable drug targets against human cancer cell lines

Andrew Howell, Julia Wulfkhule, Rosa Gallagher, Jonathan Baker, Ashleigh Hannah, Emanuel F. Petricoin, Amy H. Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5248.
https://doi.org/10.1158/1538-7445.AM2023-5248
Published: 04 April 2023
View article titled, Abstract 5248: The use of reverse phase protein array (RPPA) to identify new tumor vulnerability and actionable drug targets against human cancer cell lines
Journal Articles

Abstract 1961: Stratifying high-risk patients, quantifying therapy efficacy, and detecting treatment/racial disparity in triple-negative breast cancer (TNBC) at Sentara-EVMS-VOA

Taylor N. Drake, Brandon Euker, Angela M. Tang-Tan, Caroline Dasom Lee, Emily L. Breeding, Janet S. Winston, Billur Samli, Rick J. Jansen, Michael Danso, Mary L. Guye, Richard A. Hoefer, Amy H. Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1961.
https://doi.org/10.1158/1538-7445.AM2023-1961
Published: 04 April 2023
View article titled, Abstract 1961: Stratifying high-risk patients, quantifying therapy efficacy, and detecting treatment/racial disparity in triple-negative breast cancer (TNBC) at Sentara-EVMS-VOA
Journal Articles

Abstract P4-08-13: The Use of Reverse Phase Protein Arrays (RPPA), Principal Component Analysis (PCA), and CScape Pathway Mapping to Identify New Tumor Vulnerability and Actionable Targets in Human Malignant Triple-Negative Breast cancer cell lines

Andrew P. Howell, Julia Wulfkuhle, Rosa I. Gallagher, Emanuel F. Petricoin, Amy H. Tang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-13.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-13
Published: 01 March 2023
View article titled, Abstract P4-08-13: The Use of Reverse Phase Protein Arrays (RPPA), Principal Component Analysis (PCA), and CScape Pathway Mapping to Identify New Tumor Vulnerability and Actionable Targets in Human Malignant Triple-Negative Breast cancer cell lines
Journal Articles

Abstract 83: The critical role of seven-in-absentia (SINA) family E3 ligases in normal development and oncogenic K-RAS-driven human cancer

Robert E. Van Sciver, Yajun Cao, Atique U. Ahmed, Amy H. Tang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 83.
https://doi.org/10.1158/1538-7445.AM2019-83
Published: 01 July 2019
View article titled, Abstract 83: The critical role of seven-in-absentia (SINA) family E3 ligases in normal development and oncogenic K-RAS-driven human cancer
Journal Articles

Abstract 2145: Detect early tumor relapse in high-risk breast cancer

Amy H. Tang, Lauren L. Siewertsz van Reesema, Vasilena P. Zheleva, Janet S. Winston, Rick J. Jansen, Emanuel F. Petricoin, Matthew P. Goetz, Matthew P. Goetz, Harry D. Bear, Richard A. Hoefer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2145.
https://doi.org/10.1158/1538-7445.AM2019-2145
Published: 01 July 2019
View article titled, Abstract 2145: Detect early tumor relapse in high-risk breast cancer
Journal Articles

Abstract 584: Conquering undruggable oncogenic K-RAS-driven incurable metastatic cancer, and delivering precision medicine at neoadjuvant settings

Amy H. Tang, Robert E. Van Sciver, Elizaveta Svyatova, Kevin Kanda, Michael P. Lee, Caroline Dasom Lee, Lauren L. Siewertsz Van Reesema, Alex C. Lafever, Amber L. Collier, Apoorva S. Iyer, L.D. Britt, Janet S. Winston, Cynthia A. Allen, David Z. Chang, Gloria M. Petersen, Richard A. Hoefer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 584.
https://doi.org/10.1158/1538-7445.AM2018-584
Published: 01 July 2018
View article titled, Abstract 584: Conquering undruggable oncogenic K-RAS-driven incurable metastatic cancer, and delivering precision medicine at neoadjuvant settings
Journal Articles

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction

Xin Jin, Yunqian Pan, Liguo Wang, Tao Ma, Lizhi Zhang, Amy H. Tang, Daniel D. Billadeau, Heshui Wu, Haojie Huang
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4328–4341.
https://doi.org/10.1158/0008-5472.CAN-16-3143
Published: 14 August 2017
View article titled, Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction
Open the PDF for Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction in another window
Includes: Supplementary data
Journal Articles

Abstract 4824: The “gatekeeper” function of Drosophila Seven-IN-Absentia (SINA) E3 ligase and its human homologs, SIAH1 and SIAH2, is highly conserved for proper RAS signal transduction in Drosophila development

Robert E. Van Sciver, Yajun Cao, Atique U. Ahmed, Amy H. Tang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4824.
https://doi.org/10.1158/1538-7445.AM2017-4824
Published: 01 July 2017
View article titled, Abstract 4824: The “gatekeeper” function of <em>Drosophila</em> Seven-IN-Absentia (SINA) E3 ligase and its human homologs, SIAH1 and SIAH2, is highly conserved for proper RAS signal transduction in <em>Drosophila</em> development
Journal Articles

Abstract B63: An effective new strategy to control and inhibit the “undruggable” oncogenic K-RAS hyperactivation in human pancreatic cancer

Amy H. Tang, Minglei Bian1, Vasilena Zheleva, Monicah M. Njogu, Justin J. Odanga, Roger R. Perry, Richard A. Hoefer, Bruce E. Knudsen
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B63.
https://doi.org/10.1158/1538-7445.PANCA16-B63
Published: 14 December 2016
View article titled, Abstract B63: An effective new strategy to control and inhibit the “undruggable” oncogenic K-RAS hyperactivation in human pancreatic cancer
Journal Articles

Abstract 5049: SIAH2 E3 ligase targets LIM-domain proteins for degradation to modulate focal adhesion and cell motility

Minglei Bian, Yang Liao, Monicah Njogu, Rebecca Schmidt, Rie Takahashi, Zandra Walton, Amy H. Tang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5049.
https://doi.org/10.1158/1538-7445.AM2016-5049
Published: 15 July 2016
View article titled, Abstract 5049: SIAH2 E3 ligase targets LIM-domain proteins for degradation to modulate focal adhesion and cell motility
Journal Articles

Abstract 3498: Increased cellular stress and apoptosis induced by anti-SIAH2 therapy in human cancer cells with oncogenic K-RAS addiction

Monicah M. Njogu, Caroline Lee, Jamie Eisner, Minglei Bian, Robert Vansciver, Amy H. Tang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3498.
https://doi.org/10.1158/1538-7445.AM2016-3498
Published: 15 July 2016
View article titled, Abstract 3498: Increased cellular stress and apoptosis induced by anti-SIAH2 therapy in human cancer cells with oncogenic K-RAS addiction
Journal Articles

Abstract 4366: Inhibition of late-stage tumor growth of human pancreatic and triple-negative breast cancer by blocking the most downstream “gatekeeper” signaling module, SIAH E3 ligase, in the oncogenic ERBB/ K-RAS signaling pathway

Minglei Bian, Vasilena Zheleva, Xiaofei Gao, Justin Odanga, Monica Njogu, Zena Urban, Bruce Knudsen, Richard A. Hoefer, Roger R. Perry, Amy H. Tang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4366.
https://doi.org/10.1158/1538-7445.AM2015-4366
Published: 01 August 2015
View article titled, Abstract 4366: Inhibition of late-stage tumor growth of human pancreatic and triple-negative breast cancer by blocking the most downstream “gatekeeper” signaling module, SIAH E3 ligase, in the oncogenic ERBB/ K-RAS signaling pathway
Journal Articles

Abstract 2008: Proteomic analysis of SIAH2 E3 ligase complex in oncogenic K-Ras-driven cell transformation in human cancer

Monicah M. Njogu, Ming Lei Bian, Jamie Eisner, Amy H. Tang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2008.
https://doi.org/10.1158/1538-7445.AM2015-2008
Published: 01 August 2015
View article titled, Abstract 2008: Proteomic analysis of SIAH2 E3 ligase complex in oncogenic K-Ras-driven cell transformation in human cancer
Journal Articles

Abstract B70: Developing a new and potent anti-K-RAS strategy by inhibiting SIAH E3 ligase, the most downstream “gatekeeper” in the oncogenic K-RAS signal pathway, to block well-established pancreatic tumor growth

Vasilena Zheleva, Minglei Bian, Xiaofei Gao, Justin J. Odanga, Monicah M. Njogu, Zena M. Urban, Bruce E. Knudsen, Richard A. Hoefer, Roger R. Perry, Amy H. Tang
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B70.
https://doi.org/10.1158/1538-7445.PANCA2014-B70
Published: 30 June 2015
View article titled, Abstract B70: Developing a new and potent anti-K-RAS strategy by inhibiting SIAH E3 ligase, the most downstream “gatekeeper” in the oncogenic K-RAS signal pathway, to block well-established pancreatic tumor growth
Journal Articles

Abstract A1: SIAH E3 ligase as a novel anticancer drug target to inhibit RAS‐mediated tumorigenesis and metastasis in human cancer cells

Yang Liao, Cheol Hong Park, Rebecca L. Schmidt, Atique U. Ahmed, Rie Takahashi, Amy H. Tang
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A1.
https://doi.org/10.1158/0008-5472.FBCR09-A1
Published: 28 October 2014
View article titled, Abstract A1: SIAH E3 ligase as a novel anticancer drug target to inhibit RAS‐mediated tumorigenesis and metastasis in human cancer cells
Journal Articles

Abstract B14: Attacking the Achilles' heel in the oncogenic K-RAS signaling pathway to block tumorigenesis and metastasis in human cancers

Amy H. Tang, Yang Liao, Cheol Hong Park, Minglei Bian, Rebecca L. Schmidt, Atique U. Ahmed, Rie Takahashi, John A. Crooks, Zandra Walton
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): B14.
https://doi.org/10.1158/1538-7445.FBCR11-B14
Published: 28 October 2014
View article titled, Abstract B14: Attacking the Achilles' heel in the oncogenic K-RAS signaling pathway to block tumorigenesis and metastasis in human cancers
Journal Articles

Abstract 1965: Inhibiting SIAH2 E3 ligase function disrupts focal adhesion and cell junction, inhibits cell mobility and attachment, and blocks tumor invasion and metastasis in oncogenic K-Ras-driven tumors

Ming Bian, Yang Liao, Rebecca L. Schmidt, Monicah M. Njogu, Rie Takahashi, Zandra E. Walton, Amy H. Tang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1965.
https://doi.org/10.1158/1538-7445.AM2014-1965
Published: 01 October 2014
View article titled, Abstract 1965: Inhibiting SIAH2 E3 ligase function disrupts focal adhesion and cell junction, inhibits cell mobility and attachment, and blocks tumor invasion and metastasis in oncogenic K-Ras-driven tumors