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Journal Articles

Abstract 5832: Utilizing small noncoding RNAs as biomarkers for selinexor treatment in gastric cancer

Rachel E. Sexton, Amro Aboukameel, Yiwei Li, Husain Y. Khan, Md Hafiz Uddin, Trishyan Kashyap, Yosef Landesman, Anteneh Tesfaye, Asfar S. Azmi

Cancer Res (2022) 82 (12_Supplement): 5832.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5832

Published: 15 June 2022

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Journal Articles

Abstract 5315: Anti-tumor activity of KRAS^G12C inhibitors is enhanced when combined with Cdc42 effector p21-activated kinase 4 targeting agents

Husain Yar Khan, Sahar Bannoura, Hirva Mamdani, Amro Aboukameel, Yousef Mzannar, Yiwei Li, Mohammad Najeeb Al-Hallak, Ibrahim Azar, Steve Kim, Rafic Beydoun, Ramzi Mohammad, Yosef Landesman, Yue Zhang, Erkan Baloglu, William Senapedis, Ammar Sukari, Misako Nagasaka, Anthony Shields, Asfar S. Azmi

Cancer Res (2022) 82 (12_Supplement): 5315.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5315

Published: 15 June 2022

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Journal Articles

Abstract 5330: Nuclear protein export inhibitor selinexor chemotherapy combination for pancreatic cancer therapy

Md. Hafiz Uddin, Sahar Bannoura, Yiwei Li, Husain Y. Khan, Amro Aboukameel, Mohammed N. Al-Hallak, Rafic Beydoun, Steve Kim, Yosef Landesman, Ramzi M. Mohammad, Anthony Shields, Asfar S. Azmi

Cancer Res (2022) 82 (12_Supplement): 5330.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5330

Published: 15 June 2022

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Journal Articles

Abstract 2383: Mir-7974: An oncogenic miRNA that perpetuates gastric cancer

Rachel E. Sexton, Mohammad Najeeb Al-Hallak, Bayan Al-Share, Yiwei Li, Amro Aboukameel, Yosef Landesman, Trinayan Kashyap, Steve Kim, Ramzi M. Mohammad, Philip A. Philip, Asfar S. Azmi

Cancer Res (2021) 81 (13_Supplement): 2383.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2383

Published: 01 July 2021

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Journal Articles

Abstract 1122: Novel targets for therapy resistant pancreatic neuroendocrine tumors

Gabriel B. Mpilla, Amro Aboukameel, Md Hafiz Uddin, Mohammed N. Al-Hallak, Bayan Al-Share, Yosef Landesman, Yiwei Li, Steve Kim, Rafic Beydoun, Ramzi M. Mohammad, Philip A. Philip, Bassel El-Rayes, Asfar S. Azmi

Cancer Res (2021) 81 (13_Supplement): 1122.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1122

Published: 01 July 2021

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Journal Articles

Abstract 1722: Nanoparticle pro-drug to overcome the stromal barrier in pancreatic ductal adenocarcinoma

Rami Alzhrani, Samaresh Sau, Amro Aboukameel, Hashem Alsaab, Asfar Azmi, Arun Iyer

Cancer Res (2020) 80 (16_Supplement): 1722.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1722

Published: 15 August 2020

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Journal Articles

Abstract 234: A novel, small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), RP7214, potentiates activity of chemotherapeutics in breast and colorectal cancers

Asfar S. Azmi, Amro Aboukameel, Mohammad Najeeb Al-Hallak, Philip A. Philip, Kumar Penmetsa, Srikant Visvanadha, Gabriel Mpilla, Rachel Sexton, Ramzi M. Mohammad

Cancer Res (2020) 80 (16_Supplement): 234.

DOI: https://doi.org/10.1158/1538-7445.AM2020-234

Published: 15 August 2020

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Journal Articles

Abstract 3476: Evaluable antitumor activity in metastatic pancreatic adenocarcinoma with specific inhibitor of nuclear export based treatment

Asfar S. Azmi, Yosef Landesman, Michael Kauffman, Sharon Shacham, Gabriel Mpilla, Amro Aboukameel, Steve Kim, Mandana Kamgar, Anteneh Tesfaye, Ramzi M. Mohammad, Philip A. Philip

Cancer Res (2019) 79 (13_Supplement): 3476.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3476

Published: 01 July 2019

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Journal Articles

Abstract 3069: Efficacy of RP4010, a calcium release-activated calcium (CRAC) channel inhibitor, in preclinical models of gastrointestinal cancers

Irfana Muqbil, Rachel Sexton, Gabriel Mpilla, Anteneh Tesfaye, Steve Kim, Philip A. Philip, Amro Aboukameel, Srikant Viswanadah, Kumar V. Penmesta, Ramzi M. Mohammad, Asfar S. Azmi

Cancer Res (2019) 79 (13_Supplement): 3069.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3069

Published: 01 July 2019

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Journal Articles

Abstract 5036: Induction of highly efficacious anti-tumor activity and modulation of tumor microenvironment: Cell-free off the shelf therapeutic modality

Archana Thakur, SriVidya Yarlagadda, Kyungmin Ji, Dana L. Schalk, Johnson Ung, Edwin T. Bliemeister, Amro Aboukameel, Eli Casarez, Bonnie F. Sloane, Lawrence G. Lum

Cancer Res (2019) 79 (13_Supplement): 5036.

DOI: https://doi.org/10.1158/1538-7445.AM2019-5036

Published: 01 July 2019

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Journal Articles

Abstract 4368: PAK4-NAMPT dual inhibition as a feasible strategy for treatment of resistant pancreatic neuroendocrine tumors

Gabriel Mpilla, Irfana Muqbil, Amro Aboukameel, Philip A. Philip, William Senapedis, Erkan Baloglu, Yosef Landesman, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad, Asfar S. Azmi

Cancer Res (2018) 78 (13_Supplement): 4368.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4368

Published: 01 July 2018

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Journal Articles

Abstract 1358: p21 activated kinase 4 (pak4) as a novel therapeutic target for non-hodgkin's lymphoma

Asfar S. Azmi, Amro Aboukameel, Irfana Muqbil, Yiwei Li, William Senapedis, Erkan Baloglu, Yosef Landesman, Michael Kauffman, Sharon Shacham, Ayad Al-Katib, Ramzi M. Mohammad

Cancer Res (2017) 77 (13_Supplement): 1358.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1358

Published: 01 July 2017

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Journal Articles

Abstract 464: Novel role of xpo1 in regulating MicroRNAs related to pancreatic ductal adenocarcinoma invasion and metastasis

Asfar S. Azmi, Yiwei Li, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Michael Kauffman, Sharon Shacham, Philip A. Philip, Ramzi M. Mohammad

Cancer Res (2017) 77 (13_Supplement): 464.

DOI: https://doi.org/10.1158/1538-7445.AM2017-464

Published: 01 July 2017

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Journal Articles

Abstract B38: Clinical translation of nuclear export inhibitor in metastatic pancreatic cancer

Asfar S. Azmi, Irfana Muqbil, Amro Aboukameel, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad, Philip A. Philip

Cancer Res (2016) 76 (24_Supplement): B38.

DOI: https://doi.org/10.1158/1538-7445.PANCA16-B38

Published: 14 December 2016

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Journal Articles

Abstract 1873: The role of p21-activated kinase 4 (PAK4) in cancer stemness and epithelial-to-mesenchymal transition

Asfar S. Azmi, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael Kauffman, Philip A. Philip, Ramzi M. Mohammad

Cancer Res (2016) 76 (14_Supplement): 1873.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1873

Published: 15 July 2016

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Journal Articles

Abstract 1424: F-box protein fbxl5 nuclear retention by specific inhibitors of nuclear export induces snail ubiquitination leading to reversal of EMT

Irfana Muqbil, Amro Aboukameel, Yosef Landesman, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad, Asfar S. Azmi

Cancer Res (2015) 75 (15_Supplement): 1424.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1424

Published: 01 August 2015

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Journal Articles

Abstract 4688: Overcoming drug resistance and stemness in oncogenic kras driven pancreatic ductal adenocarcinoma through PAK4 inhibition

Asfar S. Azmi, William Senapedis, Erkan Baloglu, Yosef Landesman, Michael Kauffman, Sharon Shacham, Jack Wu, Amro Aboukameel, Irfana Muqbil, Ramzi M. Mohammad

Cancer Res (2015) 75 (15_Supplement): 4688.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4688

Published: 01 August 2015

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Journal Articles

Abstract 1756: Preclinical activity in non-Hodgkin's lymphoma of Selinexor, a selective inhibitor of nuclear export (SINE), is enhanced through combination with standard-of-care therapies

Asfar S. Azmi, Amro Aboukameel, Robert O. Carlson, Sivan Elloul, Sharon Shacham, Michael Kauffman, Ran Frenkel, Ramzi M. Mohammad

Cancer Res (2015) 75 (15_Supplement): 1756.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1756

Published: 01 August 2015

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Journal Articles

Abstract 1771: Novel small molecule pak4 allosteric modulators with activity against pancreatic cancer

Asfar S. Azmi, William Senapedis, Yosef Landesman, Erkan Baloglu, Ori Kalid, Jack Wu, Bin Bao, Amro Aboukameel, Sharon Shacham, Michael Kauffman, Ramzi M. Mohammad

Cancer Res (2014) 74 (19_Supplement): 1771.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1771

Published: 01 October 2014

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Journal Articles

Abstract LB-185: Novel activity of selective inhibitors of nuclear export in epithelial-to-mesenchymal transition models

Asfar S. Azmi, Sharon Shacham, Michael Kauffman, Dilara McCauley, Amro Aboukameel, Ramzi M. Mohammad

Cancer Res (2014) 74 (19_Supplement): LB-185.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-185

Published: 01 October 2014

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NARROW

Abstract 5832: Utilizing small noncoding RNAs as biomarkers for selinexor treatment in gastric cancer

Abstract 5315: Anti-tumor activity of KRAS^G12C inhibitors is enhanced when combined with Cdc42 effector p21-activated kinase 4 targeting agents

Abstract 5330: Nuclear protein export inhibitor selinexor chemotherapy combination for pancreatic cancer therapy

Abstract 2383: Mir-7974: An oncogenic miRNA that perpetuates gastric cancer

Abstract 1122: Novel targets for therapy resistant pancreatic neuroendocrine tumors

Abstract 1722: Nanoparticle pro-drug to overcome the stromal barrier in pancreatic ductal adenocarcinoma

Abstract 234: A novel, small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), RP7214, potentiates activity of chemotherapeutics in breast and colorectal cancers

Abstract 3476: Evaluable antitumor activity in metastatic pancreatic adenocarcinoma with specific inhibitor of nuclear export based treatment

Abstract 3069: Efficacy of RP4010, a calcium release-activated calcium (CRAC) channel inhibitor, in preclinical models of gastrointestinal cancers

Abstract 5036: Induction of highly efficacious anti-tumor activity and modulation of tumor microenvironment: Cell-free off the shelf therapeutic modality

Abstract 4368: PAK4-NAMPT dual inhibition as a feasible strategy for treatment of resistant pancreatic neuroendocrine tumors

Abstract 1358: p21 activated kinase 4 (pak4) as a novel therapeutic target for non-hodgkin's lymphoma

Abstract 464: Novel role of xpo1 in regulating MicroRNAs related to pancreatic ductal adenocarcinoma invasion and metastasis

Abstract B38: Clinical translation of nuclear export inhibitor in metastatic pancreatic cancer

Abstract 1873: The role of p21-activated kinase 4 (PAK4) in cancer stemness and epithelial-to-mesenchymal transition

Abstract 1424: F-box protein fbxl5 nuclear retention by specific inhibitors of nuclear export induces snail ubiquitination leading to reversal of EMT

Abstract 4688: Overcoming drug resistance and stemness in oncogenic kras driven pancreatic ductal adenocarcinoma through PAK4 inhibition

Abstract 1756: Preclinical activity in non-Hodgkin's lymphoma of Selinexor, a selective inhibitor of nuclear export (SINE), is enhanced through combination with standard-of-care therapies

Abstract 1771: Novel small molecule pak4 allosteric modulators with activity against pancreatic cancer

Abstract LB-185: Novel activity of selective inhibitors of nuclear export in epithelial-to-mesenchymal transition models

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