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Amato J. Giaccia
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Journal Articles

Abstract 3273: Tirapazamine sensitizes homologous recombination-proficient cancers by enhancing DNA damage andferroptosis

Yanyan Jiang, Hala Estephan, Yizhou Wang, Ftoon Aljarbou, Nuria V. Lopera, Eui Jung Moon, Ester M. Hammond, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3273.
https://doi.org/10.1158/1538-7445.AM2024-3273
Published: 22 March 2024
View articletitled, Abstract 3273: Tirapazamine sensitizes homologous recombination-proficient cancers by enhancing DNA damage andferroptosis
Journal Articles

Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4–pRB Axis in Fibroblasts at the Invasive Tumor Edge

Gina Bouchard, Fernando Jose Garcia-Marques, Loukia Georgiou Karacosta, Weiruo Zhang, Abel Bermudez, Nicholas McIlvain Riley, Sushama Varma, Lindsey Catherine Mehl, Jalen Anthony Benson, Joseph B. Shrager, Carolyn Ruth Bertozzi, Sharon J. Pitteri, Amato J. Giaccia, Sylvia Katina Plevritis
Journal: Cancer Research
Cancer Res (2022) 82 (4): 648–664.
https://doi.org/10.1158/0008-5472.CAN-21-1705
Published: 01 December 2021
View articletitled, Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4–pRB Axis in Fibroblasts at the Invasive Tumor Edge
Open the PDF for Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4–pRB Axis in Fibroblasts at the Invasive Tumor Edge in another window
Includes: Supplementary data
Journal Articles

Abstract 5708: Deciphering Warburg effect: hypoxia inhibits tumor cell differentiation through reducing acetyl-CoA generation and chromatin accessibility

Jiangbin Ye, Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu R. Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5708.
https://doi.org/10.1158/1538-7445.AM2020-5708
Published: 15 August 2020
View articletitled, Abstract 5708: Deciphering Warburg effect: hypoxia inhibits tumor cell differentiation through reducing acetyl-CoA generation and chromatin accessibility
Journal Articles

S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma

Yiren Xiao, Hongjuan Zhao, Lei Tian, Rosalie Nolley, Anh N. Diep, Anne Ernst, Katherine C. Fuh, Yu Rebecca Miao, Rie von Eyben, John T. Leppert, James D. Brooks, Donna M. Peehl, Amato J. Giaccia, Erinn B. Rankin
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5758–5768.
https://doi.org/10.1158/0008-5472.CAN-19-1366
Published: 15 November 2019
View articletitled, S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma
Open the PDF for S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3798: Acetate supplementation eliminates hypoxia mediated resistance to differentiation therapy in neuroblastoma cells

Yang Li, Yiren Zhou, John M. Maris, Amato J. Giaccia, Jiangbin Ye
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3798.
https://doi.org/10.1158/1538-7445.AM2019-3798
Published: 01 July 2019
View articletitled, Abstract 3798: Acetate supplementation eliminates hypoxia mediated resistance to differentiation therapy in neuroblastoma cells
Journal Articles

Abstract 3931: The irradiated tissue microenvironment and its role in breast cancer recurrence: Enhanced macrophage infiltration promotes tumor cell recruitment

Benjamin C. Hacker, Steven M. Alves, Dadi Jiang, Albert C. Koong, Amato J. Giaccia, Edward E. Graves, Marjan Rafat
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3931.
https://doi.org/10.1158/1538-7445.AM2019-3931
Published: 01 July 2019
View articletitled, Abstract 3931: The irradiated tissue microenvironment and its role in breast cancer recurrence: Enhanced macrophage infiltration promotes tumor cell recruitment
Journal Articles

Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Ching-Shih Chen, Bing Yu, Ioanna Papandreou, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2927.
https://doi.org/10.1158/1538-7445.AM2019-2927
Published: 01 July 2019
View articletitled, Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
Journal Articles

Macrophages Promote Circulating Tumor Cell–Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients

Marjan Rafat, Todd A. Aguilera, Marta Vilalta, Laura L. Bronsart, Luis A. Soto, Rie von Eyben, Meghana A. Golla, Yasaman Ahrari, Stavros Melemenidis, Anosheh Afghahi, Melissa J. Jenkins, Allison W. Kurian, Kathleen C. Horst, Amato J. Giaccia, Edward E. Graves
Journal: Cancer Research
Cancer Res (2018) 78 (15): 4241–4252.
https://doi.org/10.1158/0008-5472.CAN-17-3623
Published: 31 July 2018
View articletitled, Macrophages Promote Circulating Tumor Cell–Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients
Open the PDF for Macrophages Promote Circulating Tumor Cell–Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients in another window
Includes: Supplementary data
Journal Articles

Abstract 3202: Radiation increases invasive activity of breast cancer cells via altering lysosome exocytosis

Ping-Hsiu Wu, Yasuhito Onodera, Amato J. Giaccia, Quynh-Thu Le, Hiroki Shirato, Jin-Min Nam
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3202.
https://doi.org/10.1158/1538-7445.AM2018-3202
Published: 01 July 2018
View articletitled, Abstract 3202: Radiation increases invasive activity of breast cancer cells via altering lysosome exocytosis
Journal Articles

Abstract 4382: Complement system mutational landscape reveals C4BPA mutations enhance apoptosis in an immune-independent manner

Monica M. Olcina, Nikolas G. Balanis, Ryan K. Kim, Michael J. Thompson, Thomas G. Graeber, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4382.
https://doi.org/10.1158/1538-7445.AM2018-4382
Published: 01 July 2018
View articletitled, Abstract 4382: Complement system mutational landscape reveals C4BPA mutations enhance apoptosis in an immune-independent manner
Journal Articles

Abstract 5124: Tumor and immune cell infiltration are enhanced by irradiation of normal tissues in immunocompromised mice

Marjan Rafat, Marta Vilalta, Todd A. Aguilera, Amato J. Giaccia, Edward E. Graves
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5124.
https://doi.org/10.1158/1538-7445.AM2016-5124
Published: 15 July 2016
View articletitled, Abstract 5124: Tumor and immune cell infiltration are enhanced by irradiation of normal tissues in immunocompromised mice
Journal Articles

Abstract 4988: Reprogramming the immunologic microenvironment through radiation and Axl targeting

Todd A. Aguilera, Marjan R. Rafat, Laura Castellini, Mihalis S. Kariolis, Rie vonEbyen, Edward E. Graves, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4988.
https://doi.org/10.1158/1538-7445.AM2016-4988
Published: 15 July 2016
View articletitled, Abstract 4988: Reprogramming the immunologic microenvironment through radiation and Axl targeting
Journal Articles

Abstract 1181: The Apoptosis repressor with a CARD domain (ARC) is a direct HIF1 target gene and promotes survival and proliferation of VHL deficient renal cancer cells

Olga V. Razorenova, Laura Castellini, Renata Colavitti, Laura E. Edgington, Monica Nicolau, Xin Huang, Barbara Bedogni, Edward M. Mills, Matthew Bogyo, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1181.
https://doi.org/10.1158/1538-7445.AM2014-1181
Published: 01 October 2014
View articletitled, Abstract 1181: The Apoptosis repressor with a CARD domain (ARC) is a direct HIF1 target gene and promotes survival and proliferation of VHL deficient renal cancer cells
Journal Articles

Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis

Alice Banh, Jing Zhang, Hongbin Cao, Donna M. Bouley, Shirley Kwok, Christina Kong, Amato J. Giaccia, Albert C. Koong, Quynh-Thu Le
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4423–4431.
https://doi.org/10.1158/0008-5472.CAN-10-4157
Published: 30 June 2011
View articletitled, Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis
Open the PDF for Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis in another window
Includes: Supplementary data
Journal Articles

Abstract 3412: Hypoxia induces EMT in primary melanoma and MET in metastatic melanoma

Chieh-Fang Cheng, Amato J. Giaccia, Marianne B. Powell
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3412.
https://doi.org/10.1158/1538-7445.AM2011-3412
Published: 15 April 2011
View articletitled, Abstract 3412: Hypoxia induces EMT in primary melanoma and MET in metastatic melanoma
Journal Articles

Abstract 1460: AKAP12 regulates melanoma tumor growth and metastasis

Elizabeth C. Finger, Alice Banh, Erinn B. Rankin, Marta Vilalta, Adam J. Krieg, Marianne Broome-Powell, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1460.
https://doi.org/10.1158/1538-7445.AM2011-1460
Published: 15 April 2011
View articletitled, Abstract 1460: AKAP12 regulates melanoma tumor growth and metastasis
Journal Articles

Abstract LB-357: HIF-dependent over-expression of CUB domain-containing protein 1 stimulates migration in clear cell renal cell carcinoma

Olga V. Razorenova, Elizabeth C. Finger, Renata Colavitti, Sophia B. Chernikova, Alexander D. Boiko, Charles KF Chan, Adam Krieg, Barbara Bedogni, Edward LaGory, Irving L. Weissman, Marianne Broome-Powell, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-357.
https://doi.org/10.1158/1538-7445.AM2011-LB-357
Published: 15 April 2011
View articletitled, Abstract LB-357: HIF-dependent over-expression of CUB domain-containing protein 1 stimulates migration in clear cell renal cell carcinoma
Journal Articles

AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

Erinn B. Rankin, Katherine C. Fuh, Tiffany E. Taylor, Adam J. Krieg, Margaret Musser, Jenny Yuan, Kevin Wei, Calvin J. Kuo, Teri A. Longacre, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2010) 70 (19): 7570–7579.
https://doi.org/10.1158/0008-5472.CAN-10-1267
Published: 29 September 2010
View articletitled, AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer
Open the PDF for AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 67: Selective cytotoxic targeting of von Hippel-Lindau-deficient renal cell carcinoma cells

Edwin W. Lai, Denise A. Chan, Michael P. Hay, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 67.
https://doi.org/10.1158/1538-7445.AM10-67
Published: 15 April 2010
View articletitled, Abstract 67: Selective cytotoxic targeting of von Hippel-Lindau-deficient renal cell carcinoma cells
Journal Articles

The Role of Tumor Cell–Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth

Kevin L. Bennewith, Xin Huang, Christine M. Ham, Edward E. Graves, Janine T. Erler, Neeraja Kambham, Jonathan Feazell, George P. Yang, Albert Koong, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2009) 69 (3): 775–784.
https://doi.org/10.1158/0008-5472.CAN-08-0987
Published: 29 January 2009
View articletitled, The Role of Tumor Cell–Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth
Open the PDF for The Role of Tumor Cell–Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth in another window