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Alnawaz Rehemtulla
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Journal Articles

Abstract B001: Glioblastoma evolution and resistance is mediated by a shift in cell state and tumor microenvironmental interactions

Sunita Shankar, Visweswaran Ravikumar, Arushi Tripathy, Sunjong Ji, Jackson Loper, Zainab Hassan, Ziad Fehmi, Yacoub Haydin, Dah-Luen Huang, Sagnik Bhadury, Reva Kulkarni, Jeffrey Regier, Daniel Wahl, Arvind Rao, Alnawaz Rehemtulla, Wajd N. Al-Holou
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): B001.
https://doi.org/10.1158/1538-7445.BRAIN23-B001
Published: 04 March 2024
View article titled, Abstract B001: Glioblastoma evolution and resistance is mediated by a shift in cell state and tumor microenvironmental interactions
Journal Articles

Abstract 3909: THY1 regulates therapy resistance in glioblastoma recurrence

Sunita Shankar, Visweswaran Ravikumar, Hanxiao Wang, Sunjong Ji, Zainab Hasan, Ziad Fehmi, Yacoub Haydin, Daniel R. Wahl, Arvind Rao, Alnawaz Rehemtulla, Wajd Al-Holou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3909.
https://doi.org/10.1158/1538-7445.AM2023-3909
Published: 04 April 2023
View article titled, Abstract 3909: THY1 regulates therapy resistance in glioblastoma recurrence
Journal Articles

Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Morgan Oneka, Roel G. Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel Wahl, Sunita Shankar, Todd Hollon, Oren Sagher, Jason Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C. deCarvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB013.
https://doi.org/10.1158/1538-7445.AM2022-LB013
Published: 15 June 2022
View article titled, Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma
Journal Articles

Abstract 3430: TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling

Shyam Nyati, Brandon Gregg, Jiaqi Xu, Grant Young, Lauren Kimmel, Nyati Mukesh, Dipankar Ray, Hongtao Yu, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3430.
https://doi.org/10.1158/1538-7445.AM2019-3430
Published: 01 July 2019
View article titled, Abstract 3430: TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling
Journal Articles

Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy

Yajing Liu, Wenbin Ji, Andrea Shergalis, Jiaqi Xu, Amy M. Delaney, Andrew Calcaterra, Anupama Pal, Mats Ljungman, Nouri Neamati, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2923–2932.
https://doi.org/10.1158/0008-5472.CAN-18-2540
Published: 03 June 2019
View article titled, Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy
Open the PDF for Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 2931: MTX-211, a dual and selective inhibitor of EGFR and PI3 kinase, shows promising activity in combination with MEK inhibition in preclinical models of pancreatic cancer

Christy Frankowski-McGregor, Joel Maust, Elizabeth Ziemke, Rachel Mumby, Amy Delaney, Alnawaz Rehemtulla, Christopher Whitehead, Judith S. Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2931.
https://doi.org/10.1158/1538-7445.AM2018-2931
Published: 01 July 2018
View article titled, Abstract 2931: MTX-211, a dual and selective inhibitor of EGFR and PI3 kinase, shows promising activity in combination with MEK inhibition in preclinical models of pancreatic cancer
Journal Articles

Cancer Stem Cell Marker Phenotypes Are Reversible and Functionally Homogeneous in a Preclinical Model of Pancreatic Cancer

Joseph S. Dosch, Elizabeth K. Ziemke, Amrith Shettigar, Alnawaz Rehemtulla, Judith S. Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2015) 75 (21): 4582–4592.
https://doi.org/10.1158/0008-5472.CAN-14-2793
Published: 01 November 2015
View article titled, Cancer Stem Cell Marker Phenotypes Are Reversible and Functionally Homogeneous in a Preclinical Model of Pancreatic Cancer
Open the PDF for Cancer Stem Cell Marker Phenotypes Are Reversible and Functionally Homogeneous in a Preclinical Model of Pancreatic Cancer in another window
Journal Articles

Abstract 1400: Evaluation of tumor-initiating cell populations in the KPC mouse model of pancreatic cancer

Joseph S. Dosch, Elizabeth K. Ziemke, Amrith Shettigar, Alnawaz Rehemtulla, Judith S. Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1400.
https://doi.org/10.1158/1538-7445.AM2015-1400
Published: 01 August 2015
View article titled, Abstract 1400: Evaluation of tumor-initiating cell populations in the KPC mouse model of pancreatic cancer
Journal Articles

Abstract 1137: Bub1 is a key regulator of TGF-β signaling

Shyam Nyati, Katrina Schinske-Sebolt, Sethuramasundaram Pitchiaya, Katerina Chekhovskiy, Areeb Chator, Nauman Chaudhry, Joseph Dosch, Marcian E. Van Dort, Sooryanarayana Varambally, Chandan Kumar-Sinha, Mukesh K. Nyati, Dipankar Ray, Nils G. Walter, Hongtao Yu, Brian D. Ross, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1137.
https://doi.org/10.1158/1538-7445.AM2014-1137
Published: 01 October 2014
View article titled, Abstract 1137: Bub1 is a key regulator of TGF-β signaling
Journal Articles

Abstract 2061: Extended adjuvant temozolomide improves survival in a glioblastoma mouse model

Hanxiao Wang, Wajd Al-Holou, Kevin Heist, Craig J. Galbán, Ana C. deCarvalho, Tom Mikkelsen, Brian D. Ross, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2061.
https://doi.org/10.1158/1538-7445.AM2014-2061
Published: 01 October 2014
View article titled, Abstract 2061: Extended adjuvant temozolomide improves survival in a glioblastoma mouse model
Journal Articles

Abstract 4289: Noninvasive monitoring of blood-brain barrier permeability for antibodies by apoptosis imaging: optimization of treatment strategies for maximal brain delivery

Thomas G. Weber, Julia Mathejczyk, Stefanie Galbán, Alnawaz Rehemtulla, Werner Scheuer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4289.
https://doi.org/10.1158/1538-7445.AM2014-4289
Published: 01 October 2014
View article titled, Abstract 4289: Noninvasive monitoring of blood-brain barrier permeability for antibodies by apoptosis imaging: optimization of treatment strategies for maximal brain delivery
Journal Articles

Abstract 106: A requirement for FADD and its phosphorylation for KRAS-driven oncogenesis

Brittany M. Bowman, Stefanie Galban, Benjamin A. Hoff, Kevin A. Heist, Jennifer L. Boes, Craig J. Galban, Rajiv M. Patel, Jianke Zhang, Brian D. Ross, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 106.
https://doi.org/10.1158/1538-7445.AM2014-106
Published: 01 October 2014
View article titled, Abstract 106: A requirement for FADD and its phosphorylation for KRAS-driven oncogenesis
Journal Articles

Abstract B43: Co-targeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.

Terence M. Williams, Athena Flecha, Paul Keller, Ashwin Ram, David Karnak, Brian Ross, Theodore Lawrence, Alnawaz Rehemtulla, Judith Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B43.
https://doi.org/10.1158/1538-7445.PANCA2012-B43
Published: 03 April 2014
View article titled, Abstract B43: Co-targeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.
Journal Articles

Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively

Thomas G. Weber, Franz Osl, Anja Renner, Thomas Pöschinger, Stefanie Galbán, Alnawaz Rehemtulla, Werner Scheuer
Journal: Cancer Research
Cancer Res (2014) 74 (7): 1913–1923.
https://doi.org/10.1158/0008-5472.CAN-13-3001
Published: 31 March 2014
View article titled, Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Open the PDF for Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively in another window
Includes: Supplementary data
Journal Articles

Abstract 5595: Imaging biomarker development for treatment efficacy for prostate cancer to the bone.

Joshua S. George, Craig J. Galban, Jean-Christophe Brisset, Benjamin Hoff, Stephanie Galban, Alnawaz Rehemtulla, Brian D. Ross
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5595.
https://doi.org/10.1158/1538-7445.AM2013-5595
Published: 15 April 2013
View article titled, Abstract 5595: Imaging biomarker development for treatment efficacy for prostate cancer to the bone.
Journal Articles

Abstract 723: Anticancer ERK kinase inhibitor screening with molecular imaging.

Lanlan Zhou, Shengliang Zhang, David T. Dicker, Alnawaz Rehemtulla, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 723.
https://doi.org/10.1158/1538-7445.AM2013-723
Published: 15 April 2013
View article titled, Abstract 723: Anticancer ERK kinase inhibitor screening with molecular imaging.
Journal Articles

Abstract 4433: DW-MR imaging as a predictive biomarker of radiosensitization of GBM through targeted inhibition of checkpoint kinases.

Terence Williams, Stefanie Galbán, Fei Li, Kevin Heist, Craig Galbán, Theodore S. Lawrence, Eric C. Holland, Tami Thomae, Thomas Chenevert, Alnawaz Rehemtulla, Brian D. Ross
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4433.
https://doi.org/10.1158/1538-7445.AM2013-4433
Published: 15 April 2013
View article titled, Abstract 4433: DW-MR imaging as a predictive biomarker of radiosensitization of GBM through targeted inhibition of checkpoint kinases.
Journal Articles

Abstract 2434: A genetically engineered mouse for imaging of apoptosis in a tissue specific manner

Stefanie Galbán, Yong Hyun Jeon, Lisa M. Sharkey, Benjamin A. Hoff, Craig J. Galban, Brian D. Ross, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2434.
https://doi.org/10.1158/1538-7445.AM2012-2434
Published: 15 April 2012
View article titled, Abstract 2434: A genetically engineered mouse for imaging of apoptosis in a tissue specific manner
Journal Articles

Abstract 380: Optimization of novel therapeutic paradigms for ovarian cancer using molecular imaging

Hanxiao Wang, Stefanie Galban, Rong Wu, Brittany Bowman, Athena Fletcha, Amanda Witte, Komal Chughtai, Brian Ross, Kathleen Cho, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 380.
https://doi.org/10.1158/1538-7445.AM2012-380
Published: 15 April 2012
View article titled, Abstract 380: Optimization of novel therapeutic paradigms for ovarian cancer using molecular imaging
Journal Articles

Abstract 4066: Early assessment of the XL184 treatment by Diffusion-Weighted MRI in metastatic prostate cancer to the bone murine model

Jean-Christophe Brisset, Benjamin Hoff, Stefanie Galban, Benjamin Lemasson, Alnawaz Rehemtulla, Craig Galban, Brian Dale Ross
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4066.
https://doi.org/10.1158/1538-7445.AM2012-4066
Published: 15 April 2012
View article titled, Abstract 4066: Early assessment of the XL184 treatment by Diffusion-Weighted MRI in metastatic prostate cancer to the bone murine model