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Alison M. Schram
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Journal Articles

Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor

Hilla Solomon, Radha Mukherjee, Xiaoping Chen, HuiYong Zhao, Elisa de Stanchina, Britta Weigelt, Alison M. Schram, Carol Aghajanian, Mallika Singh, Jan Smith, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB089.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB089
Published: 15 June 2022
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Journal Articles

Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations

Timothy A. Yap, Seock-Ah Im, Alison M. Schram, Adam Sharp, Judith Balmana, Richard D. Baird, Jessica S. Brown, Maria Schwaederle, Elizabeth A. Pilling, Ganesh Moorthy, Spiros Linardopoulos, Adam Dowson, Carol Pound, Edit Lukacs, Sabina Cosulich, Stephen J. Luen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT007.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT007
Published: 15 June 2022
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Journal Articles

Abstract 956: The HER2×HER3 bi-specific antibody Zenocutuzumab is effective at blocking growth of tumors driven by NRG1 gene fusions

Igor Odintsov, Inna Khodos, Madelyn Espinosa-Cotton, Allan J. Lui, Marissa Mattar, Alison M. Schram, Ron C. Schackmann, Jeroen Lammerts van Bueren, Cecile A. Geuijen, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 956.
DOI: https://doi.org/10.1158/1538-7445.AM2021-956
Published: 01 July 2021
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Journal Articles

Abstract 5280: Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer

Bo Liu, Dara S. Ross, Alison M. Schram, Pedram Razavi, Stephen M. Lagana, Yanming Zhang, Maurizio Scaltriti, Jacqueline F. Bromberg, Marc Ladanyi, David M. Hyman, Alexander Drilon, Ahmet Zahir, Ryma Benayed, Jaclyn F. Hechtman, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5280.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5280
Published: 15 August 2020
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Journal Articles

Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Yi Liao, Uwe Rix, Alberto Bardelli, Jacklyn Hechtman, Elisa de Stanchina, David M. Hyman, Chandra Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5680.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5680
Published: 15 August 2020
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Journal Articles

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

Emiliano Cocco, Amanda Kulick, Sandra Misale, Rona Yaeger, Pedram Razavi, Helen H. Won, Ryan Ptashkin, Jaclyn F. Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B. Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J. Nagy, Richard B. Lanman, Michael F. Berger, Marc Ladanyi, David M. Hyman, Alexander Drilon, Maurizio Scaltriti, Alison M. Schram
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-118.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-118
Published: 01 July 2019
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Journal Articles

Abstract 1681: Prospective clinical sequencing distinguishes independent primary cancers from recurrent or metastatic disease

Alison M. Schram, Chai Bandlamudi, Ahmet Zehir, Marc Ladanyi, Michael F. Berger, Barry S. Taylor, David M. Hyman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1681.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1681
Published: 01 July 2019
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Journal Articles

Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions

Emiliano Cocco, Jamal Benhamida, Sumit Middha, Ahmet Zehir, Kerry Mullaney, Jinru Shia, Rona Yaeger, Liying Zhang, Donna Wong, Liliana Villafania, Khedoudja Nafa, Maurizio Scaltriti, Alexander Drilon, Leonard Saltz, Alison M. Schram, Zsofia K. Stadler, David M. Hyman, Ryma Benayed, Marc Ladanyi, Jaclyn F. Hechtman
Journal: Cancer Research
Cancer Res (2019) 79 (6): 1047–1053.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-3126
Published: 15 March 2019
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Journal Articles

Abstract 5533: Cell-free DNA sequencing in ERBB2-mutant breast cancer patients treated with neratinib and fulvestrant: Exploratory analysis from the Phase 2 SUMMIT ‘basket' trial

Alison M. Schram, S. Duygu Selcuklu, Rebecca J. Nagy, Lillian M. Smyth, Lisa D. Eli, Richard E. Cutler, Alshad S. Lalani, David M. Hyman, Richard B. Lanman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5533.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5533
Published: 01 July 2018
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Journal Articles

Abstract LB-302: Potential role of larotrectinib (LOXO-101), a selective pan-TRK inhibitor, in NTRK fusion-positive recurrent glioblastoma

Alison M. Schram, Barry S. Taylor, Jaclyn F. Hechtman, Ryma Benayed, Lu Wang, Bethany Hanusch, Robert Young, Christian Grommes, Nora Ku, David M. Hyman, Thomas Kaley, Alexander Drilon
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-302.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-302
Published: 01 July 2017
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Journal Articles

Abstract 375: Oncologist use and perception of large panel next generation tumor sequencing

Alison M. Schram, Dalicia Reales, Jesse Galle, Roy Cambria, Robert Durany, Darren Feldman, Eric Sherman, Jonathan Rosenberg, Gabriella D'Andrea, Shrujal Baxi, Yelena Janjigian, William Tap, Maura Dickler, José Baselga, Barry Taylor, Debyani Chakravarty, Jianjiong Gao, Nikolaus D. Schultz, David B. Solit, Michael F. Berger, David M. Hyman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 375.
DOI: https://doi.org/10.1158/1538-7445.AM2017-375
Published: 01 July 2017
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