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Journal Articles

Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Roberta Affatato, Elena Di Gennaro, Alessandra Leone, Biagio Pucci, Susan Costantini, Rita Lombardi, Eleonora Perfetto, Maria Serena Roca, Francesca Bruzzese, Francesca Collina, Claudia Cardone, Tania Moccia, Elena Sinopoli, Antonio Avallone, Alfredo Budillon

Cancer Res (2025) 85 (8_Supplement_1): 1700.

https://doi.org/10.1158/1538-7445.AM2025-1700

Published: 21 April 2025

View articletitled, Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Journal Articles

Abstract 4713: Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2: A route for drug repurposing in glioblastoma

Claudia Abbruzzese, Silvia Matteoni, Paola Matarrese, Michele Signore, Barbara Ascione, Elisabetta Iessi, Aymone Gurtner, Andrea Sacconi, Andrea Pace, Veronica Villani, Andrea Polo, Susan Costantini, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi

Cancer Res (2024) 84 (6_Supplement): 4713.

https://doi.org/10.1158/1538-7445.AM2024-4713

Published: 22 March 2024

View articletitled, Abstract 4713: Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2: A route for drug repurposing in glioblastoma

Journal Articles

Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Cancer Res (2024) 84 (6_Supplement): 3700.

https://doi.org/10.1158/1538-7445.AM2024-3700

Published: 22 March 2024

View articletitled, Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Journal Articles

Abstract 7097: Integrated proteomics and metabolomics reveals new insight into the synergistic interaction of valproic acid plus simvastatin in prostate cancer xenograft model associated with down-modulation of YAP and TAZ signaling

Federica Iannelli, Rita Lombardi, Susan Costantini, Maria Serena Roca, Laura Addi, Francesca Bruzzese, Elena Di Gennaro, Alfredo Budillon, Biagio Pucci

Cancer Res (2024) 84 (6_Supplement): 7097.

https://doi.org/10.1158/1538-7445.AM2024-7097

Published: 22 March 2024

View articletitled, Abstract 7097: Integrated proteomics and metabolomics reveals new insight into the synergistic interaction of valproic acid plus simvastatin in prostate cancer xenograft model associated with down-modulation of YAP and TAZ signaling

Journal Articles

Abstract 1353: Immunomodulatory effects of valproic acid in combination with cisplatin and cetuximab in head and neck squamous cell carcinoma

Federica Iannelli, Andrea Ilaria Zotti, Maria Serena Roca, Laura Grumetti, tania Moccia, carlo vitagliano, susan costantini, francesca capone, francesca collina, Lucia Gabriele, stefania parlato, Giulia Romagnoli, Oliver Kepp, Guido Kroemer, Elena Di Gennaro, Alfredo Budillon

Cancer Res (2022) 82 (12_Supplement): 1353.

https://doi.org/10.1158/1538-7445.AM2022-1353

Published: 15 June 2022

View articletitled, Abstract 1353: Immunomodulatory effects of valproic acid in combination with cisplatin and cetuximab in head and neck squamous cell carcinoma

Journal Articles

Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Maria Serena Roca, federica iannelli, maria rita milone, veronica barile, cristina testa, tania moccia, carlo vitagliano, fabiana tatangelo, di gennaro elena, antonio avallone, francesca bruzzese, alessandra leone, alfredo budillon

Cancer Res (2022) 82 (12_Supplement): 1840.

https://doi.org/10.1158/1538-7445.AM2022-1840

Published: 15 June 2022

View articletitled, Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Journal Articles

Abstract 3232: Combined inhibition of mTOR and HSP90 potentiates cisplatin antitumor effect and reverts cisplatin resistance in vitro and in vivo models of epithelial ovarian cancer by modulating HSF1-dependent transactivation

Rita Lombardi, Laura Addi, Biagio Pucci, Maura Sonego, Maria Serena Roca, Francesca Capone, Federica Iannelli, Francesca Bruzzese, Gustavo Baldassarre, Alfredo Budillon

Cancer Res (2022) 82 (12_Supplement): 3232.

https://doi.org/10.1158/1538-7445.AM2022-3232

Published: 15 June 2022

View articletitled, Abstract 3232: Combined inhibition of mTOR and HSP90 potentiates cisplatin antitumor effect and reverts cisplatin resistance in vitro and in vivo models of epithelial ovarian cancer by modulating HSF1-dependent transactivation

Journal Articles

Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Maria S. Roca, Tania Moccia, Cristina Testa, Federica Iannelli, Carlo Vitagliano, Elena Di Gennaro, Francesca Bruzzese, Alessandra Leone, Alfredo Budillon

Cancer Res (2021) 81 (13_Supplement): 1158.

https://doi.org/10.1158/1538-7445.AM2021-1158

Published: 01 July 2021

View articletitled, Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Journal Articles

Abstract 5270: HSP90 identified by a proteomic approach as druggable target to reverse platinum-resistance in ovarian cancer

Rita Lombardi, Maura Sonego, Laura Addi, Federica Iannelli, Francesca Capone, Maria Serena Roca, Maria Rita Milone, Alice Costa, Francesca Bruzzese, Biagio Pucci, Gustavo Baldassarre, Alfredo Budillon

Cancer Res (2020) 80 (16_Supplement): 5270.

https://doi.org/10.1158/1538-7445.AM2020-5270

Published: 15 August 2020

View articletitled, Abstract 5270: HSP90 identified by a proteomic approach as druggable target to reverse platinum-resistance in ovarian cancer

Journal Articles

Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Federica Iannelli, Andrea Ilaria Zotti, Maria Serena Roca, Laura Grumetti, Tania Moccia, Carlo Vitagliano, Chiara Ciardiello, Francesca Bruzzese, Alessandra Leone, Francesco Caponigro, Franco Ionna, Francesco Longo, Elena Di Gennaro, Alfredo Budillon

Cancer Res (2020) 80 (16_Supplement): 5223.

https://doi.org/10.1158/1538-7445.AM2020-5223

Published: 15 August 2020

View articletitled, Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Journal Articles

Abstract 5268: Outcome prediction of metastatic colorectal cancer patients undergoing liver resection by analyzing serum metabolomics

Alfredo Budillon, Susan Costantini, Angela Sorice, Francesca Capone, Silvia Marchese, Elena Di Gennaro, Carlo Vitagliano, Fabiana Tatangelo, Alfonso De Stefano, Franco Bianco, Paolo Delrio, Francesco Izzo, Antonio Avallone

Cancer Res (2019) 79 (13_Supplement): 5268.

https://doi.org/10.1158/1538-7445.AM2019-5268

Published: 01 July 2019

View articletitled, Abstract 5268: Outcome prediction of metastatic colorectal cancer patients undergoing liver resection by analyzing serum metabolomics

Journal Articles

Abstract 2877: Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting cancer stem cells compartment via YAP-pathway modulation

Federica Iannelli, Maria Serena Roca, Chiara Ciardiello, Simona De Rienzo, Rita Lombardi, Angela Sorice, Susan Costantini, Tania Moccia, Maria Rita Milone, Biagio Pucci, Alfredo Budillon, Francesca Bruzzese

Cancer Res (2018) 78 (13_Supplement): 2877.

https://doi.org/10.1158/1538-7445.AM2018-2877

Published: 01 July 2018

View articletitled, Abstract 2877: Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting cancer stem cells compartment via YAP-pathway modulation

Journal Articles

Abstract 4058: Preclinical and phase-2 clinical study of valproic acid administered in combination with cisplatin and cetuximab in recurrent/metastatic head and neck cancer

Alfredo Budillon, Andrea I. Zotti, Carlo Vitagliano, Elena Di Gennaro, Francesco Caponigro

Cancer Res (2017) 77 (13_Supplement): 4058.

https://doi.org/10.1158/1538-7445.AM2017-4058

Published: 01 July 2017

View articletitled, Abstract 4058: Preclinical and phase-2 clinical study of valproic acid administered in combination with cisplatin and cetuximab in recurrent/metastatic head and neck cancer

Journal Articles

Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Federica Iannelli, Rita Lombardi, Biagio Pucci, Maria Rita Milone, Chiara Ciardiello, Alessandra Leone, Elena Di Gennaro, Alfredo Budillon, Francesca Bruzzese

Cancer Res (2016) 76 (14_Supplement): 4745.

https://doi.org/10.1158/1538-7445.AM2016-4745

Published: 15 July 2016

View articletitled, Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Journal Articles

Abstract 1052: Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Alessia Noto, Maria Elena Pisanu, Claudia De Vitis, Giovanni Sorrentino, Giannino Del Sal, Alfredo Budillon, Gennaro Ciliberto, Rita Mancini

Cancer Res (2016) 76 (14_Supplement): 1052.

https://doi.org/10.1158/1538-7445.AM2016-1052

Published: 15 July 2016

View articletitled, Abstract 1052: Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Journal Articles

Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Manuela Terranova Barberio, Biagio Pecori, Serena Imbimbo, Alessandra Leone, Francesca Bruzzese, Maria Carmela Piccirillo, Paolo Delrio, Franco Bianco, Luigi Aloj, Antonio Sorrentino, Fabiana Tatangelo, Antonella Petrillo, Secondo Lastoria, Paolo Muto, Francesco Perrone, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro

Cancer Res (2015) 75 (15_Supplement): 2569.

https://doi.org/10.1158/1538-7445.AM2015-2569

Published: 01 August 2015

View articletitled, Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Journal Articles

Abstract 616: Blood-based molecular landscapes of resistance to EGFR blockade in colorectal cancer patients

Giulia Siravegna, Benedetta Mussolin, Michela Buscarino, Giorgio Corti, Andrea Cassingena, Giovanni Crisafulli, Ryan B. Corcoran, Agostino Ponzetti, Alfredo Budillon, Patrizia Racca, Silvia Marsoni, Federica Di Nicolantonio, Fotios Loupakis, Salvatore Siena, Andrea Sartore Bianchi, Alberto Bardelli

Cancer Res (2015) 75 (15_Supplement): 616.

https://doi.org/10.1158/1538-7445.AM2015-616

Published: 01 August 2015

View articletitled, Abstract 616: Blood-based molecular landscapes of resistance to EGFR blockade in colorectal cancer patients

Journal Articles

Abstract 4154: Large oncosomes derived from the aggressive prostate cancer sub-line, DU145R80, can modify the biological behavior of the parental DU145 cells

Chiara Ciardiello, Valentina R. Minciacchi, Mariana Reis-Sobreiro, Maria R. Milone, Biagio Pucci, Rita Lombardi, Francesca Bruzzese, Dolores Di Vizio, Alfredo Budillon

Cancer Res (2015) 75 (15_Supplement): 4154.

https://doi.org/10.1158/1538-7445.AM2015-4154

Published: 01 August 2015

View articletitled, Abstract 4154: Large oncosomes derived from the aggressive prostate cancer sub-line, DU145R80, can modify the biological behavior of the parental DU145 cells

Journal Articles

Abstract 5311: Proteomic characterization of zoledronic acid-resistant prostate cancer cells identified key proteins in cytoskeleton organization and cancer stem cell markers associated with a very aggressive phenotype

Maria Rita Milone, Biagio Pucci, Federica Iannelli, Rita Lombardi, Katia Bifulco, Francesca Bruzzese, Elena D. Gennaro, Antonio Avallone, Maria Vincenza Carriero, Alfredo Budillon

Cancer Res (2014) 74 (19_Supplement): 5311.

https://doi.org/10.1158/1538-7445.AM2014-5311

Published: 01 October 2014

View articletitled, Abstract 5311: Proteomic characterization of zoledronic acid-resistant prostate cancer cells identified key proteins in cytoskeleton organization and cancer stem cell markers associated with a very aggressive phenotype

Journal Articles

Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

Chiara Ciardiello, Alessandra Leone, Francesca Bruzzese, Maria Serena Roca, Alessia Noto, Claudia D. Vitis, Luigi Aurisicchio, Gennaro Ciliberto, Rita Mancini, Alfredo Budillon

Cancer Res (2014) 74 (19_Supplement): 5444.

https://doi.org/10.1158/1538-7445.AM2014-5444

Published: 01 October 2014

View articletitled, Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

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Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Abstract 4713: Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2: A route for drug repurposing in glioblastoma

Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Abstract 7097: Integrated proteomics and metabolomics reveals new insight into the synergistic interaction of valproic acid plus simvastatin in prostate cancer xenograft model associated with down-modulation of YAP and TAZ signaling

Abstract 1353: Immunomodulatory effects of valproic acid in combination with cisplatin and cetuximab in head and neck squamous cell carcinoma

Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Abstract 3232: Combined inhibition of mTOR and HSP90 potentiates cisplatin antitumor effect and reverts cisplatin resistance in vitro and in vivo models of epithelial ovarian cancer by modulating HSF1-dependent transactivation

Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Abstract 5270: HSP90 identified by a proteomic approach as druggable target to reverse platinum-resistance in ovarian cancer

Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Abstract 5268: Outcome prediction of metastatic colorectal cancer patients undergoing liver resection by analyzing serum metabolomics

Abstract 2877: Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting cancer stem cells compartment via YAP-pathway modulation

Abstract 4058: Preclinical and phase-2 clinical study of valproic acid administered in combination with cisplatin and cetuximab in recurrent/metastatic head and neck cancer

Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Abstract 1052: Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Abstract 616: Blood-based molecular landscapes of resistance to EGFR blockade in colorectal cancer patients

Abstract 4154: Large oncosomes derived from the aggressive prostate cancer sub-line, DU145R80, can modify the biological behavior of the parental DU145 cells

Abstract 5311: Proteomic characterization of zoledronic acid-resistant prostate cancer cells identified key proteins in cytoskeleton organization and cancer stem cell markers associated with a very aggressive phenotype

Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

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