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Alfred Zippelius
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Journal Articles

Abstract 4071: The first-in-class PD1-IL18 conjugate BPT567 induces potent anti-tumor immunity by preferentially activating PD1+IL18R+ intratumoral effector T cells in cis

Kea Martin, Thuy Luu, Jean-Philippe Carralot, Lilian Gremlich, Petra Herzig, Caoimhe Herr, Roy Meoded, Philipp Moosmann, Arnaud Goepfert, Alfred Zippelius, Vijaya Pattabiraman, Bertolt Kreft
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4071.
https://doi.org/10.1158/1538-7445.AM2024-4071
Published: 22 March 2024
View article titled, Abstract 4071: The first-in-class PD1-IL18 conjugate BPT567 induces potent anti-tumor immunity by preferentially activating PD1<sup>+</sup>IL18R<sup>+</sup> intratumoral effector T cells in <em>cis</em>
Journal Articles

Unraveling T-cell Exhaustion: Genetic Screening Meets In Vitro Modeling

Dominic Schmid, Priska Auf der Maur, Marcel P. Trefny, Alfred Zippelius
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3830–3832.
https://doi.org/10.1158/0008-5472.CAN-23-3204
Published: 01 December 2023
View article titled, Unraveling T-cell Exhaustion: Genetic Screening Meets <em>In Vitro</em> Modeling
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Journal Articles

Abstract 4149: Knock-down of Neuropilin-1 by locked nucleic acid antisense oligonucleotides facilitates cancer immune control

Andre Maaske, Nicole Kirchhammer, Julia Festag, Laura Fernandez Rodriguez, Mélanie Buchi, Monika Schell, Stefanie Raith, Sven Michel, Richard Klar, Alfred Zippelius, Frank Jaschinski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4149.
https://doi.org/10.1158/1538-7445.AM2022-4149
Published: 15 June 2022
View article titled, Abstract 4149: Knock-down of Neuropilin-1 by locked nucleic acid antisense oligonucleotides facilitates cancer immune control
Journal Articles

Abstract 5030: Microtubule destabilization by plinabulin generates anti-tumor immune response through repolarization of intratumoral macrophages

Elham Pishali Bejestani, G. Kenneth Lloyd, Melanie Buchi, Reto Ritschard, Petra Herzig, Ramon Mohanlal, Lan Huang, James R. Tonra, Alfred Zippelius, Abhishek Kashyap
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5030.
https://doi.org/10.1158/1538-7445.AM2019-5030
Published: 01 July 2019
View article titled, Abstract 5030: Microtubule destabilization by plinabulin generates anti-tumor immune response through repolarization of intratumoral macrophages
Journal Articles

Abstract 5021: LNAplusTM antisense oligonucleotides targeting CD39 and CD73 have potent anti-tumor activity by modulating immunosuppressive tumor microenvironment

Julia Festag, Tamara Thelemann, Abhishek S. Kashyap, Richard Klar, Sandra Kallert, Melanie Buchi, Lisa Hinterwimmer, Monika Schell, Stefanie Raith, Sven Michel, Alfred Zippelius, Frank Jaschinski
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5021.
https://doi.org/10.1158/1538-7445.AM2019-5021
Published: 01 July 2019
View article titled, Abstract 5021: LNAplus<sup>TM</sup> antisense oligonucleotides targeting CD39 and CD73 have potent anti-tumor activity by modulating immunosuppressive tumor microenvironment
Journal Articles

Abstract LB-059: Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

Natalia Rodrigues Mantuano, Michal Stanczak, Isadora Oliveira, Alessandra Filardy, Ronan Silva, Alfred Zippelius, Adriane Regina Todeschini, Heinz Laubli
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-059.
https://doi.org/10.1158/1538-7445.AM2019-LB-059
Published: 01 July 2019
View article titled, Abstract LB-059: Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation
Journal Articles

Abstract 5909: Inhibition of Cd39 and Cd73 by 3rd-generation antisense oligonucleotides to improve immunity against tumors

Tamara Hilmenyuk, Sandra Kallert, Richard Klar, Lisa Hinterwimmer, Monika Schell, Marina Van Ark, Alfred Zippelius, Frank Jaschinski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5909.
https://doi.org/10.1158/1538-7445.AM2018-5909
Published: 01 July 2018
View article titled, Abstract 5909: Inhibition of Cd39 and Cd73 by 3<sup>rd</sup>-generation antisense oligonucleotides to improve immunity against tumors
Journal Articles

Abstract A07: Plinabulin: Evidence for an immune-mediated mechanism of action

George Kenneth Lloyd, Philipp Mueller, ALfred Zippelius, Lan Huang
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): A07.
https://doi.org/10.1158/1538-7445.TME16-A07
Published: 28 July 2016
View article titled, Abstract A07: Plinabulin: Evidence for an immune-mediated mechanism of action
Journal Articles

Abstract 4681: The use of patient derived malignant effusions as in vitro models for a personalized healthcare-approach in anticancer therapy

Christian Ruiz, Tatjana Vlajnic, Leila Arabi, Sina Wyttenbach, Betty Baschiera, Sacha Rothschild, Stefan Kustermann, Alfred Zippelius, Adrian Roth, Lukas Bubendorf
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4681.
https://doi.org/10.1158/1538-7445.AM2014-4681
Published: 01 October 2014
View article titled, Abstract 4681: The use of patient derived malignant effusions as <em>in vitro</em> models for a personalized healthcare-approach in anticancer therapy
Journal Articles

Integrated immune response to the cancer-testis antigen CT7 (MAGE-C1) in patients with plasma cell myeloma

Alessandra Curioni, Ashley Knights, Olga de la Rosa, Marianne Tinguely, Bruno Lopez, Holger Moch, Christoph Renner, Alexander Knuth, Alfred Zippelius
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5112.
Published: 01 May 2007
View article titled, Integrated immune response to the cancer-testis antigen CT7 (MAGE-C1) in patients with plasma cell myeloma
Journal Articles

High Frequency of Functionally Active Melan-A–Specific T Cells in a Patient with Progressive Immunoproteasome-Deficient Melanoma

Norbert Meidenbauer, Alfred Zippelius, Mikaël J. Pittet, Monika Laumer, Sandra Vogl, Jana Heymann, Michael Rehli, Barbara Seliger, Stephan Schwarz, Frederique-Anne Le Gal, Pierre Y. Dietrich, Reinhard Andreesen, Pedro Romero, Andreas Mackensen
Journal: Cancer Research
Cancer Res (2004) 64 (17): 6319–6326.
https://doi.org/10.1158/0008-5472.CAN-04-1341
Published: 01 September 2004
View article titled, High Frequency of Functionally Active Melan-A–Specific T Cells in a Patient with Progressive Immunoproteasome-Deficient Melanoma
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Journal Articles

Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance

Alfred Zippelius, Pascal Batard, Verena Rubio-Godoy, Gilles Bioley, Danielle Liénard, Ferdy Lejeune, Donata Rimoldi, Philippe Guillaume, Norbert Meidenbauer, Andreas Mackensen, Nathalie Rufer, Norbert Lubenow, Daniel Speiser, Jean-Charles Cerottini, Pedro Romero, Mikaël J. Pittet
Journal: Cancer Research
Cancer Res (2004) 64 (8): 2865–2873.
https://doi.org/10.1158/0008-5472.CAN-03-3066
Published: 15 April 2004
View article titled, Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance
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Journal Articles

Heterogeneous Expression of MAGE-A Genes in Occult Disseminated Tumor Cells: A Novel Multimarker Reverse Transcription-Polymerase Chain Reaction for Diagnosis of Micrometastatic Disease

Peter Kufer, Alfred Zippelius, Ralf Lutterbüse, Ingo Mecklenburg, Thomas Enzmann, Anthony Montag, Dorothea Weckermann, Bernward Passlick, Nadja Prang, Peter Reichardt, Martin Dugas, Manfred W. Köllermann, Klaus Pantel, Gert Riethmüller
Journal: Cancer Research
Cancer Res (2002) 62 (1): 251–261.
Published: 01 January 2002
View article titled, Heterogeneous Expression of <em>MAGE-A</em> Genes in Occult Disseminated Tumor Cells: <subtitle>A Novel Multimarker Reverse Transcription-Polymerase Chain Reaction for Diagnosis of Micrometastatic Disease</subtitle>
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Journal Articles

Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases

Elmar Putz, Klaus Witter, Sonja Offner, Peter Stosiek, Alfred Zippelius, Judith Johnson, Robert Zahn, Gert Riethmüller, Klaus Pantel
Journal: Cancer Research
Cancer Res (1999) 59 (1): 241–248.
Published: 01 January 1999
View article titled, Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: <subtitle>Establishment of Working Models for Human Micrometastases</subtitle>
Open the PDF for Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: <subtitle>Establishment of Working Models for Human Micrometastases</subtitle> in another window