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Alfred E. Chang
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Journal Articles

Abstract 2256: Cancer stem cells and exosomal PD-L1 suppress anti-tumor B cells

Ying Xin, Jiayu Liu, You Qin, Kexing Lyu, Sifei Yu, Ming Lin, Max Wicha, Alfred E. Chang, Qiao Li
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2256.
https://doi.org/10.1158/1538-7445.AM2023-2256
Published: 04 April 2023
View article titled, Abstract 2256: Cancer stem cells and exosomal PD-L1 suppress anti-tumor B cells
Journal Articles

Abstract 2046: Potential suppression of B effector cells by exosomal PD-L1 on anti-cancer stem cell immunity

You Qin, Kexing Lyu, Sifei Yu, Ming Lin, Max Wicha, Alfred E. Chang, Qiao Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2046.
https://doi.org/10.1158/1538-7445.AM2022-2046
Published: 15 June 2022
View article titled, Abstract 2046: Potential suppression of B effector cells by exosomal PD-L1 on anti-cancer stem cell immunity
Journal Articles

Abstract 514: Specific anti-HER2 host immunity conferred by HER2-targeted antibody drug conjugate therapy and checkpoint blockade

You Qin, Hannah E. Dobson, Frank I. Comer, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 514.
https://doi.org/10.1158/1538-7445.AM2021-514
Published: 01 July 2021
View article titled, Abstract 514: Specific anti-HER2 host immunity conferred by HER2-targeted antibody drug conjugate therapy and checkpoint blockade
Journal Articles

Abstract 2157: Generation of Rab27ako and PD-L1ko tumor cells to evaluate potential suppression of exosomal PD-L1 on host immune components involved in cancer immunotherapy

You Qin, Kexing Lyu, Sifei Yu, Ming Lin, Max Wicha, Alfred E. Chang, Qiao Li
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2157.
https://doi.org/10.1158/1538-7445.AM2020-2157
Published: 15 August 2020
View article titled, Abstract 2157: Generation of Rab27ako and PD-L1ko tumor cells to evaluate potential suppression of exosomal PD-L1 on host immune components involved in cancer immunotherapy
Journal Articles

Abstract 3803: Synergistic inhibition of thioridazine combined with carboplatin on triple negative breast cancer by targeting cancer stem cells

Yi Wang, Leiming Xia, Li Gong, Yang Xia, Liu Liu, Yuanyuan Liu, Wicha Max, Alfred E. Chang, Qiao Li, Yangyi Bao
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3803.
https://doi.org/10.1158/1538-7445.AM2020-3803
Published: 15 August 2020
View article titled, Abstract 3803: Synergistic inhibition of thioridazine combined with carboplatin on triple negative breast cancer by targeting cancer stem cells
Journal Articles

Integrin β4–Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis

Shasha Ruan, Ming Lin, Yong Zhu, Lawrence Lum, Archana Thakur, Runming Jin, Wenlong Shao, Yalei Zhang, Yangyang Hu, Shiang Huang, Elaine M. Hurt, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (4): 771–783.
https://doi.org/10.1158/0008-5472.CAN-19-1145
Published: 14 February 2020
View article titled, Integrin β4–Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis
Open the PDF for Integrin β4–Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 4981: HER2-targeted antibody drug conjugates (ADCs) induce host immunity against cancer stem cells and are enhanced by anti-PD-L1

Leiming Xia, Lu Wen, Gang Wu, Tao Zhang, Frank Comer, Mary Jane Masson Hinrichs, Michael Oberst, Steven R. Coats, Alfred E. Chang, Yuanyuan Liu, Yangyi Bao, Max Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4981.
https://doi.org/10.1158/1538-7445.AM2019-4981
Published: 01 July 2019
View article titled, Abstract 4981: HER2-targeted antibody drug conjugates (ADCs) induce host immunity against cancer stem cells and are enhanced by anti-PD-L1
Journal Articles

Abstract 375: Integrin β4-targeted cancer immunotherapies

Shasha Ruan, Ming Lin, Yongshun Chen, Elaine Hurt, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 375.
https://doi.org/10.1158/1538-7445.AM2019-375
Published: 01 July 2019
View article titled, Abstract 375: Integrin β4-targeted cancer immunotherapies
Journal Articles

Abstract LB-297: HER2-targeted antibody drug conjugates induce host immunity and target cancer stem cells and the efficacy can be enhanced by anti-PD-L1

Leiming Xia, Lu Wen, Ming Lin, Comer Frank, Hinrichs Mary Jane, Oberst Michael, Coats Steven, Yangyi Bao, Alfred E. Chang, Max Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-297.
https://doi.org/10.1158/1538-7445.AM2018-LB-297
Published: 01 July 2018
View article titled, Abstract LB-297: HER2-targeted antibody drug conjugates induce host immunity and target cancer stem cells and the efficacy can be enhanced by anti-PD-L1
Journal Articles

Abstract 1621: Adoptively transferred B cells directly kill tumor cells via the CXCR4/CXCL12 & perforin pathways

Leiming Xia, Yang Xia, Quanning Chen, Yi Wang, Yangyi Bao, Steven K. Lundy Lundy, Fu Dai, Alfred E Chang, Qiao Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1621.
https://doi.org/10.1158/1538-7445.AM2017-1621
Published: 01 July 2017
View article titled, Abstract 1621: Adoptively transferred B cells directly kill tumor cells via the CXCR4/CXCL12 & perforin pathways
Journal Articles

Therapeutic Efficacy of Cancer Stem Cell Vaccines in the Adjuvant Setting

Yangyang Hu, Lin Lu, Yang Xia, Xin Chen, Alfred E. Chang, Robert E. Hollingsworth, Elaine Hurt, John Owen, Jeffrey S. Moyer, Mark E.P. Prince, Fu Dai, Yangyi Bao, Yi Wang, Joel Whitfield, Jian-Chuan Xia, Shiang Huang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (16): 4661–4672.
https://doi.org/10.1158/0008-5472.CAN-15-2664
Published: 14 August 2016
View article titled, Therapeutic Efficacy of Cancer Stem Cell Vaccines in the Adjuvant Setting
Open the PDF for Therapeutic Efficacy of Cancer Stem Cell Vaccines in the Adjuvant Setting in another window
Journal Articles

Abstract 3329: Increasing the efficacy of cancer stem cell-based vaccine in the PD-L1/PD-1 blockade

Yangyang Hu, Yang Xia, Xin Chen, Li Zhou, Yangyi Bao, Shiang Huang, Xiubao Ren, Elaine Hurt, Robert E. Hollingsworth, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3329.
https://doi.org/10.1158/1538-7445.AM2016-3329
Published: 15 July 2016
View article titled, Abstract 3329: Increasing the efficacy of cancer stem cell-based vaccine in the PD-L1/PD-1 blockade
Journal Articles

Abstract 540: Adjuvant effect of anti-PD-L1 in boosting HER2-targeted T cell adoptive immunotherapy

Yang Xia, Yangyang Hu, Yi Wang, Yangyi Bao, Fu Dai, Shiang Huang, Elaine Hurt, Robert E. Hollingsworth, Archana Thakur, Lawrence Lum, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 540.
https://doi.org/10.1158/1538-7445.AM2016-540
Published: 15 July 2016
View article titled, Abstract 540: Adjuvant effect of anti-PD-L1 in boosting HER2-targeted T cell adoptive immunotherapy
Journal Articles

Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory

Hidehito Saito, Keisuke Okita, Alfred E. Chang, Fumito Ito
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3473–3483.
https://doi.org/10.1158/0008-5472.CAN-15-1742
Published: 14 June 2016
View article titled, Adoptive Transfer of CD8<sup>+</sup> T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory
Open the PDF for Adoptive Transfer of CD8<sup>+</sup> T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory in another window
Includes: Supplementary data
Journal Articles

Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling

Dongjun Peng, Takashi Tanikawa, Wei Li, Lili Zhao, Linda Vatan, Wojciech Szeliga, Shanshan Wan, Shuang Wei, Yin Wang, Yan Liu, Elzbieta Staroslawska, Franciszek Szubstarski, Jacek Rolinski, Ewelina Grywalska, Andrzej Stanisławek, Wojciech Polkowski, Andrzej Kurylcio, Celina Kleer, Alfred E. Chang, Max Wicha, Michael Sabel, Weiping Zou, Ilona Kryczek
Journal: Cancer Research
Cancer Res (2016) 76 (11): 3156–3165.
https://doi.org/10.1158/0008-5472.CAN-15-2528
Published: 31 May 2016
View article titled, Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Open the PDF for Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 1340: Antitumor effector B cells directly kill tumor cells involving the CXCL12/CXCR4 pathway and their therapeutic efficacy is enhanced by IL-2

Yang Xia, Huimin Tao, Yangyang Hu, Li Zhou, Yangyi Bao, Steven K Lundy, Shiang Huang, Qiao Li, Alfred E Chang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1340.
https://doi.org/10.1158/1538-7445.AM2015-1340
Published: 01 August 2015
View article titled, Abstract 1340: Antitumor effector B cells directly kill tumor cells involving the CXCL12/CXCR4 pathway and their therapeutic efficacy is enhanced by IL-2
Journal Articles

Abstract 1410: Evaluation of the immunogenicity of ALDHhigh human head and neck squamous cell carcinoma cancer stem cells in vitro

Mark E.P. Prince, Li Zhou, Yang Xia, Huimin Tao, Jeffrey S. Moyer, Lin Lu, John Owen, Alfred E. Chang, Jianchuan Xia, Gregory Wolf, Max S. Wicha, Xiubao Ren, Yangyi Bao, Shiang Huang, Qiao Li
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1410.
https://doi.org/10.1158/1538-7445.AM2015-1410
Published: 01 August 2015
View article titled, Abstract 1410: Evaluation of the immunogenicity of ALDH<sup>high</sup> human head and neck squamous cell carcinoma cancer stem cells <em>in vitro</em>
Journal Articles

Abstract 1530: Therapeutic efficacy of cancer stem cell vaccine in an adjuvant setting

Yangyang Hu, Lin Lu, Alfred E. Chang, Martin Egenti, John Owen, Jeffrey S. Moyer, Mark E.P. Prince, Jianchuan Xia, Shiang Huang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1530.
https://doi.org/10.1158/1538-7445.AM2015-1530
Published: 01 August 2015
View article titled, Abstract 1530: Therapeutic efficacy of cancer stem cell vaccine in an adjuvant setting
Journal Articles

Abstract 4796: Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells

Lin Lu, Huimin Tao, Yang Xia, John Owen, Jeffrey S. Moyer, Mark E.P Prince, Alfred E. Chang, Max S. Wicha, Qiao Li
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4796.
https://doi.org/10.1158/1538-7445.AM2014-4796
Published: 01 October 2014
View article titled, Abstract 4796: Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells
Journal Articles

Abstract 487: Effector B cells in cancer adoptive immunotherapy.

Huimin Tao, Lin Lu, Martin Egenti, Alfred E. Chang, Qiao Li
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 487.
https://doi.org/10.1158/1538-7445.AM2013-487
Published: 15 April 2013
View article titled, Abstract 487: Effector B cells in cancer adoptive immunotherapy.