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Alexander N. Shoushtari
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Journal Articles

Abstract CT285: Trial in progress: A phase 1/2 study to investigate the safety and efficacy of OBX-115 engineered tumor-infiltrating lymphocyte (TIL) cell therapy in patients (pts) with immune checkpoint inhibitor (ICI)-resistant advanced or metastatic melanoma

Sajeve S. Thomas, Jason A. Chesney, Omid Hamid, Gino K. In, Alexander N. Shoushtari, Yazan Samhouri, Parameswaran Hari, Giridharan Ramsingh, Prakash Prabhakar, Lauren Mclaughlin, Allison Betof Warner
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT285.
https://doi.org/10.1158/1538-7445.AM2024-CT285
Published: 05 April 2024
View article titled, Abstract CT285: Trial in progress: A phase 1/2 study to investigate the safety and efficacy of OBX-115 engineered tumor-infiltrating lymphocyte (TIL) cell therapy in patients (pts) with immune checkpoint inhibitor (ICI)-resistant advanced or metastatic melanoma
Journal Articles

Abstract CT223: Long-term survival follow-up of tebentafusp in previously treated metastatic uveal melanoma (mUM)

Joseph J. Sacco, Richard D. Carvajal, Marcus O. Butler, Alexander N. Shoushtari, Jessica C. Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M. Piulats, Matthew Rioth, Douglas B. Johnson, Jason J. Luke, Erique Espinosa, Serge Leyvraz, Laura Collins, Chris Holland, Michelle L. McCully, Takami Sato
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT223.
https://doi.org/10.1158/1538-7445.AM2023-CT223
Published: 14 April 2023
View article titled, Abstract CT223: Long-term survival follow-up of tebentafusp in previously treated metastatic uveal melanoma (mUM)
Journal Articles

Abstract 1035: Early ctDNA reduction is associated with better overall survival in the Ph 3 trial of tebentafusp in previously untreated metastatic uveal melanoma

Ryan Sullivan, Laura Collins, Manuel Rodrigues, Paul Nathan, Jessica C. Hassel, Reinhard Dummer, John Kirkwood, Piotr Rutkowski, Jean-Francois Baurain, Marcus O. Butler, Max Schlaak, Sebastian Ochsenreither, Shaad E. Abdullah, Chris Holland, Koustubh Ranade, Alexander N. Shoushtari
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1035.
https://doi.org/10.1158/1538-7445.AM2023-1035
Published: 04 April 2023
View article titled, Abstract 1035: Early ctDNA reduction is associated with better overall survival in the Ph 3 trial of tebentafusp in previously untreated metastatic uveal melanoma
Journal Articles

Abstract 517: Tebentafusp induces transient systemic inflammation and modifies the micro-environment to sensitize uveal melanoma tumors to cytotoxic CD8 cells

Marcus O. Butler, Sarah Stanhope, Revashnee Naidoo, Emma Leach, Sarnjeet Kaur, Laura Collins, Shaad Abdullah, Koustubh Ranade, Alexander N. Shoushtari
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 517.
https://doi.org/10.1158/1538-7445.AM2021-517
Published: 01 July 2021
View article titled, Abstract 517: Tebentafusp induces transient systemic inflammation and modifies the micro-environment to sensitize uveal melanoma tumors to cytotoxic CD8 cells
Journal Articles

Abstract CT038: Kinetics of radiographic response for tebentafusp (tebe) in previously treated metastatic uveal melanoma (mUM) patients (pts) achieving prolonged survival

Marcus O. Butler, Takami Sato, Richard D. Carvajal, Joseph J. Sacco, Shaad E. Abdullah, Chris Holland, Howard Goodall, Alexander N. Shoushtari
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT038.
https://doi.org/10.1158/1538-7445.AM2021-CT038
Published: 01 July 2021
View article titled, Abstract CT038: Kinetics of radiographic response for tebentafusp (tebe) in previously treated metastatic uveal melanoma (mUM) patients (pts) achieving prolonged survival
Journal Articles

Abstract CT002: Phase 3 randomized trial comparing tebentafusp with investigator's choice in first line metastatic uveal melanoma

Sophie Piperno-Neumann, Jessica C. Hassel, Piotr Rutkowski, Jean-Francois Baurain, Marcus O. Butler, Max Schlaak, Ryan J. Sullivan, Sebastian Ochsenreither, Reinhard Dummer, John M. Kirkwood, Anthony M. Joshua, Joseph J. Sacco, Alexander N. Shoushtari, Marlana Orloff, Richard D. Carvajal, Omid Hamid, Shaad E. Abdullah, Chris Holland, Howard Goodall, Paul Nathan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT002.
https://doi.org/10.1158/1538-7445.AM2021-CT002
Published: 01 July 2021
View article titled, Abstract CT002: Phase 3 randomized trial comparing tebentafusp with investigator's choice in first line metastatic uveal melanoma
Journal Articles

Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition

Tyler D. Hitchman, Emilie Ceraudo, Amanda R. Moore, Alexander N. Shoushtari, Jasmine H. Francis, Youxin Guan, Juliet Chen, Matthew T. Chang, Barry S. Taylor, Thomas P. Sakmar, Thomas Huber, Ping Chi, Yu Chen
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): A07.
https://doi.org/10.1158/1538-7445.MEL2019-A07
Published: 02 October 2020
View article titled, Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition
Journal Articles

Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer

Aphrothiti J. Hanrahan, Brooke E. Sylvester, Matthew T. Chang, Arijh Elzein, Jianjiong Gao, Weiwei Han, Ye Liu, Dong Xu, Sizhi P. Gao, Alexander N. Gorelick, Alexis M. Jones, Amber J. Kiliti, Moriah H. Nissan, Clare A. Nimura, Abigail N. Poteshman, Zhan Yao, Yijun Gao, Wenhuo Hu, Hannah C. Wise, Elena I. Gavrila, Alexander N. Shoushtari, Shakuntala Tiwari, Agnes Viale, Omar Abdel-Wahab, Taha Merghoub, Michael F. Berger, Neal Rosen, Barry S. Taylor, David B. Solit
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4233–4243.
https://doi.org/10.1158/0008-5472.CAN-20-0865
Published: 02 October 2020
View article titled, Leveraging Systematic Functional Analysis to Benchmark an <em>In Silico</em> Framework Distinguishes Driver from Passenger MEK Mutants in Cancer
Open the PDF for Leveraging Systematic Functional Analysis to Benchmark an <em>In Silico</em> Framework Distinguishes Driver from Passenger MEK Mutants in Cancer in another window
Includes: Supplementary data
Journal Articles

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell–Lymphatic Cross-talk Promote Invasive Phenotype

Amine Issa, Thomas X. Le, Alexander N. Shoushtari, Jacqueline D. Shields, Melody A. Swartz
Journal: Cancer Research
Cancer Res (2009) 69 (1): 349–357.
https://doi.org/10.1158/0008-5472.CAN-08-1875
Published: 31 December 2008
View article titled, Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell–Lymphatic Cross-talk Promote Invasive Phenotype
Open the PDF for Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell–Lymphatic Cross-talk Promote Invasive Phenotype in another window
Includes: Supplementary data