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Alexander N. Gorelick
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Journal Articles

Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer

Aphrothiti J. Hanrahan, Brooke E. Sylvester, Matthew T. Chang, Arijh Elzein, Jianjiong Gao, Weiwei Han, Ye Liu, Dong Xu, Sizhi P. Gao, Alexander N. Gorelick, Alexis M. Jones, Amber J. Kiliti, Moriah H. Nissan, Clare A. Nimura, Abigail N. Poteshman, Zhan Yao, Yijun Gao, Wenhuo Hu, Hannah C. Wise, Elena I. Gavrila, Alexander N. Shoushtari, Shakuntala Tiwari, Agnes Viale, Omar Abdel-Wahab, Taha Merghoub, Michael F. Berger, Neal Rosen, Barry S. Taylor, David B. Solit
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4233–4243.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-0865
Published: 02 October 2020
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Includes: Supplementary data
Journal Articles

Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Yi Liao, Uwe Rix, Alberto Bardelli, Jacklyn Hechtman, Elisa de Stanchina, David M. Hyman, Chandra Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5680.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5680
Published: 15 August 2020
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Journal Articles

Abstract 5355: Multiple mutations to the same gene are selected for and cooperate to drive cancer

Alexander N. Gorelick, Ed Reznik, Yanyan Cai, Craig Bielski, Chaitanya Bandlamudi, Alexander Penson, Philip Jonsson, Konnor La, Maurizio Scaltriti, Nikolaus Schultz, Barry S. Taylor
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5355.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5355
Published: 01 July 2018
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