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Journal Articles

Abstract 4547: Clustering CD137 via cell-expressed PD-L1 crosslinking avoided Fc-mediated agonism and resulted in safe and potent conditional lymphocyte activation

Matthew A. Lakins, Alexander Koers, Raffaella Giambalvo, Robert Hughes, Sylwia Marshall, Mateusz Wydro, Cristian Gradinaru, Sarah Batey, Daniel Gliddon, Michelle Morrow, Neil Brewis

Cancer Res (2020) 80 (16_Supplement): 4547.

https://doi.org/10.1158/1538-7445.AM2020-4547

Published: 15 August 2020

View article titled, Abstract 4547: Clustering CD137 via cell-expressed PD-L1 crosslinking avoided Fc-mediated agonism and resulted in safe and potent conditional lymphocyte activation

Journal Articles

Noninvasive MRI Native T₁ Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma

Konstantinos Zormpas-Petridis, Evon Poon, Matthew Clarke, Neil P. Jerome, Jessica K.R. Boult, Matthew D. Blackledge, Fernando Carceller, Alexander Koers, Giuseppe Barone, Andrew D.J. Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Louis Chesler, Yinyin Yuan, Simon P. Robinson, Yann Jamin

Cancer Res (2020) 80 (16): 3424–3435.

https://doi.org/10.1158/0008-5472.CAN-20-0133

Published: 14 August 2020

View article titled, Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract 2399: LAG-3/PD-L1 mAb² can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade

Mustapha Faroudi, Matthew Kraman, Natalie Fosh, Claire Reader, Daniel Gliddon, Claire Seal, Christa Lucas, Alexander Koers, Mateusz Wydro, Michelle Morrow, Neil Brewis

Cancer Res (2019) 79 (13_Supplement): 2399.

https://doi.org/10.1158/1538-7445.AM2019-2399

Published: 01 July 2019

View article titled, Abstract 2399: LAG-3/PD-L1 mAb2 can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade

Journal Articles

Abstract 1540: FS222 mAb², a bispecific conditional agonist antibody targeting CD137 and PD-L1, induces potent lymphocyte activation and has a favorable safety profile

Matthew A. Lakins, Alexander Koers, Jose Munoz Olaya, Raffaella Giambalvo, Daniel Jones, Sarka Pechouckova, Emma Goodman, Sylwia Marshall, Mateusz Wydro, Cristian Gradinaru, Francisca Wollerton, Sarah Batey, Daniel Gliddon, Michael Davies, Michelle Morrow, Mihriban Tuna, Neil Brewis

Cancer Res (2019) 79 (13_Supplement): 1540.

https://doi.org/10.1158/1538-7445.AM2019-1540

Published: 01 July 2019

View article titled, Abstract 1540: FS222 mAb2, a bispecific conditional agonist antibody targeting CD137 and PD-L1, induces potent lymphocyte activation and has a favorable safety profile

Journal Articles

Abstract 2398: Dual agonist bispecific antibody targeting OX40 and CD137 mediates anti-tumor immunity and synergizes with PD-1/PD-L1 blockade to improve survival in a syngeneic mouse model

Edmund Poon, Miguel Gaspar, Leonor Nunes Rodrigues, John Pravin, Anne Skogø Lind, Alexander Koers, Emma McConnell, Mihriban Tuna, Michelle Morrow, Neil Brewis

Cancer Res (2019) 79 (13_Supplement): 2398.

https://doi.org/10.1158/1538-7445.AM2019-2398

Published: 01 July 2019

View article titled, Abstract 2398: Dual agonist bispecific antibody targeting OX40 and CD137 mediates anti-tumor immunity and synergizes with PD-1/PD-L1 blockade to improve survival in a syngeneic mouse model

Journal Articles

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

Cancer Res (2019) 79 (11): 2978–2991.

https://doi.org/10.1158/0008-5472.CAN-18-3412

Published: 03 June 2019

View article titled, MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

Includes: Supplementary data

Journal Articles

Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitumor immune responses

Matthew Kraman, Natalie Fosh, Katarzyna Kmiecik, Katy Everett, Carlo Zimarino, Mustapha Faroudi, Mateusz Wydro, Alexander Koers, Lesley Young, Daniel Gliddon, Michelle Morrow, Jacqueline Doody, Mihriban Tuna, Neil Brewis

Cancer Res (2018) 78 (13_Supplement): 2719.

https://doi.org/10.1158/1538-7445.AM2018-2719

Published: 01 July 2018

View article titled, Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitumor immune responses

Journal Articles

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Cancer Res (2017) 77 (5): 1127–1141.

https://doi.org/10.1158/0008-5472.CAN-16-1829

Published: 28 February 2017

View article titled, Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Includes: Supplementary data

Journal Articles

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

Orli Yogev, Karen Barker, Arti Sikka, Gilberto S. Almeida, Albert Hallsworth, Laura M. Smith, Yann Jamin, Ruth Ruddle, Alexander Koers, Hannah T. Webber, Florence I. Raynaud, Sergey Popov, Chris Jones, Kevin Petrie, Simon P. Robinson, Hector C. Keun, Louis Chesler

Cancer Res (2016) 76 (10): 3025–3035.

https://doi.org/10.1158/0008-5472.CAN-15-1939

Published: 12 May 2016

View article titled, p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

Includes: Supplementary data

Journal Articles

Abstract B65: IgG4 subclass antibodies impair antitumor immunity in melanoma.

Cancer Res (2013) 73 (1_Supplement): B65.

https://doi.org/10.1158/1538-7445.TUMIMM2012-B65

Published: 02 April 2014

View article titled, Abstract B65: IgG4 subclass antibodies impair antitumor immunity in melanoma.

Journal Articles

Abstract B46: Immunotherapy of solid tumors with IgE antibodies: Paradigm of a novel concept towards clinical application.

Sophia N. Karagiannis, Debra H. Josephs, Panagiotis Karagiannis, Louise Saul, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Philip J. Blower, Andrew J. Beavil, Frank O. Nestle, James F. Spicer, Hannah J. Gould

Cancer Res (2013) 73 (1_Supplement): B46.

https://doi.org/10.1158/1538-7445.TUMIMM2012-B46

Published: 02 April 2014

View article titled, Abstract B46: Immunotherapy of solid tumors with IgE antibodies: Paradigm of a novel concept towards clinical application.

Journal Articles

Abstract 2524: Antibodies of the IgG and IgE classes against the melanoma-associated antigen HMW-MAA: Investigating a new therapeutic approach

Panagiotis Karagiannis, Amy E. Gilbert, Tihomir Dodev, Debra H. Josephs, Niwa Ali, Dimitra Dafou, Chrysanthi Ainali, Alexander Koers, Sophia Tsoka, Stanley B. Kaye, James Spicer, Hannah J. Gould, Andrew Beavil, Frank O. Nestle, Sophia N. Karagiannis

Cancer Res (2012) 72 (8_Supplement): 2524.

https://doi.org/10.1158/1538-7445.AM2012-2524

Published: 15 April 2012

View article titled, Abstract 2524: Antibodies of the IgG and IgE classes against the melanoma-associated antigen HMW-MAA: Investigating a new therapeutic approach

NARROW

Abstract 4547: Clustering CD137 via cell-expressed PD-L1 crosslinking avoided Fc-mediated agonism and resulted in safe and potent conditional lymphocyte activation

Noninvasive MRI Native T₁ Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma

Abstract 2399: LAG-3/PD-L1 mAb² can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade

Abstract 1540: FS222 mAb², a bispecific conditional agonist antibody targeting CD137 and PD-L1, induces potent lymphocyte activation and has a favorable safety profile

Abstract 2398: Dual agonist bispecific antibody targeting OX40 and CD137 mediates anti-tumor immunity and synergizes with PD-1/PD-L1 blockade to improve survival in a syngeneic mouse model

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitumor immune responses

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

Abstract B65: IgG4 subclass antibodies impair antitumor immunity in melanoma.

Abstract B46: Immunotherapy of solid tumors with IgE antibodies: Paradigm of a novel concept towards clinical application.

Abstract 2524: Antibodies of the IgG and IgE classes against the melanoma-associated antigen HMW-MAA: Investigating a new therapeutic approach

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