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Journal Articles

Abstract A055: Multiomics profiling reveals druggable tumor-stroma interactions in ATM-deficient pancreatic cancer

Elodie Roger, Hannah M. Mummey, Eleni Zimmer, Julia Ragg, Yuna Lee, Kyle J. Gaulton, Alica K. Beutel, Christopher J. Halbrook, Lukas Perkhofer, Johann Gout, Alexander Kleger

Cancer Res (2024) 84 (17_Supplement_2): A055.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A055

Published: 15 September 2024

View articletitled, Abstract A055: Multiomics profiling reveals druggable tumor-stroma interactions in ATM-deficient pancreatic cancer

Journal Articles

Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits

Elodie Roger, Anna Härle, Lukas Perkhofer, Elisabeth Hessmann, Alexander Kleger, Johann Gout

Cancer Res (2024) 84 (17_Supplement_2): B088.

https://doi.org/10.1158/1538-7445.PANCREATIC24-B088

Published: 15 September 2024

View articletitled, Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits

Journal Articles

Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution

Johann Gout, Yazid J Resheq, Jessica Lindenmayer, Julian D Schwab, Elodie Roger, Johann M Kraus, Thomas Ettrich, Alica K Beutel, Lukas Perkhofer, Hans A Kestler, Thomas Seufferlein, Alexander Kleger

Cancer Res (2024) 84 (17_Supplement_2): C053.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C053

Published: 15 September 2024

View articletitled, Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution

Journal Articles

Abstract C010: Single-cell profiling unleashes KRAS-driven redrafting of the tumor microenvironment before cancer onset

Chantal Allgoewer, Markus Breunig, Meike Hohwieler, Medhanie Mulaw, Alexander Kleger

Cancer Res (2024) 84 (17_Supplement_2): C010.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C010

Published: 15 September 2024

View articletitled, Abstract C010: Single-cell profiling unleashes KRAS-driven redrafting of the tumor microenvironment before cancer onset

Journal Articles

Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Sabrina Calderon, Alica K. Beutel, Ethan Nghiem, Rima Singh, Natalie Yousefian, Cecily Anaraki, Kevin Gulay, Dennis Juarez, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Herve Tiriac, David Fruman, Christopher Halbrook

Cancer Res (2024) 84 (17_Supplement_2): C052.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C052

Published: 15 September 2024

View articletitled, Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Journal Articles

Abstract A061: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Dharini Srinivasan, Frank Arnold, Elodie Roger, Anna Härle, Michael K Melzer, Chantal Allgöwer, Patrick C Hermann, Lukas Perkhofer, Johann Gout, Alexander Kleger

Cancer Res (2024) 84 (17_Supplement_2): A061.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A061

Published: 15 September 2024

View articletitled, Abstract A061: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Journal Articles

Abstract A077: The EZH2 epigenetic factor orchestrates oncogenic properties in ATM-deficient pancreatic cancer

Elodie Roger, Anna Härle, Johann Gout, Lukas Perkhofer, Elisabeth Hessmann, Alexander Kleger

Cancer Res (2024) 84 (2_Supplement): A077.

https://doi.org/10.1158/1538-7445.PANCA2023-A077

Published: 16 January 2024

View articletitled, Abstract A077: The EZH2 epigenetic factor orchestrates oncogenic properties in ATM-deficient pancreatic cancer

Journal Articles

Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids

Johann Gout, Yazid J. Resheq, Jessica Lindenmayer, Thomas Ettrich, Lukas Perkhofer, Thomas Seufferlein, Alexander Kleger

Cancer Res (2024) 84 (2_Supplement): C061.

https://doi.org/10.1158/1538-7445.PANCA2023-C061

Published: 16 January 2024

View articletitled, Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids

Journal Articles

Abstract C028: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Dharini Srinivasan, Frank Arnold, Elodie Roger, Anna Härle, Michael Melzer, Patrick Hermann, Lukas Perkhofer, Johann Gout, Alexander Kleger

Cancer Res (2024) 84 (2_Supplement): C028.

https://doi.org/10.1158/1538-7445.PANCA2023-C028

Published: 16 January 2024

View articletitled, Abstract C028: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Journal Articles

Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Alica K. Beutel, Sabrina Calderon, Ethan Nghiem, Rima Singh, Cecily Anaraki, Kevin Gulay, Herve Tiriac, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Dennis Juarez, David Fruman, Christopher Halbrook

Cancer Res (2024) 84 (2_Supplement): A056.

https://doi.org/10.1158/1538-7445.PANCA2023-A056

Published: 16 January 2024

View articletitled, Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Journal Articles

Abstract B035: CXCL12 / CXCR4 signaling enhances and sustains migrating cancer stem cells via BMI1 in pancreatic ductal adenocarcinomas

Kanishka Tiwary, Anton Lahusen, Syeda Inaas, Stefanie Hauff, Karolin Walter, Alexander Kleger, Thomas Seufferlein, Bruno Sainz, Jr., Patrick Christian Hermann

Cancer Res (2023) 83 (2_Supplement_2): B035.

https://doi.org/10.1158/1538-7445.METASTASIS22-B035

Published: 15 January 2023

View articletitled, Abstract B035: CXCL12 / CXCR4 signaling enhances and sustains migrating cancer stem cells via BMI1 in pancreatic ductal adenocarcinomas

Journal Articles

Abstract B034: CXCR4 targeting endogenous human peptides eliminate migrating cancer stem cells by disrupting tumor-stroma crosstalk in pancreatic ductal adenocarcinomas

Kanishka Tiwary, Mirja Harms, Bastian Beitzinger, Roman Schmid, Syeda Inaas, Karolin Walter, Alexander Kleger, Mika Lindén, Thomas Seufferlein, Jan Münch, Patrick Christian Hermann

Cancer Res (2023) 83 (2_Supplement_2): B034.

https://doi.org/10.1158/1538-7445.METASTASIS22-B034

Published: 15 January 2023

View articletitled, Abstract B034: CXCR4 targeting endogenous human peptides eliminate migrating cancer stem cells by disrupting tumor-stroma crosstalk in pancreatic ductal adenocarcinomas

Journal Articles

Abstract PR023: Targeting gemcitabine resistance in pancreatic cancer

Alica Katrin Beutel, Rima Singh, Cecily Anaraki, Gregory Tong, Thomas Martinez, Alexander Kleger, Zeljka Jutric, Christopher James Halbrook

Cancer Res (2022) 82 (22_Supplement): PR023.

https://doi.org/10.1158/1538-7445.PANCA22-PR023

Published: 15 November 2022

View articletitled, Abstract PR023: Targeting gemcitabine resistance in pancreatic cancer

Journal Articles

Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ouralidis, Michael Allgäuer, Michael Menzel, Eugen Rempel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger

Cancer Res (2022) 82 (12_Supplement): 810.

https://doi.org/10.1158/1538-7445.AM2022-810

Published: 15 June 2022

View articletitled, Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

Journal Articles

RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

Cancer Res (2021) 81 (7): 1758–1774.

https://doi.org/10.1158/0008-5472.CAN-20-2633

Published: 01 April 2021

View articletitled, RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

Includes: Supplementary data

Journal Articles

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Cancer Res (2017) 77 (20): 5576–5590.

https://doi.org/10.1158/0008-5472.CAN-17-0634

Published: 15 October 2017

View articletitled, ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Includes: Supplementary data

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Abstract A055: Multiomics profiling reveals druggable tumor-stroma interactions in ATM-deficient pancreatic cancer

Abstract B088: Epigenetic reprograming in ATM-deficient pancreatic cancer: targeting EZH2- mediated oncogenic traits

Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution

Abstract C010: Single-cell profiling unleashes KRAS-driven redrafting of the tumor microenvironment before cancer onset

Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Abstract A061: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Abstract A077: The EZH2 epigenetic factor orchestrates oncogenic properties in ATM-deficient pancreatic cancer

Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids

Abstract C028: DKK3 in pancreatic cancer – Elucidating the roles of a double-edged sword

Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Abstract B035: CXCL12 / CXCR4 signaling enhances and sustains migrating cancer stem cells via BMI1 in pancreatic ductal adenocarcinomas

Abstract B034: CXCR4 targeting endogenous human peptides eliminate migrating cancer stem cells by disrupting tumor-stroma crosstalk in pancreatic ductal adenocarcinomas

Abstract PR023: Targeting gemcitabine resistance in pancreatic cancer

Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

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