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Alexander Drilon
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Journal Articles

Abstract 868: Splicing factor mutant lung cancers: A comprehensive molecular and clinicopathologic characterization

Guilherme Harada, Christina J. Falcon, Fernando C. Santini, Jason C. Chang, Soo R. Yang, Maria E. Arcila, Natasha Rekhtman, Alexander Drilon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 868.
DOI: https://doi.org/10.1158/1538-7445.AM2022-868
Published: 15 June 2022
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Abstract 5363: The preclinical selectivity and activity of APS03118, a highly selective and potent next-generation RET inhibitor

Alexander Drilon, Jun Zhong, Ying Lu, Yongbo Liu, Hao Wang, Minchun Chen, Xiaohu Chen, John Zhu, Shun Lu, Vivek Subbiah
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5363.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5363
Published: 15 June 2022
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Abstract CT545: Variability in NTRK gene fusions does not appear to impact response to larotrectinib

Marc Ladanyi, Sinchita Roy-Chowdhuri, Lauren Ritterhouse, Felix Sahm, Ricarda Norenberg, Kui Shen, Chi Chen, Marc Fellous, Nicoletta Brega, Cornelis M. van Tilburg, Jessica J. Lin, Marcia S. Brose, Ulrik N. Lassen, Ray McDermott, Theodore W. Laetsch, David S. Hong, Alexander Drilon, Erin R. Rudzinski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT545.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT545
Published: 15 June 2022
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Abstract 5239: Switching inhibitor class overcomes crizotinib resistance in a MET fusion-positive NSCLC with a novel acquired MET G1090A mutation

Yonina R. Murciano-Goroff, Srinivasaraghavan Kannan, Jason C. Chang, Ryma Benayed, Ilya Blokhin, Natasha Rekhtman, Ann Elizabeth Sisk, Jaime Gibson, Lia Judka, Lauren Kaplanis, Madeline Merrill, Erica Sgroe, Chandra S. Verma, Alexander Drilon, Emiliano Cocco
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5239.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5239
Published: 15 June 2022
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Journal Articles

Abstract OT2-23-01: A Phase 1b/2a, open-label platform study to evaluate mirdametinib in combination with fulvestrant in ER+ metastatic breast cancers harboring MAPK-activating mutations

Ezra Y. Rosen, Payal Patel, Nenad Sarapa, Badreddin Edris, Alexia Iasonos, Komal Jhaveri, Pedram Razavi, Mark Robson, Alexander Drilon, Michael F. Berger, David B. Solit, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): OT2-23-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-OT2-23-01
Published: 15 February 2022
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Journal Articles

Abstract CT011: Efficacy and safety of selpercatinib in RET fusion-positive cancers other than lung or thyroid cancers

Vivek Subbiah, Bhavana Konda, Todd Bauer, Caroline McCoach, Gerald Falchook, Masayuki Takeda, Jyoti Patel, Jared Weiss, Nir Peled, Lyudmila Bazhenova, Victoria Soldatenkova, Pearl French, Nora Drove, Oliver Gautschi, Alexander Drilon
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT011.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT011
Published: 01 July 2021
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Abstract CT020: Long-term outcomes of patients with TRK fusion cancer treated with larotrectinib

Alexander Drilon, Shivaani Kummar, Catherine M. Albert, Ramamoorthy Nagasubramanian, Jaclyn F. Hechtman, John A. Reeves, Georg Beckmann, Marion Rudolph, Justyna A. Wierzbińska, Laura Dima, Nicoletta Brega, Theodore W. Laetsch, David S. Hong
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT020.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT020
Published: 01 July 2021
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Journal Articles

Abstract 1119: Molecular characteristics of repotrectinib that enable potent inhibition of TRK fusion proteins and broad mutant selectivity

Alexander Drilon, Dayong Zhai, Evan Rogers, Wei Deng, Xi Chen, Paul Sprengeler, Siegfried H. Reich, Brion W. Murray
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1119.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1119
Published: 01 July 2021
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Abstract 1111: MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion positive lung cancers

Sudarshan R. Iyer, Igor Odintsov, Adam J. Schoenfeld, Hiroki Sato, Evan Siau, Alexander Drilon, Gregory J. Riely, Romel Somwar, Marc Ladanyi, Monika A. Davare
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1111.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1111
Published: 01 July 2021
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Journal Articles

Abstract PS11-06: Efficacy and safety of larotrectinib in patients with TRK fusion breast cancer

Ezra Y. Rosen, Antoine Italiano, Dejan Juric, John A. Reeves, Laura Dima, Nicoletta Brega, Alexander Drilon
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS11-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS11-06
Published: 15 February 2021
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Journal Articles

Abstract CT199: Larotrectinib in TRK fusion cancer patients: Outcomes by prior therapy and performance status

Alexander Drilon, Cornelis M. van Tilburg, Anna F. Farago, Shivaani Kummar, Jordan Berlin, Catherine M. Albert, Ray McDermott, Ulrik N. Lassen, John A. Reeves, Nicoletta Brega, Barrett H. Childs, Theodore W. Laetsch, David S. Hong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT199.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT199
Published: 15 August 2020
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Journal Articles

Abstract 5280: Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer

Bo Liu, Dara S. Ross, Alison M. Schram, Pedram Razavi, Stephen M. Lagana, Yanming Zhang, Maurizio Scaltriti, Jacqueline F. Bromberg, Marc Ladanyi, David M. Hyman, Alexander Drilon, Ahmet Zahir, Ryma Benayed, Jaclyn F. Hechtman, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5280.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5280
Published: 15 August 2020
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Abstract 5680: TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Yi Liao, Uwe Rix, Alberto Bardelli, Jacklyn Hechtman, Elisa de Stanchina, David M. Hyman, Chandra Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5680.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5680
Published: 15 August 2020
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Journal Articles

Abstract CT062: Efficacy and safety of larotrectinib in patients with cancer and NTRK gene fusions or other alterations

David S. Hong, Afshin Dowlati, Howard Burris, Edward Chu, Marcia S. Brose, Anna F. Farago, Cornelis M. van Tilburg, Shivaani Kummar, Leo Mascarenhas, John A. Reeves, Marion Rudolph, Patricia Maeda, Barrett H. Childs, Theodore W. Laetsch, Alexander Drilon
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT062.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT062
Published: 15 August 2020
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Journal Articles

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

Emiliano Cocco, Amanda Kulick, Sandra Misale, Rona Yaeger, Pedram Razavi, Helen H. Won, Ryan Ptashkin, Jaclyn F. Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B. Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J. Nagy, Richard B. Lanman, Michael F. Berger, Marc Ladanyi, David M. Hyman, Alexander Drilon, Maurizio Scaltriti, Alison M. Schram
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-118.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-118
Published: 01 July 2019
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Journal Articles

Abstract 442: Repotrectinib, a next generation TRK inhibitor, overcomes TRK resistance mutations including solvent front, gatekeeper and compound mutations

Alexander Drilon, Dayong Zhai, Wei Deng, Xin Zhang, Dong Lee, Evan Rogers, Jeffrey Whitten, Zhongdong Huang, Armin Graber, Juliet Liu, Shanna Stopatschinskaja, J. Jean Cui, Dong-Wan Kim, Byoung Chul Cho, Robert C. Doebele, Sai-Hong Ignatius Ou, Jeeyun Lee, Alice T. Shaw
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 442.
DOI: https://doi.org/10.1158/1538-7445.AM2019-442
Published: 01 July 2019
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Abstract CT127: Phase I and expanded access experience of LOXO-195 (BAY 2731954), a selective next-generation TRK inhibitor (TRKi)

David Hyman, Shivaani Kummar, Anna Farago, Birgit Geoerger, Morten Mau-Sorensen, Matthew Taylor, Elena Garralda, Ramamoorthy Nagasubramanian, Michael Natheson, Lucy Song, Michael Capra, Mette Jorgensen, Alan Ho, Neerav Shukla, Steve Smith, Xin Huang, Brian Tuch, Nora Ku, Theodore W. Laetsch, Alexander Drilon, David Hong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT127.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT127
Published: 01 July 2019
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Abstract CT192: Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2

Alexander Drilon, Fabrice Barlesi, Filippo De Braud, Byoung Chul Cho, Myung-Ju Ahn, Salvatore Siena, Matthew G. Krebs, Chia-Chi Lin, Tom John, Daniel SW Tan, Takashi Seto, Rafal Dziadziuszko, Hendrick-Tobias Arkenau, Christian Rolfo, Jürgen Wolf, Chenglin Ye, Todd Riehl, Susan Eng, Robert C. Doebele
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT192.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT192
Published: 01 July 2019
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Abstract CT195: Long-term survival outcomes with nivolumab (NIVO) in pts with previously treated advanced non-small cell lung cancer (NSCLC): Impact of early disease control and response

Julie Brahmer, Hossein Borghaei, Suresh S. Ramalingam, Leora Horn, Esther Holgado, Adam Pluzanski, Marco A. Burgio, Marina Garassino, Laura Q. Chow, Scott Gettinger, Lucio Crino, David Planchard, Charles Butts, Alexander Drilon, Joanna Wojcik-Tomaszewska, Gregory Otterson, Vinny Hayreh, Ang Li, John R. Penrod, Scott J. Antonia
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT195.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT195
Published: 01 July 2019
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Journal Articles

Abstract 2516: A bioinformatics framework for high-sensitivity detection and monitoring of oncogenic gene fusions in plasma cfDNA

Juber Patel, Maysun Hasan, Fanli Meng, Xiaohong Jing, Grittney Tam, Ian Johnson, Youyun Zheng, Chaitanya Bandlamudi, Caitlin Stewart, Helen Won, Oliver Hampton, Alison Schram, Ezra Rosen, Alexander Drilon, Anna Varghese, David Hyman, Dana Tsui, Brian Houck-Loomis, Michael Berger
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2516.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2516
Published: 01 July 2019
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