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Alexander Dobrovic
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Journal Articles

Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma

Ksenija Nesic, Olga Kondrashova, Rachel M. Hurley, Cordelia D. McGehee, Cassandra J. Vandenberg, Gwo-Yaw Ho, Elizabeth Lieschke, Genevieve Dall, Nirashaa Bound, Kristy Shield-Artin, Marc Radke, Ashan Musafer, Zi Qing Chai, Mohammad Reza Eftekhariyan Ghamsari, Maria I. Harrell, Damien Kee, Inger Olesen, Orla McNally, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D.L. Bowtell, Elizabeth M. Swisher, S. John Weroha, Katia Nones, Nicola Waddell, Scott H. Kaufmann, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4709–4722.
https://doi.org/10.1158/0008-5472.CAN-21-0774
Published: 15 September 2021
View articletitled, Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma
Open the PDF for Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 823: A case-control study of constitutional BRCA1 methylation in a mammographically screened cohort

Basant Ebaid, Hongdo Do, Jia Min Pang, Lisa Devereux, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 823.
https://doi.org/10.1158/1538-7445.AM2019-823
Published: 01 July 2019
View articletitled, Abstract 823: A case-control study of constitutional BRCA1 methylation in a mammographically screened cohort
Journal Articles

Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance

Rachel M. Hurley, Ksenija Nesic, Cordelia McGehee, Olga Kondrashova, Maria I. Harrell, Paula A. Schneider, Xiaonan Hou, Cristina Correia, Karen S. Flatten, Giada V. Zapparoli, Alexander Dobrovic, Kevin K. Lin, Thomas C. Harding, Andrea E. Wahner Hendrickson, Elizabeth M. Swisher, Matthew Wakefield, S. John Weroha, Clare L. Scott, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5885.
https://doi.org/10.1158/1538-7445.AM2018-5885
Published: 01 July 2018
View articletitled, Abstract 5885: Loss of RAD51C promoter hypermethylation confers PARP inhibitor resistance
Journal Articles

Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation

Jia-Min Pang, Ashwini Chand, Kevin Knower, Elena Takano, David Byrne, Evelien Sprenkeler, Ramyar Molania, Ewan Millar, Soon Lee, Sandra O'Toole, Colin Clyne, Alexander Dobrovic, Stephen Fox
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2962.
https://doi.org/10.1158/1538-7445.AM2015-2962
Published: 01 August 2015
View articletitled, Abstract 2962: LRH-1 expression in breast cancer tissue and its association with phenotype and DNA methylation
Journal Articles

Abstract 290: Constitutional BRCA1 methylation is a major predisposition factor for high-grade serous ovarian cancer

Alexander Dobrovic, Thomas Mikeska, Kathryn Alsop, Ida Candiloro, Joshy George, Gillian Mitchell, David Bowtell
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 290.
https://doi.org/10.1158/1538-7445.AM2014-290
Published: 01 October 2014
View articletitled, Abstract 290: Constitutional BRCA1 methylation is a major predisposition factor for high-grade serous ovarian cancer
Journal Articles

Abstract 383: Is loss of MGMT a therapeutic target in lung cancer

Hongdo Do, Paul Mitchell, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 383.
https://doi.org/10.1158/1538-7445.AM2014-383
Published: 01 October 2014
View articletitled, Abstract 383: Is loss of MGMT a therapeutic target in lung cancer
Journal Articles

Abstract 4693: Characterization of the differential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas and correlation with patient outcome.

Annette M. Lim, Hongdo Do, Richard J. Young, Stephen Q. Wong, Christopher Angel, Marnie Collins, Elena Takano, June Corry, Stephen B. Fox, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyon, Danny Rischin, Alexander Dobrovic, Benjamin Solomon
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4693.
https://doi.org/10.1158/1538-7445.AM2013-4693
Published: 15 April 2013
View articletitled, Abstract 4693: Characterization of the differential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas and correlation with patient outcome.
Journal Articles

Abstract 54: Marked reduction of sequence artifacts in massively parallel sequencing of formalin-fixed paraffin-embedded DNA by depletion of uracil containing templates.

Hongdo Do, Stephen Q. Wong, Jason Li, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 54.
https://doi.org/10.1158/1538-7445.AM2013-54
Published: 15 April 2013
View articletitled, Abstract 54: Marked reduction of sequence artifacts in massively parallel sequencing of formalin-fixed paraffin-embedded DNA by depletion of uracil containing templates.
Journal Articles

Abstract 2098: Reducing sequence artefacts from FFPE DNA for cancer diagnostics

Hongdo Do, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2098.
https://doi.org/10.1158/1538-7445.AM2012-2098
Published: 15 April 2012
View articletitled, Abstract 2098: Reducing sequence artefacts from FFPE DNA for cancer diagnostics
Journal Articles

Abstract 2977: Epithelial mesenchymal plasticity in xenograft models of circulating and disseminated tumour cells from human breast cancer

Anthony Tachtsidis, Devika Gunasinghe, Tony Blick, Dexing Huang, Emma L. de Sousa, Alexander Dobrovic, Mark Waltham, Erik W. Thompson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2977.
https://doi.org/10.1158/1538-7445.AM2012-2977
Published: 15 April 2012
View articletitled, Abstract 2977: Epithelial mesenchymal plasticity in xenograft models of circulating and disseminated tumour cells from human breast cancer
Journal Articles

Abstract LB-377: Promoter methylation of the DAPK1 CLL predisposition gene is associated with chronic lymphocytic leukaemia risk

Ida Candiloro, Thomas Mikeska, Graham Giles, Gianluca Severi, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-377.
https://doi.org/10.1158/1538-7445.AM2012-LB-377
Published: 15 April 2012
View articletitled, Abstract LB-377: Promoter methylation of the DAPK1 CLL predisposition gene is associated with chronic lymphocytic leukaemia risk
Journal Articles

Abstract 113: Aberrant DNA methylation of the HIF-1α inhibitor gene CITED4 in breast cancer

Katie T. Huang, Elena A. Takano, Thomas Mikeska, David J. Byrne, Alexander Dobrovic, Stephen B. Fox
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 113.
https://doi.org/10.1158/1538-7445.AM2011-113
Published: 15 April 2011
View articletitled, Abstract 113: Aberrant DNA methylation of the HIF-1α inhibitor gene CITED4 in breast cancer
Journal Articles

BRCA1 promoter methylation in peripheral blood DNA of mutation negative breast cancer patients.

Alexander Dobrovic, Michael Krypuy, Ee Ming Wong, Cameron Snell, Lasse Kristensen, Thomas Mikeska, Melissa Southey, Stephen Fox
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2793.
Published: 01 May 2008
View articletitled, BRCA1 promoter methylation in peripheral blood DNA of mutation negative breast cancer patients.
Journal Articles

High resolution melting allows sensitive high-throughput assessment of methylation in tumour samples.

Tomasz Wojdacz, Ee Ming Wong, Michael Krypuy, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 365.
Published: 01 May 2007
View articletitled, High resolution melting allows sensitive high-throughput assessment of methylation in tumour samples.
Journal Articles

Rapid detection of methylation changes at the H19 differentially methylated region in human imprinting disorders using methylation sensitive high resolution melting.

Tomasz Wojdacz, Alexander Dobrovic, Elizabeth Algar
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-166.
Published: 01 May 2007
View articletitled, Rapid detection of methylation changes at the H19 differentially methylated region in human imprinting disorders using methylation sensitive high resolution melting.
Journal Articles

Distinct clinical and pathological features are associated with the BRAF (T1799A) mutation in primary melanoma

Wendy W. Liu, William K. Murray, John P. Dowling, John W. Kelly, Rory Wolfe, Graham Mason, Jill Magee, Christopher Angel, Alexander Dobrovic, Grant A. McArthur
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 235.
Published: 01 May 2005
View articletitled, Distinct clinical and pathological features are associated with the BRAF (T1799A) mutation in primary melanoma
Journal Articles

Methylation of the BRCA1 Gene in Sporadic Breast Cancer

Alexander Dobrovic, David Simpfendorfer
Journal: Cancer Research
Cancer Res (1997) 57 (16): 3347–3350.
Published: 01 August 1997
View articletitled, Methylation of the BRCA1 Gene in Sporadic Breast Cancer
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Journal Articles

Immunobead-PCR: A Technique for the Detection of Circulating Tumor Cells Using Immunomagnetic Beads and the Polymerase Chain Reaction

Jennifer E. Hardingham, Dusan Kotasek, Belinda Farmer, Ross N. Butler, Jing-Xian Mi, Robert E. Sage, Alexander Dobrovic
Journal: Cancer Research
Cancer Res (1993) 53 (15): 3455–3458.
Published: 01 August 1993
View articletitled, Immunobead-PCR: A Technique for the Detection of Circulating Tumor Cells Using Immunomagnetic Beads and the Polymerase Chain Reaction
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Journal Articles

erbA-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21–3p25 and Deleted in Small Cell Lung Carcinoma

Alexander Dobrovic, Benoit Houle, Abdelmajid Belouchi, W. E. C. Bradley
Journal: Cancer Research
Cancer Res (1988) 48 (3): 682–685.
Published: 01 February 1988
View articletitled, erbA-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21–3p25 and Deleted in Small Cell Lung Carcinoma
Open the PDF for erbA-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21–3p25 and Deleted in Small Cell Lung Carcinoma in another window