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Alexander D. Borowsky
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Journal Articles

Abstract 5581: The DACH1 gene, frequently co-deleted with BRCA2 in prostate cancer, governs PARP inhibitor resistance

Zhiping Li, Xuanmao Jiao, Taimoor Khan, Danni Li, Shan Zha, Lai Yee Phoon, Li Lan, A. Gordon Robertson, Anthony W. Ashton, Kenneth A. Iczkowski, Alexander D. Borowsky, Alan Ashworth, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5581.
https://doi.org/10.1158/1538-7445.AM2024-5581
Published: 22 March 2024
View article titled, Abstract 5581: The DACH1 gene, frequently co-deleted with BRCA2 in prostate cancer, governs PARP inhibitor resistance
Journal Articles

Abstract A026: An alternative to HER2 IHC 0/1+/2+ status to predict which clinically HER2-negative patients will respond to anti-HER2 therapies: A rationale for the likely superiority of quantitative HER2 pathway RPPA measurements

Julia Wulfkuhle, Denise M. Wolf, Angela DeMichele, Christina Yau, Laura van ‘t Veer, Hope S. Rugo, Lajos Pusztai, Lamorna Brown-Swigart, Gillian L. Hirst, Rosa I. Gallagher, Amy L. Delson, Alexander D. Borowsky, Laura J. Esserman, Paula R. Pohlmann, Emanuel F. Petricoin
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): A026.
https://doi.org/10.1158/1538-7445.ADVBC23-A026
Published: 01 February 2024
View article titled, Abstract A026: An alternative to HER2 IHC 0/1+/2+ status to predict which clinically HER2-negative patients will respond to anti-HER2 therapies: A rationale for the likely superiority of quantitative HER2 pathway RPPA measurements
Journal Articles

Abstract PR07: Intratumoral injection of mRNA-2752 and anti-PD-1 results in rapid regression of HER2 positive and or Hormone Receptor Negative DCIS: Phase 1 study results

Laura J. Esserman, Kirithiga Ramalingam, Rachel Woody, Alexa Glencer, Christopher Schwartz, Hidetoshi Mori, Jasmine Wong, Gillian Hirst, Jennifer Rosenbluth, Nola Hylton, Natsuko Onishi, Alexander D. Borowsky, Michael J. Campbell
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): PR07.
https://doi.org/10.1158/1538-7445.ADVBC23-PR07
Published: 01 February 2024
View article titled, Abstract PR07: Intratumoral injection of mRNA-2752 and anti-PD-1 results in rapid regression of HER2 positive and or Hormone Receptor Negative DCIS: Phase 1 study results
Journal Articles

Abstract PS4-09: Pathologic features of the inter-regimen biopsy predict response to neoadjuvant therapy in the I-SPY 2 TRIAL

Jodi M Carter, Molly E Klein, Sara J Venters, Kimmie Rabe, I Tolgay Ocal, Kamaljeet Singh, Denise M Wolf, Sunati Sahoo, Shuko Harada, Laila Khazai, Malini Harigopal, Alexander D Borowsky, Gregor Krings, Ronald Balassanian, Yunn-Yi Chen, Kimberley Cole, Sonal Shad, Amy Delson, Lamorna Brown-Swigart, I-SPY 2 TRIAL Consortium, Laura Esserman, Laura van ‘t Veer, W Fraser Symmans
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS4-09.
https://doi.org/10.1158/1538-7445.SABCS20-PS4-09
Published: 15 February 2021
View article titled, Abstract PS4-09: Pathologic features of the inter-regimen biopsy predict response to neoadjuvant therapy in the I-SPY 2 TRIAL
Journal Articles

Abstract PS4-10: Serial MRI and pathology combined to select candidates for therapy de-escalation in the I-SPY 2 TRIAL

Sara J Venters, Wen Li, Denise M Wolf, Jodi M Carter, Molly E Klein, Kamaljeet Singh, Kimmie Rabe, I Tolgay Ocal, David Newitt, Christina Yau, Natsuko Onishi, Jessica Gibbs, Sunati Sahoo, Shuko Harada, Laila Khazai, Malini Harigopal, Alexander D Borowsky, Gregor Krings, Ronald Balassanian, Yunn-Yi Chen, Kimberley Cole, Sonal Shad, Barbara LeStage, Amy Delson, Sandra Finestone, Lamorna Brown-Swigart, I-SPY 2 Imaging Working Group, I-SPY 2 TRIAL Consortium, Laura Esserman, Laura van ‘t Veer, W Fraser Symmans, Nola M Hylton
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS4-10.
https://doi.org/10.1158/1538-7445.SABCS20-PS4-10
Published: 15 February 2021
View article titled, Abstract PS4-10: Serial MRI and pathology combined to select candidates for therapy de-escalation in the I-SPY 2 TRIAL
Journal Articles

Abstract P6-06-07: Gene expression changes in the epithelium and stroma of invasive ductal carcinoma and ductal carcinoma in situ: A meta-analysis

Andre Dempsey, Christina Yau, Olivier Harismendy, Jonah Donnenfield, Amrita Basu, Michael Campbell, Alexander D Borowsky, Gillian Hirst, Laura J Esserman
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-06-07.
https://doi.org/10.1158/1538-7445.SABCS19-P6-06-07
Published: 15 February 2020
View article titled, Abstract P6-06-07: Gene expression changes in the epithelium and stroma of invasive ductal carcinoma and ductal carcinoma <em>in situ</em>: A meta-analysis
Journal Articles

Abstract P5-02-13: A novel detection technique for collagen (and other macromolecules) on H&E slides without special stains for improved cancer prognostics

Farzad Fereidouni, Alexander D. Borowsky, Richard M. Levenson
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-02-13.
https://doi.org/10.1158/1538-7445.SABCS19-P5-02-13
Published: 15 February 2020
View article titled, Abstract P5-02-13: A novel detection technique for collagen (and other macromolecules) on H&amp;E slides without special stains for improved cancer prognostics
Journal Articles

Abstract P5-08-01: Breast cancer risk thresholds as a predictor of chemoprevention uptake in the Athena Breast Health Network

Yash S Huilgol, Holly Keane, Yiwey Shieh, Jeffrey Tice, Elad Ziv, Lisa Madlensky, Leah Sabacan, Irene Acerbi, Mandy Che, Allison Stover Fiscalini, Hoda Anton-Culver, Alexander D Borowsky, Sharon Hunt, Arash Naeim, Barbara Parker, Laura J van 't Veer, Athena Breast Health Network Investigators and Advocate Partners and Laura J Esserman
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P5-08-01.
https://doi.org/10.1158/1538-7445.SABCS19-P5-08-01
Published: 15 February 2020
View article titled, Abstract P5-08-01: Breast cancer risk thresholds as a predictor of chemoprevention uptake in the Athena Breast Health Network
Journal Articles

Abstract OT3-09-01: Use of Oncotype DX DCIS for disease management in a prospective DCIS registry

Jane M Wei, Paul Kim, Cheryl Ewing, Jasmine Wong, Laura J Esserman, Michael D Alvarado, Abimbola O Olusanya, Skye Stewart, Ashley Tydon, Parima Daroui, Jeffrey V Kuo, Hannah L Park, Karen T Lane, Eliza Jeong, Kelsey Brown, Ava Hosseini, Barbara A Parker, Sarah L Blair, Athena Breast Health Network Investigators, Frederick Baehner, Olivier Harismendy, Antonia Petruse, Carlie K Thompson, Helena R Chang, Alexander D Borowsky, Christina Yau, Gillian L Hirst, Richard J Bold, Rita A Mukhtar
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT3-09-01.
https://doi.org/10.1158/1538-7445.SABCS19-OT3-09-01
Published: 15 February 2020
View article titled, Abstract OT3-09-01: Use of Oncotype DX DCIS for disease management in a prospective DCIS registry
Journal Articles

Abstract 2171: Activatable nanodelivery of high payload gemcitabine augments therapeutic efficacy in murine breast and pancreatic cancer models

Samantha T. Tucci, Azadeh Kheirolomoom, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Josquin Foiret, Neil E. Hubbard, Alexander D. Borowsky, Mo Baikoghli, R. Holland Cheng, Katherine W. Ferrara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2171.
https://doi.org/10.1158/1538-7445.AM2019-2171
Published: 01 July 2019
View article titled, Abstract 2171: Activatable nanodelivery of high payload gemcitabine augments therapeutic efficacy in murine breast and pancreatic cancer models
Journal Articles

Abstract 3952: Localized nanodelivery combined with immunotherapy promotes curative anti-tumor responses in a murine breast cancer model

Azadeh Kheirolomoom, Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Spencer K. Tumbale, Josquin Foiret, Neil E. Hubbard, Alexander D. Borowsky, William J. Murphy, Katherine W. Ferrara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3952.
https://doi.org/10.1158/1538-7445.AM2019-3952
Published: 01 July 2019
View article titled, Abstract 3952: Localized nanodelivery combined with immunotherapy promotes curative anti-tumor responses in a murine breast cancer model
Journal Articles

Abstract 576: Neoadjuvant immunotherapy improves efficacy of image-guided thermal ablation to generate curative responses in a murine breast cancer model

Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Azadeh Kheirolomoom, Yu Liu, Brett Z. Fite, Sarah M. Tam, Samantha Tucci, Katherine D. Watson, Andrew W. Wong, Arta M. Monjazeb, Neil E. Hubbard, William J. Murphy, Alexander D. Borowsky, Katherine W. Ferrara
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 576.
https://doi.org/10.1158/1538-7445.AM2017-576
Published: 01 July 2017
View article titled, Abstract 576: Neoadjuvant immunotherapy improves efficacy of image-guided thermal ablation to generate curative responses in a murine breast cancer model
Journal Articles

Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study

Jennifer Schmitz, Julian Schwab, Johannes Schwenck, Qian Chen, Leticia Quintanilla-Martinez, Markus Hahn, Beate Wietek, Nina Schwenzer, Annette Staebler, Ursula Kohlhofer, Olulanu H. Aina, Neil E. Hubbard, Gerald Reischl, Alexander D. Borowsky, Sara Brucker, Konstantin Nikolaou, Christian la Fougère, Robert D. Cardiff, Bernd J. Pichler, Andreas M. Schmid
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5512–5522.
https://doi.org/10.1158/0008-5472.CAN-15-0642
Published: 15 September 2016
View article titled, Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric <em>In Vivo</em> Imaging: A Translational Study
Open the PDF for Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric <em>In Vivo</em> Imaging: A Translational Study in another window
Includes: Supplementary data
Journal Articles

Abstract LB-052: Activatable nanodelivery combined with CpG-ODN and anti-PD-1 achieves a complete response in directly-treated and contralateral tumors in a murine breast cancer model

Matthew T. Silvestrini, Azadeh Kheirolomoom, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Josquin Foiret, Samantha Tucci, Neil E. Hubbard, Alexander D. Borowsky, Katherine W. Ferrara
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-052.
https://doi.org/10.1158/1538-7445.AM2016-LB-052
Published: 15 July 2016
View article titled, Abstract LB-052: Activatable nanodelivery combined with CpG-ODN and anti-PD-1 achieves a complete response in directly-treated and contralateral tumors in a murine breast cancer model
Journal Articles

Abstract 32: The role of Lrig1 signaling in mammary gland development and tumorigenesis

Catalina Simion, Qian J. Chen, Charles L. Wilkerson, Hanine Rafidi, Alexander D. Borowsky, Colleen Sweeney
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 32.
https://doi.org/10.1158/1538-7445.AM2015-32
Published: 01 August 2015
View article titled, Abstract 32: The role of Lrig1 signaling in mammary gland development and tumorigenesis
Journal Articles

Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells

Demet Candas, Chung-Ling Lu, Ming Fan, Frank Y.S. Chuang, Colleen Sweeney, Alexander D. Borowsky, Jian Jian Li
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (24): 7498–7509.
https://doi.org/10.1158/0008-5472.CAN-14-0844
Published: 14 December 2014
View article titled, Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Open the PDF for Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

James C. Garbe, Francois Pepin, Fanny A. Pelissier, Klara Sputova, Agla J. Fridriksdottir, Diana E. Guo, Rene Villadsen, Morag Park, Ole W. Petersen, Alexander D. Borowsky, Martha R. Stampfer, Mark A. LaBarge
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3687–3701.
https://doi.org/10.1158/0008-5472.CAN-12-0157
Published: 15 July 2012
View article titled, Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia
Open the PDF for Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia in another window
Includes: Supplementary data
Journal Articles

Abstract LB-5: The dominant-negative effect of an insulin-like growth factor-1 mutant that is defective in binding to integrins (αvβ3 and α6β4)

Masaaki Fujita, Katsuaki Ieguchi, Robert Cardiff, Alexander D. Borowsky, Yoshikazu Takada
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-5.
https://doi.org/10.1158/1538-7445.AM2011-LB-5
Published: 15 April 2011
View article titled, Abstract LB-5: The dominant-negative effect of an insulin-like growth factor-1 mutant that is defective in binding to integrins (αvβ3 and α6β4)
Journal Articles

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2

Ekaterina V. Kalashnikova, Alexey S. Revenko, Abigael T. Gemo, Nicolas P. Andrews, Clifford G. Tepper, June X. Zou, Robert D. Cardiff, Alexander D. Borowsky, Hong-Wu Chen
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9402–9412.
https://doi.org/10.1158/0008-5472.CAN-10-1199
Published: 14 November 2010
View article titled, ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2
Open the PDF for ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2 in another window
Includes: Supplementary data
Journal Articles

Abstract 5538: Enhanced tumor cytotoxicity of a combinational therapy using liposomal copper-doxorubicin, rapamycin, and ultrasound

Azadeh Kheirolomoom, Lisa Mahakian, Chun-Yen Lai, Heather Lindfors, Jai Woong Seo, Katherine E. Watson, Eric Haynam, Elizabeth Ingham, Li Xing, Alexander D. Borowsky, Robert D. Cardiff, Katherine W. Ferrara
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5538.
https://doi.org/10.1158/1538-7445.AM10-5538
Published: 15 April 2010
View article titled, Abstract 5538: Enhanced tumor cytotoxicity of a combinational therapy using liposomal copper-doxorubicin, rapamycin, and ultrasound