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Journal Articles

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

Alissandra L. Hillis, Timothy D. Martin, Haley E. Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S. Persky, David E. Root, Myles Brown, Karen Cichowski, Stephen J. Elledge, Taru Muranen, David A. Fruman, Simon T. Barry, John G. Clohessy, Ralitsa R. Madsen, Alex Toker
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3250–3266.
https://doi.org/10.1158/0008-5472.CAN-24-0970
Published: 01 October 2024
View article titled, Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Open the PDF for Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States

Laura E. Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Zheqi Li, Anne Trinh, Marco Seehawer, Bojana Jovanović, Maša Alečković, Callahan M. Wilde, Renee C. Geck, Shaokun Shu, Natalie L. Kingston, Nicholas W. Harper, Vanessa Almendro, Alanna L. Pyke, Shawn B. Egri, Malvina Papanastasiou, Kendell Clement, Ningxuan Zhou, Sarah Walker, Jacqueline Salas, So Yeon Park, David A. Frank, Alexander Meissner, Jacob D. Jaffe, Piotr Sicinski, Alex Toker, Franziska Michor, Henry W. Long, Beth A. Overmoyer, Kornelia Polyak
Journal: Cancer Research
Cancer Res (2023) 83 (2): 264–284.
https://doi.org/10.1158/0008-5472.CAN-22-0423
Published: 18 January 2023
View article titled, JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States
Open the PDF for JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States in another window
Includes: Supplementary data
Journal Articles

Abstract P4-01-04: FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces therapeutic resistance in triple negative breast cancer

Yihao Li, Xintao Qiu, Xiaoqing Wang, Hui Liu, Renee Geck Geck, Alok Tewari, Kin-Hoe Chow, Tengfei Xiao, Paloma Cejas, Quang-Dé Nguyen, Henry Long, Shirley X Liu, Alex Toker, Myles Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-01-04.
https://doi.org/10.1158/1538-7445.SABCS21-P4-01-04
Published: 15 February 2022
View article titled, Abstract P4-01-04: FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces therapeutic resistance in triple negative breast cancer
Journal Articles

Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?

Emily C. Erickson, Alex Toker
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6083–6086.
https://doi.org/10.1158/0008-5472.CAN-21-2035
Published: 15 December 2021
View article titled, Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?
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Journal Articles

Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer

Yihao Li, Xintao Qiu, Hui Liu, Xiaoqing Wang, Renee C. Geck, Alok Tewari, Kin-Hoe Chow, Paloma Cejas, Quang-Dé Nguyen, Henry Long, Shirley X. Liu, Alex Toker, Myles Brown
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1400.
https://doi.org/10.1158/1538-7445.AM2021-1400
Published: 01 July 2021
View article titled, Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer
Journal Articles

Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling

Whitney S. Henry, Tyler Laszewski, Tiffany Tsang, Francisco Beca, Andrew H. Beck, Sandra S. McAllister, Alex Toker
Journal: Cancer Research
Cancer Res (2017) 77 (3): 790–801.
https://doi.org/10.1158/0008-5472.CAN-16-2400
Published: 31 January 2017
View article titled, Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling
Open the PDF for Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 2634: Investigating the chemotherapeutic effects of aspirin in mutant PIK3CA breast cancer

Whitney Henry, Alex Toker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2634.
https://doi.org/10.1158/1538-7445.AM2015-2634
Published: 01 August 2015
View article titled, Abstract 2634: Investigating the chemotherapeutic effects of aspirin in mutant PIK3CA breast cancer
Journal Articles

Abstract 5477: MERIT40 is an Akt substrate that promotes resolution of DNA damage induced by chemotherapy

Kristin K. Brown, Laleh Montaser-Kouhsari, Andrew H. Beck, Alex Toker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5477.
https://doi.org/10.1158/1538-7445.AM2015-5477
Published: 01 August 2015
View article titled, Abstract 5477: MERIT40 is an Akt substrate that promotes resolution of DNA damage induced by chemotherapy
Journal Articles

Abstract B8: The two isoforms of ADAM9 have opposing roles in breast cancer cell migration

Jessica L. Fry, Alex Toker
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): B8.
https://doi.org/10.1158/0008-5472.FBCR09-B8
Published: 28 October 2014
View article titled, Abstract B8: The two isoforms of ADAM9 have opposing roles in breast cancer cell migration
Journal Articles

Abstract 4421: PTEN-deficient tumors depend on Akt2 for maintenance

Rebecca Chin, Steve P. Balk, Alex Toker
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4421.
https://doi.org/10.1158/1538-7445.AM2014-4421
Published: 01 October 2014
View article titled, Abstract 4421: PTEN-deficient tumors depend on Akt2 for maintenance
Journal Articles

Targeting Akt3 Signaling in Triple-Negative Breast Cancer

Y. Rebecca Chin, Taku Yoshida, Andriy Marusyk, Andrew H. Beck, Kornelia Polyak, Alex Toker
Journal: Cancer Research
Cancer Res (2014) 74 (3): 964–973.
https://doi.org/10.1158/0008-5472.CAN-13-2175
Published: 02 February 2014
View article titled, Targeting Akt3 Signaling in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 547: Inhibition of PI 3-K isoforms lead to reactivation of Akt signaling in a subset of breast cancer cell lines.

Emilie Collmann, Alex Toker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 547.
https://doi.org/10.1158/1538-7445.AM2013-547
Published: 15 April 2013
View article titled, Abstract 547: Inhibition of PI 3-K isoforms lead to reactivation of Akt signaling in a subset of breast cancer cell lines.
Journal Articles

Abstract 549: MAGI3-Akt3, a novel fusion protein in the PI 3-K pathway in cancer.

Kristin Brown, Alex Toker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 549.
https://doi.org/10.1158/1538-7445.AM2013-549
Published: 15 April 2013
View article titled, Abstract 549: MAGI3-Akt3, a novel fusion protein in the PI 3-K pathway in cancer.
Journal Articles

Abstract 4998: NFAT signaling modulates tumor microenvironment.

Aura Kaunisto, Alex Toker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4998.
https://doi.org/10.1158/1538-7445.AM2013-4998
Published: 15 April 2013
View article titled, Abstract 4998: NFAT signaling modulates tumor microenvironment.
Journal Articles

Abstract 4090: Akt2-specific signaling in prostate cancer maintenance.

Yuet Ming Rebecca Chin, Steve Balk, Alex Toker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4090.
https://doi.org/10.1158/1538-7445.AM2013-4090
Published: 15 April 2013
View article titled, Abstract 4090: Akt2-specific signaling in prostate cancer maintenance.
Journal Articles

RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis

Shiva Kazerounian, Damien Gerald, Minzhou Huang, Y. Rebecca Chin, Durga Udayakumar, Ningning Zheng, Rebekah K. O'Donnell, Carole Perruzzi, Lee Mangiante, Jacob Pourat, Thuy L. Phung, Arturo Bravo-Nuevo, Sharon Shechter, Stephanie McNamara, James B. DuHadaway, Olivier N. Kocher, Lawrence F. Brown, Alex Toker, George C. Prendergast, Laura E. Benjamin
Journal: Cancer Research
Cancer Res (2013) 73 (1): 50–61.
https://doi.org/10.1158/0008-5472.CAN-11-3055
Published: 02 January 2013
View article titled, RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis
Open the PDF for RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration

Jessica L. Fry, Alex Toker
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8187–8198.
https://doi.org/10.1158/0008-5472.CAN-09-4231
Published: 13 October 2010
View article titled, Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration
Open the PDF for Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration in another window
Journal Articles

Abstract 3838: Akt isoform-specific signaling in breast cancer cell invasive migration

Yuet Ming Rebecca Chin, Alex Toker
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3838.
https://doi.org/10.1158/1538-7445.AM10-3838
Published: 15 April 2010
View article titled, Abstract 3838: Akt isoform-specific signaling in breast cancer cell invasive migration
Journal Articles

3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

Matthew Maurer, Tao Su, Lao H. Saal, Susan Koujak, Benjamin D. Hopkins, Christina R. Barkley, Jiaping Wu, Subhadra Nandula, Bhaskar Dutta, Yuli Xie, Y. Rebecca Chin, Da-In Kim, Jennifer S. Ferris, Sofia K. Gruvberger-Saal, Mervi Laakso, Xiaomei Wang, Lorenzo Memeo, Albert Rojtman, Tulio Matos, Jennifer S. Yu, Carlos Cordon-Cardo, Jorma Isola, Mary Beth Terry, Alex Toker, Gordon B. Mills, Jean J. Zhao, Vundavalli V.V.S. Murty, Hanina Hibshoosh, Ramon Parsons
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6299–6306.
https://doi.org/10.1158/0008-5472.CAN-09-0820
Published: 29 July 2009
View article titled, 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Open the PDF for 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract #3819: Differential regulation of breast cancer cell invasive migration by Akt isoforms

Yuet Ming Rebecca Chin, Alex Toker
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3819.
Published: 01 May 2009
View article titled, Abstract #3819: Differential regulation of breast cancer cell invasive migration by Akt isoforms