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Journal Articles

Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies

Cancer Res (2022) 82 (12_Supplement): 1060.

https://doi.org/10.1158/1538-7445.AM2022-1060

Published: 15 June 2022

View article titled, Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies

Journal Articles

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

Christina D. Drenberg, Alice A. Gibson, Stanley B. Pounds, Lei Shi, Dena P. Rhinehart, Lie Li, Shuiying Hu, Guoqing Du, Anne T. Nies, Matthias Schwab, Navjotsingh Pabla, William Blum, Tanja A. Gruber, Sharyn D. Baker, Alex Sparreboom

Cancer Res (2017) 77 (8): 2102–2111.

https://doi.org/10.1158/0008-5472.CAN-16-2548

Published: 13 April 2017

View article titled, OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

Includes: Supplementary data

Journal Articles

Abstract 257: Evaluation of organic cation transporter 1 (OCT1, SLC22A1) as transporter for sorafenib

Claudia Neul, Sharyn D. Baker, Alex Sparreboom, Elke Schaeffeler, Stefan Laufer, Matthias Schwab, Anne T. Nies

Cancer Res (2016) 76 (14_Supplement): 257.

https://doi.org/10.1158/1538-7445.AM2016-257

Published: 15 July 2016

View article titled, Abstract 257: Evaluation of organic cation transporter 1 (OCT1, SLC22A1) as transporter for sorafenib

Journal Articles

Abstract 255: Docetaxel inhibits testosterone mediated activation of the AR pathway by SLCO1B3

Ellen S. de Morree, Ashraf Aghai, Alice A. Gibson, Ron H.J. Mathijssen, Eric A.C. Wiemer, Alex Sparreboom, Wytske M. van Weerden, Ronald de Wit

Cancer Res (2016) 76 (14_Supplement): 255.

https://doi.org/10.1158/1538-7445.AM2016-255

Published: 15 July 2016

View article titled, Abstract 255: Docetaxel inhibits testosterone mediated activation of the AR pathway by SLCO1B3

Journal Articles

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

Eric I. Zimmerman, Alice A. Gibson, Shuiying Hu, Aksana Vasilyeva, Shelley J. Orwick, Guoqing Du, Gerard P. Mascara, Su Sien Ong, Taosheng Chen, Peter Vogel, Hiroto Inaba, Michael L. Maitland, Alex Sparreboom, Sharyn D. Baker

Cancer Res (2016) 76 (1): 117–126.

https://doi.org/10.1158/0008-5472.CAN-15-0694

Published: 03 January 2016

View article titled, Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

Includes: Supplementary data

Journal Articles

Abstract 5464: Host variation in OATP1B1 is associated with treatment outcome in pediatric AML

Christina D. Drenberg, Stanley Pounds, Lei Shi, Shelley Orwick, Lie Li, Shuiying Hu, Alice Gibson, Raul Ribeiro, Jeffrey Rubnitz, Alex Sparreboom, Sharyn D. Baker

Cancer Res (2015) 75 (15_Supplement): 5464.

https://doi.org/10.1158/1538-7445.AM2015-5464

Published: 01 August 2015

View article titled, Abstract 5464: Host variation in OATP1B1 is associated with treatment outcome in pediatric AML

Journal Articles

Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs

Navjotsingh Pabla, Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Guoqing Du, Wenwei Lin, Shuiying Hu, Lie Li, Taosheng Chen, Alex Sparreboom

Cancer Res (2015) 75 (15_Supplement): 4415.

https://doi.org/10.1158/1538-7445.AM2015-4415

Published: 01 August 2015

View article titled, Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs

Journal Articles

Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Shuiying Hu, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl, Alex Sparreboom

Cancer Res (2015) 75 (15_Supplement): 5471.

https://doi.org/10.1158/1538-7445.AM2015-5471

Published: 01 August 2015

View article titled, Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Journal Articles

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmus, Lie Li, Els Wagenaar, Shuiying Hu, Alice A. Gibson, John C. Panetta, Sridhar Mani, Alex Sparreboom, Sharyn D. Baker, Alfred H. Schinkel

Cancer Res (2015) 75 (13): 2729–2736.

https://doi.org/10.1158/0008-5472.CAN-15-0280

Published: 30 June 2015

View article titled, Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Includes: Supplementary data

Journal Articles

Abstract 3696: Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations

Shuiying Hu, Peter D. Bruijn, Ron H.j. Mathijssen, Sharyn D. Baker, Alex Sparreboom

Cancer Res (2014) 74 (19_Supplement): 3696.

https://doi.org/10.1158/1538-7445.AM2014-3696

Published: 01 October 2014

View article titled, Abstract 3696: Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations

Journal Articles

Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

Annemieke J.M. Nieuweboer, Shuiying Hu, Chunshan Gui, Bruno Hagenbuch, Inge M. Ghobadi Moghaddam-Helmantel, Alice A. Gibson, Peter de Bruijn, Ron H.J. Mathijssen, Alex Sparreboom

Cancer Res (2014) 74 (11): 3137–3145.

https://doi.org/10.1158/0008-5472.CAN-13-3634

Published: 29 May 2014

View article titled, Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

Includes: Supplementary data

Journal Articles

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Shinjiro Nagai, Kazumasa Takenaka, Deepa Nachagari, Charles Rose, Kali Domoney, Daxi Sun, Alex Sparreboom, John D. Schuetz

Cancer Res (2011) 71 (5): 1781–1791.

https://doi.org/10.1158/0008-5472.CAN-10-1919

Published: 01 March 2011

View article titled, Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Includes: Supplementary data

Journal Articles

Abstract 1522: Identification of pifithrin-α as a potent inhibitor of OCT2-mediated transport of cisplatin

Cynthia S. Lancaster, Ryan M. Franke, Kelly K. Filipski, Ashley M. Kosloske, Alex Sparreboom

Cancer Res (2010) 70 (8_Supplement): 1522.

https://doi.org/10.1158/1538-7445.AM10-1522

Published: 15 April 2010

View article titled, Abstract 1522: Identification of pifithrin-α as a potent inhibitor of OCT2-mediated transport of cisplatin

Journal Articles

Abstract 3529: Cisplatin-induced downregulation of OCTN2 affects carnitine (vitamin BT) wasting

Chaoxin Hu, Cynthia S. Lancaster, Ryan M. Franke, Kelly K. Filipski, Alex Sparreboom

Cancer Res (2010) 70 (8_Supplement): 3529.

https://doi.org/10.1158/1538-7445.AM10-3529

Published: 15 April 2010

View article titled, Abstract 3529: Cisplatin-induced downregulation of OCTN2 affects carnitine (vitamin BT) wasting

Journal Articles

Abstract 1521: Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-β-D-glucosaminidase

Ryan M. Franke, Ashley M. Kosloske, Kelly K. Filipski, Alex Sparreboom

Cancer Res (2010) 70 (8_Supplement): 1521.

https://doi.org/10.1158/1538-7445.AM10-1521

Published: 15 April 2010

View article titled, Abstract 1521: Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-β-D-glucosaminidase

Journal Articles

Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Brian D. Furmanski, Ken-ichi Fujita, Li Lie, Shelley Orwick, Praveen Potukuchi, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker

Cancer Res (2010) 70 (8_Supplement): 1528.

https://doi.org/10.1158/1538-7445.AM10-1528

Published: 15 April 2010

View article titled, Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Journal Articles

Abstract #2912: A mathematical model of intracellular methotrexate accumulation and the inhibition of folate pathway enzymes in acute lymphoblastic leukemia

John Panetta, Alex Sparreboom, Ching-Hon Pui, Mary Relling, William Evans

Cancer Res (2009) 69 (9_Supplement): 2912.

Published: 01 May 2009

View article titled, Abstract #2912: A mathematical model of intracellular methotrexate accumulation and the inhibition of folate pathway enzymes in acute lymphoblastic leukemia

Journal Articles

Abstract #918: Interaction of the multi-targeted tyrosine kinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

Shuiying Hu, Zhaoyuan Chen, Ryane Franke, Ming Zhao, Michelle Rudek, Alex Sparreboom, Sharyn Baker

Cancer Res (2009) 69 (9_Supplement): 918.

Published: 01 May 2009

View article titled, Abstract #918: Interaction of the multi-targeted tyrosine kinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

Journal Articles

ABCB1 genetic variation influences the toxicity and clinical outcome of patients treated with docetaxel

Tristan Sissung, Caitlin Baum, John Deeken, Douglas Price, Seth Steinberg, William Dahut, Alex Sparreboom, William Figg

Cancer Res (2008) 68 (9_Supplement): 4781.

Published: 01 May 2008

View article titled, ABCB1 genetic variation influences the toxicity and clinical outcome of patients treated with docetaxel

Journal Articles

Association of a CYP17 polymorphism with the overall survival in androgen independent prostate cancer patients

Akinobu Hamada, Romano Danesi, Douglas Price, Tristan Sissung, Cindy Chau, David Venzon, Alex Sparreboom, William Duhut, William Figg

Cancer Res (2007) 67 (9_Supplement): 942.

Published: 01 May 2007

View article titled, Association of a CYP17 polymorphism with the overall survival in androgen independent prostate cancer patients

NARROW

Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

Abstract 257: Evaluation of organic cation transporter 1 (OCT1, SLC22A1) as transporter for sorafenib

Abstract 255: Docetaxel inhibits testosterone mediated activation of the AR pathway by SLCO1B3

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

Abstract 5464: Host variation in OATP1B1 is associated with treatment outcome in pediatric AML

Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs

Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Abstract 3696: Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations

Influence of Drug Formulation on OATP1B-Mediated Transport of Paclitaxel

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Abstract 1522: Identification of pifithrin-α as a potent inhibitor of OCT2-mediated transport of cisplatin

Abstract 3529: Cisplatin-induced downregulation of OCTN2 affects carnitine (vitamin BT) wasting

Abstract 1521: Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-β-D-glucosaminidase

Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Abstract #2912: A mathematical model of intracellular methotrexate accumulation and the inhibition of folate pathway enzymes in acute lymphoblastic leukemia

Abstract #918: Interaction of the multi-targeted tyrosine kinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters

ABCB1 genetic variation influences the toxicity and clinical outcome of patients treated with docetaxel

Association of a CYP17 polymorphism with the overall survival in androgen independent prostate cancer patients

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