1-19 of 19
Alex K. Shalek
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 4536: Dissecting tumor-immune microenvironment in response and resistance to immune checkpoint blockade in metastatic melanoma

Free
Xinyu Cui, Giuseppe Tarantino, Yiwen He, Priyanka Solanky, Kathleen Pfaff, Aaron R. Thorner, Tyler J. Aprati, Boyang Zhang, Timothy Blosser, Emily Robitschek, Jiajia Chen, Junko Tsuji, Elliot Boblitt, Allison Frangieh, Hannah M. Faulkner, Marta Holovatska, Aleigha Lawless, Michael Manos, Karla Helvie, Tatyana Sharova, Dennie Frederick, James L. Fahey, Diego Villamarin, Sachi Krishna, Chanell Mangum, Ajit J. Nirmal, Domenic Abbondanza, Cai McCann, Bruce Johnson, Alex K. Shalek, Eliezer Van Allen, Xiaowei Zhuang, Ryan Sullivan, Barbara E. Engelhardt, Samouil L. Farhi, Scott Rodig, F. Stephen Hodi, Genevieve M. Boland, David Liu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4536.
https://doi.org/10.1158/1538-7445.AM2025-4536
Published: 21 April 2025
View articletitled, Abstract 4536: Dissecting tumor-immune microenvironment in response and resistance to immune checkpoint blockade in metastatic melanoma
Journal Articles

Abstract 4399: Systematic interrogation of cell states that drive inflammation tolerance and therapy resistance in cancer

Free
Srivatsan Raghavan, Evelyn Y. Tong, Aswanth H. Mahalingam, Zixin Chen, Jacob Smigiel, Tsukasa Shibue, Andrew Navia, Alex K. Shalek, Lorin Crawford, Ava Amini, Peter S. Winter
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4399.
https://doi.org/10.1158/1538-7445.AM2025-4399
Published: 21 April 2025
View articletitled, Abstract 4399: Systematic interrogation of cell states that drive inflammation tolerance and therapy resistance in cancer
Journal Articles

Abstract 6605: Spatially-resolved single-cell transcriptome landscape of response and resistance to CDK4/6 inhibitors in patients with hormone receptor-positive metastatic breast cancer

Free
Junko Tsuji, Jorge Gómez Tejeda Zañudo, Timothy R. Blosser, Ha T. Vu, Danielle Firer, Nick Maus, Kathleen L. Pfaff, Billie A. Porter, Jason L. Weirather, Anne Carlisle, Allison M. Frangieh, Elliot Boblitt, Aaron R. Thorner, Karla E. Helvie, Isabella E. Kallassy, Laura K. DelloStritto, Ragnhild Laursen, François Aguet, Mendy Miller, Melissa E. Hughes, Nancy U. Lin, Sara M. Tolaney, Eliezer M. Van Allen, Samouil L. Farhi, Xiaowei Zhuang, Barbara Engelhardt, Scott J. Rodig, Alex K. Shalek, Aviv Regev, Bruce E. Johnson, Nikhil Wagle, Gad Getz, Daniel L. Abravanel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6605.
https://doi.org/10.1158/1538-7445.AM2025-6605
Published: 21 April 2025
View articletitled, Abstract 6605: Spatially-resolved single-cell transcriptome landscape of response and resistance to CDK4/6 inhibitors in patients with hormone receptor-positive metastatic breast cancer
Journal Articles

Abstract C066: Identifying Transcriptional Drivers of Plasticity in Pancreatic Cancer

Free
Yuzhou Evelyn Tong, Aswanth Mahalingam, Walaa E Katan, Julia Joung, Alex K Shalek, Peter S Winter, Srivatsan Raghavan
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C066.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C066
Published: 15 September 2024
View articletitled, Abstract C066: Identifying Transcriptional Drivers of Plasticity in Pancreatic Cancer
Journal Articles

Abstract 2486: Dissecting tumor-immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma

Free
Giuseppe Tarantino, Yiwen He, Priyanka Solanky, Aaron Thorner, Tyler Aprati, Ryan Sullivan, Emily Robitschek, Timothy Blosser, Xiaowei Zhuang, Xiaowei Zhuang, Elliot Boblitt, Allison Frangieh, Marta Holovatska, Aleigha Lawless, Michael Manos, Kathleen Pfaff, Karla Helvie, Tatyana Sharova, Dennie Frederick, James Liam Fahey, Diego Villamarin, Sami Farhi, Scott Rodig, Bruce Johnson, Alex K. Shalek, Eliezer Van Allen, Stephen Hodi, Genevieve M. Boland, David Liu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2486.
https://doi.org/10.1158/1538-7445.AM2024-2486
Published: 22 March 2024
View articletitled, Abstract 2486: Dissecting tumor-immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma
Journal Articles

Abstract 1933: Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Free
Julien Dilly, Laleh Abbassi, Connor J. Hennessey, Giselle A. Uribe, Brendan Parent, Annan Yang, Kevin S. Kapner, Ziyue Li, Kyle E. Evans, Shatavisha Dasgupta, Megan T. Hoffman, Li Qiang, Felix P. Hambitzer, Seema Chugh, Alex K. Shalek, Stephanie K. Dougan, Brian M. Wolpin, Jonathan A. Nowak, Srivatsan Raghavan, Peter S. Winter, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1933.
https://doi.org/10.1158/1538-7445.AM2024-1933
Published: 22 March 2024
View articletitled, Abstract 1933: Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
Journal Articles

Abstract C058: Identifying cell-intrinsic drivers of transcriptional plasticity in pancreatic cancer

Free
Yuzhou Evelyn Tong, Walaa E. Katan, Alex Bott, Julia Joung, Alex K. Shalek, Peter S. Winter, Srivatsan Raghavan
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C058.
https://doi.org/10.1158/1538-7445.PANCA2023-C058
Published: 16 January 2024
View articletitled, Abstract C058: Identifying cell-intrinsic drivers of transcriptional plasticity in pancreatic cancer
Journal Articles

Abstract A093: Deciphering acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Free
Julien Dilly, Laleh Abbassi, Connor J. Hennessey, Giselle A. Uribe, Brendan Parent, Annan Yang, Kevin S. Kapner, Ziyue Li, Shatavisha Dasgupta, Alexander Jordan, Megan T. Hoffman, Li Qiang, Felix P. Hambitzer, Seema Chugh, Alex K. Shalek, Stephanie K. Dougan, Brian M. Wolpin, Jonathan A. Nowak, Srivatsan Raghavan, Peter S. Winter, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A093.
https://doi.org/10.1158/1538-7445.PANCA2023-A093
Published: 16 January 2024
View articletitled, Abstract A093: Deciphering acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 95: Uncommitted cells and phenotypic plasticity elucidate the complexity of the epithelial-mesenchymal molecular gradient of pleural mesothelioma

Free
David T. Severson, Samuel Freyaldenhoven, Benjamin Wadowski, Travis Hughes, Yin P. Hung, Roderick V. Jensen, William G. Richards, Corinne E. Gustafson, Kimberly Vermilya, Simona Innocenti, Julianne S. Barlow, Matthew B. Cougar, Jamie Anderson, Vivian Wang, Mary N. Dao, Alex K. Shalek, Assunta De Rienzo, Raphael Bueno
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 95.
https://doi.org/10.1158/1538-7445.AM2023-95
Published: 04 April 2023
View articletitled, Abstract 95: Uncommitted cells and phenotypic plasticity elucidate the complexity of the epithelial-mesenchymal molecular gradient of pleural mesothelioma
Journal Articles

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Available to Purchase
Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 441–455.
https://doi.org/10.1158/0008-5472.CAN-22-3050
Published: 03 February 2023
View articletitled, Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Open the PDF for Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Abstract IA007: Does cancer cell state matter? Moving from DNA genotype to RNA phenotype-directed therapies in cancer

Free
Alex K. Shalek
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): IA007.
https://doi.org/10.1158/1538-7445.PANCA22-IA007
Published: 15 November 2022
View articletitled, Abstract IA007: Does cancer cell state matter? Moving from DNA genotype to RNA phenotype-directed therapies in cancer
Journal Articles

Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer

Free
Srivatsan Raghavan, Peter S. Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Radha L. Kalekar, Jennyfer Galvez-Reyes, Kristen E. Lowder, Nolawit Mulugeta, Manisha S. Raghavan, Ashir A. Borah, Sara A. Vayrynen, Andressa Dias Costa, Junning Wang, Emma Reilly, Dorisanne Y. Ragon, Lauren K. Brais, Alex M. Jaeger, James M. Cleary, Lorin Crawford, Jonathan A. Nowak, Brian M. Wolpin, William C. Hahn, Andrew J. Aguirre, Alex K. Shalek
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-058.
https://doi.org/10.1158/1538-7445.PANCA20-PO-058
Published: 13 November 2020
View articletitled, Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer
Journal Articles

Abstract IA20: Aberrant leukemic developmental hierarchies and MRD-specific targeting informed by single-cell biophysical and molecular profiling

Free
Peter S. Winter, Andrew Navia, Haley Strouf, Mahnoor Mirza, Jennyfer Galvez-Reyes, Nolawit Mulugeta, Laura Bilal, Nezha Senhaji, Peter Dennis, Catharine S. Leahy, Kay Shigemori, Foster Powers, Alejandro Gupta, Nicholas Calistri, Alex Van Scoyk, Kristen Jones, Huiyun Liu, Kristen E. Stevenson, Robert Kimmerling, Mark Stevens, David M. Weinstock, Scott R. Manalis, Mark A. Murakami, Alex K. Shalek
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): IA20.
https://doi.org/10.1158/1538-7445.TUMHET2020-IA20
Published: 03 November 2020
View articletitled, Abstract IA20: Aberrant leukemic developmental hierarchies and MRD-specific targeting informed by single-cell biophysical and molecular profiling
Journal Articles

Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade

Free
Parin Shah, Michael Cuoco, Mei-Ju Su, Johannes Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rozenblatt-Rosen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev, Livnat Jerby-Arnon
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR01.
https://doi.org/10.1158/1538-7445.MEL2019-PR01
Published: 02 October 2020
View articletitled, Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade
Journal Articles

Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk

Free
Peter S. Winter, Srivatsan Raghavan, Andrew W. Navia, Hannah Williams, Jennyfer Galvez-Reyes, Radha Kalekar, Ashir Borah, Alan DenAdel, Manisha Raghavan, Kristen Lowder, Nolawit Mulugeta, Junning Wang, Emma Reilly, Lauren Brais, Lorin Crawford, James McFarland, James M. Cleary, Jonathan Nowak, Brian M. Wolpin, Andrew J. Aguirre, William C. Hahn, Alex K. Shalek
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): PR02.
https://doi.org/10.1158/1538-7445.CAMODELS2020-PR02
Published: 02 June 2020
View articletitled, Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk
Journal Articles

Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids

Free
Srivatsan Raghavan, Peter S. Winter, Andrew Navia, Radha Kalekar, Jennyfer Galvez-Reyes, Sanjay Prakadan, Junning Wang, Emma Reilly, Lauren Brais, James M. Cleary, Jonathan Nowak, Brian M. Wolpin, Alex K. Shalek, Andrew J. Aguirre, William C. Hahn
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): PR15.
https://doi.org/10.1158/1538-7445.PANCA19-PR15
Published: 13 December 2019
View articletitled, Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids
Journal Articles

Abstract 3647: Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas

Free
Zachary J. Reitman, Brenton Paolella, Guillaume Bergthold, Kristine Pelton, Robert Jones, Sarah Becker, Claire E. Sinai, Haley Malkin, Ying Huang, Leslie Grimmett, Zachary T. Herbert, Yu Sun, Jessica Weatherbee, John Alberta, John Daley, Orit Rozenblatt-Rosen, Rosalind Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3647.
https://doi.org/10.1158/1538-7445.AM2019-3647
Published: 01 July 2019
View articletitled, Abstract 3647: Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas
Journal Articles

Abstract 2450: Single-cell profiling reveals programs mediating oncogenic kinase-independence and minimal residual disease in BCR-ABL-rearranged acute lymphoblastic leukemia

Free
Mark A. Murakami, Peter S. Winter, Andrew W. Navia, Laura L. Bilal, Haley Strouf, Kay Shigemori, Alejandro Gupta, Mahnoor Mirza, Catharine S. Leahy, Nick Calistri, Kristen Jones, Alexandra Van Scoyk, Huiyun Liu, Foster Powers, Robert Kimmerling, Mark Stevens, Kristen E. Stevenson, Scott R. Manalis, David M. Weinstock, Alex K. Shalek
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2450.
https://doi.org/10.1158/1538-7445.AM2019-2450
Published: 01 July 2019
View articletitled, Abstract 2450: Single-cell profiling reveals programs mediating oncogenic kinase-independence and minimal residual disease in BCR-ABL-rearranged acute lymphoblastic leukemia
Journal Articles

Abstract 3027: Dissecting mechanisms of anti-PD-1 therapy with massively parallel single-cell RNA-sequencing

Free
Brian C. Miller, Marc H. Wadsworth, Kevin Bi, Travis K. Hughes, Robert Manguso, Arlene H. Sharpe, Alex K. Shalek, Nicholas Haining
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3027.
https://doi.org/10.1158/1538-7445.AM2017-3027
Published: 01 July 2017
View articletitled, Abstract 3027: Dissecting mechanisms of anti-PD-1 therapy with massively parallel single-cell RNA-sequencing