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Alex Gaither
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Journal Articles

Abstract 4769: Gene expression profiling of response to short- and long-term treatment of LSZ102 in MCF7 cells

Choi Lai Tiong Yip, Joshua Korn, David Ruddy, Daniel Rakiec, Darrin Stuart, Alex Gaither
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4769.
https://doi.org/10.1158/1538-7445.AM2019-4769
Published: 01 July 2019
View article titled, Abstract 4769: Gene expression profiling of response to short- and long-term treatment of LSZ102 in MCF7 cells
Journal Articles

Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER

L. Alex Gaither, Choi Lai Tiong Yip, Chunrong Wang, Weiyi Toy, Qing Sheng, Jinyun Chen, Yuji Mishina, Rita Das, Stefan Peukert, Alice Loo, Sarat Chandarlapaty, Adam Crystal, Tinya J. Abrams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 922.
https://doi.org/10.1158/1538-7445.AM2019-922
Published: 01 July 2019
View article titled, Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER
Journal Articles

Abstract 3825: Targeting activated PI3K/mTOR signaling overcomes resistance to CDK4/6-based therapies in preclinical ER+ breast cancer models

Neil A. O'Brien, Martina SJ McDermott, Dylan F. Conklin, Alex Gaither, Tong Luo, Raul Ayala, Suruchi Salgar, Emmanuelle DiTomaso, Naveen Babbar, Faye Su, Sara A. Hurvitz, Ronald Linnartz, Kristine Rose, Samit Hirawat, Dennis J. Slamon
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3825.
https://doi.org/10.1158/1538-7445.AM2019-3825
Published: 01 July 2019
View article titled, Abstract 3825: Targeting activated PI3K/mTOR signaling overcomes resistance to CDK4/6-based therapies in preclinical ER+ breast cancer models
Journal Articles

Abstract 3070: Lenalidomide and SMAC mimetic LCL161 show combination activity in cells harboring loss of chromosome 5q

Nafeeza Hafeez, Alex Gaither, Dale Porter
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3070.
https://doi.org/10.1158/1538-7445.AM2017-3070
Published: 01 July 2017
View article titled, Abstract 3070: Lenalidomide and SMAC mimetic LCL161 show combination activity in cells harboring loss of chromosome 5q
Journal Articles

Abstract LB-205: The calcium activated chloride channel ANO1 promotes breast cancer progression by activating EGFR- and CAMK-signaling.

Adrian Britschgi, Anke Bill, Heike Brinkhaus, Christopher Rothwell, Ieuan Clay, Stephan Duss, Michael Rebhan, Pichai Raman, Chantale Guy, Kristie Wetzel, Elizabeth George, M. Oana Popa, Sarah Lilley, Hedaythul Choudhury, Martin Gosling, Louis Wang, Stephanie Fitzgerald, Jason Borawski, Jonathan Baffoe, Mark Labow, L. Alex Gaither, Mohamed Bentires-Alj
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-205.
https://doi.org/10.1158/1538-7445.AM2013-LB-205
Published: 15 April 2013
View article titled, Abstract LB-205: The calcium activated chloride channel ANO1 promotes breast cancer progression by activating EGFR- and CAMK-signaling.
Journal Articles

Abstract 854: Patient stratification strategies for NVP-BGJ398, a selective pan-FGFR inhibitor in phase I clinical trials

Diana Graus Porta, Vito Guagnano, Christelle Stamm, Simon Woehrle, Audrey Kauffmann, Yao Yao, Thomas Brümmendorf, Vincent Bordas, Mickaël Le Douget, Yun Zhang, Zhi Chen, Moriko Ito, Fang Li, John Monahan, Alex Gaither, Jason Borawski, Christopher J. Wilson, Kavitha Venkatesan, Francesco Hofmann, William Sellers
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 854.
https://doi.org/10.1158/1538-7445.AM2012-854
Published: 15 April 2012
View article titled, Abstract 854: Patient stratification strategies for NVP-BGJ398, a selective pan-FGFR inhibitor in phase I clinical trials
Journal Articles

Protein Kinase D3 Sensitizes RAF Inhibitor RAF265 in Melanoma Cells by Preventing Reactivation of MAPK Signaling

Jian Chen, Qiong Shen, Mark Labow, L. Alex Gaither
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4280–4291.
https://doi.org/10.1158/0008-5472.CAN-10-3761
Published: 14 June 2011
View article titled, Protein Kinase D3 Sensitizes RAF Inhibitor RAF265 in Melanoma Cells by Preventing Reactivation of MAPK Signaling
Open the PDF for Protein Kinase D3 Sensitizes RAF Inhibitor RAF265 in Melanoma Cells by Preventing Reactivation of MAPK Signaling in another window
Includes: Supplementary data
Journal Articles

Mechanism of action studies using a Smac mimetic reveal positive and negative roles of inhibitor of apoptosis proteins (IAPs) in TNFα signaling

Leigh Zawel, Alex Gaither, Dale Porter, Yao Yao, Christopher Straub, Tim Ramsey, Vadim Iourgenko, Huang Alan, Robert Schlegel, Mark Labow, Stephen Fawell, William Sellers
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): SY26-04.
Published: 01 May 2008
View article titled, Mechanism of action studies using a Smac mimetic reveal positive and negative roles of inhibitor of apoptosis proteins (IAPs) in TNFα signaling
Journal Articles

A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

Alex Gaither, Dale Porter, Yao Yao, Jason Borawski, Guang Yang, Jerry Donovan, David Sage, Joanna Slisz, Mary Tran, Christopher Straub, Tim Ramsey, Vadim Iourgenko, Alan Huang, Yan Chen, Robert Schlegel, Mark Labow, Stephen Fawell, William R. Sellers, Leigh Zawel
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11493–11498.
https://doi.org/10.1158/0008-5472.CAN-07-5173
Published: 18 December 2007
View article titled, A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling
Open the PDF for A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling in another window
Includes: Supplementary data