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Journal Articles

Abstract 2137: JAK2 as a novel therapeutic target in anaplastic thyroid cancer

Nicole C. Pinto, Kara Ruicci, Stephenie Prokopec, Karlee Searle, Matthew Lowerison, John Yoo, Kevin Fung, Danielle MacNeil, Hon S. Leong, Alessandro Datti, Paul C. Boutros, John W. Barrett, Anthony C. Nichols

Cancer Res (2017) 77 (13_Supplement): 2137.

https://doi.org/10.1158/1538-7445.AM2017-2137

Published: 01 July 2017

View article titled, Abstract 2137: JAK2 as a novel therapeutic target in anaplastic thyroid cancer

Journal Articles

Abstract 3767: Highly effective inhibitory agent identified by high-throughput screening of genetically characterized anaplastic thyroid cancer cell lines

Nicole C. Pinto, Morgan Black, Kara Ruicci, John Yoo, Danielle MacNeil, Kevin Fung, Alessandro Datti, Stephenie Prokopec, Paul Boutros, John Barrett, Anthony Nichols

Cancer Res (2016) 76 (14_Supplement): 3767.

https://doi.org/10.1158/1538-7445.AM2016-3767

Published: 15 July 2016

View article titled, Abstract 3767: Highly effective inhibitory agent identified by high-throughput screening of genetically characterized anaplastic thyroid cancer cell lines

Journal Articles

Abstract 3019: High throughput drug screening identified spleen tyrosine kinase as a novel therapeutic target in head and neck cancer with potent in vitro and in vivo activity

Morgan Black, Laurie Ailles, Ren Sun, Alessandro Datti, Frederick Vizeacoumar, Nicole Pinto, Kara Ruicci, John Yoo, Kevin Fung, Danielle MacNeil, David A. Palma, Eric Winquist, Joe S. Mymryk, Paul C. Boutros, John W. Barrett, Anthony C. Nichols

Cancer Res (2016) 76 (14_Supplement): 3019.

https://doi.org/10.1158/1538-7445.AM2016-3019

Published: 15 July 2016

View article titled, Abstract 3019: High throughput drug screening identified spleen tyrosine kinase as a novel therapeutic target in head and neck cancer with potent in vitro and in vivo activity

Journal Articles

Abstract 4666: Phosphatidylinositol 3-kinase (PI3K) and mTOR inhibitors demonstrate broad efficacy and synergy in head and neck cancer cell lines and patient-derived xenografts

Anthony C. Nichols, Laurie Ailkes, Ren Sun, Morgan Black, Alessandro Datti, Frederick Vizeacoumar, Nicole Pinto, Kara Ruicci, John Yoo, Kevin Fung, Danielle MacNeil, Joe Mymryk, Paul C. Boutros, John W. Barrett

Cancer Res (2016) 76 (14_Supplement): 4666.

https://doi.org/10.1158/1538-7445.AM2016-4666

Published: 15 July 2016

View article titled, Abstract 4666: Phosphatidylinositol 3-kinase (PI3K) and mTOR inhibitors demonstrate broad efficacy and synergy in head and neck cancer cell lines and patient-derived xenografts

Journal Articles

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Cancer Res (2015) 75 (12): 2478–2488.

https://doi.org/10.1158/0008-5472.CAN-14-2676

Published: 14 June 2015

View article titled, Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Includes: Supplementary data

Journal Articles

Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

Natalie Grinshtein, Alessandro Datti, Mayumi Fujitani, David Uehling, Michael Prakesch, Methvin Isaac, Meredith S. Irwin, Jeffrey L. Wrana, Rima Al-awar, David R. Kaplan

Cancer Res (2011) 71 (4): 1385–1395.

https://doi.org/10.1158/0008-5472.CAN-10-2484

Published: 14 February 2011

View article titled, Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

Includes: Supplementary data

Journal Articles

Abstract SSY01-03: An RNAi screen identifies a heme biosynthetic mediator as a novel radiosensitizing target for head and neck cancer

Emma Ito, Shijun Yue, Eduardo H. Moriyama, Angela B. Hui, Inki Kim, Wei Shi, Nehad M. Alajez, Nirmal Bhogal, GuoHua Li, Alessandro Datti, Aaron D. Schimmer, Brian C. Wilson, Peter P. Liu, Daniel Durocher, Benjamin G. Neel, Brian O'Sullivan, Bernard Cummings, Rob Bristow, Fei-Fei Liu

Cancer Res (2010) 70 (8_Supplement): SSY01-03.

https://doi.org/10.1158/1538-7445.AM10-SSY01-03

Published: 15 April 2010

View article titled, Abstract SSY01-03: An RNAi screen identifies a heme biosynthetic mediator as a novel radiosensitizing target for head and neck cancer

Journal Articles

Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Marko Skrtic, Paul Spagnuolo, Xiaoming Wang, Marcela Gronda, Rose Hurren, Craig D. Simpson, Sonali Fonseca, Alessandro Datti, Jean C Y Wang, John E. Dick, Jeffrey L. Wrana, Shana O. Kelley, Aaron D. Schimmer

Cancer Res (2010) 70 (8_Supplement): 4538.

https://doi.org/10.1158/1538-7445.AM10-4538

Published: 15 April 2010

View article titled, Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Journal Articles

Abstract #1556: High-throughput based identification of small molecules that disrupt the oncogenic E2A-PBX1:CBP/p300 interaction

Amelia Purvis, Christopher Denis, Kim Munro, Alessandro Datti, Steven Smith, David LeBrun

Cancer Res (2009) 69 (9_Supplement): 1556.

Published: 01 May 2009

View article titled, Abstract #1556: High-throughput based identification of small molecules that disrupt the oncogenic E2A-PBX1:CBP/p300 interaction

Journal Articles

Abstract #1950: Inhibition of the Na⁺/K⁺ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Craig Simpson, Imtiaz Mawji, Kika Anyiwe, Moyo Williams, Xiaoming Wang, Amudha Venugopal, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey Wrana, Shereen Ezzat, Aaron Schimmer

Cancer Res (2009) 69 (9_Supplement): 1950.

Published: 01 May 2009

View article titled, Abstract #1950: Inhibition of the Na+/K+ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Journal Articles

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Craig D. Simpson, Imtiaz A. Mawji, Kika Anyiwe, Moyo A. Williams, Xiaoming Wang, Amudha L. Venugopal, Marcela Gronda, Rose Hurren, Sonia Cheng, Stefano Serra, Reza Beheshti Zavareh, Alessandro Datti, Jeffrey L. Wrana, Shereen Ezzat, Aaron D. Schimmer

Cancer Res (2009) 69 (7): 2739–2747.

https://doi.org/10.1158/0008-5472.CAN-08-2530

Published: 01 April 2009

View article titled, Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Includes: Supplementary data

Journal Articles

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Cancer Res (2008) 68 (16): 6688–6697.

https://doi.org/10.1158/0008-5472.CAN-07-6833

Published: 12 August 2008

View article titled, Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Journal Articles

Complex N-Glycan and Metabolic Control in Tumor Cells

Richard Mendelsohn, Pam Cheung, Lloyd Berger, Emily Partridge, Ken Lau, Alessandro Datti, Judy Pawling, James W. Dennis

Cancer Res (2007) 67 (20): 9771–9780.

https://doi.org/10.1158/0008-5472.CAN-06-4580

Published: 17 October 2007

View article titled, Complex N-Glycan and Metabolic Control in Tumor Cells

Includes: Supplementary data

Journal Articles

A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

Imtiaz A. Mawji, Craig D. Simpson, Marcela Gronda, Moyo A. Williams, Rose Hurren, Clare J. Henderson, Alessandro Datti, Jeffrey L. Wrana, Aaron D. Schimmer

Cancer Res (2007) 67 (17): 8307–8315.

https://doi.org/10.1158/0008-5472.CAN-07-1687

Published: 05 September 2007

View article titled, A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

Journal Articles

A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

Reza Beheshti Zavareh, Rose Hurren, Alessandro Datti, Marcela Gronda, Pam Cheung, Ken Lau, Amanda Wasylishen, Hui Shi, David Ashline, Vern Reinhold, David Rose, Harry Schachter, James Dennis, Aaron Schimmer

Cancer Res (2007) 67 (9_Supplement): 1413.

Published: 01 May 2007

View article titled, A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

NARROW

Abstract 2137: JAK2 as a novel therapeutic target in anaplastic thyroid cancer

Abstract 3767: Highly effective inhibitory agent identified by high-throughput screening of genetically characterized anaplastic thyroid cancer cell lines

Abstract 3019: High throughput drug screening identified spleen tyrosine kinase as a novel therapeutic target in head and neck cancer with potent in vitro and in vivo activity

Abstract 4666: Phosphatidylinositol 3-kinase (PI3K) and mTOR inhibitors demonstrate broad efficacy and synergy in head and neck cancer cell lines and patient-derived xenografts

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

Abstract SSY01-03: An RNAi screen identifies a heme biosynthetic mediator as a novel radiosensitizing target for head and neck cancer

Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells

Abstract #1556: High-throughput based identification of small molecules that disrupt the oncogenic E2A-PBX1:CBP/p300 interaction

Abstract #1950: Inhibition of the Na⁺/K⁺ ATPase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

Inhibition of the Sodium/Potassium ATPase Impairs N-Glycan Expression and Function

Complex N-Glycan and Metabolic Control in Tumor Cells

A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis

A high-throughput screen identifies cardiac glycosides as inhibitors of N-glycosylation synthesis and function

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