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Journal Articles

Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Roberta Affatato, Elena Di Gennaro, Alessandra Leone, Biagio Pucci, Susan Costantini, Rita Lombardi, Eleonora Perfetto, Maria Serena Roca, Francesca Bruzzese, Francesca Collina, Claudia Cardone, Tania Moccia, Elena Sinopoli, Antonio Avallone, Alfredo Budillon

Cancer Res (2025) 85 (8_Supplement_1): 1700.

https://doi.org/10.1158/1538-7445.AM2025-1700

Published: 21 April 2025

View articletitled, Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Journal Articles

Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Cancer Res (2024) 84 (6_Supplement): 3700.

https://doi.org/10.1158/1538-7445.AM2024-3700

Published: 22 March 2024

View articletitled, Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Journal Articles

Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Maria Serena Roca, federica iannelli, maria rita milone, veronica barile, cristina testa, tania moccia, carlo vitagliano, fabiana tatangelo, di gennaro elena, antonio avallone, francesca bruzzese, alessandra leone, alfredo budillon

Cancer Res (2022) 82 (12_Supplement): 1840.

https://doi.org/10.1158/1538-7445.AM2022-1840

Published: 15 June 2022

View articletitled, Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Journal Articles

Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Maria S. Roca, Tania Moccia, Cristina Testa, Federica Iannelli, Carlo Vitagliano, Elena Di Gennaro, Francesca Bruzzese, Alessandra Leone, Alfredo Budillon

Cancer Res (2021) 81 (13_Supplement): 1158.

https://doi.org/10.1158/1538-7445.AM2021-1158

Published: 01 July 2021

View articletitled, Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Journal Articles

Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Federica Iannelli, Andrea Ilaria Zotti, Maria Serena Roca, Laura Grumetti, Tania Moccia, Carlo Vitagliano, Chiara Ciardiello, Francesca Bruzzese, Alessandra Leone, Francesco Caponigro, Franco Ionna, Francesco Longo, Elena Di Gennaro, Alfredo Budillon

Cancer Res (2020) 80 (16_Supplement): 5223.

https://doi.org/10.1158/1538-7445.AM2020-5223

Published: 15 August 2020

View articletitled, Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Journal Articles

Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Federica Iannelli, Rita Lombardi, Biagio Pucci, Maria Rita Milone, Chiara Ciardiello, Alessandra Leone, Elena Di Gennaro, Alfredo Budillon, Francesca Bruzzese

Cancer Res (2016) 76 (14_Supplement): 4745.

https://doi.org/10.1158/1538-7445.AM2016-4745

Published: 15 July 2016

View articletitled, Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Journal Articles

Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Manuela Terranova Barberio, Biagio Pecori, Serena Imbimbo, Alessandra Leone, Francesca Bruzzese, Maria Carmela Piccirillo, Paolo Delrio, Franco Bianco, Luigi Aloj, Antonio Sorrentino, Fabiana Tatangelo, Antonella Petrillo, Secondo Lastoria, Paolo Muto, Francesco Perrone, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro

Cancer Res (2015) 75 (15_Supplement): 2569.

https://doi.org/10.1158/1538-7445.AM2015-2569

Published: 01 August 2015

View articletitled, Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Journal Articles

Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

Chiara Ciardiello, Alessandra Leone, Francesca Bruzzese, Maria Serena Roca, Alessia Noto, Claudia D. Vitis, Luigi Aurisicchio, Gennaro Ciliberto, Rita Mancini, Alfredo Budillon

Cancer Res (2014) 74 (19_Supplement): 5444.

https://doi.org/10.1158/1538-7445.AM2014-5444

Published: 01 October 2014

View articletitled, Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

Journal Articles

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Francesca Bruzzese, Christina Hägglöf, Alessandra Leone, Elin Sjöberg, Maria Serena Roca, Sara Kiflemariam, Tobias Sjöblom, Peter Hammarsten, Lars Egevad, Anders Bergh, Arne Östman, Alfredo Budillon, Martin Augsten

Cancer Res (2014) 74 (13): 3408–3417.

https://doi.org/10.1158/0008-5472.CAN-13-2259

Published: 30 June 2014

View articletitled, Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Includes: Supplementary data

Journal Articles

Abstract 4695: Predictive role of FDG PET-CT in monitoring locally advanced rectal cancer (LARC) during preoperative radiochemotherapy with an experimental bevacizumab schedule.

Antonio Avallone, Paolo Delrio, Biagio Pecori, Fabiana Tatangelo, Elena Di Gennaro, Antonella Petrillo, Vincenzo Rosario Iaffaioli, Alessandra Leone, Corradina caracò, Alfredo Budillon, Secondo Lastoria, Luigi Aloj

Cancer Res (2013) 73 (8_Supplement): 4695.

https://doi.org/10.1158/1538-7445.AM2013-4695

Published: 15 April 2013

View articletitled, Abstract 4695: Predictive role of FDG PET-CT in monitoring locally advanced rectal cancer (LARC) during preoperative radiochemotherapy with an experimental bevacizumab schedule.

Journal Articles

Abstract LB-219: Neoadjuvant multidisciplinary phase II study (BRANCH) of an early bevacizumab schedule plus chemo-radiation therapy in rectal cancer: efficacy, safety, and biomarkers.

Antonio Avallone, Elena Di Gennaro, Paolo Delrio, Luigi Aloj, Fabiana Tatangelo, Biagio Pecori, Alessandra Leone, Corradina Caracò, Tania Moccia, Vincenzo R. Iaffaioli, Giovanni Romano, Secondo Lastoria, Alfredo Budillon

Cancer Res (2012) 72 (8_Supplement): LB-219.

https://doi.org/10.1158/1538-7445.AM2012-LB-219

Published: 15 April 2012

View articletitled, Abstract LB-219: Neoadjuvant multidisciplinary phase II study (BRANCH) of an early bevacizumab schedule plus chemo-radiation therapy in rectal cancer: efficacy, safety, and biomarkers.

Journal Articles

Abstract 3721: Critical role of Bevacizumab schedule in combination with chemo-radiotherapy in neo-adjuvant treatment of rectal cancer: Circulating endothelial cells and FDG-PET as markers for early prediction

Antonio Avallone, Elena Di Gennaro, Luigi Aloi, Alessandra Leone, Maria I. Chianese, Paolo Delrio, Biagio Pecori, Corradina Caracò, Rosario V. Iaffaioli, Secondo Lastoria, Pasquale Comella, Alfredo Budillon

Cancer Res (2010) 70 (8_Supplement): 3721.

https://doi.org/10.1158/1538-7445.AM10-3721

Published: 15 April 2010

View articletitled, Abstract 3721: Critical role of Bevacizumab schedule in combination with chemo-radiotherapy in neo-adjuvant treatment of rectal cancer: Circulating endothelial cells and FDG-PET as markers for early prediction

Journal Articles

Abstract #LB-285: Circulating endothelial cells and FDG-PET for prediction of response in rectal cancer patients treated with two different schedules of bevacizumab in combination with preoperative chemo-radiotherapy

Antonio Avallone, Elena Di Gennaro, Alessandra Leone, Monia Rocco, Tania Moccia, Immacolata Chianese, Fabiana Tatangelo, Corradina Caracò, Pasquale Comella, Paolo Delrio, Alfredo Budillon

Cancer Res (2009) 69 (9_Supplement): LB-285.

Published: 01 May 2009

View articletitled, Abstract #LB-285: Circulating endothelial cells and FDG-PET for prediction of response in rectal cancer patients treated with two different schedules of bevacizumab in combination with preoperative chemo-radiotherapy

Journal Articles

Anti-tumor effect and modulation of tumor susceptibility to natural cytotoxicity by RITA, a small molecule that induces accumulation of p53 in tumor cells

Elena Di Gennaro, IIiana Aversa, Alessandra Di Cintio, Valerio Mazzei, Alessandra Leone, Galina Selivanova, Ennio Carbone, Alfredo Budillon

Cancer Res (2008) 68 (9_Supplement): 2388.

Published: 01 May 2008

View articletitled, Anti-tumor effect and modulation of tumor susceptibility to natural cytotoxicity by RITA, a small molecule that induces accumulation of p53 in tumor cells

Journal Articles

Synergistic antitumor interaction between histone deacetylase inhibitor vorinostat and topoisomerase I inhibitor topotecan in small cell lung cancer (SCLC) cells

Francesca Bruzzese, Monia Rocco, Alessandra Leone, Geny Piro, Antonio Avallone, Elena Di Gennaro, Alfredo Budillon

Cancer Res (2007) 67 (9_Supplement): 701.

Published: 01 May 2007

View articletitled, Synergistic antitumor interaction between histone deacetylase inhibitor vorinostat and topoisomerase I inhibitor topotecan in small cell lung cancer (SCLC) cells

Journal Articles

Sequence-dependent synergistic antitumor interaction of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA, Vorinostat) in combination with the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (‘Iressa’, ZD1839) in non-small cell lung cancer cells

Alfredo Budillon, Francesca Bruzzese, Elena Di Gennaro, Massimiliano Barbieri, Alessandra Leone, Michele Caraglia

Cancer Res (2006) 66 (8_Supplement): 574.

Published: 15 April 2006

View articletitled, Sequence-dependent synergistic antitumor interaction of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA, Vorinostat) in combination with the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (‘Iressa’, ZD1839) in non-small cell lung cancer cells

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Abstract 1700: Valproic acid potentiates the efficacy of anti-EGFR monoclonal antibodies in sensitive and resistant RAS/BRAF wild type colorectal cancer models

Abstract 3700: Genomic alterations on first-line panitumumab plus FOLFIRI in metastatic colorectal cancer

Abstract 1840: Repurposing of valproic acid and simvastatin in pancreatic cancer: in vitro and in vivo synergistic antitumor interaction and sensitization to gemcitabine/nab-paclitaxel via inhibition of TGFβ-EMT signaling pathway

Abstract 1158: The HDAC inhibitor domatinostat (4SC-202) sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation

Abstract 5223: Valproic acid, by preventing cisplatin/cetuximab-induced EGFR nuclear translocation and increasing cisplatin uptake, potentiates the antitumor effect of the combination treatment in head and neck squamous cell carcinomas

Abstract 4745: Repurposing of valproic acid and simvastatin combination as anticancer agents in prostate cancer: synergistic interaction with docetaxel and suppression of docetaxel resistance

Abstract 2569: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer as a rationale for the innovative V-shoRT-R3 trial in locally advanced rectal cancer patients

Abstract 5444: Modulation of ErbB receptors expression by histone deacetylase inhibitors increased the antitumor activity of an anti-ErbB3 monoclonal antibody in primary cultures from non-small cell lung cancer patients

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Abstract 4695: Predictive role of FDG PET-CT in monitoring locally advanced rectal cancer (LARC) during preoperative radiochemotherapy with an experimental bevacizumab schedule.

Abstract LB-219: Neoadjuvant multidisciplinary phase II study (BRANCH) of an early bevacizumab schedule plus chemo-radiation therapy in rectal cancer: efficacy, safety, and biomarkers.

Abstract 3721: Critical role of Bevacizumab schedule in combination with chemo-radiotherapy in neo-adjuvant treatment of rectal cancer: Circulating endothelial cells and FDG-PET as markers for early prediction

Abstract #LB-285: Circulating endothelial cells and FDG-PET for prediction of response in rectal cancer patients treated with two different schedules of bevacizumab in combination with preoperative chemo-radiotherapy

Anti-tumor effect and modulation of tumor susceptibility to natural cytotoxicity by RITA, a small molecule that induces accumulation of p53 in tumor cells

Synergistic antitumor interaction between histone deacetylase inhibitor vorinostat and topoisomerase I inhibitor topotecan in small cell lung cancer (SCLC) cells

Sequence-dependent synergistic antitumor interaction of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA, Vorinostat) in combination with the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (‘Iressa’, ZD1839) in non-small cell lung cancer cells

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