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Alejandra Bruna
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Journal Articles

Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer

Abigail Shea, Yaniv Eyal-Lubling, Daniel Guerrero-Romero, Raquel Manzano Garcia, Wendy Greenwood, Martin O’Reilly, Dimitra Georgopoulou, Maurizio Callari, Giulia Lerda, Sophia Wix, Agnese Giovannetti, Riccardo Masina, Elham Esmaeilishirazifard, Wei Cope, Alistair G. Martin, Ai Nagano, Lisa Young, Steven Kupczak, Yi Cheng, Helen Bardwell, Elena Provenzano, Justine Kane, Jonny Lay, Louise Grybowicz, Karen McAdam, Carlos Caldas, Jean Abraham, Oscar M. Rueda, Alejandra Bruna
Journal: Cancer Research
Cancer Res (2025) 85 (3): 567–584.
https://doi.org/10.1158/0008-5472.CAN-24-1703
Published: 01 February 2025
View article titled, Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer
Open the PDF for Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2817: Metabolic heterogeneity in breast cancer integrative clusters to screen metabolic vulnerabilities for diagnosis and treatment response

Susana Ros, Alan J. Wright, Flaviu Bulat, Wendy Greenwood, De-en Hu, Maurizio Callari, Ming Li Chia, Violeta Serra, Oscar Rueda, Alejandra Bruna, Carlos Caldas, Kevin M. Brindle
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2817.
https://doi.org/10.1158/1538-7445.AM2021-2817
Published: 01 July 2021
View article titled, Abstract 2817: Metabolic heterogeneity in breast cancer integrative clusters to screen metabolic vulnerabilities for diagnosis and treatment response
Journal Articles

Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts

Emilie Vinolo, Joaquin Arribas, Andrea Bertotti, Alejandra Bruna, Annette T. Byrne, Robert B. Clarke, Nathalie Conte, Steven de Jong, Didier Decaudin, Zdenka Dudova, Jos Jonkers, Daniela Krasser, Ales Krenek, Luisa Lanfrancone, Eleonora Leucci, Elisabetta Marangoni, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Jens Henrik Norum, Hector G. Palmer, Alejandro Piris Gimenez, Leo Price, Sergio Roman-Roman, Francesca Sarno, Violeta Serra, Laura Soucek, Livio Trusolino, Marieke van de Ven, Luca Vezzadini, Alberto Villanueva, Andrea Wutte, Enzo Medico, on behalf of the EurOPDX Research Infrastructure
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2020-1685
Published: 15 August 2020
View article titled, Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
Journal Articles

Abstract 4077: Quantitative proteomics reveals novel immunomodulatory pathways of resistance to PARP therapy

Jakob Vowinckel, Yuehan Feng, Dimitra Georgopoulou, Alejandra Bruna, Tobias Treiber, Abigail Shea, Giulia Lerda, Martin O'Reilly, Kristina Beeler, Carlos Caldas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4077.
https://doi.org/10.1158/1538-7445.AM2020-4077
Published: 15 August 2020
View article titled, Abstract 4077: Quantitative proteomics reveals novel immunomodulatory pathways of resistance to PARP therapy
Journal Articles

Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

Jorge Gómez-Miragaya, Ander Díaz-Navarro, Raul Tonda, Sergi Beltran, Luis Palomero, Marta Palafox, Lacey E. Dobrolecki, Chen Huang, Suhas Vasaikar, Bing Zhang, Gerburg M. Wulf, Alejandro Collado-Sole, Eva M. Trinidad, Purificación Muñoz, Laia Paré, Aleix Prat, Alejandra Bruna, Carlos Caldas, Joaquín Arribas, María Teresa Soler-Monso, Anna Petit, Judith Balmaña, Cristina Cruz, Violeta Serra, Miguel Angel Pujana, Michael T. Lewis, Xose S. Puente, Eva González-Suárez
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4258–4270.
https://doi.org/10.1158/0008-5472.CAN-18-3835
Published: 15 August 2019
View article titled, Chromosome 12p Amplification in Triple-Negative/<em>BRCA1-</em>Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Open the PDF for Chromosome 12p Amplification in Triple-Negative/<em>BRCA1-</em>Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

Mark J. O'Connor, Cristina Cruz, Marta Castroviejo-Bermejo, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Zhongwu Lai, Josep Forment, Krishna Bulusu, Alba Llop-Guevara, Brian Dougherty, Cristina Saura, Rachel Brough, Chris J. Lord, Alejandra Bruna, Carlos Caldas, Stephen Fawell, J Carl Barrett, Susan E. Critchlow, Judith Balmaña, Elaine Cadogan, Violeta Serra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 932.
https://doi.org/10.1158/1538-7445.AM2019-932
Published: 01 July 2019
View article titled, Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response
Journal Articles

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

Violeta Serra, Cristina Cruz, Zhongwu Lai, Marta Castroviejo-Bermejo, Marta Palafox, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Filippos Michopoulos, Rachel Brough, Brian Dougherty, Elaine Cadogan, Susan Critchlow, Alejandra Bruna, J. Carl Barrett, Cristina Saura, Christopher J. Lord, Carlos Caldas, Joaquin Arribas, Judith Balmaña, Mark J. O’Connor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3503.
https://doi.org/10.1158/1538-7445.AM2019-3503
Published: 01 July 2019
View article titled, Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer
Journal Articles

Abstract 3596: Biomarkers of response to CDK4/6 inhibitor (CDK4/6i) in hormone receptor (HR) positive and HER2-positive breast cancer (BC) patient-derived xenografts (PDX)

Marta Palafox, María Teresa Herrera-Abreu, Meritxell Bellet, Mafalda Oliveira, Alejandra Bruna, Olga Rodriguez, Marta Guzmán, Judit Grueso, Cristina Vilaplana, Joaquín Arribas, Emmanuelle di Tomaso, Faye Su, Carlos Caldas, Nicholas C. Turner, Rodrigo Dienstmann, José Baselga, Maurizio Scaltriti, Javier Cortés, Cristina Saura, Violeta Serra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3596.
https://doi.org/10.1158/1538-7445.AM2018-3596
Published: 01 July 2018
View article titled, Abstract 3596: Biomarkers of response to CDK4/6 inhibitor (CDK4/6i) in hormone receptor (HR) positive and HER2-positive breast cancer (BC) patient-derived xenografts (PDX)
Journal Articles

Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Enzo Medico, Mohamed Bentires-Alj, Andrew V. Biankin, Alejandra Bruna, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Georges Coukos, Olivier Elemento, Manuel Hidalgo, Giorgio Inghirami, Steven de Jong, Jos Jonkers, Ales Krenek, Eleonora Leucci, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Simone P. Niclou, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Leo Price, Sergio Roman-Roman, Livio Trusolino, Luca Vezzadini, Alberto Villanueva, Emilie Vinolo, on behalf of the EurOPDX Consortium
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 985.
https://doi.org/10.1158/1538-7445.AM2018-985
Published: 01 July 2018
View article titled, Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models
Journal Articles

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis

Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino, Letizia Lanzetti
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (13): 3432–3444.
https://doi.org/10.1158/0008-5472.CAN-17-3018
Published: 01 July 2018
View article titled, High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Open the PDF for High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis in another window
Includes: Supplementary data
Journal Articles

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry, James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa A. Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K.C. Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte, Carol J. Bult
Journal: Cancer Research
Cancer Res (2017) 77 (21): e62–e66.
https://doi.org/10.1158/0008-5472.CAN-17-0582
Published: 01 November 2017
View article titled, PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2853: Imaging tumor metabolism to guide treatment of breast cancer with drugs targeted at PI3K alpha

Susana Ros, Paula D'Santos, De-en Hu, Ankita S. Batra, Alan J. Wright, Elizabeth Mannion, Alejandra Bruna, Carlos Caldas, Kevin M. Brindle
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2853.
https://doi.org/10.1158/1538-7445.AM2017-2853
Published: 01 July 2017
View article titled, Abstract 2853: Imaging tumor metabolism to guide treatment of breast cancer with drugs targeted at PI3K alpha
Journal Articles

Abstract 2991: Integrative analysis of molecular and drug response data from clinical samples and PDTXs to identify pharmacogenomic associations in breast cancer

Maurizio Callari, Rajbir N. Batra, Ankita Sati Batra, Wendy Greenwood, Suet-Feung Chin, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2991.
https://doi.org/10.1158/1538-7445.AM2017-2991
Published: 01 July 2017
View article titled, Abstract 2991: Integrative analysis of molecular and drug response data from clinical samples and PDTXs to identify pharmacogenomic associations in breast cancer
Journal Articles

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts

John W. Cassidy, Carlos Caldas, Alejandra Bruna
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (15): 2963–2968.
https://doi.org/10.1158/0008-5472.CAN-15-0727
Published: 02 August 2015
View article titled, Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts
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