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Alan N. Houghton
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Journal Articles

Abstract 4167: Combination of cyclophosphamide with immune checkpoint blockade inhibition elicits potent tumor control in a preclinical melanoma model

Mariam M. George, Allison Betof Warner, Linda Hamadene, Daniel Hirschhorn, Alan N. Houghton, Jedd D. Wolchok, Taha Merghoub
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4167.
https://doi.org/10.1158/1538-7445.AM2022-4167
Published: 15 June 2022
View article titled, Abstract 4167: Combination of cyclophosphamide with immune checkpoint blockade inhibition elicits potent tumor control in a preclinical melanoma model
Journal Articles

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

Alexander M. Lesokhin, Tobias M. Hohl, Shigehisa Kitano, Czrina Cortez, Daniel Hirschhorn-Cymerman, Francesca Avogadri, Gabrielle A. Rizzuto, John J. Lazarus, Eric G. Pamer, Alan N. Houghton, Taha Merghoub, Jedd D. Wolchok
Journal: Cancer Research
Cancer Res (2012) 72 (4): 876–886.
https://doi.org/10.1158/0008-5472.CAN-11-1792
Published: 14 February 2012
View article titled, Monocytic CCR2<sup>+</sup> Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 4742: Anti-tyrosinase related protein 1 (TRP1) antibody combined with cyclophosphamide induces adaptive immunity against melanoma

Yvonne M. Saenger, Michael Pan, Daigo Hashimoto, Bradley Glodny, Shaily Shah, Alan N. Houghton, Taha Merghoub, Jedd D. Wolchok, Miriam Merad
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4742.
https://doi.org/10.1158/1538-7445.AM2011-4742
Published: 15 April 2011
View article titled, Abstract 4742: Anti-tyrosinase related protein 1 (TRP1) antibody combined with cyclophosphamide induces adaptive immunity against melanoma
Journal Articles

Immune Rejection of Mouse Tumors Expressing Mutated Self

Fei Duan, Yun Lin, Cailian Liu, Manuel E. Engelhorn, Adam D. Cohen, Michael Curran, Shimon Sakaguchi, Taha Merghoub, Stephanie Terzulli, Jedd D. Wolchok, Alan N. Houghton
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3545–3553.
https://doi.org/10.1158/0008-5472.CAN-08-2779
Published: 15 April 2009
View article titled, Immune Rejection of Mouse Tumors Expressing Mutated Self
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Includes: Supplementary data
Journal Articles

Improved Tumor Immunity Using Anti-Tyrosinase Related Protein-1 Monoclonal Antibody Combined with DNA Vaccines in Murine Melanoma

Yvonne M. Saenger, Yanyun Li, Karoline C. Chiou, Brian Chan, Gabrielle Rizzuto, Stephanie L. Terzulli, Taha Merghoub, Alan N. Houghton, Jedd D. Wolchok
Journal: Cancer Research
Cancer Res (2008) 68 (23): 9884–9891.
https://doi.org/10.1158/0008-5472.CAN-08-2233
Published: 01 December 2008
View article titled, Improved Tumor Immunity Using Anti-Tyrosinase Related Protein-1 Monoclonal Antibody Combined with DNA Vaccines in Murine Melanoma
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Journal Articles

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

Adam D. Cohen, Adi Diab, Miguel-Angel Perales, Jedd D. Wolchok, Gabrielle Rizzuto, Taha Merghoub, Deonka Huggins, Cailian Liu, Mary Jo Turk, Nicholas P. Restifo, Shimon Sakaguchi, Alan N. Houghton
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4904–4912.
https://doi.org/10.1158/0008-5472.CAN-05-2813
Published: 01 May 2006
View article titled, Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8<sup>+</sup> T-Cell Responses and Tumor Immunity
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Journal Articles

Immune rejection of mouse melanoma expressing mutated self

Fei Duan, Gabrielle Noffz, Susanne Preiss, Manuel Engelhorn, Alan N. Houghton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1213.
Published: 01 May 2005
View article titled, Immune rejection of mouse melanoma expressing mutated self
Journal Articles

An agonist anti-GITR antibody enhances effector and memory CD8 T cell responses and tumor immunity following xenogeneic DNA immunization against melanoma

Adam D. Cohen, Adi Diab, Miguel Angel-Perales, Jedd D. Wolchok, Deonka Huggins, Calian Liu, Mary Jo Turk, Shimon Sakaguchi, Alan N. Houghton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 624.
Published: 01 May 2005
View article titled, An agonist anti-GITR antibody enhances effector and memory CD8 T cell responses and tumor immunity following xenogeneic DNA immunization against melanoma
Journal Articles

The paradoxical effect of glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) stimulation on alloreactive CD4 and CD8 T cells and the development of GVHD

Teresa Ramirez-Montagut, Stephanie J. Muriglan, Onder Alpdogan, Jeffrey M. Eng, Vanessa M. Hubbard, Adam A. Kochman, Alan N. Houghton, Marcel R. M. Van Den Brink
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1080.
Published: 01 April 2004
View article titled, The paradoxical effect of glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) stimulation on alloreactive CD4 and CD8 T cells and the development of GVHD
Journal Articles

Analysis of BRAF and N-RAS Mutations in Metastatic Melanoma Tissues

Alexis Gorden, Iman Osman, Weiming Gai, Dan He, Weiqing Huang, Anne Davidson, Alan N. Houghton, Klaus Busam, David Polsky
Journal: Cancer Research
Cancer Res (2003) 63 (14): 3955–3957.
Published: 21 July 2003
View article titled, Analysis of <em>BRAF</em> and <em>N-RAS</em> Mutations in Metastatic Melanoma Tissues
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Journal Articles

Increased Facilitated Transport of Dehydroascorbic Acid without Changes in Sodium-dependent Ascorbate Transport in Human Melanoma Cells

Charles Spielholz, David W. Golde, Alan N. Houghton, Francisco Nualart, Juan Carlos Vera
Journal: Cancer Research
Cancer Res (1997) 57 (12): 2529–2537.
Published: 01 June 1997
View article titled, Increased Facilitated Transport of Dehydroascorbic Acid without Changes in Sodium-dependent Ascorbate Transport in Human Melanoma Cells
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Journal Articles

Phase I Evaluation of a Combination of Monoclonal Antibody R24 and Interleukin 2 in Patients with Metastatic Melanoma

Dean F. Bajorin, Paul B. Chapman, George Wong, Daniel G. Coit, Jolanta Kunicka, Joseph Dimaggio, Carlos Cordon-Cardo, Carlos Urmacher, Lucy Dantes, Mary Agnes Templeton, John Liu, Herbert F. Oettgen, Alan N. Houghton
Journal: Cancer Research
Cancer Res (1990) 50 (23): 7490–7495.
Published: 01 December 1990
View article titled, Phase I Evaluation of a Combination of Monoclonal Antibody R24 and Interleukin 2 in Patients with Metastatic Melanoma
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Journal Articles

Light Chain Variants of an IgG3 Anti-GD3 Monoclonal Antibody and the Relationship among Avidity, Effector Functions, Tumor Targeting, and Antitumor Activity

Paul B. Chapman, Mathew Lonberg, Alan N. Houghton
Journal: Cancer Research
Cancer Res (1990) 50 (5): 1503–1509.
Published: 01 March 1990
View article titled, Light Chain Variants of an IgG3 Anti-G<sub>D3</sub> Monoclonal Antibody and the Relationship among Avidity, Effector Functions, Tumor Targeting, and Antitumor Activity
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Journal Articles

Heritable High Frequency Modulation of Antigen Expression in Neoplastic Cells Exposed to 5-Aza-2′-deoxycytidine or Hydroxyurea: Analysis and Implications

Edi Alvarez, Bruce E. Elliott, Alan N. Houghton, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (1988) 48 (9): 2440–2445.
Published: 01 May 1988
View article titled, Heritable High Frequency Modulation of Antigen Expression in Neoplastic Cells Exposed to 5-Aza-2′-deoxycytidine or Hydroxyurea: Analysis and Implications
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Journal Articles

Surface Antigens of Human Melanoma Cells Cultured in Serum-free Medium: Induction of Expression of Major Histocompatibility Complex Class II Antigens

Francisco X. Real, Bettina Fliegel, Alan N. Houghton
Journal: Cancer Research
Cancer Res (1988) 48 (3): 686–693.
Published: 01 February 1988
View article titled, Surface Antigens of Human Melanoma Cells Cultured in Serum-free Medium: Induction of Expression of Major Histocompatibility Complex Class II Antigens
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Journal Articles

Loss of Heterozygosity at Autosomal and X-linked Loci during Tumor Progression in a Patient with Melanoma

Nicholas C. Dracopoli, Becky Alhadeff, Alan N. Houghton, Lloyd J. Old
Journal: Cancer Research
Cancer Res (1987) 47 (15): 3995–4000.
Published: 01 August 1987
View article titled, Loss of Heterozygosity at Autosomal and X-linked Loci during Tumor Progression in a Patient with Melanoma
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Journal Articles

Surface Antigens of Melanomas and Melanocytes Defined by Mouse Monoclonal Antibodies: Specificity Analysis and Comparison of Antigen Expression in Cultured Cells and Tissues

Francisco X. Real, Alan N. Houghton, Anthony P. Albino, Carlos Cordon-Cardo, Myron R. Melamed, Herbert F. Oettgen, Lloyd J. Old
Journal: Cancer Research
Cancer Res (1985) 45 (9): 4401–4411.
Published: 01 September 1985
View article titled, Surface Antigens of Melanomas and Melanocytes Defined by Mouse Monoclonal Antibodies: Specificity Analysis and Comparison of Antigen Expression in Cultured Cells and Tissues
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