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Journal Articles

FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA

Ann-Marie Baker, Gayathri Nageswaran, Pablo Nenclares, Tahel Ronel, Kane Smith, Christopher Kimberley, Miangela M. Laclé, Shreerang Bhide, Kevin J. Harrington, Alan Melcher, Manuel Rodriguez-Justo, Benny Chain, Trevor A. Graham
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1560–1569.
https://doi.org/10.1158/0008-5472.CAN-23-3340
Published: 15 May 2024
View article titled, FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA
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Includes: Supplementary data
Journal Articles

Abstract CT569: Combination of reovirus (pelareorep) and granulocyte-macrophage colony-stimulating factor (GM-CSF) alongside standard chemoradiotherapy and adjuvant chemotherapy (temozolomide) for patients with glioblastoma multiforme (GBM): Long term follow up results of the ReoGlio phase Ib trial

Susan C. Short, Jessica Kendall, Anthony Chalmers, Catherine McBain, Alan Melcher, Adel Samson, Rachel Phillip, Sarah Brown
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT569.
https://doi.org/10.1158/1538-7445.AM2022-CT569
Published: 15 June 2022
View article titled, Abstract CT569: Combination of reovirus (pelareorep) and granulocyte-macrophage colony-stimulating factor (GM-CSF) alongside standard chemoradiotherapy and adjuvant chemotherapy (temozolomide) for patients with glioblastoma multiforme (GBM): Long term follow up results of the ReoGlio phase Ib trial
Journal Articles

Abstract 1960: Mechanisms of therapeutic synergy between pattern recognition response agonists and cdk4 inhibitors

Victoria Roulstone, Joan Kyula, Richard Elliot, Christopher J. Lord, Nik Matthews, Vicki Jennings, Harriet Whittock, David Mansfield, Jyoti Choudhary, James Wright, Lu Yu, Alan Melcher, Richard Vile, Matt Coffey, Martin McLaughlin, Kevin Harrington
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1960.
https://doi.org/10.1158/1538-7445.AM2021-1960
Published: 01 July 2021
View article titled, Abstract 1960: Mechanisms of therapeutic synergy between pattern recognition response agonists and cdk4 inhibitors
Journal Articles

Abstract 1932: Talazoparib interacts with oncolytic reovirus to enhance death-inducing signaling complex (DISC)-mediated apoptosis and immune response

Joan N. Kyula, Victoria Roulstone, Richard Elliott, Harriet Whittock, Galabina Bozhanova, Martin McLaughlin, Malin Pedersen, Dragomir Krastev, Stephen Pettitt, Arnaud Legrand, Tencho Tenev, James Wright, Lu Yu, Jyoti Choudhary, Pascal Meier, Christopher J. Lord, Alan Melcher, Grey Wilkinson, Matt Coffey, Kevin J. Harrington
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1932.
https://doi.org/10.1158/1538-7445.AM2021-1932
Published: 01 July 2021
View article titled, Abstract 1932: Talazoparib interacts with oncolytic reovirus to enhance death-inducing signaling complex (DISC)-mediated apoptosis and immune response
Journal Articles

Abstract 3987: Direct cancer cell/cancer-associated fibroblast interaction elicits resistance to oncolytic virus therapy in squamous cell carcinoma

Antonio Rullan, Emma Milford, Esther Arwert, Alan Melcher, Kevin Harrington, Erik Sahai
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3987.
https://doi.org/10.1158/1538-7445.AM2020-3987
Published: 15 August 2020
View article titled, Abstract 3987: Direct cancer cell/cancer-associated fibroblast interaction elicits resistance to oncolytic virus therapy in squamous cell carcinoma
Journal Articles

Abstract 3415: Mutant BRAF small molecule inhibition enhances oncolytic herpes virus immunotherapy through increased immune cell recruitment and activation in melanoma

Galabina Bozhanova, Victoria Jennings, Malin Pedersen, Joan Kyula, Emmanuel Patin, Jehanne Hassan, Masahiro Ono, Kevin Harrington, Alan Melcher
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3415.
https://doi.org/10.1158/1538-7445.AM2020-3415
Published: 15 August 2020
View article titled, Abstract 3415: Mutant BRAF small molecule inhibition enhances oncolytic herpes virus immunotherapy through increased immune cell recruitment and activation in melanoma
Journal Articles

Abstract CT115: Phase 1b KEYNOTE 200 (STORM study): A study of an intravenously delivered oncolytic virus, Coxsackievirus A21 in combination with pembrolizumab in advanced cancer patients

Hardev Pandha, Kevin Harrington, Cristy Ralph, Alan Melcher, Sumati Gupta, Wallace Akerley, Rachael E. Sandborn, Charles Rudin, Jonathan Rosenberg, David Kaufman, Emmett Schmidt, Mark Grose, Darren R. Shafren
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT115.
https://doi.org/10.1158/1538-7445.AM2017-CT115
Published: 01 July 2017
View article titled, Abstract CT115: Phase 1b <em>KEYNOTE 200 (STORM study):</em> A study of an intravenously delivered oncolytic virus, Coxsackievirus A21 in combination with pembrolizumab in advanced cancer patients
Journal Articles

Abstract CT205: Intravenous delivery of a novel oncolytic immunotherapy agent, CAVATAK, in advanced cancer patients

Hardev Pandha, Kevin Harrington, Cristy Ralph, Alan Melcher, Darren R. Shafren
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT205.
https://doi.org/10.1158/1538-7445.AM2015-CT205
Published: 01 August 2015
View article titled, Abstract CT205: Intravenous delivery of a novel oncolytic immunotherapy agent, CAVATAK, in advanced cancer patients
Journal Articles

Abstract 1360: Combination therapy of reovirus and PD-1 blockade effectively establishes tumor control via innate and adaptive immune responses

Karishma Rajani, Christopher Parrish, Kevin Shim, Liz Ilett, Fiona Errington-Mais, Jill Thompson, Tim Kottke, Rosa Maria-Diaz, Peter Selby, Hardev Pandha, Kevin Harrington, Alan Melcher, Matt Coffey, Shane Zaidi, Richard Vile
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1360.
https://doi.org/10.1158/1538-7445.AM2015-1360
Published: 01 August 2015
View article titled, Abstract 1360: Combination therapy of reovirus and PD-1 blockade effectively establishes tumor control via innate and adaptive immune responses
Journal Articles

Type III IFN Interleukin-28 Mediates the Antitumor Efficacy of Oncolytic Virus VSV in Immune-Competent Mouse Models of Cancer

Phonphimon Wongthida, Rosa Maria Diaz, Feorillo Galivo, Timothy Kottke, Jill Thompson, Jose Pulido, Kevin Pavelko, Larry Pease, Alan Melcher, Richard Vile
Journal: Cancer Research
Cancer Res (2010) 70 (11): 4539–4549.
https://doi.org/10.1158/0008-5472.CAN-09-4658
Published: 01 June 2010
View article titled, Type III IFN Interleukin-28 Mediates the Antitumor Efficacy of Oncolytic Virus VSV in Immune-Competent Mouse Models of Cancer
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Journal Articles

Antitumor Immunity Can Be Uncoupled from Autoimmunity following Heat Shock Protein 70–Mediated Inflammatory Killing of Normal Pancreas

Timothy Kottke, Jose Pulido, Jill Thompson, Luis Sanchez-Perez, Heung Chong, Stuart K. Calderwood, Peter Selby, Kevin Harrington, Scott E. Strome, Alan Melcher, Richard G. Vile
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7767–7774.
https://doi.org/10.1158/0008-5472.CAN-09-1597
Published: 01 October 2009
View article titled, Antitumor Immunity Can Be Uncoupled from Autoimmunity following Heat Shock Protein 70–Mediated Inflammatory Killing of Normal Pancreas
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Journal Articles

Induction of hsp70-Mediated Th17 Autoimmunity Can Be Exploited as Immunotherapy for Metastatic Prostate Cancer

Timothy Kottke, Luis Sanchez-Perez, Rosa Maria Diaz, Jill Thompson, Heung Chong, Kevin Harrington, Stuart K. Calderwood, Jose Pulido, Nick Georgopoulos, Peter Selby, Alan Melcher, Richard Vile
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11970–11979.
https://doi.org/10.1158/0008-5472.CAN-07-2259
Published: 18 December 2007
View article titled, Induction of hsp70-Mediated Th17 Autoimmunity Can Be Exploited as Immunotherapy for Metastatic Prostate Cancer
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Journal Articles

Potent Selection of Antigen Loss Variants of B16 Melanoma following Inflammatory Killing of Melanocytes In vivo

Luis Sanchez-Perez, Timothy Kottke, Rosa Maria Diaz, Atique Ahmed, Jill Thompson, Heung Chong, Alan Melcher, Sheri Holmen, Gregory Daniels, Richard G. Vile
Journal: Cancer Research
Cancer Res (2005) 65 (5): 2009–2017.
https://doi.org/10.1158/0008-5472.CAN-04-3216
Published: 07 March 2005
View article titled, Potent Selection of Antigen Loss Variants of B16 Melanoma following Inflammatory Killing of Melanocytes <em>In vivo</em>
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Journal Articles

Enhancing the Efficacy of a Weak Allogeneic Melanoma Vaccine by Viral Fusogenic Membrane Glycoprotein-mediated Tumor Cell-Tumor Cell Fusion

Emmanouela Linardakis, Andrew Bateman, Vy Phan, Atique Ahmed, Michael Gough, Kenneth Olivier, Rick Kennedy, Fiona Errington, Kevin J. Harrington, Alan Melcher, Richard Vile
Journal: Cancer Research
Cancer Res (2002) 62 (19): 5495–5504.
Published: 01 October 2002
View article titled, Enhancing the Efficacy of a Weak Allogeneic Melanoma Vaccine by Viral Fusogenic Membrane Glycoprotein-mediated Tumor Cell-Tumor Cell Fusion
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Journal Articles

Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity

Alan Melcher, Stephen Todryk, Andrew Bateman, Heung Chong, Nicholas R Lemoine, Richard G Vile
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2802–2805.
Published: 15 June 1999
View article titled, Adoptive Transfer of Immature Dendritic Cells with Autologous or Allogeneic Tumor Cells Generates Systemic Antitumor Immunity
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