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Journal Articles

Abstract 4490: Triapine sensitizes chemoresistant ovarian cancer cells to platinum therapy.

Elena S. Ratner, Margaret Whicker, Z. Ping Lin, Alan C. Sartorelli

Cancer Res (2013) 73 (8_Supplement): 4490.

https://doi.org/10.1158/1538-7445.AM2013-4490

Published: 15 April 2013

View article titled, Abstract 4490: Triapine sensitizes chemoresistant ovarian cancer cells to platinum therapy.

Journal Articles

Abstract 2743: Triapine sensitizes ovarian cancer cells to platinum drugs and PARP inhibitors

Z. Ping Lin, Elena S. Ratner, Alan C. Sartorelli

Cancer Res (2012) 72 (8_Supplement): 2743.

https://doi.org/10.1158/1538-7445.AM2012-2743

Published: 15 April 2012

View article titled, Abstract 2743: Triapine sensitizes ovarian cancer cells to platinum drugs and PARP inhibitors

Journal Articles

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Cancer Res (2011) 71 (8_Supplement): 954.

https://doi.org/10.1158/1538-7445.AM2011-954

Published: 15 April 2011

View article titled, Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Journal Articles

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Catherine A. Burkhart, Fujiko Watt, Jayne Murray, Marina Pajic, Anatoly Prokvolit, Chengyuan Xue, Claudia Flemming, Janice Smith, Andrei Purmal, Nadezhda Isachenko, Pavel G. Komarov, Katerina V. Gurova, Alan C. Sartorelli, Glenn M. Marshall, Murray D. Norris, Andrei V. Gudkov, Michelle Haber

Cancer Res (2009) 69 (16): 6573–6580.

https://doi.org/10.1158/0008-5472.CAN-09-1075

Published: 12 August 2009

View article titled, Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Includes: Supplementary data

Journal Articles

Differential inhibition of cellular glutathione reductase activity from isocyanates generated by the antitumor prodrugs Cloretazine and BCNU

Kevin P. Rice, Philip G. Penketh, Krishnamurthy Shyam, Alan C. Sartorelli

Cancer Res (2005) 65 (9_Supplement): 322.

Published: 01 May 2005

View article titled, Differential inhibition of cellular glutathione reductase activity from isocyanates generated by the antitumor prodrugs Cloretazine and BCNU

Journal Articles

Suppression of the R2 subunit of ribonucleotide reductase by R2-siRNA sensitizes p53(-/-) HCT-116 human colon cancer cells to DNA damaging agents.

Z. Ping Lin, Michael F. Belcourt, Joseph G. Cory, Alan C. Sartorelli

Cancer Res (2004) 64 (7_Supplement): 702.

Published: 01 April 2004

View article titled, Suppression of the R2 subunit of ribonucleotide reductase by R2-siRNA sensitizes p53(-/-) HCT-116 human colon cancer cells to DNA damaging agents.

Journal Articles

Role of the Scl protein in myeloid leukemia cell differentiation

Anna M. Rice, Viet-Anh Nguyen, David J. Austin, Alan C. Sartorelli

Cancer Res (2004) 64 (7_Supplement): 123.

Published: 01 April 2004

View article titled, Role of the Scl protein in myeloid leukemia cell differentiation

Journal Articles

Analysis of the contribution of MRP3 to in vivo chemosensitivity using knock out mice.

Martin G. Belinsky, Irina L. Shchaveleva, Zhe-Sheng Chen, Alan C. Sartorelli, Gary D. Kruh

Cancer Res (2004) 64 (7_Supplement): 568.

Published: 01 April 2004

View article titled, Analysis of the contribution of MRP3 to in vivo chemosensitivity using knock out mice.

Journal Articles

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): A novel agent with preferential cytotoxicity to hypoxic cells

Helen A. Seow, Krishnamurthy Shyam, Philip G. Penketh, Sara Rockwell, Alan C. Sartorelli

Cancer Res (2004) 64 (7_Supplement): 260.

Published: 01 April 2004

View article titled, 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): A novel agent with preferential cytotoxicity to hypoxic cells

Journal Articles

Reversal of Mitomycin C Resistance by Overexpression of Bioreductive Enzymes in Chinese Hamster Ovary Cells

Raymond P. Baumann, William F. Hodnick, Helen A. Seow, Michael F. Belcourt, Sara Rockwell, David H. Sherman, Alan C. Sartorelli

Cancer Res (2001) 61 (21): 7770–7776.

Published: 01 November 2001

View article titled, Reversal of Mitomycin C Resistance by Overexpression of Bioreductive Enzymes in Chinese Hamster Ovary Cells

Journal Articles

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): A Novel Sulfonylhydrazine Prodrug with Broad-Spectrum Antineoplastic Activity

Rick A. Finch, Krishnamurthy Shyam, Philip G. Penketh, Alan C. Sartorelli

Cancer Res (2001) 61 (7): 3033–3038.

Published: 01 April 2001

View article titled, 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): A Novel Sulfonylhydrazine Prodrug with Broad-Spectrum Antineoplastic Activity

Journal Articles

The Pharmacological Phenotype of Combined Multidrug-Resistance mdr1a/1b- and mrp1-deficient Mice

Dennis R. Johnson, Rick A. Finch, Z. Ping Lin, Caroline J. Zeiss, Alan C. Sartorelli

Cancer Res (2001) 61 (4): 1469–1476.

Published: 02 February 2001

View article titled, The Pharmacological Phenotype of Combined Multidrug-Resistance mdr1a/1b- and mrp1-deficient Mice

Journal Articles

Evidence That the Multidrug Resistance Protein (MRP) Functions as a Co-Transporter of Glutathione and Natural Product Toxins

Germana Rappa, Aurelio Lorico, Richard A. Flavell, Alan C. Sartorelli

Cancer Res (1997) 57 (23): 5232–5237.

Published: 01 December 1997

View article titled, Evidence That the Multidrug Resistance Protein (MRP) Functions as a Co-Transporter of Glutathione and Natural Product Toxins

Journal Articles

Disruption of the Murine MRP (Multidrug Resistance Protein) Gene Leads to Increased Sensitivity to Etoposide (VP-16) and Increased Levels of Glutathione

Aurelio Lorico, Germana Rappa, Rick A. Finch, Di Yang, Richard A. Flavell, Alan C. Sartorelli

Cancer Res (1997) 57 (23): 5238–5242.

Published: 01 December 1997

View article titled, Disruption of the Murine MRP (Multidrug Resistance Protein) Gene Leads to Increased Sensitivity to Etoposide (VP-16) and Increased Levels of Glutathione

Journal Articles

Double Knockout of the MRP Gene Leads to Increased Drug Sensitivity in Vitro

Aurelio Lorico, Germana Rappa, Richard A. Flavell, Alan C. Sartorelli

Cancer Res (1996) 56 (23): 5351–5355.

Published: 01 December 1996

View article titled, Double Knockout of the MRP Gene Leads to Increased Drug Sensitivity in Vitro

Journal Articles

Increased Rate of Adenosine Triphosphate-dependent Etoposide (VP-16) Efflux in a Murine Leukemia Cell Line Overexpressing the Multidrug Resistance-associated Protein (MRP) Gene

Aurelio Lorico, Germana Rappa, Srinivasan Srimatkandada, Carlo V. Catapano, Daniel J. Fernandes, Joseph F. Germino, Alan C. Sartorelli

Cancer Res (1995) 55 (19): 4352–4360.

Published: 01 October 1995

View article titled, Increased Rate of Adenosine Triphosphate-dependent Etoposide (VP-16) Efflux in a Murine Leukemia Cell Line Overexpressing the Multidrug Resistance-associated Protein (MRP) Gene

Journal Articles

Reversal of Etoposide Resistance in Non-P-Glycoprotein Expressing Multidrug Resistant Tumor Cell Lines by Novobiocin

Germana Rappa, Aurelio Lorico, Alan C. Sartorelli

Cancer Res (1993) 53 (22): 5487–5493.

Published: 01 November 1993

View article titled, Reversal of Etoposide Resistance in Non-P-Glycoprotein Expressing Multidrug Resistant Tumor Cell Lines by Novobiocin

Journal Articles

Adducts of Mitomycin C and DNA in EMT6 Mouse Mammary Tumor Cells: Effects of Hypoxia and Dicumarol on Adduct Patterns

Roland Bizanek, Dondapati Chowdary, Hitoshi Arai, Masaji Kasai, Christine S. Hughes, Alan C. Sartorelli, Sara Rockwell, Maria Tomasz

Cancer Res (1993) 53 (21): 5127–5134.

Published: 01 November 1993

View article titled, Adducts of Mitomycin C and DNA in EMT6 Mouse Mammary Tumor Cells: Effects of Hypoxia and Dicumarol on Adduct Patterns

Journal Articles

Reductive Activation of Mitomycin C by NADH:Cytochrome b₅ Reductase

William F. Hodnick, Alan C. Sartorelli

Cancer Res (1993) 53 (20): 4907–4912.

Published: 01 October 1993

View article titled, Reductive Activation of Mitomycin C by NADH:Cytochrome b5 Reductase

Journal Articles

Changes in Actin and Actin-binding Proteins during the Differentiation of HL-60 Leukemia Cells

Mun-Fai Leung, Thomas S. Lin, Alan C. Sartorelli

Cancer Res (1992) 52 (11): 3063–3066.

Published: 01 June 1992

View article titled, Changes in Actin and Actin-binding Proteins during the Differentiation of HL-60 Leukemia Cells

NARROW

Abstract 4490: Triapine sensitizes chemoresistant ovarian cancer cells to platinum therapy.

Abstract 2743: Triapine sensitizes ovarian cancer cells to platinum drugs and PARP inhibitors

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Differential inhibition of cellular glutathione reductase activity from isocyanates generated by the antitumor prodrugs Cloretazine and BCNU

Suppression of the R2 subunit of ribonucleotide reductase by R2-siRNA sensitizes p53(-/-) HCT-116 human colon cancer cells to DNA damaging agents.

Role of the Scl protein in myeloid leukemia cell differentiation

Analysis of the contribution of MRP3 to in vivo chemosensitivity using knock out mice.

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): A novel agent with preferential cytotoxicity to hypoxic cells

Reversal of Mitomycin C Resistance by Overexpression of Bioreductive Enzymes in Chinese Hamster Ovary Cells

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): A Novel Sulfonylhydrazine Prodrug with Broad-Spectrum Antineoplastic Activity

The Pharmacological Phenotype of Combined Multidrug-Resistance mdr1a/1b- and mrp1-deficient Mice

Evidence That the Multidrug Resistance Protein (MRP) Functions as a Co-Transporter of Glutathione and Natural Product Toxins

Disruption of the Murine MRP (Multidrug Resistance Protein) Gene Leads to Increased Sensitivity to Etoposide (VP-16) and Increased Levels of Glutathione

Double Knockout of the MRP Gene Leads to Increased Drug Sensitivity in Vitro

Increased Rate of Adenosine Triphosphate-dependent Etoposide (VP-16) Efflux in a Murine Leukemia Cell Line Overexpressing the Multidrug Resistance-associated Protein (MRP) Gene

Reversal of Etoposide Resistance in Non-P-Glycoprotein Expressing Multidrug Resistant Tumor Cell Lines by Novobiocin

Adducts of Mitomycin C and DNA in EMT6 Mouse Mammary Tumor Cells: Effects of Hypoxia and Dicumarol on Adduct Patterns

Reductive Activation of Mitomycin C by NADH:Cytochrome b₅ Reductase

Changes in Actin and Actin-binding Proteins during the Differentiation of HL-60 Leukemia Cells

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