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Journal Articles

Abstract 5581: The DACH1 gene, frequently co-deleted with BRCA2 in prostate cancer, governs PARP inhibitor resistance

Zhiping Li, Xuanmao Jiao, Taimoor Khan, Danni Li, Shan Zha, Lai Yee Phoon, Li Lan, A. Gordon Robertson, Anthony W. Ashton, Kenneth A. Iczkowski, Alexander D. Borowsky, Alan Ashworth, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5581.
https://doi.org/10.1158/1538-7445.AM2024-5581
Published: 22 March 2024
View article titled, Abstract 5581: The DACH1 gene, frequently co-deleted with BRCA2 in prostate cancer, governs PARP inhibitor resistance
Journal Articles

Abstract B031: Investigation of the ubiquitin ligase RNF31 as a mediator of immune evasion in advanced prostate cancer

Tianyi Liu, Haolong Li, Tony Junjie Hua, Hyunjin Shin, Tanushree Shenoy, Martin Sjoestroem, Arian Lundberg, Luke Gilbert, David Quigley, Alan Ashworth, Lewis Lanier, Felix Feng
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B031.
https://doi.org/10.1158/1538-7445.PRCA2023-B031
Published: 02 June 2023
View article titled, Abstract B031: Investigation of the ubiquitin ligase RNF31 as a mediator of immune evasion in advanced prostate cancer
Journal Articles

Abstract B041: AR suppresses MHC Class I expression and T-cell response in prostate cancer

Lisa Chesner, Julie Graff, Fanny Polesso, Alexis Smith, Arian Lundberg, Martin Sjoestroem, Zheng Xia, Simon Linder, Andries Bergman, Alan Ashworth, David Quigley, Wilbert Zwart, Luke Gilbert, Amy Moran, Felix Feng
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B041.
https://doi.org/10.1158/1538-7445.PRCA2023-B041
Published: 02 June 2023
View article titled, Abstract B041: AR suppresses MHC Class I expression and T-cell response in prostate cancer
Journal Articles

Abstract 299: Large tandem duplications in cancer resulting from transcription and DNA replication collisions

Yang Yang, Michelle Badura, Patrick O’Leary, Emily Egusa, Troy Robinson, Xiaoming Zhong, Jason Swinderman, Minkyu Kim, Haolong Li, Alan Ashworth, Felix Feng, Jonathan Chou, Lixing Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 299.
https://doi.org/10.1158/1538-7445.AM2023-299
Published: 04 April 2023
View article titled, Abstract 299: Large tandem duplications in cancer resulting from transcription and DNA replication collisions
Journal Articles

Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer

Jonathan Chou, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M. Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Wang, Eric J. Small, Emily Chan, Bradley A. Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S. Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M. Bailis, Felix Y. Feng, Robert R. Flavell, Rahul Aggarwal
Journal: Cancer Research
Cancer Res (2023) 83 (2): 301–315.
https://doi.org/10.1158/0008-5472.CAN-22-1433
Published: 18 January 2023
View article titled, Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Open the PDF for Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Martin Sjöström, Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T. Hua, Haolong Li, Anna Bergamaschi, Corinne Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W.S. Ng, Wenbin Ye, Jessica Petricca, Michael Fraser, Lisa Chesner, Marc D. Perry, Thaidy Moreno-Rodriguez, William S. Chen, Joshi J. Alumkal, Jonathan Chou, Alicia K. Morgans, Tomasz M. Beer, George V. Thomas, Martin Gleave, Paul Lloyd, Tierney Phillips, Erin McCarthy, Michael C. Haffner, Amina Zoubeidi, Matti Annala, Robert E. Reiter, Matthew B. Rettig, Owen N. Witte, Lawrence Fong, Rohit Bose, Franklin W. Huang, Jianhua Luo, Anders Bjartell, Joshua M. Lang, Nupam P. Mahajan, Primo N. Lara, Christopher P. Evans, Phuoc T. Tran, Edwin M. Posadas, Chuan He, Xiao-Long Cui, Jiaoti Huang, Wilbert Zwart, Luke A. Gilbert, Christopher A. Maher, Paul C. Boutros, Kim N. Chi, Alan Ashworth, Eric J. Small, Housheng H. He, Alexander W. Wyatt, David A. Quigley, Felix Y. Feng
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3888–3902.
https://doi.org/10.1158/0008-5472.CAN-22-1123
Published: 02 November 2022
View article titled, The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
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Includes: Supplementary data
Journal Articles

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

Patrick C. O'Leary, Huadong Chen, Yagmur U. Doruk, Tess Williamson, Benjamin Polacco, Andrew S. McNeal, Tanushree Shenoy, Nupura Kale, Julia Carnevale, Erica Stevenson, David A. Quigley, Jonathan Chou, Felix Y. Feng, Danielle L. Swaney, Nevan J. Krogan, Minkyu Kim, Morgan E. Diolaiti, Alan Ashworth
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3950–3961.
https://doi.org/10.1158/0008-5472.CAN-21-4335
Published: 02 November 2022
View article titled, Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
Open the PDF for Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2 in another window
Includes: Supplementary data
Journal Articles

Abstract PD15-08: Window of opportunity trial of neoadjuvant olaparib and durvalumab for triple negative or low ER-positive breast cancer

Seock-Ah Im, Kyung-Hun Lee, Ahrum Min, Daewon Lee, Tae Yong Kim, Han Suk Ryu, Jiwon Koh, Gi-Jeong Cheon, Yoon-Jung Shin, Yujin Kim, Hyeong-Gon Moon, Wonshik Han, Han-Byoel Lee, Morgan Diolaiti, David Quigley, Alan Ashworth, Nariya Cho
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD15-08.
https://doi.org/10.1158/1538-7445.SABCS21-PD15-08
Published: 15 February 2022
View article titled, Abstract PD15-08: Window of opportunity trial of neoadjuvant olaparib and durvalumab for triple negative or low ER-positive breast cancer
Journal Articles

Abstract 2308: The protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Patrick O'Leary, Denise Wolf, Dominique C. Mitchell, Fan Zheng, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Laura van' t Veer, Alan Ashworth, Trey Ideker, Nevan J. Krogan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2308.
https://doi.org/10.1158/1538-7445.AM2021-2308
Published: 01 July 2021
View article titled, Abstract 2308: The protein interaction landscape of breast cancer
Journal Articles

A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg, Sr., Denis R. Beckford-Vera, Daniel V. Santi
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1076–1086.
https://doi.org/10.1158/0008-5472.CAN-20-1741
Published: 15 February 2021
View article titled, A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models
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Includes: Supplementary data
Journal Articles

Abstract 783: Epigenomic detection of multiple cancers in plasma derived cell free DNA

Anna Bergamaschi, Jeremy Ku, Yuhong Ning, Francois Collin, Chris Ellison, Tierney Phillips, Erin McCarthy, Wendy Wang, Michael Antoine, David Haan, Aaron Scott, Paul Lloyd, Gulfem Guler, Alan Ashworth, Stephen Quake, Samuel Levy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 783.
https://doi.org/10.1158/1538-7445.AM2020-783
Published: 15 August 2020
View article titled, Abstract 783: Epigenomic detection of multiple cancers in plasma derived cell free DNA
Journal Articles

Abstract LB-060: A very long-acting poly(ADP-ribose) polymerase inhibitor

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan Kurmasheva, Morgan Diolati, Alan Ashworth, Daniel V. Santi
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-060.
https://doi.org/10.1158/1538-7445.AM2020-LB-060
Published: 15 August 2020
View article titled, Abstract LB-060: A very long-acting poly(ADP-ribose) polymerase inhibitor
Journal Articles

Abstract 1372: Detection of early stage pancreatic cancer using 5–hydroxymethylcytosine signatures in circulating cell free DNA

Francois Collin, Yuhong Ning, Gulfem D. Guler, Tierney Phillips, Erin McCarthy, Aaron Scott, Chris Ellison, Chin-Jen Ku, Kim Chau, Alan Ashworth, Stephen R. Quake, Samuel Levy
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1372.
https://doi.org/10.1158/1538-7445.AM2019-1372
Published: 01 July 2019
View article titled, Abstract 1372: Detection of early stage pancreatic cancer using 5–hydroxymethylcytosine signatures in circulating cell free DNA
Journal Articles

Abstract 1225: Rare variants in DNA damage repair genes are associated with male breast cancer predisposition

Sarah L. Maguire, Katarzyna Tomczyk, Eleni Perrakis, Edward Saunders, Daniel Leongamornlert, ZSofia Kote-Jarai, Rosalind Eeles, Montserrat Garcia-Closas, Paul Pharoah, Douglas Easton, Christopher J. Lord, Alan Ashworth, Anthony Swerdlow, Nick Orr
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1225.
https://doi.org/10.1158/1538-7445.AM2018-1225
Published: 01 July 2018
View article titled, Abstract 1225: Rare variants in DNA damage repair genes are associated with male breast cancer predisposition
Journal Articles

Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets

Dragomir B. Krastev, Stephen J. Pettitt, James Campbell, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1360.
https://doi.org/10.1158/1538-7445.AM2018-1360
Published: 01 July 2018
View article titled, Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets
Journal Articles

Abstract 2975: Synthetic lethality in synovial sarcoma: SS18-SSX fusions and DNA damage response (DDR) inhibitors

Emmy DG Fleuren, Sam Jones, Jessica Frankum, Chris Williamson, Malini Menon, Janet Shipley, Alan Ashworth, Winette van der Graaf, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2975.
https://doi.org/10.1158/1538-7445.AM2018-2975
Published: 01 July 2018
View article titled, Abstract 2975: Synthetic lethality in synovial sarcoma: SS18-SSX fusions and DNA damage response (DDR) inhibitors
Journal Articles

Abstract 2986: E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer

Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N. Pemberton, Jessica Frankum, Fei Fei Song, Rumana Rafiq, Asha Konde, Malini Menon, James Campbell, Aditi Gulati, Rahul Kumar, Stephen J. Pettitt, Mark D. Gurden, Marta Llorca Cardenosa, Irene Chong, Patrycja Gazinska, Fredrik Wallberg, Elinor J. Sawyer, Lesley-Ann Martin, Mitch Dowsett, Spiros Linardopoulos, Colm Ryan, Patrick W. Derksen, Jos Jonkers, Andrew N.J. Tutt, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2986.
https://doi.org/10.1158/1538-7445.AM2018-2986
Published: 01 July 2018
View article titled, Abstract 2986: E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer
Journal Articles

Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in PARP1

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Maria I. Harrell, Rachel Brough, Jessica Frankum, Jung-Min Lee, Elizabeth M. Swisher, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 410.
https://doi.org/10.1158/1538-7445.AM2018-410
Published: 01 July 2018
View article titled, Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in <em>PARP1</em>
Journal Articles

ATR Is a Therapeutic Target in Synovial Sarcoma

Samuel E. Jones, Emmy D.G. Fleuren, Jessica Frankum, Asha Konde, Chris T. Williamson, Dragomir B. Krastev, Helen N. Pemberton, James Campbell, Aditi Gulati, Richard Elliott, Malini Menon, Joanna L. Selfe, Rachel Brough, Stephen J. Pettitt, Wojciech Niedzwiedz, Winette T.A. van der Graaf, Janet Shipley, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (24): 7014–7026.
https://doi.org/10.1158/0008-5472.CAN-17-2056
Published: 14 December 2017
View article titled, ATR Is a Therapeutic Target in Synovial Sarcoma
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Includes: Supplementary data
Journal Articles

Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens

Stephen Pettitt, Dragomir B. Krastev, Feifei Song, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2743.
https://doi.org/10.1158/1538-7445.AM2016-2743
Published: 15 July 2016
View article titled, Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens