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Agnieszka Witkiewicz
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Journal Articles

Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression

Free
Jiayu Ye, John M. Baer, Douglas V. Faget, Vasilios A. Morikis, Qihao Ren, Anupama Melam, Ana Paula Delgado, Erik Knudsen, Agnieszka Witkiewicz, Robert S. Powers, Gregory D. Longmore, David G. DeNardo, Sheila A. Stewart
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): A043.
https://doi.org/10.1158/1538-7445.TUMBODY-A043
Published: 17 November 2024
View articletitled, Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression
Journal Articles

Abstract PO2-27-05: Composite biomarkers for the prediction of progression-free survival with CDK4/6 inhibitors in metastatic HR+/HER2- breast cancer

Free
Agnieszka Witkiewicz, Jianxin Wang, Erik Knudsen, Ellis Levine, Tracey O'Connor
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-27-05.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-27-05
Published: 02 May 2024
View articletitled, Abstract PO2-27-05: Composite biomarkers for the prediction of progression-free survival with CDK4/6 inhibitors in metastatic HR+/HER2- breast cancer
Journal Articles

Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping

Free
Carsten Denkert, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Erik S. Knudsen, Seock-Ah Im, Angela DeMichele, Agnieszka Witkiewicz, Laura Van ’t Veer, Sung-Bae Kim, Harry D. Bear, Nicole McCarthy, Karen Gelmon, Frederik Marmé, José Ángel García-Sáenz, Nicholas Turner, Federico Rojo, Martin Filipits, Lesley-Ann Martin, Peter A. Fasching, Christian Schem, Catherine M. Kelly, Toralf Reimer, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Yuan Liu, Karsten Weber, Sivaramakrishna Rachakonda, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): HER2-06.
https://doi.org/10.1158/1538-7445.SABCS22-HER2-06
Published: 01 March 2023
View articletitled, Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping
Journal Articles

Abstract PD17-05: Development and Validation of a Composite Biomarker Predictive of Palbociclib + Endocrine Treatment Benefit in Early Breast Cancer: PENELOPE-B and PALLAS Trials

Free
Sibylle Loibl, Carsten Denkert, Yuan Liu, Erik S. Knudsen, Angela DeMichele, Zhe Zhang, Julia Teply-Szymanski, Martin Filipits, Peter A. Fasching, Michael Gnant, Shibing Deng, Marija Balic, Federico Rojo, Mark Watson, Chetan Deshpande, Nicholas Turner, Otto Metzger, Kathy Puyana Theall, Agnieszka Witkiewicz, Olga Valota, W. Fraser Symmans, Erica L. Mayer
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD17-05.
https://doi.org/10.1158/1538-7445.SABCS22-PD17-05
Published: 01 March 2023
View articletitled, Abstract PD17-05: Development and Validation of a Composite Biomarker Predictive of Palbociclib + Endocrine Treatment Benefit in Early Breast Cancer: PENELOPE-B and PALLAS Trials
Journal Articles

Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial

Free
Erik S. Knudsen, Sivaramakrishna Rachakonda, Frederik Marmé, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Wolfgang D. Schmitt, Sung-Bae Kim, Harry D. Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Nicole McCarthy, Bruno V. Sinn, Karen Gelmon, José Ángel García-Sáenz, Catherine M. Kelly, Toralf Reimer, Nicholas Turner, Federico Rojo, Martin Filipits, Peter A. Fasching, Christian Schem, Lesley-Ann Martin, Yuan Liu, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Jenny Furlanetto, Karsten Weber, Carsten Denkert, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD17-06.
https://doi.org/10.1158/1538-7445.SABCS22-PD17-06
Published: 01 March 2023
View articletitled, Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial
Journal Articles

Abstract P5-02-08: Biomarker associated with response to CDK4/6 inhibitors in metastatic hormone receptor positive breast cancer

Free
Agnieszka Witkiewicz
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P5-02-08.
https://doi.org/10.1158/1538-7445.SABCS22-P5-02-08
Published: 01 March 2023
View articletitled, Abstract P5-02-08: Biomarker associated with response to CDK4/6 inhibitors in metastatic hormone receptor positive breast cancer
Journal Articles

Abstract P3-10-01: Deciphering the heterogeneity of cell cycle in breast cancer and relevance to clinical application of CDK inhibitors

Free
Erik S. Knudsen, Vishnu M. Kumarasamy, Jianxin Wang, Agnieszka Witkiewicz
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-10-01.
https://doi.org/10.1158/1538-7445.SABCS22-P3-10-01
Published: 01 March 2023
View articletitled, Abstract P3-10-01: Deciphering the heterogeneity of cell cycle in breast cancer and relevance to clinical application of CDK inhibitors
Journal Articles

Abstract 6402: Associations of sodium glucose cotransporter-2 (SGLT2), metabolic disorders, and survival following incident epithelial ovarian cancer

Free
Jennifer M. Mongiovi, Jo L. Freudenheim, Jeff C. Miecznikowski, Susan E. McCann, Ashley E. Stenzel, Wiam Bshara, Agnieszka Witkiewicz, Leighton Stein, Lisa D. Kellenberger, Ahmad Al Sulimani, Kirsten B. Moysich
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6402.
https://doi.org/10.1158/1538-7445.AM2022-6402
Published: 15 June 2022
View articletitled, Abstract 6402: Associations of sodium glucose cotransporter-2 (SGLT2), metabolic disorders, and survival following incident epithelial ovarian cancer
Journal Articles

Abstract CT568: β-2 adrenergic receptor (AR): Another immune checkpoint (IC)" A phase II clinical trial of propranolol (P) with pembrolizumab (Pem) in patients with unresectable stage III and stage IV melanoma

Free
Benjamin Switzer, Manu R. Pandey, Alexandra Valentine, Agnieszka Witkiewicz, Erik Knudsen, Kristopher Attwood, Joseph Tario, Pauline Funchain, Joseph J. Drabick, Hemn Mohammadpour, Marc S. Ernstoff, Igor Puzanov, Elizabeth A. Repasky, Shipra Gandhi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT568.
https://doi.org/10.1158/1538-7445.AM2022-CT568
Published: 15 June 2022
View articletitled, Abstract CT568: β-2 adrenergic receptor (AR): Another immune checkpoint (IC)" A phase II clinical trial of propranolol (P) with pembrolizumab (Pem) in patients with unresectable stage III and stage IV melanoma
Journal Articles

Abstract 921: The Nrf2E79Q activating mutation accelerates growth of pure-small cell lung cancer but not combined small cell lung cancer Tp53floxed/floxed/Cdkn2afloxed/floxed mice

Free
Samera Hamad, Stephanie A. Montgomery, Jeremy M. Simon, Brittany M. Bowman, Kyle B. Spainhower, Ryan M. Murphy, Agnieszka Witkiewicz, Suzanne E. Fenton, Scott H. Randell, Neil Hayes, Erik Knudsen, Trudy G. Oliver, Ben Major, Bernard E. Weissman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 921.
https://doi.org/10.1158/1538-7445.AM2022-921
Published: 15 June 2022
View articletitled, Abstract 921: The Nrf2E79Q activating mutation accelerates growth of pure-small cell lung cancer but not combined small cell lung cancer Tp53floxed/floxed/Cdkn2afloxed/floxed mice
Journal Articles

Abstract PD2-04: Molecular plasticity of luminal breast cancer and response to CDK 4/6 inhibition - The biomarker program of the PENELOPE-B trial investigating post-neoadjuvant palbociclib

Free
Carsten Denkert, Frederik Marmé, Miguel Martin, Michael Untch, Hervé Bonnefoi, Sung-Bae Kim, Harry Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Nicole McCarthy, Thorsten Stiewe, Karen A. Gelmon, José A. García-Sáenz, Catherine M. Kelly, Toralf Reimer, Erik Knudsen, Nicholas Turner, Federico Rojo, Peter A. Fasching, Julia Teply-Szymanski, Yuan Liu, Masakazu Toi, Hope S. Rugo, Michael Gnant, Andreas Makris, Bärbel Felder, Karsten Weber, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-04.
https://doi.org/10.1158/1538-7445.SABCS21-PD2-04
Published: 15 February 2022
View articletitled, Abstract PD2-04: Molecular plasticity of luminal breast cancer and response to CDK 4/6 inhibition - The biomarker program of the PENELOPE-B trial investigating post-neoadjuvant palbociclib
Journal Articles

Abstract P5-13-36: Germline BRCA1/2 and other predisposition genes in high-risk early-stage HR+/HER2- breast cancer (BC) patients treated with endocrine therapy (ET) with or without palbociclib: A secondary analysis from the PENELOPE-B study

Free
Sibylle Loibl, Jan Hauke, Karen Gelmon, Frederik Marmé, Corinna Ernst, Miguel Martin, Michael Untch, Hervé Bonnefoi, Erik Knudsen, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Sung-Bae Kim, Harry Bear, Nicole McCarthy, Nicholas Turner, Agnieszka Witkiewicz, Federico Rojo, Peter A Fasching, José A García-Sáenz, Catherine M Kelly, Toralf Reimer, Masakazu Toi, Hope S Rugo, Carsten Denkert, Michael Gnant, Andreas Makris, Yuan Liu, Olga Valota, Bärbel Felder, Karsten Weber, Valentina Nekljudova, Eric Hahnen
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-36.
https://doi.org/10.1158/1538-7445.SABCS21-P5-13-36
Published: 15 February 2022
View articletitled, Abstract P5-13-36: Germline BRCA1/2 and other predisposition genes in high-risk early-stage HR+/HER2- breast cancer (BC) patients treated with endocrine therapy (ET) with or without palbociclib: A secondary analysis from the PENELOPE-B study
Journal Articles

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

Free
Miao Wang, Mary Topalovski, Jason E. Toombs, Christopher M. Wright, Zachary R. Moore, David A. Boothman, Hiromi Yanagisawa, Huamin Wang, Agnieszka Witkiewicz, Diego H. Castrillon, Rolf A. Brekken
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5058–5069.
https://doi.org/10.1158/0008-5472.CAN-15-0744
Published: 30 November 2015
View articletitled, Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer
Open the PDF for Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-119: Therapeutic sensitivity and predictive markers for CDK4/6 inhibition defined by ex vivo analyses of human tumors

Free
Agnieszka Witkiewicz, Jeffry Dean, Amy McClendon, Erik S. Knudsen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-119.
https://doi.org/10.1158/1538-7445.AM2012-LB-119
Published: 15 April 2012
View articletitled, Abstract LB-119: Therapeutic sensitivity and predictive markers for CDK4/6 inhibition defined by ex vivo analyses of human tumors
Journal Articles

Abstract 3388: Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia

Free
Agnieszka Witkiewicz, Adam Ertel, Erik S. Knudsen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3388.
https://doi.org/10.1158/1538-7445.AM2012-3388
Published: 15 April 2012
View articletitled, Abstract 3388: Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia
Journal Articles

Abstract 591: Expanding the therapeutic window through pharmacological activation of the RB pathway in breast cancer treatment

Free
Kathleen McClendon, Jeffry L. Dean, Dayana Rivadeneira, Christopher A. Reed, Agnieszka Witkiewicz, Erhe Gao, Walter J. Koch, Thomas Force, Erik S. Knudsen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 591.
https://doi.org/10.1158/1538-7445.AM2011-591
Published: 15 April 2011
View articletitled, Abstract 591: Expanding the therapeutic window through pharmacological activation of the RB pathway in breast cancer treatment
Journal Articles

Abstract #5286: Nuclear expression of transcription factors Stat5a and Stat5b confers favorable prognosis in breast cancer

Free
Agnieszka Witkiewicz, Thai Tran, Ozlem Er, Terry Hyslop, Hallgeir Rui
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5286.
Published: 01 May 2009
View articletitled, Abstract #5286: Nuclear expression of transcription factors Stat5a and Stat5b confers favorable prognosis in breast cancer
Journal Articles

Abstract #5539: Increased HuR expression in pancreatic cancer cells dramatically optimizes gemcitabine efficacy

Free
Christina Costantino, Agnieszka Witkiewicz, Yuki Kuwano, Joseph Cozzitorto, Charles Yeo, Myriam Gorospe, Jonathan Brody
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5539.
Published: 01 May 2009
View articletitled, Abstract #5539: Increased HuR expression in pancreatic cancer cells dramatically optimizes gemcitabine efficacy
Journal Articles

Cyclin D1b Is Aberrantly Regulated in Response to Therapeutic Challenge and Promotes Resistance to Estrogen Antagonists

Free
Ying Wang, Jeffry L. Dean, Ewan K.A. Millar, Thai Hong Tran, Catriona M. McNeil, Craig J. Burd, Susan M. Henshall, Fransiscus E. Utama, Agnieszka Witkiewicz, Hallgeir Rui, Robert L. Sutherland, Karen E. Knudsen, Erik S. Knudsen
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5628–5638.
https://doi.org/10.1158/0008-5472.CAN-07-3170
Published: 15 July 2008
View articletitled, Cyclin D1b Is Aberrantly Regulated in Response to Therapeutic Challenge and Promotes Resistance to Estrogen Antagonists
Open the PDF for Cyclin D1b Is Aberrantly Regulated in Response to Therapeutic Challenge and Promotes Resistance to Estrogen Antagonists in another window