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Adrienne D. Cox
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Journal Articles

Abstract LB288: Determination of the MYC- and TEAD-dependent transcriptome in pancreatic cancer

Free
Brandon L. Mouery, Priya S. Hibshman, A Cole Edwards, Ryan D. Mouery, Runying Yang, Jeff A. Klomp, Angie L. Mordant, Thomas S. Webb, Aurora Cabrera, Laura E. Herring, Adrienne D. Cox, Timour Baslan, Channing J. Der, Clint A. Stalnecker
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB288.
https://doi.org/10.1158/1538-7445.AM2025-LB288
Published: 25 April 2025
View articletitled, Abstract LB288: Determination of the MYC- and TEAD-dependent transcriptome in pancreatic cancer
Journal Articles

Abstract 3786: Combination of MTA-cooperative PRMT5 inhibitor BMS-986504 and KRAS inhibitors for the treatment of MTAP-deleted KRAS-mutant pancreatic cancer

Free
Kristina Drizyte-Miller, Lars D. Engstrom, Jeffrey A. Klomp, Clint A. Stalnecker, Laura Waters, Andrew Calinisan, Ryan Robb, Khalilah E. Taylor, Mallory K. Roach, Addison G. Stamey, Seamus Degan, Wen-Hsuan Chang, Xousaen M. Helu, David Nguyen, Laura D. Hover, Elisa Baldelli, Mariaelena Pierobon, Emanuel F. Petricoin, Kirsten L. Bryant, David M. Briere, James G. Christensen, Jill Hallin, Adrienne D. Cox, Peter Olson, Channing J. Der
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3786.
https://doi.org/10.1158/1538-7445.AM2025-3786
Published: 21 April 2025
View articletitled, Abstract 3786: Combination of MTA-cooperative PRMT5 inhibitor BMS-986504 and KRAS inhibitors for the treatment of MTAP-deleted KRAS-mutant pancreatic cancer
Journal Articles

Abstract 6368: Correlative preclinical studies to elucidate mechanisms of synergy of the combination of the RAF/MEK clamp avutometinib and the FAK inhibitor defactinib in low grade serous ovarian cancer

Free
Lisa Pickard, Konstantinos Mitsopolous, Theo Roumeliotis, Silvia Coma, Laura Hover, Alexis De Haven Brandon, Bora Gurel, Jiin Song, Priya S. Hibshman, A Cole Edwards, Jeffrey A. Klomp, Clint A. Stalnecker, Adrienne D. Cox, Jyoti Choudhary, Channing Der, Jonathan A. Pachter, Udai Banerji
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6368.
https://doi.org/10.1158/1538-7445.AM2025-6368
Published: 21 April 2025
View articletitled, Abstract 6368: Correlative preclinical studies to elucidate mechanisms of synergy of the combination of the RAF/MEK clamp avutometinib and the FAK inhibitor defactinib in low grade serous ovarian cancer
Journal Articles

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer

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Jonathan M. DeLiberty, Mallory K. Roach, Clint A. Stalnecker, Ryan Robb, Elyse G. Schechter, Noah L. Pieper, Khalilah E. Taylor, Lily M. Pita, Runying Yang, Scott Bang, Kristina Drizyte-Miller, Sarah E. Ackermann, Sheila R. Nicewarner Peña, Elisa Baldelli, Sophia M. Min, David H. Drewry, Emanuel F. Petricoin, III, John P. Morris, IV, Channing J. Der, Adrienne D. Cox, Kirsten L. Bryant
Journal: Cancer Research
Cancer Res (2025) 85 (8): 1479–1495.
https://doi.org/10.1158/0008-5472.CAN-24-1757
Published: 15 April 2025
View articletitled, Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer
Open the PDF for Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve is a Therapeutic Strategy for Pancreatic Cancer

Available to Purchase
Jonathan M. DeLiberty, Mallory K. Roach, Clint A. Stalnecker, Ryan Robb, Elyse G. Schechter, Noah L. Pieper, Khalilah E. Taylor, Lily M. Pita, Runying Yang, Scott Bang, Kristina Drizyte-Miller, Sarah E. Ackermann, Sheila R. Nicewarner Peña, Elisa Baldelli, Sophia M. Min, David H. Drewry, Emanuel F. Petricoin, John P. Morris, Channing J. Der, Adrienne D. Cox, Kirsten L. Bryant
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-1757
Published: 11 February 2025
View articletitled, Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve is a Therapeutic Strategy for Pancreatic Cancer
Open the PDF for Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve is a Therapeutic Strategy for Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C026: Concurrent inhibition of the RAS ERK-MAPK pathway and PIKfyve as a therapeutic strategy for pancreatic cancer

Free
Jonathan M DeLiberty, Mallory K Roach, Clint A Stalnecker, Ryan Robb, Elyse G Schechter, Noah L Pieper, Runying Yang, Scott Bang, Khalilah E Taylor, Kristina Drizyte-Miller, John P Morris, IV, Channing J Der, Adrienne D Cox, Kirsten L Bryant
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C026.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C026
Published: 15 September 2024
View articletitled, Abstract C026: Concurrent inhibition of the RAS ERK-MAPK pathway and PIKfyve as a therapeutic strategy for pancreatic cancer
Journal Articles

Abstract 4588: Combination of MTA-cooperative PRMT5 inhibitor and direct mutant-selective KRAS inhibitors as a novel therapeutic approach for MTAP-deficient pancreatic cancer

Free
Kristina Drizyte-Miller, Wen-Hsuan Chang, Andrew M. Waters, Clint A. Stalnecker, Junning Wang, Andrew J. Aguirre, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4588.
https://doi.org/10.1158/1538-7445.AM2024-4588
Published: 22 March 2024
View articletitled, Abstract 4588: Combination of MTA-cooperative PRMT5 inhibitor and direct mutant-selective KRAS inhibitors as a novel therapeutic approach for MTAP-deficient pancreatic cancer
Journal Articles

Abstract 1936: KEAP1-NRF2 mediated resistance against KRASG12D inhibitor in pancreatic ductal adenocarcinoma

Free
Wen-Hsuan Chang, Addison G. Stamey, Andrew M. Waters, Kirsten L. Bryant, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1936.
https://doi.org/10.1158/1538-7445.AM2024-1936
Published: 22 March 2024
View articletitled, Abstract 1936: KEAP1-NRF2 mediated resistance against KRASG12D inhibitor in pancreatic ductal adenocarcinoma
Journal Articles

Abstract C047: Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma

Free
Jonathan M. DeLiberty, Mallory K. Roach, Noah L. Pieper, Kristina Drizyte-Miller, Elyse G. Schechter, Runying Yang, Channing J. Der, Adrienne D. Cox, Clint A. Stalnecker, Kirsten L. Bryant
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C047.
https://doi.org/10.1158/1538-7445.PANCA2023-C047
Published: 16 January 2024
View articletitled, Abstract C047: Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma
Journal Articles

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

Free
A. Cole Edwards, Clint A. Stalnecker, Alexis Jean Morales, Khalilah E. Taylor, Jennifer E. Klomp, Jeffrey A. Klomp, Andrew M. Waters, Niranjan Sudhakar, Jill Hallin, Tracy T. Tang, Peter Olson, Leonard Post, James G. Christensen, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4112–4129.
https://doi.org/10.1158/0008-5472.CAN-23-2994
Published: 15 December 2023
View articletitled, TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract 4851: Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma

Free
Jonathan M. DeLiberty, Clint A. Stalnecker, Kristina Drizyte-Miller, Elyse G. Schechter, Noah L. Pieper, Runying Yang, Channing J. Der, Adrienne D. Cox, Kirsten L. Bryant
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4851.
https://doi.org/10.1158/1538-7445.AM2023-4851
Published: 04 April 2023
View articletitled, Abstract 4851: Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1075: Identification of resistance mechanisms to direct KRAS inhibition in pancreatic cancer

Free
Andrew Michael Waters, Wen-Hsuan Chang, Clint Stalnecker, Cole Edwards, Runying Yang, Craig M. Goodwin, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1075.
https://doi.org/10.1158/1538-7445.AM2023-1075
Published: 04 April 2023
View articletitled, Abstract 1075: Identification of resistance mechanisms to direct KRAS inhibition in pancreatic cancer
Journal Articles

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer

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Craig M. Goodwin, Andrew M. Waters, Jennifer E. Klomp, Sehrish Javaid, Kirsten L. Bryant, Clint A. Stalnecker, Kristina Drizyte-Miller, Bjoern Papke, Runying Yang, Amber M. Amparo, Irem Ozkan-Dagliyan, Elisa Baldelli, Valerie Calvert, Mariaelena Pierobon, Jessica A. Sorrentino, Andrew P. Beelen, Natalie Bublitz, Mareen Lüthen, Kris C. Wood, Emanuel F. Petricoin, III, Christine Sers, Autumn J. McRee, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2023) 83 (1): 141–157.
https://doi.org/10.1158/0008-5472.CAN-22-0391
Published: 04 January 2023
View articletitled, Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer
Open the PDF for Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

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Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Michael F. Coleman, Runying Yang, Jonathan M. DeLiberty, Björn Papke, Craig M. Goodwin, Mariaelena Pierobon, Emanuel F. Petricoin, III, Prson Gautam, Krister Wennerberg, Adrienne D. Cox, Channing J. Der, Stephen D. Hursting, Kirsten L. Bryant
Journal: Cancer Research
Cancer Res (2022) 82 (4): 586–598.
https://doi.org/10.1158/0008-5472.CAN-21-1443
Published: 15 February 2022
View articletitled, Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Open the PDF for Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors in another window
Includes: Supplementary data
Journal Articles

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

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Danielle R. Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza, Dimitri G. Trembath, Verline Justilien, Karen A. Pickering, David F. Vincent, Armin Jarosch, Philipp Jurmeister, Andrew M. Waters, Priya S. Hibshman, Andrew D. Campbell, Catriona A. Ford, Temitope O. Keku, Jen Jen Yeh, Michael S. Lee, Adrienne D. Cox, Alan P. Fields, Robert S. Sandler, Owen J. Sansom, Christine Sers, Antje Schaefer, Channing J. Der
Journal: Cancer Research
Cancer Res (2022) 82 (1): 90–104.
https://doi.org/10.1158/0008-5472.CAN-20-4218
Published: 04 January 2022
View articletitled, Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth
Open the PDF for Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth in another window
Includes: Supplementary data
Journal Articles

Abstract PR10: Enhancing the effect of autophagy inhibition for pancreatic cancer treatment

Free
Kirsten L. Bryant, Jennifer E. Klomp, Ye S. Lee, Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Sen Peng, Mariaelena Pierobon, Emanuel F. Petricoin, III, Nhan Tran, Alec C. Kimmelman, Adrienne D. Cox, Channing J. Der
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): PR10.
https://doi.org/10.1158/1538-7445.PANCA19-PR10
Published: 13 December 2019
View articletitled, Abstract PR10: Enhancing the effect of autophagy inhibition for pancreatic cancer treatment
Journal Articles

Abstract LB-276: Farnesyltransferase inhibitor (FTI)-induced growth inhibition of HRAS-mutant head and neck cancers is enhanced by concurrently inhibiting compensatory upregulation of the ERK-MAPK kinase cascade

Free
Sehrish Javaid, Victoria V. Nguyen, Andrew M. Waters, Craig M. Goodwin, Channing J. Der, Adrienne D. Cox
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-276.
https://doi.org/10.1158/1538-7445.AM2019-LB-276
Published: 01 July 2019
View articletitled, Abstract LB-276: Farnesyltransferase inhibitor (FTI)-induced growth inhibition of HRAS-mutant head and neck cancers is enhanced by concurrently inhibiting compensatory upregulation of the ERK-MAPK kinase cascade
Journal Articles

Abstract LB-287: Combination therapies with CDK4/6 inhibitors to treat KRAS-mutant pancreatic cancer

Free
Craig M. Goodwin, Sehrish Javaid, Andrew M. Waters, Bjoern Papke, Runying Yang, Mariaelena Pierobon, Daniel M. Freed, Patrick J. Roberts, Adrienne D. Cox, Kris C. Wood, Emanuel F. Petricoin, Autumn J. McRee, Channing J. Der
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-287.
https://doi.org/10.1158/1538-7445.AM2019-LB-287
Published: 01 July 2019
View articletitled, Abstract LB-287: Combination therapies with CDK4/6 inhibitors to treat KRAS-mutant pancreatic cancer
Journal Articles

Abstract SY20-02: Inhibitor combinations targeting KRAS effector signaling in KRAS-mutant pancreatic cancer

Free
Adrienne D. Cox, Craig M. Goodwin, Kirsten L. Bryant, Irem Dagliyan, Samuel D. George, Kelly E. Lucas, Prson Gautam, Krister Wennerberg, Channing J. Der
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): SY20-02.
https://doi.org/10.1158/1538-7445.AM2018-SY20-02
Published: 01 July 2018
View articletitled, Abstract SY20-02: Inhibitor combinations targeting KRAS effector signaling in KRAS-mutant pancreatic cancer
Journal Articles

Abstract LB-276: Application of a CRISPR/Cas9 screen to identify novel therapeutic strategies with CDK4/6 inhibitors in pancreatic cancer

Free
Craig Goodwin, Sehrish Javaid, Adrienne D. Cox, Kris Wood, Channing Der
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-276.
https://doi.org/10.1158/1538-7445.AM2018-LB-276
Published: 01 July 2018
View articletitled, Abstract LB-276: Application of a CRISPR/Cas9 screen to identify novel therapeutic strategies with CDK4/6 inhibitors in pancreatic cancer