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Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

Cancer Res (2022) 82 (1): 90–104.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-4218

Published: 04 January 2022

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Includes: Supplementary data

Journal Articles

Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Michael F. Coleman, Runying Yang, Jonathan M. DeLiberty, Björn Papke, Craig M. Goodwin, Mariaelena Pierobon, Emanuel F. Petricoin, III, Prson Gautam, Krister Wennerberg, Adrienne D. Cox, Channing J. Der, Stephen D. Hursting, Kirsten L. Bryant

Cancer Res (2022) 82 (4): 586–598.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1443

Published: 17 December 2021

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Includes: Supplementary data

Journal Articles

Abstract PR10: Enhancing the effect of autophagy inhibition for pancreatic cancer treatment

Kirsten L. Bryant, Jennifer E. Klomp, Ye S. Lee, Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Sen Peng, Mariaelena Pierobon, Emanuel F. Petricoin, III, Nhan Tran, Alec C. Kimmelman, Adrienne D. Cox, Channing J. Der

Cancer Res (2019) 79 (24_Supplement): PR10.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-PR10

Published: 13 December 2019

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Journal Articles

Abstract LB-276: Farnesyltransferase inhibitor (FTI)-induced growth inhibition of HRAS-mutant head and neck cancers is enhanced by concurrently inhibiting compensatory upregulation of the ERK-MAPK kinase cascade

Sehrish Javaid, Victoria V. Nguyen, Andrew M. Waters, Craig M. Goodwin, Channing J. Der, Adrienne D. Cox

Cancer Res (2019) 79 (13_Supplement): LB-276.

DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-276

Published: 01 July 2019

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Journal Articles

Abstract LB-287: Combination therapies with CDK4/6 inhibitors to treat KRAS-mutant pancreatic cancer

Craig M. Goodwin, Sehrish Javaid, Andrew M. Waters, Bjoern Papke, Runying Yang, Mariaelena Pierobon, Daniel M. Freed, Patrick J. Roberts, Adrienne D. Cox, Kris C. Wood, Emanuel F. Petricoin, Autumn J. McRee, Channing J. Der

Cancer Res (2019) 79 (13_Supplement): LB-287.

DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-287

Published: 01 July 2019

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Journal Articles

Abstract SY20-02: Inhibitor combinations targeting KRAS effector signaling in KRAS-mutant pancreatic cancer

Adrienne D. Cox, Craig M. Goodwin, Kirsten L. Bryant, Irem Dagliyan, Samuel D. George, Kelly E. Lucas, Prson Gautam, Krister Wennerberg, Channing J. Der

Cancer Res (2018) 78 (13_Supplement): SY20-02.

DOI: https://doi.org/10.1158/1538-7445.AM2018-SY20-02

Published: 01 July 2018

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Journal Articles

Abstract LB-276: Application of a CRISPR/Cas9 screen to identify novel therapeutic strategies with CDK4/6 inhibitors in pancreatic cancer

Craig Goodwin, Sehrish Javaid, Adrienne D. Cox, Kris Wood, Channing Der

Cancer Res (2018) 78 (13_Supplement): LB-276.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-276

Published: 01 July 2018

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Journal Articles

RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression

Xuan Meng, Nicole R. Tackmann, Shijie Liu, Jing Yang, Jiahong Dong, Congying Wu, Adrienne D. Cox, Yanping Zhang

Cancer Res (2016) 76 (17): 5030–5039.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-3420

Published: 31 August 2016

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Includes: Supplementary data

Journal Articles

Abstract 4660: Inhibition of p38 enhances ERK inhibitor efficacy in pancreatic ductal adenocarcinoma

Meagan B. Ryan, Kirsten L. Bryant, Tikvah K. Hayes, Swapnil Kher, Kris C. Wood, Ahmed A. Samatar, Adrienne D. Cox, Channing J. Der

Cancer Res (2016) 76 (14_Supplement): 4660.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4660

Published: 15 July 2016

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Journal Articles

Abstract LB-217: CK2 protein kinase promotes resistance to MAPK pathway inhibition

Bingying Zhou, Michelle Kassner, Holly Yin, Channing J. Der, Adrienne D. Cox

Cancer Res (2014) 74 (19_Supplement): LB-217.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-217

Published: 01 October 2014

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Journal Articles

Abstract B69: Evaluation of Src-mediated signaling events in pancreatic cancer.

Leanna R. Gentry, Andrei V. Karginov, James J. Fiordalisi, Channing J. Der, Adrienne D. Cox

Cancer Res (2012) 72 (14_Supplement): B69.

DOI: https://doi.org/10.1158/1538-7445.PANCA2012-B69

Published: 03 April 2014

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Journal Articles

Abstract LB-30: A functional analysis of the nuclear RhoGEF Ect2 in ovarian cancer

Molly J. DeCristo, Lauren E. Parker, Dimitri Trembath, Pei-Fen Kuan, Margaret Yim, Jinsong Liu, C. Ryan Miller, Channing J. Der, Adrienne D. Cox

Cancer Res (2012) 72 (8_Supplement): LB-30.

DOI: https://doi.org/10.1158/1538-7445.AM2012-LB-30

Published: 15 April 2012

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Journal Articles

Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras

Keren Farin, Sari Schokoroy, Roni Haklai, Ifat Cohen-Or, Galit Elad-Sfadia, Merit E. Reyes-Reyes, Paula J. Bates, Adrienne D. Cox, Yoel Kloog, Ronit Pinkas-Kramarski

Cancer Res (2011) 71 (6): 2140–2151.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-2887

Published: 14 March 2011

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Journal Articles

PRL Tyrosine Phosphatases Regulate Rho Family GTPases to Promote Invasion and Motility

James J. Fiordalisi, Patricia J. Keller, Adrienne D. Cox

Cancer Res (2006) 66 (6): 3153–3161.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-3116

Published: 15 March 2006

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Journal Articles

Rac3-Mediated Transformation Requires Multiple Effector Pathways

Patricia J. Keller, Christyn M. Gable, Michele R. Wing, Adrienne D. Cox

Cancer Res (2005) 65 (21): 9883–9890.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-3116

Published: 01 November 2005

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Journal Articles

PRL-3, a farnesylated tyrosine phosphatase associated with colorectal cancer invasion and metastasis, upregulates activity of the small GTPase Rho and the nonreceptor tyrosine kinase Src.

James J. Fiordalisi, Vanessa Gonzalez-Perez, Evan Merkhofer, Adrienne D. Cox

Cancer Res (2005) 65 (9_Supplement): 70–71.

Published: 01 May 2005

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Journal Articles

Rac1 and Rac3 Are Targets for Geranylgeranyltransferase I Inhibitor-Mediated Inhibition of Signaling, Transformation, and Membrane Ruffling

Patricia L. Joyce, Adrienne D. Cox

Cancer Res (2003) 63 (22): 7959–7967.

Published: 21 November 2003

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Journal Articles

Epidermal Growth Factor Receptor Autocrine Signaling in RIE-1 Cells Transformed by the Ras Oncogene Enhances Radiation Resistance

Theresa M. Grana, Carolyn I. Sartor, Adrienne D. Cox

Cancer Res (2003) 63 (22): 7807–7814.

Published: 21 November 2003

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Journal Articles

Ras Mediates Radioresistance through Both Phosphatidylinositol 3-Kinase-dependent and Raf-dependent but Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase-independent Signaling Pathways

Theresa M. Grana, Elena V. Rusyn, Hong Zhou, Carolyn I. Sartor, Adrienne D. Cox

Cancer Res (2002) 62 (14): 4142–4150.

Published: 15 July 2002

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Journal Articles

The Farnesyltransferase Inhibitor FTI-277 Radiosensitizes H-ras-transformed Rat Embryo Fibroblasts

Eric J. Bernhard, Gary Kao, Adrienne D. Cox, Said M. Sebti, Andrew D. Hamilton, Ruth J. Muschel, W. Gillies McKenna

Cancer Res (1996) 56 (8): 1727–1730.

Published: 01 April 1996

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NARROW

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors

Abstract PR10: Enhancing the effect of autophagy inhibition for pancreatic cancer treatment

Abstract LB-276: Farnesyltransferase inhibitor (FTI)-induced growth inhibition of HRAS-mutant head and neck cancers is enhanced by concurrently inhibiting compensatory upregulation of the ERK-MAPK kinase cascade

Abstract LB-287: Combination therapies with CDK4/6 inhibitors to treat KRAS-mutant pancreatic cancer

Abstract SY20-02: Inhibitor combinations targeting KRAS effector signaling in KRAS-mutant pancreatic cancer

Abstract LB-276: Application of a CRISPR/Cas9 screen to identify novel therapeutic strategies with CDK4/6 inhibitors in pancreatic cancer

RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression

Abstract 4660: Inhibition of p38 enhances ERK inhibitor efficacy in pancreatic ductal adenocarcinoma

Abstract LB-217: CK2 protein kinase promotes resistance to MAPK pathway inhibition

Abstract B69: Evaluation of Src-mediated signaling events in pancreatic cancer.

Abstract LB-30: A functional analysis of the nuclear RhoGEF Ect2 in ovarian cancer

Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras

PRL Tyrosine Phosphatases Regulate Rho Family GTPases to Promote Invasion and Motility

Rac3-Mediated Transformation Requires Multiple Effector Pathways

PRL-3, a farnesylated tyrosine phosphatase associated with colorectal cancer invasion and metastasis, upregulates activity of the small GTPase Rho and the nonreceptor tyrosine kinase Src.

Rac1 and Rac3 Are Targets for Geranylgeranyltransferase I Inhibitor-Mediated Inhibition of Signaling, Transformation, and Membrane Ruffling

Epidermal Growth Factor Receptor Autocrine Signaling in RIE-1 Cells Transformed by the Ras Oncogene Enhances Radiation Resistance

Ras Mediates Radioresistance through Both Phosphatidylinositol 3-Kinase-dependent and Raf-dependent but Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase-independent Signaling Pathways

The Farnesyltransferase Inhibitor FTI-277 Radiosensitizes H-ras-transformed Rat Embryo Fibroblasts

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