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Adrian Wiestner
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Journal Articles

TLR Signaling Is Activated in Lymph Node–Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib

Eman L. Dadashian, Erin M. McAuley, Delong Liu, Arthur L. Shaffer, III, Ryan M. Young, Jessica R. Iyer, Michael J. Kruhlak, Louis M. Staudt, Adrian Wiestner, Sarah E. M. Herman
Journal: Cancer Research
Cancer Res (2019) 79 (2): 360–371.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-0781
Published: 15 January 2019
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Includes: Supplementary data
Journal Articles

MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia

Nakhle S. Saba, Deanna H. Wong, Georges Tanios, Jessica R. Iyer, Patricia Lobelle-Rich, Eman L. Dadashian, Delong Liu, Lorena Fontan, Erik K. Flemington, Cydney M. Nichols, Chingiz Underbayev, Hana Safah, Ari Melnick, Adrian Wiestner, Sarah E. M. Herman
Journal: Cancer Research
Cancer Res (2017) 77 (24): 7038–7048.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-2485
Published: 14 December 2017
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Includes: Supplementary data
Journal Articles

Abstract 2686: Dual inhibition of BCR and TLR signaling has therapeutic potential in chronic lymphocytic leukemia

Eman L. Dadashian, Sarah Herman, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2686.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2686
Published: 01 July 2017
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Journal Articles

Abstract 292: Integrated analysis of ibrutinib resistance in chronic lymphocytic leukemia

Inhye E. Ahn, Adam Albitar, Chingiz Underbayev, Sarah Herman, Xin Tian, Susan Soto, Maryalice Stetler-Stevenson, Irina Maric, Mohammed Z. Farooqui, Maher Albitar, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 292.
DOI: https://doi.org/10.1158/1538-7445.AM2016-292
Published: 15 July 2016
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Journal Articles

Abstract 1490: Potentiating immunotherapy by targeting complement deposited on cancer cell surfaces

Elizabeth J. Carstens, Martin Skarzynski, Vicent Butera, Margaret Lindorfer, Berengere Vire, Mohammed Farooqui, Christoph Rader, Ronald Taylor, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1490.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1490
Published: 15 July 2016
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Journal Articles

Abstract 4797: The combination of ACP-196 and ACP-319 leads to increased survival in the TCL1-192 CLL mouse model

Helena I. Mora-Jensen, Carsten U. Niemann, Michael Gulrajani, Fanny Krantz, Todd Covey, Brian J. Lannutti, Adrian Wiestner, Sarah EM Herman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4797.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4797
Published: 15 July 2016
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Journal Articles

Harnessing the Fcμ Receptor for Potent and Selective Cytotoxic Therapy of Chronic Lymphocytic Leukemia

Bérengère Vire, Martin Skarzynski, Joshua D. Thomas, Christopher G. Nelson, Alexandre David, Georg Aue, Terrence R. Burke, Jr, Christoph Rader, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7510–7520.
DOI: https://doi.org/10.1158/0008-5472.CAN-14-2030
Published: 14 December 2014
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Includes: Supplementary data
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Abstract 2624: The novel Bruton's tyrosine kinase inhibitor ACP-196 shows in vivo efficacy against human chronic lymphocytic leukemia cells xenografted to the NSG mouse model

Carsten U. Niemann, Arnau Montraveta, Sarah E. M. Herman, Tim Ingallinera, Tjeerd Barf, Dolors Colomer, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2624.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2624
Published: 01 October 2014
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Journal Articles

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

Warren Fiskus, Nakhle Saba, Min Shen, Mondana Ghias, Jinyun Liu, Soumyasri Das Gupta, Lata Chauhan, Rekha Rao, Sumedha Gunewardena, Kevin Schorno, Christopher P. Austin, Kami Maddocks, John Byrd, Ari Melnick, Peng Huang, Adrian Wiestner, Kapil N. Bhalla
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2520–2532.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-2033
Published: 30 April 2014
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Abstract LB-141: Potent single agent activity of Ibrutinib (PCI-32765) in patients with chronic lymphocytic leukemia (CLL): clinical and translational results from an ongoing phase II study.

Adrian Wiestner, Sarah Herman, Rashida Mustafa, Janet Valdez, Jade Jones, Nakhle Saba, Andrew Lipsky, Diane C. Arthur, Gerald Marti, Francine Thomas, Irina Maric, Stefania Pittaluga, Xin Tian, Susan Soto, Georg Aue, Mohammed Z. Farooqui
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-141.
DOI: https://doi.org/10.1158/1538-7445.AM2013-LB-141
Published: 15 April 2013
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Journal Articles

Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Alba Navarro, Guillem Clot, Cristina Royo, Pedro Jares, Anastasia Hadzidimitriou, Andreas Agathangelidis, Vasilis Bikos, Nikos Darzentas, Theodora Papadaki, Itziar Salaverria, Magda Pinyol, Xavier Puig, Jara Palomero, Maria Carmela Vegliante, Virgina Amador, Alejandra Martinez-Trillos, Lenka Stefancikova, Adrian Wiestner, Wyndham Wilson, Christiane Pott, Maria Jose Calasanz, Nicola Trim, Wendy Erber, Birgitta Sander, German Ott, Andreas Rosenwald, Dolors Colomer, Eva Giné, Reiner Siebert, Armando Lopez-Guillermo, Kostas Stamatopoulos, Sílvia Beà, Elías Campo
Journal: Cancer Research
Cancer Res (2012) 72 (20): 5307–5316.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-1615
Published: 14 October 2012
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Includes: Supplementary data
Journal Articles

Abstract 5080: Improved ZAP-70 assay using two clones: Multiple methods of analysis, and a scoring system

Heba A. Degheidy, David Venzon, Mohammed Farooqui, Fatima Abbasi, Diane Arthur, Adrian Wiestner, Maryalice Stetler-Stevenson, Marti Gerald
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5080.
DOI: https://doi.org/10.1158/1538-7445.AM2011-5080
Published: 15 April 2011
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Journal Articles

Abstract 3493: ON 01910. Na, a clinical trial stage multi-kinase inhibitor, induces apoptosis in chronic lymphocytic leukemia (CLL) cells through inhibition of PI3K/AKT and activation of the JNK pathway resulting in NOXA and BIM upregulation

Patricia Perez-Galan, Colby M. Chapman, Xiameng Sun, Federica Gibellini, Poching Liu, Nalini Raghavachari, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3493.
DOI: https://doi.org/10.1158/1538-7445.AM10-3493
Published: 15 April 2010
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Journal Articles

Abstract #4540: Resistance to bortezomib in mantle cell lymphoma is associated with differentiation towards a plasma cell phenotype

Patricia Perez-Galan, Helena Mora-Jensen, Marc Weniger, Colby Chapman, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4540.
Published: 01 May 2009
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Journal Articles

Abstract #3654: ON 01910.Na, a novel clinical grade PLK-1 inhibitor, selectively induces apoptosis in human B-cell chronic lymphocytic leukemia (B-CLL)

Colby Chapman, Patricia Perez-Galan, Adrian Wiestner
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3654.
Published: 01 May 2009
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