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Journal Articles

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

M. Danielle Bareford, Margaret A. Park, Adly Yacoub, Hossein A. Hamed, Yong Tang, Nichola Cruickshanks, Patrick Eulitt, Nisan Hubbard, Gary Tye, Matthew E. Burow, Paul B. Fisher, Richard G. Moran, Kenneth P. Nephew, Steven Grant, Paul Dent

Cancer Res (2011) 71 (14): 4955–4967.

https://doi.org/10.1158/0008-5472.CAN-11-0898

Published: 14 July 2011

View article titled, Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death in vitro and in vivo

Hossein A. Hamed, Clint Mitchell, Paul Dent, Adly Yacoub, Gary Tye, Mary Danielle Bareford

Cancer Res (2011) 71 (8_Supplement): 5383.

https://doi.org/10.1158/1538-7445.AM2011-5383

Published: 15 April 2011

View article titled, Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death in vitro and in vivo

Journal Articles

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca²⁺-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy Allegood, Dieter Häussinger, Roland Reinehr, Andrew Larner, Sarah Spiegel, Paul B. Fisher, Christina Voelkel-Johnson, Besim Ogretmen, Steven Grant, Paul Dent

Cancer Res (2010) 70 (15): 6313–6324.

https://doi.org/10.1158/0008-5472.CAN-10-0999

Published: 28 July 2010

View article titled, Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Includes: Supplementary data

Journal Articles

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Rupesh Dash, Joanna E. Richards, Zhao-zhong Su, Sujit K. Bhutia, Belal Azab, Mohamed Rahmani, Girija Dasmahapatra, Adly Yacoub, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, Paul B. Fisher

Cancer Res (2010) 70 (12): 5034–5045.

https://doi.org/10.1158/0008-5472.CAN-10-0563

Published: 14 June 2010

View article titled, Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Includes: Supplementary data

Journal Articles

Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

Sujit K. Bhutia, Rupesh Dash, Swadesh K. Das, Belal Azab, Zhao-zhong Su, Seok-Geun Lee, Steven Grant, Adly Yacoub, Paul Dent, David T. Curiel, Devanand Sarkar, Paul B. Fisher

Cancer Res (2010) 70 (9): 3667–3676.

https://doi.org/10.1158/0008-5472.CAN-09-3647

Published: 28 April 2010

View article titled, Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

Includes: Supplementary data

Journal Articles

PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Adly Yacoub, Hossein A. Hamed, Jeremy Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Ogretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, Paul Dent

Cancer Res (2010) 70 (3): 1120–1129.

https://doi.org/10.1158/0008-5472.CAN-09-4043

Published: 31 January 2010

View article titled, PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Includes: Supplementary data

Journal Articles

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Nathan T. Ihle, Robert Lemos, Jr., Peter Wipf, Adly Yacoub, Clint Mitchell, Doris Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, Garth Powis

Cancer Res (2009) 69 (1): 143–150.

https://doi.org/10.1158/0008-5472.CAN-07-6656

Published: 31 December 2008

View article titled, Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Journal Articles

MEK1/2 inhibitors and 17AAG synergize to kill human hepatoma cells in vitro via suppression of c-FLIP-s levels and activation of the extrinsic apoptosis pathway

Adly Yacoub, Guo Zhang, Margaret PARK, Hossein Hamed, Clint Mitchell, Mohammed Rhamani, Shigang Lin, David Curiel, Michael Hagan, Paul Fisher, Steven Grant, Paul Dent

Cancer Res (2008) 68 (9_Supplement): 4011.

Published: 01 May 2008

View article titled, MEK1/2 inhibitors and 17AAG synergize to kill human hepatoma cells in vitro via suppression of c-FLIP-s levels and activation of the extrinsic apoptosis pathway

Journal Articles

Caspase-, cathepsin- and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Paul Dent, Adly Yacoub, Margaret Park, Mohammed Rhamani, Hossein Hamed, Pankaj Gupta, David Hanna, Devavand Sarkar, Irina Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, Michael Hagan, David Curiel, Steven Grant, Paul Fisher

Cancer Res (2008) 68 (9_Supplement): 3528.

Published: 01 May 2008

View article titled, Caspase-, cathepsin- and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Journal Articles

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K and JNK1-3 pathway signaling.

Adly Yacoub, Pankaj Gupta, Hossein Hamed, Margaret PARK, Mohammed Rhamani, David Hanna, Guo Zhang, Devavand Sarkar, Irina Lebedeva, Luni Emdad, Costas Koumenis, David Curiel, Steven Grant, Paul Fisher, Paul Dent

Cancer Res (2008) 68 (9_Supplement): 3526.

Published: 01 May 2008

View article titled, Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K and JNK1-3 pathway signaling.

Journal Articles

OSU-03012 stimulates PERK-dependent increases in HSP70 expression, attenuating its lethal actions in transformed cells

Margaret Park, Adly Yacoub, Mohammed Rahmani, Guo Zhang, Lori Hart, Michael Hagan, Stuart Calderwood, Michael Sherman, Costas Koumenis, Sarah Spiegel, Ching-Shih Chen, Martin Graf, David Curiel, Paul Fisher, Steven Grant, Paul Dent

Cancer Res (2008) 68 (9_Supplement): 2565.

Published: 01 May 2008

View article titled, OSU-03012 stimulates PERK-dependent increases in HSP70 expression, attenuating its lethal actions in transformed cells

Journal Articles

RLIP76 Is a Major Determinant of Radiation Sensitivity

Sanjay Awasthi, Sharad S. Singhal, Sushma Yadav, Jyotsana Singhal, Kenneth Drake, Aalok Nadkar, Ewa Zajac, Dilki Wickramarachchi, Nancy Rowe, Adly Yacoub, Paul Boor, Seema Dwivedi, Paul Dent, Wendy E. Jarman, Berchmans John, Yogesh C. Awasthi

Cancer Res (2005) 65 (14): 6022–6028.

https://doi.org/10.1158/0008-5472.CAN-05-0968

Published: 15 July 2005

View article titled, RLIP76 Is a Major Determinant of Radiation Sensitivity

Includes: Supplementary data

Journal Articles

Strategy for promoting apoptosis selectively in pancreatic cancer cells

Irina V. Lebedeva, Zhao-Zhong Su, Devanand Sarkar, Rahul V. Gopalkrishnan, Samuel Waxman, Adly Yacoub, Paul Dent, Paul B. Fisher

Cancer Res (2004) 64 (7_Supplement): 680–681.

Published: 01 April 2004

View article titled, Strategy for promoting apoptosis selectively in pancreatic cancer cells

Journal Articles

GST-MDA-7 radiosensitizes non-established glioma cells in vitro

Adly Yacoub, Rahul Gopalkrishnan, William C. Broaddus, Steven Grant, Myrna R. Rosenfeld, C. David James, Paul B. Fisher, Paul Dent

Cancer Res (2004) 64 (7_Supplement): 1116.

Published: 01 April 2004

View article titled, GST-MDA-7 radiosensitizes non-established glioma cells in vitro

Journal Articles

Differential ability of mutant H-RAS and mutant K-RAS to enhance radiation-induced signaling and cell survival

Ruben Caron, Adly Yacoub, Michael P. Hagan, Steven Grant, Paul Dent

Cancer Res (2004) 64 (7_Supplement): 297.

Published: 01 April 2004

View article titled, Differential ability of mutant H-RAS and mutant K-RAS to enhance radiation-induced signaling and cell survival

Journal Articles

The DNA Repair Activity of Human Redox/Repair Protein APE/Ref-1 Is Inactivated by Phosphorylation

Adly Yacoub, Mark R. Kelley, Walter A. Deutsch

Cancer Res (1997) 57 (24): 5457–5459.

Published: 01 December 1997

View article titled, The DNA Repair Activity of Human Redox/Repair Protein APE/Ref-1 Is Inactivated by Phosphorylation

NARROW

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death in vitro and in vivo

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca²⁺-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

MEK1/2 inhibitors and 17AAG synergize to kill human hepatoma cells in vitro via suppression of c-FLIP-s levels and activation of the extrinsic apoptosis pathway

Caspase-, cathepsin- and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K and JNK1-3 pathway signaling.

OSU-03012 stimulates PERK-dependent increases in HSP70 expression, attenuating its lethal actions in transformed cells

RLIP76 Is a Major Determinant of Radiation Sensitivity

Strategy for promoting apoptosis selectively in pancreatic cancer cells

GST-MDA-7 radiosensitizes non-established glioma cells in vitro

Differential ability of mutant H-RAS and mutant K-RAS to enhance radiation-induced signaling and cell survival

The DNA Repair Activity of Human Redox/Repair Protein APE/Ref-1 Is Inactivated by Phosphorylation

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