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Journal Articles

The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma

R. Taylor Durall, Julianna Huang, Luke Wojenski, Yeying Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Joshua O. Nash, Pedro L. Ballester, Scott Davidson, Adam Shlien, Emmanuel Sotirakis, Fabien Bertaux, Vincent Dubus, Jia Luo, Catherine J. Wu, Derin B. Keskin, Kyle P. Eagen, Geoffrey I. Shapiro, Christopher A. French
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-2545
Published: 11 October 2023
View article titled, The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma
Open the PDF for The BRD4-NUT fusion alone drives malignant transformation of NUT carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 6545: Investigating secondary findings in a pediatric cancer cohort: preliminary findings

Safa Majeed, Stephenie Prokopec, Brianne Laverty, Vallijah Subasri, Michael Taylor, Yvonne Bombard, Trevor Pugh, Adam Shlien, Anita Villani, David Malkin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6545.
https://doi.org/10.1158/1538-7445.AM2023-6545
Published: 04 April 2023
View article titled, Abstract 6545: Investigating secondary findings in a pediatric cancer cohort: preliminary findings
Journal Articles

Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Guillaume Bourque, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Paul Moorehead, Michael F. Moran, Daniel A. Morgenstern, Sapna Oberoi, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, Stephanie Villeneuve, James A. Whitlock, David Malkin, on behalf of the PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4509.
https://doi.org/10.1158/1538-7445.AM2023-4509
Published: 04 April 2023
View article titled, Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program
Journal Articles

Abstract 53: Zebrafish tp53 mutants recapitulate Li-Fraumeni syndrome phenotypes and provide a preclinical platform for evaluating tumor preventive compounds

Kim Kobar, Erin Burnley, Lissandra Tuzi, Craig Midgen, Adam Shlien, David Malkin, Sergey V. Prykhozhij, Jason N. Berman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 53.
https://doi.org/10.1158/1538-7445.AM2023-53
Published: 04 April 2023
View article titled, Abstract 53: Zebrafish <em>tp53</em> mutants recapitulate Li-Fraumeni syndrome phenotypes and provide a preclinical platform for evaluating tumor preventive compounds
Journal Articles

Abstract LB177: Widespread hypertranscription in aggressive human cancer

Matthew Zatzman, Fabio Fuligni, Ryan Ripsman, Tannu Suwal, Lisa-Monique Edward, Rob Denroche, Gun Ho Jang, Faiyaz Notta, Steven Gallinger, Saravana P. Selvanathan, Jeffrey Toretsky, Matthew D. Hellmann, Uri Tabori, Annie Huang, Adam Shlien
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB177.
https://doi.org/10.1158/1538-7445.AM2022-LB177
Published: 15 June 2022
View article titled, Abstract LB177: Widespread hypertranscription in aggressive human cancer
Journal Articles

Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Michael F. Moran, Daniel A. Morgenstern, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2022-5224
Published: 15 June 2022
View article titled, Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada
Journal Articles

Abstract 2021: Wilms tumor and pure erythroid leukemia arising from the same clone in an adolescent

Anita Villani, Winnie Lo, Yisu Li, Mohamed Abdelhaleem, Mary Shago, Federico Comitani, My Linh Thibodeau, Sarah Alexander, Uri Tabori, David Malkin, Adam Shlien, Jack Brzezinski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2021.
https://doi.org/10.1158/1538-7445.AM2022-2021
Published: 15 June 2022
View article titled, Abstract 2021: Wilms tumor and pure erythroid leukemia arising from the same clone in an adolescent
Journal Articles

Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma

Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien, Jonathan D. Wasserman
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5625–5637.
https://doi.org/10.1158/0008-5472.CAN-21-0761
Published: 15 November 2021
View article titled, Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Open the PDF for Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Thierry Alcindor, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Abha Gupta, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael F. Moran, Daniel A. Morgenstern, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 636.
https://doi.org/10.1158/1538-7445.AM2021-636
Published: 01 July 2021
View article titled, Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

Melissa A. Galati, Karl P. Hodel, Miki S. Gams, Sumedha Sudhaman, Taylor Bridge, Walter J. Zahurancik, Nathan A. Ungerleider, Vivian S. Park, Ayse B. Ercan, Lazar Joksimovic, Iram Siddiqui, Robert Siddaway, Melissa Edwards, Richard de Borja, Dana Elshaer, Jiil Chung, Victoria J. Forster, Nuno M. Nunes, Melyssa Aronson, Xia Wang, Jagadeesh Ramdas, Andrea Seeley, Tomasz Sarosiek, Gavin P. Dunn, Jonathan N. Byrd, Oz Mordechai, Carol Durno, Alberto Martin, Adam Shlien, Eric Bouffet, Zucai Suo, James G. Jackson, Cynthia E. Hawkins, Cynthia J. Guidos, Zachary F. Pursell, Uri Tabori
Journal: Cancer Research
Cancer Res (2020) 80 (24): 5606–5618.
https://doi.org/10.1158/0008-5472.CAN-20-0624
Published: 15 December 2020
View article titled, Cancers from Novel <em>Pole</em>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade
Open the PDF for Cancers from Novel <em>Pole</em>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract SY09-03: PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative

David Malkin, Jason N. Berman, Jennifer A. Chan, Avram Denburg, Rebecca Deyell, David Eisenstadt, Conrad Fernandez, Stephanie Grover, Abha Gupta, Cynthia Hawkings, Meredith Irwin, Nada Jabado, Steven Jones, Daniel Morgenstern, Michael Moran, Rod Rasesekh, Adam Shlien, Daniel Sinnett, Poul Sorensen, Patrick Sullivan, Michael Taylor, Anita Villani, Jim Whitlock
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): SY09-03.
https://doi.org/10.1158/1538-7445.AM2020-SY09-03
Published: 15 August 2020
View article titled, Abstract SY09-03: PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative
Journal Articles

Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Jason N. Berman, Jennifer A. Chan, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael Moran, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5413.
https://doi.org/10.1158/1538-7445.AM2020-5413
Published: 15 August 2020
View article titled, Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer
Journal Articles

Abstract IA18: Clinically relevant mutational signatures in childhood cancer

Adam Shlien
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA18.
https://doi.org/10.1158/1538-7445.PEDCA19-IA18
Published: 15 July 2020
View article titled, Abstract IA18: Clinically relevant mutational signatures in childhood cancer
Journal Articles

Abstract B07: Prospective germline next-generation sequencing in pediatric patients with neuroblastoma identifies frequent alterations in genes involved in DNA damage repair

Sarah Cohen-Gogo, Karin Langenberg-Ververgaert, Anita Villani, Winnie Lo, Ted Young, Nisha Kanwar, Scott Davidson, Nathaniel Anderson, Bailey Gallinger, Mehdi Layeghifard, Larissa Waldman, Daniel Morgenstern, Ledia Brunga, Stephen Meyn, David Malkin, Adam Shlien, Meredith Irwin
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B07.
https://doi.org/10.1158/1538-7445.PEDCA19-B07
Published: 15 July 2020
View article titled, Abstract B07: Prospective germline next-generation sequencing in pediatric patients with neuroblastoma identifies frequent alterations in genes involved in DNA damage repair
Journal Articles

Abstract IA02: Novel strategies for early cancer detection and prevention: The Li-Fraumeni syndrome story

David Malkin, Nicholas Light, Valli Subrasi, Benjamin Brew, Sangeetha Paramathas, Arash Nabbi, Sergei Prykhozhij, Trevor Pugh, Jason Berman, Anna Goldenberg, Adam Shlien
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA02.
https://doi.org/10.1158/1538-7445.PEDCA19-IA02
Published: 15 July 2020
View article titled, Abstract IA02: Novel strategies for early cancer detection and prevention: The Li-Fraumeni syndrome story
Journal Articles

Abstract 3666: The genomic landscape and clonal evolution of tumours arising in TP53 mutation carriers

Nicholas Light, Matthew Zatzman, Nathaniel Anderson, Vallijah Subasri, Mehdi Layeghifard, Ana Novokmet, James Tran, Richard de Borja, Fabio Fuligni, Joshua Schiffman, David Malkin, Adam Shlien
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3666.
https://doi.org/10.1158/1538-7445.AM2019-3666
Published: 01 July 2019
View article titled, Abstract 3666: The genomic landscape and clonal evolution of tumours arising in <em>TP53</em> mutation carriers
Journal Articles

Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer

Nathaniel D. Anderson, Richard de Borja, Matthew D. Young, Fabio Fuligni, Andrej Rosic, Nicola D. Roberts, Nischalan Pillay, Jeffrey A. Toretsky, Yoshida Akihiko, Tatsuhiro Shibata, Markus Metzler, Gino Somers, Stephen W. Scherer, Adrienne M. Flanagan, Peter J. Campbell, Joshua D. Schiffman, Mary Shago, Ludmil B. Alexandrov, Jay S. Wunder, Irene L. Andrulis, David Malkin, Sam Behjati, Adam Shlien
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2506.
https://doi.org/10.1158/1538-7445.AM2019-2506
Published: 01 July 2019
View article titled, Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer
Journal Articles

Abstract 1639: Predictive modeling of cancer-type in Li-Fraumeni syndrome

Vallijah Subasri, Nicholas Light, Benjamin Brew, Nathaniel Anderson, Adam Shlien, Anna Goldenberg, David Malkin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1639.
https://doi.org/10.1158/1538-7445.AM2019-1639
Published: 01 July 2019
View article titled, Abstract 1639: Predictive modeling of cancer-type in Li-Fraumeni syndrome
Journal Articles

Abstract 3409: Age of cancer onset differentiated by sex and TP53 codon change in Li-Fraumeni Syndrome patient population

Lauren Erdman, Ben Brew, Jason Berman, Adam Shlien, Andrea Doria, David Malkin, Anna Goldenberg
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3409.
https://doi.org/10.1158/1538-7445.AM2017-3409
Published: 01 July 2017
View article titled, Abstract 3409: Age of cancer onset differentiated by sex and TP53 codon change in Li-Fraumeni Syndrome patient population
Journal Articles

Abstract 973: Methylation accurately predicts age of cancer onset in patients with Li Fraumeni Syndrome

Benjamin M. Brew, David Malkin, Lauren Erdman, Andrea Doria, Jason Berman, Adam Shlien, Tanya Guha, Ana Novokmet, Anna Goldenberg
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2017-973
Published: 01 July 2017
View article titled, Abstract 973: Methylation accurately predicts age of cancer onset in patients with Li Fraumeni Syndrome