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Journal Articles

Abstract CT016: First-in-human (FIH) phase 1 trial of the oral first-in-class covalent Werner helicase (WRN) inhibitor RO7589831 in patients with microsatellite instable (MSI) and/or mismatch repair deficient (dMMR) advanced solid tumors

Free
Timothy A. Yap, Natalie Cook, Elisa Fontana, Erica S. Tsang, Oliver Bechter, Marwan Fakih, Kristoffer S. Rohrberg, Emiliano Calvo, Elena M. Elez, Meredith Pelster, John H. Strickler, Ignacio Matos, Adam Sharp, Sophia Blake, David Dejardin, Stephen Fowler, Nina Henkel, Michael Hettich, Angelika Lahr, Ting Liu, Christophe Meille, Piergiorgio Pettazzoni, Denise Reeves, Barbara Romagnoli, Sotirios Sotiriou, Daniel Waterkamp, Yali Fu, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT016.
https://doi.org/10.1158/1538-7445.AM2025-CT016
Published: 25 April 2025
View articletitled, Abstract CT016: First-in-human (FIH) phase 1 trial of the oral first-in-class covalent Werner helicase (WRN) inhibitor RO7589831 in patients with microsatellite instable (MSI) and/or mismatch repair deficient (dMMR) advanced solid tumors
Journal Articles

Abstract LB011: Combining CBP/p300 and PARP inhibitors to enhance anti-tumor efficacy in lethal prostate cancer

Free
Orly Richter, Sumaira Sardar, Lakshmi Ravindranath, Christopher McNair, Xiaofeng Su, Adam Sharp, Johann de Bono, Kris Frese, Karen Knudsen, Ayesha Shafi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB011.
https://doi.org/10.1158/1538-7445.AM2025-LB011
Published: 25 April 2025
View articletitled, Abstract LB011: Combining CBP/p300 and PARP inhibitors to enhance anti-tumor efficacy in lethal prostate cancer
Journal Articles

Abstract 1145: Morphological evaluation of chromosomal instability in circulating tumor cells and prediction of taxane resistance in metastatic prostate cancer: a prespecified sub-analysis of the CARD trial

Free
Ossian Longoria, Jan Rekowski, Santosh Gupta, Nick Beije, Klaus Pantel, Eleni Efstathiou, Cora Sternberg, Daniel Castellano, Karim Fizazi, Bertrand Tombal, Adam Sharp, Oliver Sartor, Sandrine Mace, Christine Geffriaud-Ricouard, Richard Wenstrup, Ronald de Wit, Johann de Bono
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1145.
https://doi.org/10.1158/1538-7445.AM2025-1145
Published: 21 April 2025
View articletitled, Abstract 1145: Morphological evaluation of chromosomal instability in circulating tumor cells and prediction of taxane resistance in metastatic prostate cancer: a prespecified sub-analysis of the CARD trial
Journal Articles

Abstract CT087: A phase 1/2, open-label, randomized, dose-finding and dose expansion study of gedatolisib in combination with darolutamide in metastatic castration-resistant prostate cancer (mCRPC)

Free
Adam Sharp, Alice Bernard-Tessier, Delphine Borchiellini, Johann de Bono, Karim Fizazi, Gwenaelle Gravis, David Lorente, Hakim Mahammedi, Begona Mellado, David Olmos, Simon Pacey, Jose Piulats, Sara P. Ramirez, Igor Gorbatchevsky, Elisabeth Heath
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT087.
https://doi.org/10.1158/1538-7445.AM2024-CT087
Published: 05 April 2024
View articletitled, Abstract CT087: A phase 1/2, open-label, randomized, dose-finding and dose expansion study of gedatolisib in combination with darolutamide in metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract CT035: Proof-of-concept and preliminary efficacy of triple IAP blockade to maximize immunogenic cell death and induce efficient adaptive immune response: First report on the ASTEROID phase 1 trial

Free
Crescens Tiu, Wing Yau, Victoria Sanchez-Perez, Giovanni Codacci-Pisanelli, Ching Leung, Eden S. Andrews, Bristi Basu, Anna Zachariou, Toby Prout, Mona Parmar, Alison Turner, Xiaoran Lai, Zhulin Yin, Karen E. Swales, Syed Haider, Thomas Lund, Diego C. Dos Reis, Tatiany L. Silveira, Alan S. Dunlop, Ann-Marie Baker, Bora Gurel, Ana Ferreira, Claudia Bertan, Nina Tunariu, Edward W. Johnston, Alistair Ring, Tencho Tenev, Tomoko Smyth, Simone Jueliger, Udai Banerji, Johann S. de Bono, Alec Paschalis, Adam Sharp, Anna Minchom, Christina Yap, Pascal Meier, Juanita S. Lopez
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT035.
https://doi.org/10.1158/1538-7445.AM2024-CT035
Published: 05 April 2024
View articletitled, Abstract CT035: Proof-of-concept and preliminary efficacy of triple IAP blockade to maximize immunogenic cell death and induce efficient adaptive immune response: First report on the ASTEROID phase 1 trial
Journal Articles

Abstract 7116: Targeting the CBP/p300 axis in lethal prostate cancer impacts DNA repair

Free
Sumaira Sardar, Lakshmi Ravindranath, Christopher McNair, Saswati N. Chand, Wei Yuan, Denisa Bogdan, Jonathan Welti, Adam Sharp, Matthew Schiewer, Lisa Butler, Johann de Bono, Kris Frese, Nigel Brooks, Neil Pegg, Karen Knudsen, Ayesha A. Shafi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7116.
https://doi.org/10.1158/1538-7445.AM2024-7116
Published: 22 March 2024
View articletitled, Abstract 7116: Targeting the CBP/p300 axis in lethal prostate cancer impacts DNA repair
Journal Articles

Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer

Free
Daniel Westaby, Juan M. Jimenez-Vacas, Ines Figueiredo, Claire Pettinger, Bora Gurel, Denisa Bogdan, Jan Rekowski, Lorenzo Buroni, Antje Neeb, Ruth Riisnaes, Mateus Crespo, Susana Miranda, Ana Ferreira, Daniel Nava Rodrigues, George Seed, Claudia Bertan, Maria de los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Rafael Grochot, Khobe Chandran, Andreas Varkaris, Steven P. Balk, Wei Yuan, Suzanne Carreira, Peter S. Nelson, Michael Haffner, Eva Corey, Johann de Bono, Adam Sharp
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B020.
https://doi.org/10.1158/1538-7445.PRCA2023-B020
Published: 02 June 2023
View articletitled, Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer
Journal Articles

Abstract B074: Targeting CBP/p300 and its downstream transcriptional machinery in advanced PCa

Free
Sumaira Sardar, Lakshmi Ravindranath, Christopher McNair, Saswati Chand, Wei Yuan, Denisa Bogdan, Jon Welti, Adam Sharp, Matthew Schiewer, Lisa Butler, Johann DeBono, Kris Frese, Nigel Brooks, Neil Pegg, Karen Knudsen, Ayesha A. Shafi
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B074.
https://doi.org/10.1158/1538-7445.PRCA2023-B074
Published: 02 June 2023
View articletitled, Abstract B074: Targeting CBP/p300 and its downstream transcriptional machinery in advanced PCa
Journal Articles

Abstract CT093: Preliminary evidence of antitumor activity of Ipatasertib (Ipat) and Atezolizumab (A) in glioblastoma (GBM) patients (pts) with PTEN loss in the Phase 1 Ice-CAP trial (NCT03673787)

Free
Crescens Tiu, Wing Hing Yau, Liam C. Welsh, Timothy L. Jones, Anna Zachariou, Toby Prout, Mona Parmar, Alison J. Turner, Robert W. Daly, Christina Yap, Mateus Crespo, Bora Gurel, Ruth M. Riisnaes, Shaun A. DeCordova, Karen E. Swales, Udai Banerji, Anna R. Minchom, Adam Sharp, Johann S. de Bono, Juanita S. Lopez
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT093.
https://doi.org/10.1158/1538-7445.AM2023-CT093
Published: 14 April 2023
View articletitled, Abstract CT093: Preliminary evidence of antitumor activity of Ipatasertib (Ipat) and Atezolizumab (A) in glioblastoma (GBM) patients (pts) with PTEN loss in the Phase 1 Ice-CAP trial (NCT03673787)
Journal Articles

Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients

Free
Benedetta Lombardi, Paola Marco-Casanova, Athanasios Karapetsas, Mya Hornett, Edit Lukacs, Ko Sugibayashi, Sabina Cosulich, Adam Dowson, Ganesh Moorthy, Jessica Brown, Timothy A. Yap, Alison M. Schram, Judith Balmana, Stephen J. Luen, Seock-Ah Im, Adam Sharp, Richard Baird, Elizabeth A. Harrington, Spiros Linardopoulos
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT269.
https://doi.org/10.1158/1538-7445.AM2023-CT269
Published: 14 April 2023
View articletitled, Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients
Journal Articles

Abstract 1449: Targeting CBP/p300 and its downstream transcriptional machinery in advanced prostate cancer

Free
Sumaira Sardar, Lakshmi Ravindranath, Christopher McNair, Saswati Chand, Wei Yuan, Denisa Bogdan, Jon Welti, Adam Sharp, Matthew Schiewer, Lisa Butler, Johann de Bono, Kris Frese, Nigel Brooks, Neil Pegg, Karen Knudsen, Ayesha Shafi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1449.
https://doi.org/10.1158/1538-7445.AM2023-1449
Published: 04 April 2023
View articletitled, Abstract 1449: Targeting CBP/p300 and its downstream transcriptional machinery in advanced prostate cancer
Journal Articles

Abstract 3415: The neutrophil-to-lymphocyte ratio (NLR) reflects intratumor myeloid derived suppressor cell (MDSC) infiltration in metastatic castration-resistant prostate cancers (mCRPC)

Free
Christina Guo, Jan Rekowski, Mateus Crespo, Bora Gurel, Wei Yuan, Adam Sharp, Rafael Grochot, Khobe Chandran, Semini Sumanasuriya, Ana Ferreira, Andrea Alimonti, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3415.
https://doi.org/10.1158/1538-7445.AM2022-3415
Published: 15 June 2022
View articletitled, Abstract 3415: The neutrophil-to-lymphocyte ratio (NLR) reflects intratumor myeloid derived suppressor cell (MDSC) infiltration in metastatic castration-resistant prostate cancers (mCRPC)
Journal Articles

Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations

Free
Timothy A. Yap, Seock-Ah Im, Alison M. Schram, Adam Sharp, Judith Balmana, Richard D. Baird, Jessica S. Brown, Maria Schwaederle, Elizabeth A. Pilling, Ganesh Moorthy, Spiros Linardopoulos, Adam Dowson, Carol Pound, Edit Lukacs, Sabina Cosulich, Stephen J. Luen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT007.
https://doi.org/10.1158/1538-7445.AM2022-CT007
Published: 15 June 2022
View articletitled, Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations
Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Free
Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
View articletitled, Abstract 2807: HER3 is an actionable target in advanced prostate cancer
Journal Articles

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Free
Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigues, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1087–1100.
https://doi.org/10.1158/0008-5472.CAN-20-1807
Published: 15 February 2022
View articletitled, JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer
Open the PDF for JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Open Access
Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, PCF/SU2C International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
View articletitled, HER3 Is an Actionable Target in Advanced Prostate Cancer
Open the PDF for HER3 Is an Actionable Target in Advanced Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB035: B7-H3 as a therapeutic target in prostate cancer

Free
Christina Guo, Ines Figueiredo, Bora Gurel, Matues Crespo, Jan Rekowski, Suzanne Carreira, Antje Neeb, Adam Sharp, Maria D. Fenor de la Maza, Pasquale Rescigno, Khobe Chandran, Ana Ferreira, Ruth Riisnaes, Susana Miranda, Rita Pereira, Veronica Gil, George Seed, Claudia Bertan, Chloe Baker, Wei Yuan, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB035.
https://doi.org/10.1158/1538-7445.AM2021-LB035
Published: 01 July 2021
View articletitled, Abstract LB035: B7-H3 as a therapeutic target in prostate cancer
Journal Articles

Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors

Free
Bora Gurel, Pasquale Rescigno, Wei Yuan, Rita Pereira, Mateus Crespo, Mattia Rediti, Ines Figueiredo, Maialen Barrero, Diletta Bianchini, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Alec Paschalis, Adam Sharp, George Seed, Ruth Riisnaes, Claudia Bertan, Suzanne Carreira, Johann S. De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-075.
https://doi.org/10.1158/1538-7445.AM2020-LB-075
Published: 15 August 2020
View articletitled, Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors
Journal Articles

Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer

Free
Shangze Li, Ka-wing Fong, Galina Gritsina, Ali Zhang, Jonathan C. Zhao, Jung Kim, Adam Sharp, Wei Yuan, Caterina Aversa, Ximing J. Yang, Peter S. Nelson, Felix Y. Feng, Arul M. Chinnaiyan, Johann S. de Bono, Colm Morrissey, Matthew B. Rettig, Jindan Yu
Journal: Cancer Research
Cancer Res (2020) 80 (10): 2072.
https://doi.org/10.1158/0008-5472.CAN-20-0768
Published: 15 May 2020
View articletitled, Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Open the PDF for Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer in another window
Journal Articles

Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer

Free
Shangze Li, Ka-wing Fong, Galina Gritsina, Ali Zhang, Jonathan C. Zhao, Jung Kim, Adam Sharp, Wei Yuan, Caterina Aversa, Ximing J. Yang, Peter S. Nelson, Felix Y. Feng, Arul M. Chinnaiyan, Johann S. de Bono, Colm Morrissey, Matthew B. Rettig, Jindan Yu
Journal: Cancer Research
Cancer Res (2019) 79 (10): 2580–2592.
https://doi.org/10.1158/0008-5472.CAN-18-2812
Published: 15 May 2019
View articletitled, Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Open the PDF for Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer in another window
Includes: Supplementary data