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Adam J. Dupuy
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Journal Articles

Abstract 1998: ABCB1 promotes uveal melanoma cell resistance to FR900359 and identifies a tumor cell subpopulation with a distinct gene expression signature

Sarina Dion Murray, Jesse D. Riordan, Eric R. Anderson, Michael D. Onken, Kendall J. Blumer, Adam J. Dupuy, Christopher S. Stipp
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1998.
https://doi.org/10.1158/1538-7445.AM2024-1998
Published: 22 March 2024
View articletitled, Abstract 1998: ABCB1 promotes uveal melanoma cell resistance to FR900359 and identifies a tumor cell subpopulation with a distinct gene expression signature
Journal Articles

Abstract A026: Identifying mechanisms to target in combination with trametinib to improve therapeutic efficacy in low-grade serous ovarian cancer

Rebekah M. Peplinski, Silvana Pedra Nobre, Jacob L. Schillo, Keely K. Ulmer, Yasmin A. Lyons, Jesse D. Riordan, Michael J. Goodheart, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): A026.
https://doi.org/10.1158/1538-7445.OVARIAN23-A026
Published: 04 March 2024
View articletitled, Abstract A026: Identifying mechanisms to target in combination with trametinib to improve therapeutic efficacy in low-grade serous ovarian cancer
Journal Articles

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Aria Vaishnavi, Joseph Juan, Maebh Jacob, Christopher Stehn, Eric E. Gardner, Michael T. Scherzer, Sophia Schuman, J. Edward Van Veen, Brandon Murphy, Christopher S. Hackett, Adam J. Dupuy, Steven A. Chmura, Louise van der Weyden, Justin Y. Newberg, Annie Liu, Karen Mann, Alistair G. Rust, William A. Weiss, Conan G. Kinsey, David J. Adams, Allie Grossmann, Michael B. Mann, Martin McMahon
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4261–4273.
https://doi.org/10.1158/0008-5472.CAN-21-3214
Published: 15 November 2022
View articletitled, Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis
Open the PDF for Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract B08: Identification and characterization of Rho family GTPases as drivers of drug resistance in BRAFV600 mutant melanoma

Jacob L. Schillo, Charlotte R. Feddersen, Afshin Varzavand, Hayley R. Vaughn, Lexy S. Wadsworth, Andrew P. Voigt, Eliot Y. Zhu, Jesse D. Riordan, Christopher S. Stipp, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B08.
https://doi.org/10.1158/1538-7445.MEL2019-B08
Published: 02 October 2020
View articletitled, Abstract B08: Identification and characterization of Rho family GTPases as drivers of drug resistance in BRAFV600 mutant melanoma
Journal Articles

Abstract PR17: Sleeping Beauty mutagenesis reveals a Src-dependent DBL GEF family signaling mechanism driving MAPK inhibitor resistance in BRAF mutant melanoma

Charlotte R. Feddersen, Jacob Schillo, Afshin Varzavand, Hayley Vaughn, Andrew Voight, Eliot Zhu, Jesse D Riordan, Christopher S. Stipp, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR17.
https://doi.org/10.1158/1538-7445.MEL2019-PR17
Published: 02 October 2020
View articletitled, Abstract PR17: Sleeping Beauty mutagenesis reveals a Src-dependent DBL GEF family signaling mechanism driving MAPK inhibitor resistance in BRAF mutant melanoma
Journal Articles

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma

Charlotte R. Feddersen, Jacob L. Schillo, Afshin Varzavand, Hayley R. Vaughn, Lexy S. Wadsworth, Andrew P. Voigt, Eliot Y. Zhu, Brooke M. Jennings, Sarah A. Mullen, Jeremy Bobera, Jesse D. Riordan, Christopher S. Stipp, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2019) 79 (19): 5074–5087.
https://doi.org/10.1158/0008-5472.CAN-19-0244
Published: 01 October 2019
View articletitled, Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma
Open the PDF for Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB-096: A gain-of-function screen identifies drivers of drug resistance in BRAFV600E melanoma cell lines

Charlotte R. Feddersen, Jacob L. Schillo, Hayley R. Vaughn, Andrew P. Voigt, Eliot Y. Zhu, Lexy S. Wadsworth, Christopher S. Stipp, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-096.
https://doi.org/10.1158/1538-7445.AM2018-LB-096
Published: 01 July 2018
View articletitled, Abstract LB-096: A gain-of-function screen identifies drivers of drug resistance in BRAFV600E melanoma cell lines
Journal Articles

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors

Barbara R. Tschida, Nuri A. Temiz, Timothy P. Kuka, Lindsey A. Lee, Jesse D. Riordan, Carlos A. Tierrablanca, Robert Hullsiek, Sandra Wagner, Wendy A. Hudson, Michael A. Linden, Khalid Amin, Pauline J. Beckmann, Rachel A. Heuer, Aaron L. Sarver, Ju Dong Yang, Lewis R. Roberts, Joseph H. Nadeau, Adam J. Dupuy, Vincent W. Keng, David A. Largaespada
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6576–6588.
https://doi.org/10.1158/0008-5472.CAN-17-2281
Published: 30 November 2017
View articletitled, Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Open the PDF for Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors in another window
Includes: Supplementary data
Journal Articles

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer

Cristian Suárez-Cabrera, Rita M. Quintana, Ana Bravo, M. Llanos Casanova, Angustias Page, Josefa P. Alameda, Jesús M. Paramio, Alicia Maroto, Javier Salamanca, Adam J. Dupuy, Angel Ramírez, Manuel Navarro
Journal: Cancer Research
Cancer Res (2017) 77 (6): 1357–1368.
https://doi.org/10.1158/0008-5472.CAN-16-1586
Published: 14 March 2017
View articletitled, A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer
Open the PDF for A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 526: Identification of novel cancer immunotherapy targets using Sleeping Beauty mutagenesis

Laura M. Rogers, Adam J. Dupuy, George J. Weiner
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 526.
https://doi.org/10.1158/1538-7445.AM2016-526
Published: 15 July 2016
View articletitled, Abstract 526: Identification of novel cancer immunotherapy targets using Sleeping Beauty mutagenesis
Journal Articles

Abstract 4378: Discovery and characterization of two novel drivers of hepatocellular carcinoma

Charlotte R. Feddersen, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4378.
https://doi.org/10.1158/1538-7445.AM2016-4378
Published: 15 July 2016
View articletitled, Abstract 4378: Discovery and characterization of two novel drivers of hepatocellular carcinoma
Journal Articles

Abstract 4192: Identification of novel genetic drivers of vulvar carcinoma in a Sleeping Beauty model of spontaneous cancer

Amy Guimaraes-Young, Traci Neff, David K. Meyerholz, Adam J. Dupuy, Michael J. Goodheart
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4192.
https://doi.org/10.1158/1538-7445.AM2015-4192
Published: 01 August 2015
View articletitled, Abstract 4192: Identification of novel genetic drivers of vulvar carcinoma in a Sleeping Beauty model of spontaneous cancer
Journal Articles

Abstract A14: A forward genetic screen for genes that cooperate with PTEN in lung cancer development

Timothy K. Starr, Raha Allaei, M. Gerard O'Sullivan, Aaron L. Sarver, Adam J. Dupuy, Nancy A. Jenkins, Neal G. Copeland, David A. Largaespada
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A14.
https://doi.org/10.1158/0008-5472.FBCR09-A14
Published: 28 October 2014
View articletitled, Abstract A14: A forward genetic screen for genes that cooperate with PTEN in lung cancer development
Journal Articles

Abstract 4182: A screen for genes that define the strong gender bias nature of hepatocellular carcinoma using a transposon mutagenesis murine model

Vincent W. Keng, Barbara J. Ryan, Kevin A.T. Silverstein, Aaron Sarver, Danhua Fan, Adam J. Dupuy, Nancy A. Jenkins, Neal G. Copeland, David A. Largaespada
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4182.
https://doi.org/10.1158/1538-7445.AM10-4182
Published: 15 April 2010
View articletitled, Abstract 4182: A screen for genes that define the strong gender bias nature of hepatocellular carcinoma using a transposon mutagenesis murine model
Journal Articles

Abstract 2199: A murine insertional mutagenesis screen to identify oncogenes and tumor suppressor genes involved in Schwann cell tumorigenesis

David A. Largaespada, Eric P. Rahrmann, Vincent W. Keng, H B. Clark, Adam J. Dupuy, Lino Tessarollo, Nancy A. Jenkins, Neal G. Copeland, Nancy Ratner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2199.
https://doi.org/10.1158/1538-7445.AM10-2199
Published: 15 April 2010
View articletitled, Abstract 2199: A murine insertional mutagenesis screen to identify oncogenes and tumor suppressor genes involved in Schwann cell tumorigenesis
Journal Articles

Abstract 1188: Cell-of-origin determines genetic selection and defines T-cell acute lymphocytic leukemia sub-types in mouse models

Katherine E. Berquam-Vrieze, Kishore Nannapaneni, Oksana Zagorodna, Charles Mullighan, David K. Meyerholz, Neal Copeland, Nancy Jenkins, C. Michael Knudson, Todd Scheetz, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1188.
https://doi.org/10.1158/1538-7445.AM10-1188
Published: 15 April 2010
View articletitled, Abstract 1188: Cell-of-origin determines genetic selection and defines T-cell acute lymphocytic leukemia sub-types in mouse models
Journal Articles

Abstract 249: A Sleeping Beauty screen in mice identifies Zmiz1 as a candidate cancer gene in human squamous cell carcinomas

Laura M. Rogers, Brian L. Swick, David K. Meyerholz, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 249.
https://doi.org/10.1158/1538-7445.AM10-249
Published: 15 April 2010
View articletitled, Abstract 249: A Sleeping Beauty screen in mice identifies Zmiz1 as a candidate cancer gene in human squamous cell carcinomas
Journal Articles

Abstract 236: Sleeping Beauty transposon integration within the Dlk1-Dio3 imprinted domain is associated with hepatocellular carcinoma development

Jesse D. Riordan, Vincent W. Keng, Barbara J. Ryan, Kelly M. Podetz-Pedersen, Neal G. Copeland, Nancy A. Jenkins, David A. Largaespada, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 236.
https://doi.org/10.1158/1538-7445.AM10-236
Published: 15 April 2010
View articletitled, Abstract 236: Sleeping Beauty transposon integration within the Dlk1-Dio3 imprinted domain is associated with hepatocellular carcinoma development
Journal Articles

Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Lara S. Collier, David J. Adams, Christopher S. Hackett, Laura E. Bendzick, Keiko Akagi, Michael N. Davies, Miechaleen D. Diers, Fausto J. Rodriguez, Aaron M. Bender, Christina Tieu, Ilze Matise, Adam J. Dupuy, Neal G. Copeland, Nancy A. Jenkins, J. Graeme Hodgson, William A. Weiss, Robert B. Jenkins, David A. Largaespada
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8429–8437.
https://doi.org/10.1158/0008-5472.CAN-09-1760
Published: 28 October 2009
View articletitled, Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality
Open the PDF for Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality in another window
Includes: Supplementary data
Journal Articles

A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice

Adam J. Dupuy, Laura M. Rogers, Jinsil Kim, Kishore Nannapaneni, Timothy K. Starr, Pentao Liu, David A. Largaespada, Todd E. Scheetz, Nancy A. Jenkins, Neal G. Copeland
Journal: Cancer Research
Cancer Res (2009) 69 (20): 8150–8156.
https://doi.org/10.1158/0008-5472.CAN-09-1135
Published: 14 October 2009
View articletitled, A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice
Open the PDF for A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice in another window
Includes: Supplementary data