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Journal Articles

Abstract 406: Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader

Yihan Liu, Abhijit Parolia, Lianchao Liu, Tongchen He, Yuanyuan Qiao, Sanjana Eyunni, Jie Luo, Zhen Wang, Arul Chinnaiyan, Ke Ding

Cancer Res (2025) 85 (8_Supplement_1): 406.

https://doi.org/10.1158/1538-7445.AM2025-406

Published: 21 April 2025

View article titled, Abstract 406: Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader

Journal Articles

Abstract 3825: Divergent evolution of FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity

Cancer Res (2025) 85 (8_Supplement_1): 3825.

https://doi.org/10.1158/1538-7445.AM2025-3825

Published: 21 April 2025

View article titled, Abstract 3825: Divergent evolution of FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity

Journal Articles

Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice

Sanjana Eyunni, Abhijit Parolia, Eleanor Young, James Matthew George, Rahul Mannan, Sandra E. Carson, Yuping Zhang, Jean Tien, Mustapha Jaber, Jie Luo, Matthew Pang, Rohit Mehra, Xuhong Cao, Fengyun Su, Rui Wang, Marcin Cieslik, Dong Kee Lee, Jianming Xu, Arul M. Chinnaiyan

Cancer Res (2024) 84 (6_Supplement): 1433.

https://doi.org/10.1158/1538-7445.AM2024-1433

Published: 22 March 2024

View article titled, Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice

Journal Articles

Abstract 6602: Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

Lanbo Xiao, Tongchen He, Olaf Klingbeil, Young Eleanor, Xiaoli Wu, Yuanyuan Qiao, Abhijit Parolia, Sanjana Eyunni, Rahul Mannan, Somnath Mahapatra, NamHoon Kim, Heng Zheng, Fengyun Su, Xuhong Cao, Susanta Samajdar, Murali Ramachandra, Christopher R. Vakoc, Arul M. Chinnaiyan

Cancer Res (2024) 84 (6_Supplement): 6602.

https://doi.org/10.1158/1538-7445.AM2024-6602

Published: 22 March 2024

View article titled, Abstract 6602: Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

Journal Articles

Abstract PR-007: H3.3K27M diffuse midline gliomas are sensitive to SWI/SNF chromatin remodeler degradation

Mateus Mota, Stefan Sweha, Matt Pun, Siva Kumar Natarajan, Yujie Ding, Chan Chung, Debra Hawes, Fusheng Yang, Alexander Judkins, Susanta Samajdar, Xuhong Cao, Lanbo Xiao, Abhijit Parolia, Arul Chinnaiyan, Sriram Venneti

Cancer Res (2024) 84 (5_Supplement_1): PR-007.

https://doi.org/10.1158/1538-7445.BRAIN23-PR-007

Published: 04 March 2024

View article titled, Abstract PR-007: H3.3K27M diffuse midline gliomas are sensitive to SWI/SNF chromatin remodeler degradation

Journal Articles

Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis

Sanjana Eyunni, Abhijit Parolia, Eleanor Young, James George, Mustapha Jaber, Lanbo Xiao, Fengyun Su, Rui Wang, Xuhong Cao, Arul Chinnaiyan

Cancer Res (2023) 83 (11_Supplement): A056.

https://doi.org/10.1158/1538-7445.PRCA2023-A056

Published: 02 June 2023

View article titled, Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis

Journal Articles

Abstract A055: NSD2 is a requisite and targetable subunit of the AR/FOXA1 neo-enhanceosome complex in prostate cancer cells

Cancer Res (2023) 83 (11_Supplement): A055.

https://doi.org/10.1158/1538-7445.PRCA2023-A055

Published: 02 June 2023

View article titled, Abstract A055: NSD2 is a requisite and targetable subunit of the AR/FOXA1 neo-enhanceosome complex in prostate cancer cells

Journal Articles

Abstract 2036: Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Michael Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, Marcin Cieslik

Cancer Res (2023) 83 (7_Supplement): 2036.

https://doi.org/10.1158/1538-7445.AM2023-2036

Published: 04 April 2023

View article titled, Abstract 2036: Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Journal Articles

Abstract 1685: Overcoming acquired resistance to PROTAC degraders

Tongchen He, Caleb Cheng, Abhijit Parolia, Alex Hopkins, Yuanyuan Qiao, Lanbo Xiao, Arul Chinnaiyan

Cancer Res (2023) 83 (7_Supplement): 1685.

https://doi.org/10.1158/1538-7445.AM2023-1685

Published: 04 April 2023

View article titled, Abstract 1685: Overcoming acquired resistance to PROTAC degraders

Journal Articles

Abstract 3592: Targeting SWI/SNF ATPases in enhancer-addicted human cancers

Cancer Res (2022) 82 (12_Supplement): 3592.

https://doi.org/10.1158/1538-7445.AM2022-3592

Published: 15 June 2022

View article titled, Abstract 3592: Targeting SWI/SNF ATPases in enhancer-addicted human cancers

Journal Articles

Abstract 5469: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

Cancer Res (2022) 82 (12_Supplement): 5469.

https://doi.org/10.1158/1538-7445.AM2022-5469

Published: 15 June 2022

View article titled, Abstract 5469: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

Journal Articles

Abstract 4420: Polytect, a robust algorithm to detect somatic mutations in polymorphic MHC/HLA genes

Michael Brodie Mumphrey, Abhijit Parolia, Chandan Kumar-Sinha, Marcin Cieslik

Cancer Res (2020) 80 (16_Supplement): 4420.

https://doi.org/10.1158/1538-7445.AM2020-4420

Published: 15 August 2020

View article titled, Abstract 4420: Polytect, a robust algorithm to detect somatic mutations in polymorphic MHC/HLA genes

Journal Articles

Abstract 3437: Cistromically-dominant class2 mutants of FOXA1 de-repress WNT signaling to drive prostate cancer metastasis

Abhijit Parolia, Marcin Cieslik, Sandra Carson, Shih-Chun Chu, Lanbo Xiao, Takahiro Ouchi, Mustapha Jaber, Yuping Zhang, Pankaj Vats, Xuhong Cao, Arul Chinnaiyan

Cancer Res (2020) 80 (16_Supplement): 3437.

https://doi.org/10.1158/1538-7445.AM2020-3437

Published: 15 August 2020

View article titled, Abstract 3437: Cistromically-dominant class2 mutants of FOXA1 de-repress WNT signaling to drive prostate cancer metastasis

Journal Articles

Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors

Mary Guan, Mengyao Tan, Abhijit Parolia, Steve Kregel, Marcin Cieslik, Arul Chinnaiyan

Cancer Res (2019) 79 (13_Supplement): 4399.

https://doi.org/10.1158/1538-7445.AM2019-4399

Published: 01 July 2019

View article titled, Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors

Journal Articles

Abstract 4497: Distinct structural classes of activating FOXA1 alterations in prostate cancer progression

Abhijit Parolia, Marcin Cieslik, Shih-Chun Chu, Lanbo Xiao, Takahiro Ouchi, Yuping Zhang, Xiaoju Wang, Pankaj Vats, Xuhong Cao, Fengyun Su, Rui Wang, Felix Feng, Yi-Mi Wu, Robert Lonigro, Dan R. Robinson, Arul M. Chinnaiyan

Cancer Res (2019) 79 (13_Supplement): 4497.

https://doi.org/10.1158/1538-7445.AM2019-4497

Published: 01 July 2019

View article titled, Abstract 4497: Distinct structural classes of activating FOXA1 alterations in prostate cancer progression

Journal Articles

Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer

Cancer Res (2018) 78 (20): 5731–5740.

https://doi.org/10.1158/0008-5472.CAN-18-0941

Published: 15 October 2018

View article titled, Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer

Includes: Supplementary data

Journal Articles

Abstract 1945: Degradation of ERG transcription factor as a targeted therapy in B-cell and T-cell acute lymphoblastic leukemia

Xiaoju Wang, Caleb Cheng, Yuanyuan Qiao, Lanbo Xiao, Cynthia Wang, Abhijit Parolia, Arul Chinnaiyan

Cancer Res (2018) 78 (13_Supplement): 1945.

https://doi.org/10.1158/1538-7445.AM2018-1945

Published: 01 July 2018

View article titled, Abstract 1945: Degradation of ERG transcription factor as a targeted therapy in B-cell and T-cell acute lymphoblastic leukemia

Journal Articles

Abstract 975: Functional CRISPR screen towards identifying novel epigenetic co-factors of oncogenic AR-activity

Abhijit Parolia, Lanbo Xiao, Josh N. Vo, Marcin Cieslik, Xuhong Cao, Arul M. Chinnaiyan

Cancer Res (2018) 78 (13_Supplement): 975.

https://doi.org/10.1158/1538-7445.AM2018-975

Published: 01 July 2018

View article titled, Abstract 975: Functional CRISPR screen towards identifying novel epigenetic co-factors of oncogenic AR-activity

Journal Articles

Abstract 5834: Epigenetic re-programming sensitizes prostate cancer cells to anti-androgen therapy

Lanbo Xiao, Jean Ching-Yi Tien, Josh Vo, Abhijit Parolia, Lisha Wang, Mengyao Tan, Yuanyuan Qiao, Sudhanshu Shukla, Xiaoju Wang, Heng Zheng, Fengyun Su, Xuhong Cao, Arul Chinnaiyan

Cancer Res (2018) 78 (13_Supplement): 5834.

https://doi.org/10.1158/1538-7445.AM2018-5834

Published: 01 July 2018

View article titled, Abstract 5834: Epigenetic re-programming sensitizes prostate cancer cells to anti-androgen therapy

Journal Articles

Abstract 3347: Exploring the role of ASXL family of genes in enabling oncogenic AR-signaling in prostate cancer

Abhijit Parolia, Xuhong Cao, Arul Chinnaiyan

Cancer Res (2017) 77 (13_Supplement): 3347.

https://doi.org/10.1158/1538-7445.AM2017-3347

Published: 01 July 2017

View article titled, Abstract 3347: Exploring the role of ASXL family of genes in enabling oncogenic AR-signaling in prostate cancer

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Abstract 406: Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader

Abstract 3825: Divergent evolution of FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity

Abstract 1433: FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice

Abstract 6602: Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

Abstract PR-007: H3.3K27M diffuse midline gliomas are sensitive to SWI/SNF chromatin remodeler degradation

Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis

Abstract A055: NSD2 is a requisite and targetable subunit of the AR/FOXA1 neo-enhanceosome complex in prostate cancer cells

Abstract 2036: Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Abstract 1685: Overcoming acquired resistance to PROTAC degraders

Abstract 3592: Targeting SWI/SNF ATPases in enhancer-addicted human cancers

Abstract 5469: Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

Abstract 4420: Polytect, a robust algorithm to detect somatic mutations in polymorphic MHC/HLA genes

Abstract 3437: Cistromically-dominant class2 mutants of FOXA1 de-repress WNT signaling to drive prostate cancer metastasis

Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors

Abstract 4497: Distinct structural classes of activating FOXA1 alterations in prostate cancer progression

Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer

Abstract 1945: Degradation of ERG transcription factor as a targeted therapy in B-cell and T-cell acute lymphoblastic leukemia

Abstract 975: Functional CRISPR screen towards identifying novel epigenetic co-factors of oncogenic AR-activity

Abstract 5834: Epigenetic re-programming sensitizes prostate cancer cells to anti-androgen therapy

Abstract 3347: Exploring the role of ASXL family of genes in enabling oncogenic AR-signaling in prostate cancer

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