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Abdul R. Khokhar
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Journal Articles

Abstract 5361: DNA damage by platinum-based drugs induces p21-dependent recruitment of PCNA as a homotrimer into the inhibited G1-phase CDK complex

Guangan He, Jian Kuang, John Koomen, Ryuji Kobayashi, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5361.
https://doi.org/10.1158/1538-7445.AM2011-5361
Published: 15 April 2011
View articletitled, Abstract 5361: DNA damage by platinum-based drugs induces p21-dependent recruitment of PCNA as a homotrimer into the inhibited G1-phase CDK complex
Journal Articles

Abstract 2507: Defective Chk2 expression in cisplatin-resistant ovarian tumor cells impedes wild-type p53 function

Ismail M. Meraz, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2507.
https://doi.org/10.1158/1538-7445.AM10-2507
Published: 15 April 2010
View articletitled, Abstract 2507: Defective Chk2 expression in cisplatin-resistant ovarian tumor cells impedes wild-type p53 function
Journal Articles

Abstract 3513: The underlying basis for divergent cell cycle kinetics following checkpoint activation by cisplatin and a platinum (IV) analog

Guangan He, Jian Kuang, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3513.
https://doi.org/10.1158/1538-7445.AM10-3513
Published: 15 April 2010
View articletitled, Abstract 3513: The underlying basis for divergent cell cycle kinetics following checkpoint activation by cisplatin and a platinum (IV) analog
Journal Articles

Circumvention of drug resistance in human tumors harboring wild-type p53.

Zahid H. Siddik, Guangan He, Masayuki Watanabe, Kalpana Mujoo, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1273.
Published: 15 April 2006
View articletitled, Circumvention of drug resistance in human tumors harboring wild-type p53.
Journal Articles

p27 changes its binding to the Cdk4 and Cdk2 complexes during DAP-induced G1-phase checkpoint response

Zahid H. Siddik, Guangan He, John Koomen, Ryuji Kobayashi, Zaifeng Huang, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 534.
Published: 01 May 2005
View articletitled, p27 changes its binding to the Cdk4 and Cdk2 complexes during DAP-induced G1-phase checkpoint response
Journal Articles

Molecular and proteomic analysis of Cdk4 and Cdk2 complexes following G1-phase checkpoint response to DNA damage.

Zahid H. Siddik, Guangan He, John Koomen, Ryuji Kobayashi, Zai-Feng Huang, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 539.
Published: 01 April 2004
View articletitled, Molecular and proteomic analysis of Cdk4 and Cdk2 complexes following G1-phase checkpoint response to DNA damage.
Journal Articles

Axial Ligands and Alicyclic Ring Size Modulate the Activity and Biochemical Pharmacology of Ammine/Cycloalkylamine-Platinum(IV) Complexes in Tumor Cells Resistant to cis-Diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-Diaminocyclohexanetetrachloroplatinum(IV)

Motofumi Yoshida, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1994) 54 (17): 4691–4697.
Published: 01 September 1994
View articletitled, Axial Ligands and Alicyclic Ring Size Modulate the Activity and Biochemical Pharmacology of Ammine/Cycloalkylamine-Platinum(IV) Complexes in Tumor Cells Resistant to cis-Diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-Diaminocyclohexanetetrachloroplatinum(IV)
Open the PDF for Axial Ligands and Alicyclic Ring Size Modulate the Activity and Biochemical Pharmacology of Ammine/Cycloalkylamine-Platinum(IV) Complexes in Tumor Cells Resistant to cis-Diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-Diaminocyclohexanetetrachloroplatinum(IV) in another window
Journal Articles

Biochemical Pharmacology of Homologous Alicyclic Mixed Amine Platinum(II) Complexes in Sensitive and Resistant Tumor Cell Lines

Motofumi Yoshida, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1994) 54 (13): 3468–3473.
Published: 01 July 1994
View articletitled, Biochemical Pharmacology of Homologous Alicyclic Mixed Amine Platinum(II) Complexes in Sensitive and Resistant Tumor Cell Lines
Open the PDF for Biochemical Pharmacology of Homologous Alicyclic Mixed Amine Platinum(II) Complexes in Sensitive and Resistant Tumor Cell Lines in another window
Journal Articles

Cellular Pharmacology of Liposomal cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in A2780/S and A2780/PDD Cells

Insook Han, Yi-He Ling, Salaam Al-Baker, Abdul R. Khokhar, Roman Perez-Soler
Journal: Cancer Research
Cancer Res (1993) 53 (20): 4913–4919.
Published: 01 October 1993
View articletitled, Cellular Pharmacology of Liposomal cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in A2780/S and A2780/PDD Cells
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Journal Articles

Modulation of Cytotoxicity and Cellular Pharmacology of 1,2-Diaminocyclohexane Platinum(IV) Complexes Mediated by Axial and Equatorial Ligands

Yuichiro Kido, Abdul R. Khokhar, Salaam Al-Baken, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1993) 53 (19): 4567–4572.
Published: 01 October 1993
View articletitled, Modulation of Cytotoxicity and Cellular Pharmacology of 1,2-Diaminocyclohexane Platinum(IV) Complexes Mediated by Axial and Equatorial Ligands
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Journal Articles

Lipophilic Cisplatin Analogues Entrapped in Liposomes: Role of Intraliposomal Drug Activation in Biological Activity

Roman Perez-Soler, Abdul R. Khokhar
Journal: Cancer Research
Cancer Res (1992) 52 (22): 6341–6347.
Published: 01 November 1992
View articletitled, Lipophilic Cisplatin Analogues Entrapped in Liposomes: Role of Intraliposomal Drug Activation in Biological Activity
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Journal Articles

Increased Therapeutic Efficacy Induced by Tumor Necrosis Factor α Combined with Platinum Complexes and Whole-Body Hyperthermia in Rats

Shinji Ohno, Frederick R. Strebel, L. Clifton Stephens, Zahid H. Siddik, Masato Makino, Jim Klostergaard, Stephen P. Tomasovic, Abdul R. Khokhar, Joan M. C. Bull
Journal: Cancer Research
Cancer Res (1992) 52 (15): 4096–4101.
Published: 01 August 1992
View articletitled, Increased Therapeutic Efficacy Induced by Tumor Necrosis Factor α Combined with Platinum Complexes and Whole-Body Hyperthermia in Rats
Open the PDF for Increased Therapeutic Efficacy Induced by Tumor Necrosis Factor α Combined with Platinum Complexes and Whole-Body Hyperthermia in Rats in another window
Journal Articles

Effect of Carboplatin Combined with Whole Body Hyperthermia on Normal Tissue and Tumor in Rats

Shinji Ohno, Zahid H. Siddik, Hideo Baba, L. Clifton Stephens, Frederick R. Strebel, Jan Wondergem, Abdul R. Khokhar, Joan M. C. Bull
Journal: Cancer Research
Cancer Res (1991) 51 (11): 2994–3000.
Published: 01 June 1991
View articletitled, Effect of Carboplatin Combined with Whole Body Hyperthermia on Normal Tissue and Tumor in Rats
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Journal Articles

Phase I Clinical and Pharmacological Study of Liposome-entrapped cis-Bis-neodecanoato-trans-R,R,-1,2-diaminocyclohexane Platinum(II)

Roman Perez-Soler, Gabriel Lopez-Berestein, Julio Lautersztain, Salam Al-Baker, Karen Francis, Dede Macias-Kiger, Martin N. Raber, Abdul R. Khokhar
Journal: Cancer Research
Cancer Res (1990) 50 (14): 4254–4259.
Published: 01 July 1990
View articletitled, Phase I Clinical and Pharmacological Study of Liposome-entrapped cis-Bis-neodecanoato-trans-R,R,-1,2-diaminocyclohexane Platinum(II)
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Journal Articles

Increased Cytotoxicity and Reversal of Resistance to cis-Diamminedichloroplatinum(II) with Entrapment of cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in Multilamellar Lipid Vesicles

Roman Perez-Soler, Li Y. Yang, Benjamin Drewinko, Julio Lauterzstain, Abdul R. Khokhar
Journal: Cancer Research
Cancer Res (1988) 48 (16): 4509–4512.
Published: 01 August 1988
View articletitled, Increased Cytotoxicity and Reversal of Resistance to cis-Diamminedichloroplatinum(II) with Entrapment of cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in Multilamellar Lipid Vesicles
Open the PDF for Increased Cytotoxicity and Reversal of Resistance to cis-Diamminedichloroplatinum(II) with Entrapment of cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in Multilamellar Lipid Vesicles in another window
Journal Articles

Antitumor Activity against Human Tumor Samples of cis-Diamminedichloroplatinum(II) and Analogues at Equivalent in Vitro Myelotoxic Concentrations

Dominic Fan, Fraser L. Baker, Abdul R. Khokhar, Jaffer A. Ajani, Barbara Tomasovic, Robert A. Newman, William A. Brock, Elias Tueni, Gary Spitzer
Journal: Cancer Research
Cancer Res (1988) 48 (11): 3135–3139.
Published: 01 June 1988
View articletitled, Antitumor Activity against Human Tumor Samples of cis-Diamminedichloroplatinum(II) and Analogues at Equivalent in Vitro Myelotoxic Concentrations
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Journal Articles

Cellular Pharmacology of Liposomal cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in Mouse Resident Peritoneal Macrophages, Kupffer Cells, and Hepatocytes

Julio Lautersztain, Roman Perez-Soler, Jim Turpin, Abdul R. Khokhar, Zahid H. Siddik, Karmen Schmidt, Gabriel Lopez-Berestein
Journal: Cancer Research
Cancer Res (1988) 48 (5): 1300–1306.
Published: 01 March 1988
View articletitled, Cellular Pharmacology of Liposomal cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in Mouse Resident Peritoneal Macrophages, Kupffer Cells, and Hepatocytes
Open the PDF for Cellular Pharmacology of Liposomal cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in Mouse Resident Peritoneal Macrophages, Kupffer Cells, and Hepatocytes in another window
Journal Articles

Toxicity and Antitumor Activity of cis-Bis-cyclopentenecarboxylato-1,2-diaminocyclohexane Platinum(II) Encapsulated in Multilamellar Vesicles

R. Perez-Soler, Abdul R. Khokhar, M. P. Hacker, G. Lopez-Berestein
Journal: Cancer Research
Cancer Res (1986) 46 (12_Part_1): 6269–6273.
Published: 01 December 1986
View articletitled, Toxicity and Antitumor Activity of cis-Bis-cyclopentenecarboxylato-1,2-diaminocyclohexane Platinum(II) Encapsulated in Multilamellar Vesicles
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Journal Articles

Ascorbato(1,2-diaminocyclohexane):platinum(II) Complexes, a New Series of Water-soluble Antitumor Drugs

Miles P. Hacker, Abdul R. Khokhar, David B. Brown, John J. McCormack, Irwin H. Krakoff
Journal: Cancer Research
Cancer Res (1985) 45 (10): 4748–4753.
Published: 01 October 1985
View articletitled, Ascorbato(1,2-diaminocyclohexane):platinum(II) Complexes, a New Series of Water-soluble Antitumor Drugs
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