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Abdel-Majid Khatib
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Journal Articles

Abstract 1311: PCSK9 expression in liver sinusoidal endothelial cells during liver metastasis

Ander Martin-San Sebastian, Helena García-García, Géraldine Siegfried, Abdel-Majid Khatib, Iker Badiola
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1311.
https://doi.org/10.1158/1538-7445.AM2023-1311
Published: 04 April 2023
View articletitled, Abstract 1311: PCSK9 expression in liver sinusoidal endothelial cells during liver metastasis
Journal Articles

Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer

Mercedes Tomé, Angela Pappalardo, Fabienne Soulet, José Javier López, Jone Olaizola, Yannick Leger, Marielle Dubreuil, Amandine Mouchard, Delphine Fessart, Frédéric Delom, Vincent Pitard, Dominique Bechade, Mariane Fonck, Juan Antonio Rosado, François Ghiringhelli, Julie Déchanet-Merville, Isabelle Soubeyran, Geraldine Siegfried, Serge Evrard, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2019) 79 (19): 5008–5021.
https://doi.org/10.1158/0008-5472.CAN-19-0086
Published: 01 October 2019
View articletitled, Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Open the PDF for Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells

Tra-Ly Nguyen, Marie-Julie Nokin, Maxim Egorov, Mercedes Tomé, Clément Bodineau, Carmelo Di Primo, Lætitia Minder, Joanna Wdzieczak-Bakala, Maria Concepcion Garcia-Alvarez, Jérôme Bignon, Odile Thoison, Bernard Delpech, Georgiana Surpateanu, Yves-Michel Frapart, Fabienne Peyrot, Kahina Abbas, Silvia Terés, Serge Evrard, Abdel-Majid Khatib, Pierre Soubeyran, Bogdan I. Iorga, Raúl V. Durán, Pascal Collin
Journal: Cancer Research
Cancer Res (2018) 78 (18): 5384–5397.
https://doi.org/10.1158/0008-5472.CAN-18-0232
Published: 14 September 2018
View articletitled, mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells
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Includes: Supplementary data
Journal Articles

Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer

Cathy Quemener, Jessica Baud, Kevin Boyé, Alexandre Dubrac, Clotilde Billottet, Fabienne Soulet, Florence Darlot, Laurent Dumartin, Marie Sire, Renaud Grepin, Thomas Daubon, Fabienne Rayne, Harald Wodrich, Anne Couvelard, Raphael Pineau, Martin Schilling, Vincent Castronovo, Shih-Che Sue, Kim Clarke, Abderrahim Lomri, Abdel-Majid Khatib, Martin Hagedorn, Hervé Prats, Andreas Bikfalvi
Journal: Cancer Research
Cancer Res (2016) 76 (22): 6507–6519.
https://doi.org/10.1158/0008-5472.CAN-15-2864
Published: 14 November 2016
View articletitled, Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Abstract 696: Targeting the proprotein convertase PCSK6/PAECE4 abrogates human melanoma malignant phenotype

Geraldine Siegfried, Apolline Imbard, Serge Evrard, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 696.
https://doi.org/10.1158/1538-7445.AM2016-696
Published: 15 July 2016
View articletitled, Abstract 696: Targeting the proprotein convertase PCSK6/PAECE4 abrogates human melanoma malignant phenotype
Journal Articles

Abstract 2341: The Subtilisin-like proprotein convertases blockade inhibits the invasiveness of human primary melanoma with altered P53, CDKN2A and N-Ras genes

Claude Lalou, Nathalie Scamuffa, Marie-Pierre Podgorniak, Francois Plassa, Samia Mourah, Nadem Soufir, Nicolas Dumaz, Fabien Calvo, Nicole Basset-Seguin, Abdel-Majid KHATIB
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2341.
https://doi.org/10.1158/1538-7445.AM10-2341
Published: 15 April 2010
View articletitled, Abstract 2341: The Subtilisin-like proprotein convertases blockade inhibits the invasiveness of human primary melanoma with altered P53, CDKN2A and N-Ras genes
Journal Articles

Inhibition of Akt proto-oncogene activity and tumorigenecity by the Furin pro-peptide

Nathalie Scamuffa, Nabil Seidah, Fabien Calvo, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2747.
Published: 01 May 2008
View articletitled, Inhibition of Akt proto-oncogene activity and tumorigenecity by the Furin pro-peptide
Journal Articles

Opposing Function of the Proprotein Convertases Furin and PACE4 on Breast Cancer Cells' Malignant Phenotypes: Role of Tissue Inhibitors of Metalloproteinase-1

Marion Lapierre, Geraldine Siegfried, Nathalie Scamuffa, Yannick Bontemps, Fabien Calvo, Nabil G. Seidah, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2007) 67 (19): 9030–9034.
https://doi.org/10.1158/0008-5472.CAN-07-0807
Published: 01 October 2007
View articletitled, Opposing Function of the Proprotein Convertases Furin and PACE4 on Breast Cancer Cells' Malignant Phenotypes: Role of Tissue Inhibitors of Metalloproteinase-1
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Journal Articles

Inactivation of furin by its naturally occurring inhibitor pro-furin abolish breast cancer cells malignant phenotypes and tumorigenecity in mice.

Nathalie Scamuffa, Nabil Seidah, Ajoy Basak, Fabien Calvo, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1235–1236.
Published: 15 April 2006
View articletitled, Inactivation of furin by its naturally occurring inhibitor pro-furin abolish breast cancer cells malignant phenotypes and tumorigenecity in mice.
Journal Articles

Selective inhibition of proprotein convertases inhibits IGF-1-mediate activation of the mitogenesis and survival signalling pathways in colon cancer cells

Geraldine Siegfried, Ajoy Basak, Nathalie Scamuffa, Liming Ma, Ying Feng, Michel Chrétien, Nabil G. Seidah, Abdel-Majid Khatib
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1305.
Published: 01 May 2005
View articletitled, Selective inhibition of proprotein convertases inhibits IGF-1-mediate activation of the mitogenesis and survival signalling pathways in colon cancer cells
Journal Articles

Use of cDNA arrays and ProteinChip array SELDI-TOF MS to identify transcipts and/or proteins regulated by proprotein convertase activity in colon and breast cancer cells.

Abdel-Majid Khatib, Michel Chretien
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 842.
Published: 01 April 2004
View articletitled, Use of cDNA arrays and ProteinChip array SELDI-TOF MS to identify transcipts and/or proteins regulated by proprotein convertase activity in colon and breast cancer cells.
Journal Articles

The Proteolytic Processing of Pro-Platelet-derived Growth Factor-A at RRKR86 by Members of the Proprotein Convertase Family Is Functionally Correlated to Platelet-derived Growth Factor-A-induced Functions and Tumorigenicity

Géraldine Siegfried, Abdel-Majid Khatib, Suzanne Benjannet, Michel Chrétien, Nabil G. Seidah
Journal: Cancer Research
Cancer Res (2003) 63 (7): 1458–1463.
Published: 01 April 2003
View articletitled, The Proteolytic Processing of Pro-Platelet-derived Growth Factor-A at RRKR86 by Members of the Proprotein Convertase Family Is Functionally Correlated to Platelet-derived Growth Factor-A-induced Functions and Tumorigenicity
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Journal Articles

Inhibition of Hepatic Endothelial E-Selectin Expression by C-raf Antisense Oligonucleotides Blocks Colorectal Carcinoma Liver Metastasis

Abdel-Majid Khatib, Lucia Fallavollita, Edward V. Wancewicz, Brett P. Monia, Pnina Brodt
Journal: Cancer Research
Cancer Res (2002) 62 (19): 5393–5398.
Published: 01 October 2002
View articletitled, Inhibition of Hepatic Endothelial E-Selectin Expression by C-raf Antisense Oligonucleotides Blocks Colorectal Carcinoma Liver Metastasis
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Journal Articles

Rapid Induction of Cytokine and E-Selectin Expression in the Liver in Response to Metastatic Tumor Cells

Abdel-Majid Khatib, Maria Kontogiannea, Lucia Fallavollita, Bruce Jamison, Sarkis Meterissian, Pnina Brodt
Journal: Cancer Research
Cancer Res (1999) 59 (6): 1356–1361.
Published: 15 March 1999
View articletitled, Rapid Induction of Cytokine and E-Selectin Expression in the Liver in Response to Metastatic Tumor Cells
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