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Aaron D. Schimmer
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Journal Articles

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Yongwei Su, Jenna L. Carter, Xinyu Li, Yu Fukuda, Ashley Gray, John Lynch, Holly Edwards, Jun Ma, Patrick Schreiner, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Steven A. Buck, Shondra M. Pruett-Miller, Katie Hege-Hurrish, Camenzind Robinson, Xinan Qiao, Shuang Liu, Shuangshuang Wu, Guan Wang, Jing Li, Joshua E. Allen, Varun V. Prabhu, Aaron D. Schimmer, Dhananjay Joshi, Shiva Kalhor-Monfared, Iain D. G. Watson, Richard Marcellus, Methvin B. Isaac, Rima Al-awar, Jeffrey W. Taub, Hai Lin, John D. Schuetz, Yubin Ge
Journal: Cancer Research
Cancer Res (2024) 84 (7): 1084–1100.
https://doi.org/10.1158/0008-5472.CAN-23-2659
Published: 01 April 2024
View article titled, The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Open the PDF for The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML

Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L. Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2024-1646
Published: 22 March 2024
View article titled, Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML
Journal Articles

Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells

Matthew Tcheng, Marcela Gronda, Rose Hurren, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Mark D. Minden, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5898.
https://doi.org/10.1158/1538-7445.AM2024-5898
Published: 22 March 2024
View article titled, Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells
Journal Articles

Abstract 7053: Serine phosphorylation marks proteins for degradation by the mitochondrial matrix protease, ClpXP

Yue Feng, Monica M. Goncalves, Yulia Jitkova, Alexander Keszei, Chaitra Sarathy, Vincent Trudel, Jonathan St-Germain, Matthew Tcheng, Yongran Yan, Rose Hurren, Matthew Schultz, Brian Raught, Andrei Yudin, Mohammad Mazhab-Jafari, Siavash Vahidi, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7053.
https://doi.org/10.1158/1538-7445.AM2024-7053
Published: 22 March 2024
View article titled, Abstract 7053: Serine phosphorylation marks proteins for degradation by the mitochondrial matrix protease, ClpXP
Journal Articles

Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability

Nathan Duong, Dilshad H. Khan, Geethu E. Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D. Brown, Brian Raught, Andrea Arruda, Hong Chang, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadavecchio, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 333.
https://doi.org/10.1158/1538-7445.AM2023-333
Published: 04 April 2023
View article titled, Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability
Journal Articles

Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness

Geethu Emily Thomas, Grace Egan, Laura Gracia Prat, Aaron Botham, Veronique Voisin, Elias Orouji, Jordan Chin, Boaz Nachmias, Kerstin B. Kaufmann, Neil Maclean, Rose Hurren, Marcela Gronda, Xiaoming Wang, Dilshad H. Khan, Rashim P. Singh, Andrea Arruda, Mark Minden, Gary D. Bader, John E. Dick, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3099.
https://doi.org/10.1158/1538-7445.AM2021-3099
Published: 01 July 2021
View article titled, Abstract 3099: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness
Journal Articles

Abstract 2407: Serine and threonine phosphorylation marks proteins for degradation by ClpXP

Yue Feng, Yulia Jitkova, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2407.
https://doi.org/10.1158/1538-7445.AM2021-2407
Published: 01 July 2021
View article titled, Abstract 2407: Serine and threonine phosphorylation marks proteins for degradation by ClpXP
Journal Articles

Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML

Grace Egan, G.E. Thomas, Parasvi Patel, Veronique Voisin, Rose Hurren, Neil MacLean, Razq Hakem, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3098.
https://doi.org/10.1158/1538-7445.AM2021-3098
Published: 01 July 2021
View article titled, Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Journal Articles

Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP

Samir H. Barghout, Ahmed Aman, Zachary Blatman, Karen Arevalo, Geethu Thomas, Neil MacLean, Xiaoming Wang, Rose Hurren, Troy Ketela, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6321.
https://doi.org/10.1158/1538-7445.AM2020-6321
Published: 15 August 2020
View article titled, Abstract 6321: BEND3 modulates sensitivity to the UBA1 inhibitor TAK-243 by regulating expression of the multidrug transporter BCRP
Journal Articles

Abstract 3784: The metabolic enzyme Hexokinase 2 localizes to the nucleus and regulates stemness in AML through a kinase independent mechanism

Grace Egan, Geethu E. Thomas, Parasvi S. Patel, Jordan Chin, Aaron Botham, Rose Hurren, Neil MacLean, Razq Hakem, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3784.
https://doi.org/10.1158/1538-7445.AM2020-3784
Published: 15 August 2020
View article titled, Abstract 3784: The metabolic enzyme Hexokinase 2 localizes to the nucleus and regulates stemness in AML through a kinase independent mechanism
Journal Articles

Abstract 2699: Targeting an ubiquitin-activating enzyme in small-cell lung cancer (SCLC)

Safa Majeed, Mansi K. Aparnathi, Lifang Song, Aaron D. Schimmer, Ming S. Tsao, Geoffrey Liu, Benjamin H. Lok
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2699.
https://doi.org/10.1158/1538-7445.AM2019-2699
Published: 01 July 2019
View article titled, Abstract 2699: Targeting an ubiquitin-activating enzyme in small-cell lung cancer (SCLC)
Journal Articles

Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

Jo Ishizawa, Sarah F. Zarabi, R Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, John Man Chun Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2720.
https://doi.org/10.1158/1538-7445.AM2019-2720
Published: 01 July 2019
View article titled, Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Journal Articles

Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)

Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3003.
https://doi.org/10.1158/1538-7445.AM2019-3003
Published: 01 July 2019
View article titled, Abstract 3003: Inhibiting the mitochondrial enzyme phosphatidylserine decarboxylase (PISD) reduces stemness and increases differentiation in acute myeloid leukemia (AML)
Journal Articles

Abstract 5489: Characterization of mitochondrial STAT3 (mitostat3) function and the mitoStat3 interactome as a therapeutic strategy for multiple myeloma

Serges P. Tsofack, Aaron Botham, Zhihua Li, Ellen Nong Wei, Danielle Croucher, Ioulia Jitkova, Neil MacLean, Aaron D. Schimmer, Brian Raught, Suzanne Trudel
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5489.
https://doi.org/10.1158/1538-7445.AM2018-5489
Published: 01 July 2018
View article titled, Abstract 5489: Characterization of mitochondrial STAT3 (mitostat3) function and the mitoStat3 interactome as a therapeutic strategy for multiple myeloma
Journal Articles

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Eric A. Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Andrew Mitchell, Rose Hurren, Xiao Ming Wang, Marcela Gronda, Ezel Boyaci, Barbara Bojko, Mark Minden, Shrivani Sriskanthadevan, Alessandro Datti, Jeffery L. Wrana, Andrea Edginton, Janusz Pawliszyn, Jamie W. Joseph, Joe Quadrilatero, Aaron D. Schimmer, Paul A. Spagnuolo
Journal: Cancer Research
Cancer Res (2015) 75 (12): 2478–2488.
https://doi.org/10.1158/0008-5472.CAN-14-2676
Published: 14 June 2015
View article titled, Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death
Open the PDF for Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death in another window
Includes: Supplementary data
Journal Articles

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

Aleksandra Pandyra, Peter J. Mullen, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Zhihua Li, Suzanne Trudel, Karl S. Lang, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4772–4782.
https://doi.org/10.1158/0008-5472.CAN-14-0130
Published: 01 September 2014
View article titled, Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
Open the PDF for Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop in another window
Includes: Supplementary data
Journal Articles

Abstract 1887: Bone marrow-derived stromal cells and hypoxia promote glutamine dependency in leukemias.

Polina Matre, Rodrigo O. Jacamo, Ying Wang, Jing Wang, R Eric Davis, Michael Andreeff, Aaron D. Schimmer, Marina Konopleva
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1887.
https://doi.org/10.1158/1538-7445.AM2013-1887
Published: 15 April 2013
View article titled, Abstract 1887: Bone marrow-derived stromal cells and hypoxia promote glutamine dependency in leukemias.
Journal Articles

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Siyuan Song, Tania Christova, Stephen Perusini, Solmaz Alizadeh, Ren-Yue Bao, Bryan W. Miller, Rose Hurren, Yulia Jitkova, Marcela Gronda, Methvin Isaac, Babu Joseph, Ratheesh Subramaniam, Ahmed Aman, Anh Chau, Donna E. Hogge, Scott J. Weir, James Kasper, Aaron D. Schimmer, Rima Al-awar, Jeff L. Wrana, Liliana Attisano
Journal: Cancer Research
Cancer Res (2011) 71 (24): 7628–7639.
https://doi.org/10.1158/0008-5472.CAN-11-2745
Published: 15 December 2011
View article titled, Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers
Open the PDF for Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 746: Acquired bortezomib resistance in non-small cell lung cancer is associated with overexpression of the mutated β5 proteasome subunit

Leonie H.A.M. de Wilt, Gerrit Jansen, Yehuda G. Assaraf, Johan van Meerloo, Jacqueline Cloos, Aaron D. Schimmer, Godefridus J. Peters, Frank A.E. Kruyt
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 746.
https://doi.org/10.1158/1538-7445.AM2011-746
Published: 15 April 2011
View article titled, Abstract 746: Acquired bortezomib resistance in non-small cell lung cancer is associated with overexpression of the mutated β5 proteasome subunit
Journal Articles

Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells

Reza Beheshti Zavareh, Rose Hurren, Marcela Gronda, Mahadeo A. Sukhai, Craig D. Simpson, Xiaoming Wang, Neil A. MacLean, Troy Ketela, Jason Moffat, David R. Rose, Harry Schachter, James W. Dennis, Aaron D. Schimmer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1484.
https://doi.org/10.1158/1538-7445.AM2011-1484
Published: 15 April 2011
View article titled, Abstract 1484: Inhibition of the glycosylation enzyme Mgat1 blocks migration, invasion and metastasis of malignant cells