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Journal Articles

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, Rindert Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Thomas Look, Guoliang Qing, M. Celeste Simon, Hui Feng
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4417–4430.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-2153
Published: 01 September 2021
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Includes: Supplementary data
Journal Articles

Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma

Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Paul M. Park, Logan H. Sigua, Ken Morita, Amy S. Conway, Amanda L. Robichaud, Antonio Perez-Atayde, Melissa Bikowitz, Taylor Quinn, Olaf Wiest, Ernst Schonbrunn, Martha Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2318.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2318
Published: 01 July 2021
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Journal Articles

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Zhiwei Dong, Kok Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N. Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M. Levee, Zuag Paj Her, Cassie J. Howe, Xiaonan Hou, Janine H. van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S. Lehman, Alexander Meves, Gina L. Razidlo, Komal S. Rathi, S. John Weroha, A. Thomas Look, Jan M. van Deursen, Hu Li, Jennifer J. Westendorf, John M. Maris, Shizhen Zhu
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2995–3007.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1890
Published: 01 June 2021
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Includes: Supplementary data
Journal Articles

Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Ting Tao, Hui Shi, Adam D. Durbin, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3450.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3450
Published: 15 August 2020
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Journal Articles

Abstract 3408: Targeting cancer cells with potent activators of the PP2A protein phosphatase tumor suppressor

Ken Morita, Shuning He, Radosław P. Nowak, Jinhua Wang, Mark W. Zimmerman, Cong Fu, Adam D. Durbin, Nathanael S. Gray, Eric S. Fischer, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3408.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3408
Published: 15 August 2020
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Journal Articles

Abstract B22: Cell state and lineage specification are controlled by epigenetic landscapes regulating the core transcriptional regulatory circuitry in pediatric neuroblastoma

Mark W. Zimmerman, Adam D. Durbin, Brian J. Abraham, Alla Berezovskaya, Shuning He, Felix Oppel, Richard A. Young, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B22.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B22
Published: 15 July 2020
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Journal Articles

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Adam D. Durbin, Guillaume Kugener, Mark W. Zimmerman, Chuan Yan, Neekesh V. Dharia, Elizabeth S. Frank, Xiang Chen, Ken N. Ross, Brenton Paolella, Michael Krill-Burger, David E. Root, Jesse S. Boehm, Francisca Vazquez, Andrew L. Hong, Aviad Tsherniak, David M. Langenau, William C. Hahn, Todd R. Golub, Brian J. Abraham, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B10.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B10
Published: 15 July 2020
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Journal Articles

Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma

Adam D. Durbin, Virangika Wimalasena, Mark W. Zimmerman, Li Deyao, Elizabeth S. Frank, Paul Park, Ken Morita, Neekesh V. Dharia, Ken N. Ross, Ernst Schonbrunn, Richard A. Young, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): PR11.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-PR11
Published: 15 July 2020
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Journal Articles

Abstract 2953: Selective activity of XPO1 inhibitors in TET2-mutant myeloid malignancies

Nicole Prutsch, Chang-Bin Jing, Julia Etchin, Alla Berezovskaya, Hong Tiv, Michael J. Poitras, Prafulla Gokhale, Yosef Landesman, A. Thomas Look
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2953.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2953
Published: 01 July 2019
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Journal Articles

Abstract IA19: MYC activation through enhancer hijacking or focal enhancer amplification drives a subset of high-risk pediatric neuroblastoma

Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang, Nina Weichert-Leahey, Richard A. Young, Jinghui Zhang, A. Thomas Look
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA19.
DOI: https://doi.org/10.1158/1538-7445.PEDCA17-IA19
Published: 01 October 2018
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Journal Articles

Abstract 4135: c-MYC drives a subset of high-risk pediatric neuroblastoma and is activated through mechanisms including enhancer hijacking and focal enhancer amplification

Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Xu Beisi, Shizhen Zhu, Xiaoling Zhang, Zhaodong Li, Nina Weichert-Leahey, Richard A. Young, Jinghui Zhang, A. Thomas Look
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4135.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4135
Published: 01 July 2018
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Journal Articles

Abstract 2352: Defining a pediatric cancer dependency map

Neekesh V. Dharia, Clare Malone, Amanda Balboni Iniguez, Lillian Guenther, Liying Chen, Gabriela Alexe, Adam D. Durbin, Mark W. Zimmerman, Andrew Hong, Pratiti Bandopadhayay, Mariella G. Filbin, Thomas Howard, Brenton Paolella, Iris Fung, Josephine Lee, Phil Montgomery, John M. Krill-Burger, Brian J. Abraham, Jennifer Roth, David E. Root, Richard A. Young, A. Thomas Look, Rameen Beroukhim, Jesse S. Boehm, William C. Hahn, Todd R. Golub, Aviad Tsherniak, Francisca Vazquez, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2352.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2352
Published: 01 July 2018
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Journal Articles

Abstract 1287: Exploring somatic DNA structural alteration and aberrant genomic interactions in cancer through GenomePaint

Yu Liu, Xin Zhou, Jian Wang, Ying Shao, John Easton, Mark W. Zimmerman, Brian J. Abraham, A. Thomas Look, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1287.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1287
Published: 01 July 2018
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Journal Articles

Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Brian J. Abraham, Amanda Balboni-Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Todd R. Golub, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2062.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2062
Published: 01 July 2018
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Journal Articles

Abstract 1540: Creating faithful genetic zebrafish models of pediatric high grade gliomas and MPNSTs

Felix Oppel, Ting Tao, Shuning He, Mark W. Zimmerman, Dong H. Ki, Nina Weichert, A Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1540.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1540
Published: 01 July 2017
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Journal Articles

Abstract 1957: Molecular pathogenesis and drug synergism in a zebrafish model of high risk neuroblastoma

Shuning He, Marc R. Mansour, Mark W. Zimmerman, Hillary M. Layden, A. Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1957.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1957
Published: 01 July 2017
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Journal Articles

Abstract 1574: Computational approach for discovery of regulatory noncoding variants in cancer

Yu Liu, Michael Edmonson, Xiaotu Ma, Michael Rusch, Yongjin Li, Benshang Li, Shuhong Shen, A. Thomas Look, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1574.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1574
Published: 01 July 2017
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Journal Articles

Abstract 3871: Modeling the chromatin and transcriptional landscape of MYC and MYCN driven neuroblastoma in zebrafish

Mark W. Zimmerman, Shuning He, Shizhen Zhu, Song Yang, Yi Zhou, Leonard I. Zon, A Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3871.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3871
Published: 01 July 2017
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Journal Articles

Abstract 5014: Drug discovery for NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model

Dong Hyuk Ki, Shuning He, A. Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5014.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5014
Published: 01 July 2017
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Abstract 801: A zebrafish model of NF1-mutant melanomas that lack activating mutations of BRAF or NRAS

Shuning He, Marc R. Mansour, Hillary M. Layden, Scott J. Rodig, E. Elizabeth Patton, A. Thomas Look
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 801.
DOI: https://doi.org/10.1158/1538-7445.AM2017-801
Published: 01 July 2017
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