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Perspective May 19 2022
Translating "Big Data" in Oncology for Clinical Benefit: Progress or Paralysis
Cancer Res canres.0100.2022.
Review Article May 18 2022
Drug-tolerant persister cells in cancer therapy resistance
Cancer Res canres.3844.2021.
Research Article May 18 2022
Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
Dragana Kopanja; Vaibhav Chand; Eilidh Mills. O'Brien; Nishit K. Mukhopadhyay; Maria Paula. Zappia; Abul B.M.M.K. Islam; Maxim Frolov; Bradley J. Merrill; Pradip Raychaudhuri
Cancer Res canres.0410.2022.
Research Article May 18 2022
Activity and resistance of a brain-permeable paradox breaker BRAF inhibitor in melanoma brain metastasis
Ester Bonfill-Teixidor; Raffaella Iurlaro; Cornelia Handl; Jürgen Wichmann; Alexandra Arias; Isabel Cuartas; Jasmin Emmenegger; Andrea Romagnani; Luca Mangano; Thomas Lorber; Marco Berrera; Christina Godfried Sie; Fabian Köchl; Jan Eckmann; Romi Feddersen; Martin Kornacker; Gabriel Schnetzler; Marta Cicuéndez; Esteban Cordero; Thomaz E. Topczewski; Abel Ferrés-Pijoan; Josep Gonzalez; Francisco Martínez-Ricarte; Eva Muñoz-Couselo; Josep Tabernero; James R. Bischoff; Piergiorgio Pettazzoni; Joan Seoane
Cancer Res canres.4152.2021.
Research Article May 18 2022
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
Shawn M. Davidson; Daniel R. Schmidt; Julia E. Heyman; James P. O'Brien; Amy C. Liu; William J. Israelsen; Talya L. Dayton; Raghav Sehgal; Roderick T. Bronson; Elizaveta Freinkman; Howard H. Mak; Giuseppe Nicolo Fanelli; Scott Malstrom; Gary Bellinger; Arkaitz Carracedo; Pier Paolo Pandolfi; Kevin D. Courtney; Abhishek Jha; Ronald A. DePinho; James W. Horner; Craig J. Thomas; Lewis C. Cantley; Massimo Loda; Matthew G. Vander Heiden
Cancer Res canres.CAN-21-2352-E.2021.
Research Article May 18 2022
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Amrita M. Nargund; Chang Xu; Amit Mandoli; Atsushi Okabe; Gao Bin Chen; Kie Kyon Huang; Taotao Sheng; Xiaosai Yao; Jia Ming Nickolas Teo; Raghav Sundar; Yee Jiun Kok; Yi Xiang See; Manjie Xing; Zhimei Li; Chern Han Yong; Aparna Anand; Zul Fazreen A.I.; Lai Fong. Poon; Michelle Shu Wen. Ng; Javier Yu Peng Koh; Wen Fong Ooi; Su Ting Tay; Xuewen Ong; Angie Lay Keng Tan; Heike I. Grabsch; Melissa Jane. Fullwood; Tean Bin Teh; Xuezhi Bi; Atsushi Kaneda; Shang Li; Patrick Tan
Cancer Res canres.CAN-21-2072-E.2021.
Research Article May 17 2022
Claudin-12 deficiency inhibits tumor growth by impairing transendothelial migration of myeloid-derived suppressor cells
Zhihai Qin; Hong Cao; Chen Ni; Le Han; Ruoqi Wang; Rosel Blasig; Reiner Haseloff; Yue Qin; Jie Lan; Xiaohan Lou; Pan Ma; Xiaohan Yao; Linlin Wang; Fei Wang; Linyu Zhu; Ningjing Lei; Ingolf E. Blasig
Cancer Res canres.3896.2021.
Research Article May 17 2022
Targeting KDM6A suppresses SREBP1c-dependent lipid metabolism and prostate tumorigenesis
Dong-E Tang; Jia-Xi He; Yong Dai; Hui-Fen Zhou; Cancan Zhang; Qi-Xin Leng; Xinyan Geng; Dexue Fu; Hao-Wu Jiang; Rui Sun; Song-Hui Xu
Cancer Res canres.1825.2021.
Research Article May 11 2022
Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis
Chen Xie; Feng-Yi Wang; Ye Sang; Bin Chen; Jia-Hui Huang; Feng-Jun He; Hui Li; Ying Zhu; Xingguo Liu; Shi-Mei Zhuang; Jian-Hong Fang
Cancer Res canres.3910.2021.
Research Article May 10 2022
Computational identification of preneoplastic cells displaying high stemness and risk of cancer progression
Tianyuan Liu; Xuan Zhao; Yuan Lin; Qi Luo; Shaosen Zhang; Yiyi Xi; Yamei Chen; Lin Lin; Wenyi Fan; Jie Yang; Yuling Ma; Alok K. Maity; Yanyi Huang; Jianbin Wang; Jiang Chang; Dongxin Lin; Andrew E. Teschendorff; Chen Wu
Cancer Res canres.0668.2022.
Research Article May 10 2022
Bimodal gene expression in cancer patients provides interpretable biomarkers for drug sensitivity
Wail Ba-alawi; Sisira Kadambat Nair; Bo Li; Anthony Mammoliti; Petr Smirnov; Arvind Singh. Mer; Linda Z. Penn; Benjamin Haibe-Kains
Cancer Res canres.2395.2021.
Research Article May 10 2022
Hypoxia-reoxygenation couples 3βHSD1 enzyme and cofactor upregulation to facilitate androgen biosynthesis and hormone therapy resistance in prostate cancer
Liang Qin; Yoon-Mi Chung; Michael Berk; Bryan Naelitz; Ziqi Zhu; Eric Klein; Abhishek A. Chakraborty; Nima Sharifi
Cancer Res canres.4256.2021.
Research Article May 10 2022
Delineating The RAS Conformational Landscape
Cancer Res canres.0804.2022.
Research Article May 9 2022
TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling
Xinchao Zhang; Shuyan Li; Jing He; Yunjie Jin; Ruonan Zhang; Wenjing Dong; Mingen Lin; Yajing Yang; Tongguan Tian; Yuefan Zhou; Yixin Xu; Qun-Ying Lei; Jing Zhang; Qing Zhang; Yanping Xu; Lei Lv
Cancer Res (2022)
Review Article May 9 2022
Forkhead Box Transcription Factors: Double-Edged Swords in Cancer
Cancer Res (2022)
Research Article May 4 2022
Anti-HIV drug elvitegravir suppresses cancer metastasis via increased proteasomal degradation of m6A methyltransferase METTL3
Long Liao; Yan He; Shu Jun. Li; Guo Geng. Zhang; Wei Yu; Jing Yang; Zi-Jia Huang; Can-Can Zheng; Qing-Yu He; Yan Li; Bin Li
Cancer Res canres.4124.2021.
Research Article May 3 2022
Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects
Noboru Ishiyama; Matthew O'Connor; Andrei Salomatov; Darlene Romashko; Shalabh Thakur; Ahmet Mentes; Julia F. Hopkins; Garrett M. Frampton; Lee A. Albacker; Anna Kohlmann; Christopher Roberts; Elizabeth Buck
Cancer Res canres.0940.2021.
Brief Report May 3 2022
Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
Neelam Sinha; Sanju Sinha; Cristina Valero; Alejandro A. Schäffer; Kenneth Aldape; Kevin Litchfield; Timothy A. Chan; Luc G.T. Morris; Eytan Ruppin
Cancer Res (2022)
Research Article May 2 2022
Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma
Bo Zhang; Hui Peng; Mi Zhou; Lei Bao; Chenliang Wang; Feng Cai; Hongxia Zhang; Jennifer E. Wang; Yanling Niu; Yan Chen; Yijie Wang; Kimmo Hatanpaa; John A. Copland; Ralph J. DeBerardinis; Yingfei Wang; Weibo Luo
Cancer Res canres.3868.2021.
Research Article April 29 2022
Quantification of neoantigen-mediated immunoediting in cancer evolution
Tao Wu; Guangshuai Wang; Xuan Wang; Shixiang Wang; Xiangyu Zhao; Chenxu Wu; Wei Ning; Ziyu Tao; Fuxiang Chen; Xue-Song Liu
Cancer Res canres.3717.2021.
Research Article April 26 2022
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-ribosylation
Dan Huang; Cristel V. Camacho; Sara Martire; Anusha Nagari; Rohit Setlem; Xuan Gong; Andrea D. Edwards; Shu-Ping Chiu; Laura A. Banaszynski; W. Lee Kraus
Cancer Res canres.CAN-22-0742-E.2022.
Brief Report April 26 2022
ROADMAPS: An online database of response data, dosing regimens, and toxicities of approved oncology drugs as single agents to guide preclinical in vivo studies
Melinda G. Hollingshead; Nathaniel Greenberg; Michelle Gottholm Ahalt; Richard Camalier; Barry C. Johnson; Jerry M. Collins; James H. Doroshow
Cancer Res canres.4151.2021.
Research Article April 26 2022
Colorectal cancer develops inherent radiosensitivity that can be predicted using patient-derived organoids
Kuo-Shun Hsu; Mohammad Adileh; Maria Laura Martin; Vladimir Makarov; Jiapeng Chen; Chao Wu; Sahra Bodo; Stefan Klingler; Charles-Etienne Gabriel. Sauvé; Bryan C. Szeglin; J. Joshua Smith; Zvi Fuks; Nadeem Riaz; Timothy A. Chan; Makoto Nishimura; Philip B. Paty; Richard Kolesnick
Cancer Res canres.4128.2021.
Research Article April 26 2022
NR2F1 is a barrier to dissemination of early stage breast cancer cells.
Carolina Rodriguez-Tirado; Nupura Kale; Maria J. Carlini; Nitisha Shrivastava; Alcina A. Rodrigues; Bassem Khalil; Jose J. Bravo-Cordero; Melissa Alexander; Jiayi Ji; Yan Hong; Fariba Behbod; Maria Soledad Sosa
Cancer Res canres.4145.2021.
Research Article April 22 2022
Chemotherapy coupled to macrophage inhibition induces T-cell and B-cell infiltration and durable regression in triple-negative breast cancer
Swarnima Singh; Nigel Lee; Diego A. Pedroza; Igor L. Bado; Clark Hamor; Licheng Zhang; Sergio Aguirre; Jingyuan Hu; Yichao Shen; Yitian Xu; Yang Gao; Na Zhao; Shu-Hsia Chen; Ying-Wooi Wan; Zhandong Liu; Jeffrey T. Chang; Daniel Hollern; Charles M. Perou; Xiang H.F. Zhang; Jeffrey M. Rosen
Cancer Res canres.3714.2021.
Research Article April 20 2022
The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
Erik Ladewig; Flavia Michelini; Komal Jhaveri; Pau Castel; Javier Carmona; Lauren Fairchild; Adler G. Zuniga; Amaia Arruabarrena-Aristorena; Emiliano Cocco; Ryan Blawski; Srushti Kittane; Yuhan Zhang; Mirna Sallaku; Laura Baldino; Vasilis Hristidis; Sarat Chandarlapaty; Omar Abdel-Wahab; Christina Leslie; Maurizio Scaltriti; Eneda Toska
Cancer Res canres.CAN-22-0446-E.2022.
Research Article April 13 2022
Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma
Siler H. Panowski; Surabhi Srinivasan; Nguyen Tan; Silvia K. Tacheva-Grigorova; Bryan Smith; Yvonne S.L. Mak; Hongxiu Ning; Jonathan Villanueva; Dinali Wijewarnasuriya; Shanshan Lang; Zea Melton; Adit Ghosh; Mathilde Dusseaux; Roman Galetto; Jonathan R. Heyen; Tao Sai; Thomas Van Blarcom; Javier Chaparro-Riggers; Barbra J. Sasu
Cancer Res (2022)
Research Article April 12 2022
Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer
Xiuchao Wang; Yunzhan Li; Zekun Li; Shengchen Lin; Hongwei Wang; Jianwei Sun; Chungen Lan; Liangliang Wu; Dongxiao Sun; Chongbiao Huang; Pankaj K. Singh; Nadine Hempel; Mohamed Trebak; Gina M. DeNicola; Jihui Hao; Shengyu Yang
Cancer Res canres.3230.2021.
Research Article April 11 2022
A genome-wide CRISPR activation screen identifies PRRX2 as a regulator of enzalutamide resistance in prostate cancer
Yara Rodríguez; Kenji Unno; Mihai I. Truica; Zachary R. Chalmers; Young A Yoo; Rajita Vatapalli; Vinay Sagar; Jindan Yu; Barbara Lysy; Maha Hussain; Huiying Han; Sarki A. Abdulkadir
Cancer Res canres.3565.2021.
Research Article April 8 2022
Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer
Mingjie An; Hanhao Zheng; Jian Huang; Yan Lin; Yuming Luo; Yao Kong; Mingrui Pang; Dingwen Zhang; Jiabin Yang; Jiancheng Chen; Yuanlong Li; Changhao Chen; Tianxin Lin
Cancer Res canres.4349.2021.
Research Article April 8 2022
Functional genomic analysis of CDK4 and CDK6 gene dependency across human cancer cell lines
Cancer Res canres.2428.2021.
Research Article April 8 2022
Rab13 sustains breast cancer stem cells by supporting tumor-stroma crosstalk
Hui Wang; Haibo Xu; Wei Chen; Mei Cheng; Li Zou; Qin Yang; Chi Bun Chan; Hao Zhu; Ceshi Chen; Jian-Yun Nie; Baowei Jiao
Cancer Res canres.4097.2021.
Research Article April 6 2022
Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function
Xixi Zhao; Yongkun Wei; Yu-Yi Chu; Yintao Li; Jung-Mao Hsu; Zhou Jiang; Chunxiao Liu; Jennifer L. Hsu; Wei-Chao Chang; Riyao Yang; Li-Chuan Chan; Jingkun Qu; Shuqun Zhang; Haoqiang Ying; Dihua Yu; Mien-Chie Hung
Cancer Res canres.2300.2021.
Review Article April 1 2022
Epithelial-mesenchymal plasticity in tumor immune evasion
Cancer Res canres.4370.2021.
Research Article April 1 2022
Aberrant RNA splicing is a primary link between genetic variation and pancreatic cancer risk
Jianbo Tian; Can Chen; Meilin Rao; Ming Zhang; Zequn Lu; Yimin Cai; Pingting Ying; Bin Li; Haoxue Wang; Lu Wang; Yao Li; Jinyu Huang; Linyun Fan; Xiaomin Cai; Caibo Ning; Yanmin Li; Fuwei Zhang; Wenzhuo Wang; Yuan Jiang; Yizhuo Liu; Min Wang; Heng Li; Chaoqun Huang; Zhiyong yang; Jiang Chang; Ying Zhu; Xiaojun Yang; Xiaoping Miao
Cancer Res canres.4367.2021.
Review Article March 23 2022
Epigenetic and transcriptional regulation of innate immunity in cancer
Cancer Res canres.3503.2021.
Research Article March 21 2022
Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML
Anamarija Pfeiffer; Giulia Franciosa; Marie Locard-Paulet; Ilaria Piga; Kristian Reckzeh; Vidyasiri Vemulapalli; Stephen C. Blacklow; Kim Theilgaard-Mönch; Lars J. Jensen; Jesper V. Olsen
Cancer Res canres.0548.2021.
Review Article March 18 2022
Oncogenic and tumor-suppressive functions of the RNA demethylase FTO
Cancer Res canres.3710.2021.
Review Article March 18 2022
Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance
Cancer Res canres.4087.2021.
Research Article March 3 2022
Tumor-intrinsic PD-L1 promotes DNA repair in distinct cancers and suppresses PARP inhibitor-induced synthetic lethality
Anand V.R. Kornepati; Jacob T. Boyd; Clare E. Murray; Julia Saifetyarova; Bárbara de la Peña Avalos; Cody M. Rogers; Haiyan Bai; Alvaro S. Padron; Yiji Liao; Carlos Ontiveros; Robert S. Svatek; Robert Hromas; Rong Li; Yanfen Hu; Jose R. Conejo-Garcia; Ratna K. Vadlamudi; Weixing Zhao; Eloise Dray; Patrick Sung; Tyler J. Curiel
Cancer Res canres.2076.2021.
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