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Research Article December 9 2022
METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma
Manling Huang; Jianting Long; Zhijia Yao; Yi Zhao; Yutong Zhao; Junbin Liao; Kai Lei; Han Xiao; Zihao Dai; Sui Peng; Shuibin Lin; Lixia Xu; Ming Kuang
Cancer Res (2022)
Research Article December 9 2022
ATF3 Reprograms the Bone Marrow Niche in Response to Early Breast Cancer Transformation
Milena Perrone; Claudia Chiodoni; Mara Lecchi; Laura Botti; Barbara Bassani; Annamaria Piva; Elena Jachetti; Matteo Milani; Daniele Lecis; Elda Tagliabue; Paolo Verderio; Sabina Sangaletti; Mario P. Colombo
Cancer Res (2022)
Research Article December 9 2022
Protein phosphatase 1 subunit PPP1R14B stabilizes STMN1 to promote progression and paclitaxel resistance in triple-negative breast cancer
Li Liao; Yin-Ling Zhang; Ling Deng; Chao Chen; Xiao-Yan Ma; Lisa Andriani; Shao-Ying Yang; Shu-Yuan Hu; Fang-Lin Zhang; Zhi-Ming Shao; Da-Qiang Li
Cancer Res CAN-22-2709.
Brief Report December 9 2022
Mitochondrial DNA Mutations as Natural Barcodes for Lineage Tracing of Murine Tumor Models
Livius Penter; Elisa ten Hacken; Jackson Southard; Caleb A. Lareau; Leif S. Ludwig; Shuqiang Li; Donna S. Neuberg; Kenneth J. Livak; Catherine J. Wu
Cancer Res (2022)
Research Article December 8 2022
The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer
Weisi Liu; Kevin P. Newhall; Francesca Khani; LaMont Barlow; Duy Nguyen; Lilly Gu; Ken Eng; Bhavneet Bhinder; Manik Uppal; Charlotte Récapet; Andrea Sboner; Susan R. Ross; Olivier Elemento; Linda Chelico; Bishoy M. Faltas
Cancer Res CAN-22-2912.
Research Article December 8 2022
PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells
Yun Li; Hengxing Chen; Xuan Xie; Bing Yang; Xiaojuan Wang; Jingyuan Zhang; Tian Qiao; Jiao Guan; Yuntan Qiu; Yong-Xin Huang; Duanqing Tian; Xinyi Yao; Daning Lu; H. Phillip Koeffler; Yin Zhang; Dong Yin
Cancer Res CAN-22-2370.
Research Article December 8 2022
Elevated methionine flux drives pyroptosis evasion in persister cancer cells
Asmaa El-Kenawi; Anders Berglund; Veronica Estrella; Yonghong Zhang; Min Liu; Ryan M. Putney; Sean Yoder; Joseph Johnson; Joel Brown; Robert Gatenby
Cancer Res CAN-22-1002.
Brief Report December 5 2022
Estimation of neutral mutation rates and quantification of somatic variant selection using canceffectsizeR
Cancer Res CAN-22-1508.
Research Article December 5 2022
Pharmacological targeting of androgen receptor elicits context-specific effects in estrogen receptor-positive breast cancer
Lixuan Wei; Huanyao Gao; Jia Yu; Huan Zhang; Thanh Thanh L. Nguyen; Yayun Gu; Marie R. Passow; Jodi M. Carter; Bo Qin; Judy C. Boughey; Matthew P. Goetz; Richard M. Weinshilboum; James N. Ingle; Liewei Wang
Cancer Res CAN-22-1016.
Research Article December 2 2022
Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity
Hannah L. Williams; Andressa Dias Costa; Jinming Zhang; Srivatsan Raghavan; Peter S. Winter; Kevin S. Kapner; Scott P. Ginebaugh; Sara A. Väyrynen; Juha P. Väyrynen; Chen Yuan; Andrew W. Navia; Junning Wang; Annan Yang; Timothy L. Bosse; Radha L. Kalekar; Kristen E. Lowder; Mai Chan Lau; Dalia Elganainy; Vicente Morales-Oyarvide; Douglas A. Rubinson; Harshabad Singh; Kimberly Perez; James M. Cleary; Thomas E. Clancy; Jiping Wang; Joseph D. Mancias; Lauren K. Brais; Emma R. Hill; Margaret M. Kozak; David C. Linehan; Richard F. Dunne; Daniel T. Chang; Albert C. Koong; Aram F. Hezel; William C. Hahn; Alex K. Shalek; Andrew J. Aguirre; Jonathan A. Nowak; Brian M. Wolpin
Cancer Res CAN-22-3050.
Brief Report December 2 2022
Meta-analysis of human cancer single cell RNA-seq datasets using the IMMUcan database
Jordi Camps; Floriane Noël; Robin Liechti; Lucile Massenet-Regad; Sidwell Rigade; Lou Götz; Caroline Hoffmann; Elise Amblard; Melissa Saichi; Mahmoud M. Ibrahim; Jack Pollard; Jasna Medvedovic; Helge G. Roider; Vassili Soumelis
Cancer Res CAN-22-0074.
Research Article November 30 2022
Single-cell analysis in lung adenocarcinoma implicates RNA editing in cancer innate immunity and patient prognosis
Cancer Res CAN-22-1062.
Review Article November 30 2022
Breast Cancer Metastatic Dormancy and Relapse: An Enigma of Microenvironment(s)
Cancer Res (2022)
Review Article November 30 2022
Cell Competition in Carcinogenesis
Esha Madan; António M. Palma; Vignesh Vudatha; Jose G. Trevino; Kedar Nath Natarajan; Robert A. Winn; Kyoung Jae Won; Trevor A. Graham; Ronny Drapkin; Stuart AC. McDonald; Paul B. Fisher; Rajan Gogna
Cancer Res (2022)
Research Article November 30 2022
Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis
Yeh Wang; Peng Huang; Brant G. Wang; Tricia Murdock; Leslie Cope; Fang-Chi Hsu; Tian-Li Wang; Ie-Ming Shih
Cancer Res (2022)
Research Article November 30 2022
A pro-regenerative environment triggers premalignant to malignant transformation of senescent hepatocytes.
Anna WUESTEFELD; Viktoriia IAKOVLEVA; Shirlyn Xue Ling. YAP; Agnes Bee Leng. ONG; Daniel Q. Huang; Timothy Wai Ho Shuen; Han Chong Toh; Yock Young Dan; Lars Zender; Torsten WUESTEFELD
Cancer Res CAN-22-1477.
Research Article November 22 2022
Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Jesse C. Patterson; Andreas Varkaris; Peter J.P. Croucher; Maya Ridinger; Susan Dalrymple; Mannan Nouri; Fang Xie; Shohreh Varmeh; Oliver Jonas; Matthew A. Whitman; Sen Chen; Saleh Rashed; Lovemore Makusha; Jun Luo; John T. Isaacs; Mark G. Erlander; David J. Einstein; Steven P. Balk; Michael B. Yaffe
Cancer Res CAN-22-1533.
Research Article November 21 2022
The oncogenic FOXL2 C134W mutation is a key driver of granulosa cell tumors
Elena Llano; Anne Laure Todeschini; Natalia Felipe-Medina; María D. Corte-Torres; Yazmine B. Condezo; Manuel Sanchez-Martin; Sara López-Tamargo; Aurora Astudillo; Xose S. Puente; Alberto M. Pendas; Reiner A. Veitia
Cancer Res CAN-22-1880.
Research Article November 21 2022
Loss of NF1 in melanoma confers sensitivity to SYK kinase inhibition
Cara Abecunas; Christopher E. Whitehead; Elizabeth K. Ziemke; Douglas G. Baumann; Christy L. Frankowski-McGregor; Judith S. Sebolt-Leopold; Mohammad Fallahi-Sichani
Cancer Res CAN-22-0883.
Research Article November 21 2022
Aberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma
Valentina Pieri; Alberto L. Gallotti; Denise Drago; Manuela Cominelli; Ilaria Pagano; Valentina Conti; Silvia Valtorta; Angela Coliva; Sara Lago; Daniela Michelatti; Luca Massimino; Federica Ungaro; Laura Perani; Antonello Spinelli; Antonella Castellano; Andrea Falini; Alessio Zippo; Pietro L. Poliani; Rosa Maria Moresco; Annapaola Andolfo; Rossella Galli
Cancer Res CAN-22-0677.
Research Article November 21 2022
JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states
Laura E. Stevens; Guillermo Peluffo; Xintao Qiu; Daniel Temko; Anne Fassl; Zheqi Li; Anne Trinh; Marco Seehawer; Bojana Jovanovic; Masa Aleckovic; Callahan M. Wilde; Renee C. Geck; Shaokun Shu; Natalie L. Kingston; Nicholas W. Harper; Vanessa Almendro; Alanna L. Pyke; Shawn B. Egri; Malvina Papanastasiou; Kendell Clement; Ningxuan Zhou; Sarah Walker; Jacqueline Salas; So Yeon Park; David A. Frank; Alexander Meissner; Jacob D. Jaffe; Piotr Sicinski; Alex Toker; Franziska Michor; Henry W. Long; Beth A. Overmoyer; Kornelia Polyak
Cancer Res CAN-22-0423.
Research Article November 18 2022
Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
Clare F. Malone; Minjee Kim; Gabriela Alexe; Kathleen Engel; Alexandra B. Forman; Amanda Robichaud; Amy Saur Conway; Amy Goodale; Ashleigh Meyer; Delan Khalid; Allen Thayakumar; John M. Hatcher; Nathanael S. Gray; Federica Piccioni; Kimberly Stegmaier
Cancer Res CAN-21-4309.
Research Article November 15 2022
Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort
Yanhong Liu; Jennifer R. Kramer; Vlad C. Sandulache; Robert Yu; Guojun Li; Liang Chen; Zenab I. Yusuf; Yunling Shi; Saiju Pyarajan; Spyros Tsavachidis; Li Jiao; Michelle L. Mierzwa; Elizabeth Chiao; Yvonne M. Mowery; Andrew Shuman; Sanjay Shete; Andrew G. Sikora; Donna L. White
Cancer Res CAN-22-1641.
Research Article November 10 2022
Genome-wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk
Fan Wang; Wonjong Moon; William Letsou; Yadav Sapkota; Zhaoming Wang; Cindy Im; Jessica L. Baedke; Leslie Robison; Yutaka Yasui
Cancer Res CAN-22-1888.
Research Article November 10 2022
MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis
Cheng-Kai Wang; Tzu-Jou Chen; Grace Y.T. Tan; Fang-Pei Chang; Samyuktha Sridharan; Chen-Hsin Albert. Yu; Yen-Hou Chang; Yi-Jen Chen; Li-Tzu Cheng; Wendy W. Hwang-Verslues
Cancer Res CAN-22-1159.
Research Article November 10 2022
ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Massimiliano Mellone; Klaudia Piotrowska; Giulia Venturi; Lija James; Aleksandra Bzura; Maria A. Lopez; Sonya James; Chuan Wang; Matthew J. Ellis; Christopher J. Hanley; Josephine F. Buckingham; Kerry L. Cox; Gareth Hughes; Viia Valge-Archer; Emma V. King; Stephen A. Beers; Vincent Jaquet; George D.D. Jones; Natalia Savelyeva; Emre Sayan; Jason L. Parsons; Stephen Durant; Gareth J. Thomas
Cancer Res (2022)
Research Article November 9 2022
Immunotherapeutic targeting and PET imaging of DLL3 in small cell neuroendocrine prostate cancer
Jonathan Chou; Emily A. Egusa; Sinan Wang; Michelle L. Badura; Fei Lee; Anil P. Bidkar; Jun Zhu; Tanushree Shenoy; Kai Trepka; Troy M. Robinson; Veronica Steri; Jiaoti Huang; Yuzhuo Wang; Eric J. Small; Emily Chan; Bradley A. Stohr; Alan Ashworth; Brant Delafontaine; Sylvie Rottey; Keegan S. Cooke; Nooshin Hashemi Sadraei; Brian Yu; Mark Salvati; Julie M. Bailis; Felix Y. Feng; Robert R. Flavell; Rahul Aggarwal
Cancer Res CAN-22-1433.
Research Article November 9 2022
Genetic ancestry inference from cancer-derived molecular data across genomic and transcriptomic platforms
Cancer Res CAN-22-0682.
Research Article November 8 2022
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer
Craig M. Goodwin; Andrew M. Waters; Jennifer E. Klomp; Sehrish Javaid; Kirsten L. Bryant; Clint A. Stalnecker; Kristina Drizyte-Miller; Bjoern Papke; Runying Yang; Amber M. Amparo; Irem Ozkan-Dagliyan; Elisa Baldelli; Valerie Calvert; Mariaelena Pierobon; Jessica A. Sorrentino; Andrew P. Beelen; Natalie Bublitz; Mareen Lüthen; Kris C. Wood; Emanuel F. Petricoin; Christine Sers; Autumn J. McRee; Adrienne D. Cox; Channing J. Der
Cancer Res CAN-22-0391.
Brief Report November 1 2022
Gene fusion detection and characterization in long-read cancer transcriptome sequencing data with FusionSeeker
Yu Chen; Yiqing Wang; Weisheng Chen; Zhengzhi Tan; Yuwei Song; N/A Human Genome Structural Variation Consortium; Herbert Chen; Zechen Chong
Cancer Res CAN-22-1628.
Research Article November 1 2022
Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma
Haowen Jiang; Rachel L. Greathouse; Sarah Jane. Tiche; Man Zhao; Bo He; Yang Li; Albert M. Li; Balint Forgo; Michaela Yip; Allison Li; Moriah Shih; Selene Banuelos; Meng-Ning Zhou; Joshua J. Gruber; Erinn B. Rankin; Zhen Hu; Hiroyuki Shimada; Bill Chiu; Jiangbin Ye
Cancer Res CAN-22-1029.
Brief Report October 26 2022
Common germline risk variants impact somatic alterations and clinical features across cancers
Shinichi Namba; Yuki Saito; Yasunori Kogure; Tatsuo Masuda; Melissa L. Bondy; Puya Gharahkhani; Ines Gockel; Dominik Heider; Axel Hillmer; Janusz Jankowski; Stuart MacGregor; Carlo Maj; Beatrice Melin; Quinn T. Ostrom; Claire Palles; Johannes Schumacher; Ian Tomlinson; David C. Whiteman; Yukinori Okada; Keisuke Kataoka
Cancer Res CAN-22-1492.
Research Article October 25 2022
Spatial transcriptomic analysis of a diverse patient cohort reveals a conserved architecture in triple-negative breast cancer
Rania Bassiouni; Michael O. Idowu; Lee D. Gibbs; Valentina Robila; Pamela J. Grizzard; Michelle G. Webb; Jiarong Song; Ashley Noriega; David W. Craig; John D. Carpten
Cancer Res CAN-22-2682.
Research Article October 20 2022
Landscape of microRNA regulatory network architecture and functional rerouting in cancer
Xu Hua; Yongsheng Li; Sairahul R. Pentaparthi; Daniel J. McGrail; Raymond Zou; Li Guo; Aditya Shrawat; Kara M. Cirillo; Qing Li; Akshay V. Bhat; Min Xu; Dan Qi; Ashok Singh; Francis McGrath; Steven B. Andrews; Kyaw Lwin. Aung; Jishnu Das; Yunyun Zhou; Alessia Lodi; Gordon B. Mills; S. Gail Eckhardt; Marc L. Mendillo; Stefano Tiziani; Erxi Wu; Jason H. Huang; Nidhi Sahni; S. Stephen Yi
Cancer Res CAN-20-0371.
Research Article October 20 2022
Shared cancer dataset analysis identifies and predicts the quantitative effects of pan-cancer somatic driver variants
Cancer Res CAN-22-1038.
Research Article October 20 2022
N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
Duygu Kuzuoglu-Ozturk; Ozlem Aksoy; Christin Schmidt; Robin Lea; Jon D. Larson; Ryan R.L. Phelps; Nicole Nasholm; Megan Holt; Adrian Contreras; Miller Huang; Shannon Wong-Michalak; Hao Shao; Robert Wechsler-Reya; Joanna J. Phillips; Jason E. Gestwicki; Davide Ruggero; William A. Weiss
Cancer Res CAN-22-0945.
Research Article October 20 2022
The macrophage-associated lncRNA MALR facilitates ILF3 liquid-liquid phase separation to promote HIF1α signaling in esophageal cancer
Jia Liu; Ze-Xian Liu; Jia-Jun Li; Zhao-Lei Zeng; Jin-Hong Wang; Xiao-Jing Luo; Chau-Wei Wong; Jia-Bo Zheng; Heng-Ying Pu; Hai-yu Mo; Hui Sheng; Qi-Nian Wu; Hao Li; Gang Wan; Bo Li; De-shen Wang; Rui-Hua Xu; Huai-Qiang Ju
Cancer Res CAN-22-1922.
Review Article October 20 2022
Reimagining Cancer: Moving from the Cellular to the Tissue Level
Cancer Res CAN-22-1601.
Research Article October 20 2022
Extracellular vesicle-mediated transfer of lncRNA IGFL2-AS1 confers sunitinib resistance in renal cell carcinoma
Yihui Pan; Xuanxuan Lu; Guannan Shu; Junjie Cen; Jun Lu; Mi Zhou; Kangbo Huang; Jiaqi Dong; Jiaying Li; Haishan Lin; Hongde Song; Quanhui Xu; Hui Han; Zhenhua Chen; Wei Chen; Junhang Luo; Jinhuan Wei; Jiaxing Zhang
Cancer Res CAN-21-3432.
Research Article October 12 2022
Therapy-induced senescence enhances the efficacy of HER2-targeted antibody-drug conjugates in breast cancer
Santiago Duro-Sánchez; Mercedes Nadal-Serrano; Marta Lalinde-Gutiérrez; Enrique Javier. Arenas; Cristina Bernadó. Bernadó Morales; Beatriz Morancho; Marta Escorihuela; Sandra Pérez-Ramos; Santiago Escrivá-de-Romaní; Lucía Gandullo-Sánchez; Atanasio Pandiella; Anna Esteve-Codina; Veronica Rodilla; Fred A. Dijcks; Wim H.A. Dokter; Javier Cortés; Cristina Saura; Joaquín Arribas
Cancer Res CAN-22-0787.
Research Article October 12 2022
PRC2-mediated epigenetic suppression of type I IFN-STAT2 signaling impairs antitumor immunity in luminal breast cancer
Juyeong Hong; Ji Hoon Lee; Zhao Zhang; Yanming Wu; Mei Yang; Yiji Liao; Richard de la Rosa; Jessica Scheirer; Douglas Pechacek; Nu Zhang; Zhenming Xu; Tyler Curiel; Xi Tan; Tim Hui-Ming Huang; Kexin Xu
Cancer Res CAN-22-0736.
Research Article October 11 2022
Endometriosis-associated mesenchymal stem cells support ovarian clear cell carcinoma through iron regulation
Huda I. Atiya; Leonard Frisbie; Ester Goldfeld; Taylor Orellana; Nicole Donellan; Francesmary Modugno; Michael Calderon; Simon C. Watkins; Rugang Zhang; Esther Elishaev; Thing Rinda. Soong; Anda M. Vlad; Lan G. Coffman
Cancer Res CAN-22-1294.
Research Article October 11 2022
Single-cell analysis reveals a CD4+ T cell cluster that correlates with PD-1 blockade efficacy
Hiroshi Kagamu; Satoshi Yamasaki; Shigehisa Kitano; Ou Yamaguchi; Atsuto Mouri; Ayako Shiono; Fuyumi Nishihara; Yu Miura; Kosuke Hashimoto; Hisao Imai; Kyoichi Kaira; Kunihiko Kobayashi; Yae Kanai; Tatsuhiro Shibata; Katsuhisa Horimoto
Cancer Res CAN-22-0112.
Research Article October 11 2022
Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma
Anna Borgenvik; Karl O. Holmberg; Sara Bolin; Miao Zhao; Vasil Savov; Gabriela Rosén; Sonja Hutter; Alexandra Garancher; Aldwin Suryo Rahmanto; Tobias Bergström; Thale Kristin. Olsen; Oliver J. Mainwaring; Damiana Sattanino; Annemieke D. Verbaan; Jessica M. Rusert; Anders Sundstrom; Mar Ballester Bravo; Yonglong Dang; Amelie S. Wenz; Stacey Richardson; Grammatiki Fotaki; Rebecca M. Hill; Adrian M. Dubuc; Antonia Kalushkova; Marc Remke; Matko Cancer; Helena Jernberg-Wiklund; Géraldine Giraud; Xingqi Chen; Michael D. Taylor; Olle Sangfelt; Steven C. Clifford; Ulrich Schuller; Robert Wechsler-Reya; Holger Weishaupt; Fredrik J. Swartling
Cancer Res CAN-22-2108.
Research Article October 11 2022
SMAD4 loss induces c-MYC-mediated NLE1 upregulation to support protein biosynthesis, colorectal cancer growth and metastasis
Leon P. Loevenich; Markus Tschurtschenthaler; Matjaž Rokavec; Miguel G. Silva; Moritz Jesinghaus; Thomas Kirchner; Frederick Klauschen; Dieter Saur; Jens Neumann; Heiko Hermeking; Peter Jung
Cancer Res CAN-22-1247.
Research Article October 10 2022
Mono- and diunsaturated fatty acids sensitize cervical cancer to radiation therapy
Naoshad Muhammad; Fiona Ruiz; Jennifer Stanley; Ramachandran Rashmi; Kevin Cho; Kay Jayachandran; Michael C. Zahner; Yi Huang; Jin Zhang; Stephanie Markovina; Gary J. Patti; Julie K. Schwarz
Cancer Res CAN-21-4369.
Research Article October 10 2022
The lncRNA LENOX interacts with RAP2C to regulate metabolism and promote resistance to MAPK inhibition in melanoma.
Giovanni Gambi; Gabrielle Mengus; Guillaume Davidson; Ewout Demesmaeker; Alessandro Cuomo; Tiziana Bonaldi; Vasiliki Katopodi; Gabriel G. Malouf; Eleonora Leucci; Irwin Davidson
Cancer Res CAN-22-0959.
Review Article October 10 2022
Wnt signaling in the phenotype and function of tumor-associated macrophages
Cancer Res CAN-22-1403.
Research Article October 7 2022
Disruption of the gut microbiota confers cisplatin resistance in epithelial ovarian cancer
Laura M. Chambers; Emily L. Esakov Rhoades; Rashmi Bharti; Chad Braley; Surabhi Tewari; Lexie Trestan; Zahraa Alali; Defne Bayik; Justin D. Lathia; Naseer Sangwan; Peter Bazeley; Amy S. Joehlin-Price; Zeneng Wang; Sumita Dutta; Mohammed Dwidar; Adeline Hajjar; Philip P. Ahern; Jan Claesen; Peter Rose; Roberto Vargas; J. Mark. Brown; Chad M. Michener; Ofer Reizes
Cancer Res CAN-22-0455.
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