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In the Spotlight May 12 2025
The Genetic Footprint of Tobacco Smoking: Unraveling the Mutational Signatures in Head and Neck Cancer
Cancer Res (2025)
Research Article May 12 2025
A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia
Yingjia Chen; Liye He; Aleksandr Ianevski; Kristen Nader; Tanja Ruokoranta; Nora Linnavirta; Juho J. Miettinen; Markus Vähä-Koskela; Ida Vänttinen; Heikki Kuusanmaki; Mika Kontro; Kimmo Porkka; Krister Wennerberg; Caroline A. Heckman; Anil K. Giri; Tero Aittokallio
Cancer Res (2025)
Research Article May 12 2025
Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T Cell-Mediated Tumor Control
Emilija Marinkovic; Minyi Chen; Nadja Schubert; Elif Dogan Dar; Tanja Poth; Janet Y. Leung; Jack Lohre; Jennifer M. Sahni; Christine Tun; Pavithra Rajeswaran; Tanja Mehlo-Jensen; Olivia Perng; C. Mark Hill; Pallavur Sivakumar; Michael J. Barnes; Rohit Malik; Rayk Behrendt; Axel Roers
Cancer Res (2025)
Research Article May 12 2025
Modeling the PAX5P80R Mutation Reveals HIF2α Activation as a Common Feature and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia
Manon Bayet; Vincent Fregona; Mathieu Bouttier; Clémence Rouzier; Jérémy Bigot; Laura Jamrog; Sylvie Hebrard; Naïs Prade; Stéphanie Lagarde; Christine Didier; Stéphanie Gachet; Marie Passet; Laetitia Largeaud; Marlène Pasquet; Ahmed Amine Khamlichi; Emmanuelle Clappier; Eric Delabesse; Cyril Broccardo; Bastien Gerby
Cancer Res (2025)
Research Article May 6 2025
The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Shayna Thomas-Jardin; Shruthy Suresh; Ariana Arce; Nicole Novaresi; Qing Deng; Emily Stein; Lisa Thomas; Cheryl Lewis; Chul Ahn; Bret M. Evers; Esra A. Akbay; Maria E. Salvatierra; Wei Lu; Khaja Khan; Luisa M. Solis Soto; Ignacio I. Wistuba; John D. Minna; Kathryn A. O'Donnell
Cancer Res (2025)
Research Article May 6 2025
Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
Soyoung Lee; Kyunghwan Kim; Hye-Jin Jeong; Subin Choi; Himchan Cheng; Dayoung Kim; Soomin Heo; Jinhee Mun; Minjong Kim; Eunjin Lee; Yoon Ji Choi; Seon-gyeong Lee; Eun A. Lee; Yewon Jang; Kayeong Lim; Heon Seok Kim; Euihwan Jeong; Seung-Jae Myung; Deok-Beom Jung; Chang Sik Yu; In Ho Song; M. Ryan Corces; Joo H. Kang; Kyungjae Myung; Taejoon Kwon; Tae-Eun Park; Jinmyoung Joo; Seung Woo Cho
Cancer Res (2025)
Research Article May 6 2025
Targeting Innate Immune Checkpoint TREX1 is a Safe and Effective Immunotherapeutic Strategy in Cancer
Cong Xing; Xintao Tu; Wanwan Huai; Zhen Tang; Kun Song; Devon Jeltema; Kennady Knox; Nicole Dobbs; Kun Yang; Nan Yan
Cancer Res (2025)
Research Article May 6 2025
HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data
Ammal Abbasi; Christopher D. Steele; Erik N. Bergstrom; Azhar Khandekar; Akanksha Farswan; Rana R. McKay; Nischalan Pillay; Ludmil B. Alexandrov
Cancer Res (2025)
Cancer Biology May 6 2025
FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
Claudia Tonelli; Astrid Deschênes; Victoria A. Gaeth; Amanda Jensen; Nandan Vithlani; Melissa A. Yao; Zhen Zhao; Youngkyu Park; David A. Tuveson
Cancer Res (2025)
Research Article April 30 2025
Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification
Aubrey K. Hubbard; Derek W. Brown; Jie Liu; Irenaeus C. Chan; Weiyin Zhou; Giulio Genovese; Alexander DePaulis; Sruthi Srinivasan; Shu-Hong Lin; Batel Blechter; Ian D. Buller; Qinglin Zeng; Yin Cao; Wen-Yi Huang; Neal D. Freedman; Haoyu Zhang; Diptavo Dutta; Stephen J. Chanock; Kelly L. Bolton; Mitchell J. Machiela
Cancer Res (2025)
Research Article April 30 2025
Multi-task Deep Learning Based on Longitudinal CT Images Facilitates Prediction of Lymph Node Metastasis and Survival in Chemotherapy-Treated Gastric Cancer
Bingjiang Qiu; Yunlin Zheng; Shunli Liu; Ruirui Song; Lei Wu; Cheng Lu; Xianqi Yang; Wei Wang; Zaiyi Liu; Yanfen Cui
Cancer Res (2025)
Research Article April 30 2025
Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T Cell Therapy in Solid Tumors
Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enssle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger
Cancer Res (2025)
Research Article April 30 2025
Large-Scale Characterization of Orthotopic Cell Line-Derived Xenografts Identifies TGF-β Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness
Catrin Lutz; Xue Chao; Bim de Klein; Jinhyuk Bhin; Madelon Badoux; Timo Eijkman; Apostolos P. Nikolakopoulos; Stefan J. Hutten; Natalie Proost; Bjørn Siteur; Marieke van de Ven; Ji-Ying Song; Jacco van Rheenen; Jessica Morgner; Stefan Prekovic; Jos Jonkers
Cancer Res (2025)
Translational Cancer Biology April 29 2025
Perivascular Niche–Resident Alveolar Macrophages Promote Interstitial Pneumonitis Related to Trastuzumab Deruxtecan Treatment
Qing Wei; Teng Yang; Ziwen Zhang; Fei Wang; Yuxuan Yang; Jiayu Zhu; Xiu Zhu; Yuanzheng Li; Yun Xing; Ye Lu; Xuefei Tian; Mengyang Fan; Yuchao Zhang; Xiru Xue; Meng Li; Chuanfei Yu; Lan Wang; Takaya Shimura; Jianmin Fang; Zhiwei Cao; Jieer Ying; Peng Guo; Xiangdong Cheng
Cancer Res (2025)
Resource Report April 29 2025
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Ling Cai; Fangjiang Wu; Qinbo Zhou; Ying Gao; Bo Yao; Ralph J. DeBerardinis; George K. Acquaah-Mensah; Vassilis Aidinis; Jennifer E. Beane; Shyam Biswal; Ting Chen; Carla P. Concepcion-Crisol; Barbara M. Grüner; Deshui Jia; Robert A. Jones; Jonathan M. Kurie; Min Gyu Lee; Per Lindahl; Yonathan Lissanu; Corina Lorz; David MacPherson; Rosanna Martinelli; Pawel K. Mazur; Sarah A. Mazzilli; Shinji Mii; Herwig P. Moll; Roger A. Moorehead; Edward E. Morrisey; Sheng Rong Ng; Matthew G. Oser; Arun R. Pandiri; Charles A. Powell; Giorgio Ramadori; Mirentxu Santos; Eric L. Snyder; Rocio Sotillo; Kang-Yi Su; Tetsuro Taki; Kekoa Taparra; Phuoc T. Tran; Yifeng Xia; J. Edward van Veen; Monte M. Winslow; Guanghua Xiao; Charles M. Rudin; Trudy G. Oliver; Yang Xie; John D. Minna
Cancer Res (2025)
Research Article April 29 2025
Eco-evolutionary Guided Pathomic Analysis Detects Biomarkers to Predict Ductal Carcinoma In Situ Upstaging
Yujie Xiao; Manal Elmasry; Ji Dong K. Bai; Andrew Chen; Yuzhu Chen; Brooke Jackson; Joseph O. Johnson; Prateek Prasanna; Chao Chen; Mehdi Damaghi
Cancer Res (2025)
Research Article April 29 2025
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
Helen Hockings; Eszter Lakatos; Weini Huang; Maximilian Mossner; Mohammed A. Khan; Nikolina Bakali; Jacqueline McDermott; Kane Smith; Ann-Marie Baker; Trevor A. Graham; Michelle Lockley
Cancer Res (2025)
Research Article April 29 2025
Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Anti-tumor Immunity and Improve Immunotherapy Efficacy
Brian J. Laight; Danielle Harper; Natasha Dmytryk; Connie S. Zhang; Changnian Shi; Andrew Garven; Richard W. Nauman; Jacob Kment; Faizah Alotaibi; Ivan Shapovalov; Victoria Hoskin; Yan Gao; Jeffery Mewburn; Caitlyn Vlasschaert; Ami Wang; Julian Simonetti; David LeBrun; Kathrin Tyryshkin; David M. Berman; Amber L. Simpson; Charles H. Graham; Andrew W. Craig; Sameh Basta; Madhuri Koti; Peter A. Greer
Cancer Res (2025)
Cancer Immunology April 28 2025
Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell–Mediated Antitumor Immunity by Suppressing ER Stress–Associated THBS2 Signaling
Cancer Res (2025)
Research Article April 28 2025
Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer
Martin Smelik; Daniel Diaz-Roncero Gonzalez; Xiaojing An; Rakesh Heer; Lars Henningsohn; Xinxiu Li; Hui Wang; Yelin Zhao; Mikael Benson
Cancer Res (2025)
Research Article April 28 2025
A Cyanobacteria-derived RNA aptamer resensitizes prostate cancer to hormone therapy
Carlos D. Cruz-Hernández; Bethany Smith; Sandrine Billet; Manish Thiruvalluvan; Gabrielle Gonzales; David M. Underhill; Ekihiro Seki; Shelly C. Lu; Neil A. Bhowmick
Cancer Res (2025)
Research Article April 27 2025
Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors
Jyoti Srivastava; Vipin K. Yadav; Rachel V. Jimenez; Pravin R. Phadatare; Ninad A. Inamdar; Montana M. Young; Antonella Bacchiocchi; Ruth Halaban; Bin Fang; Alvaro de Mingo. Pulido; Kenneth Y. Tsai; Keiran S.M. Smalley; John M. Koomen; Paulo C. Rodriguez; Sanjay Premi
Cancer Res (2025)
Review April 22 2025
Illuminating the Noncoding Genome in Cancer using Artificial Intelligence.
Cancer Res (2025)
Research Article April 22 2025
Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma
Jung Hyun Um; Yueyuan Zheng; Qiong Mao; Chehyun Nam; Hua Zhao; Yoon Woo Koh; Su-Jin Shin; Young Min Park; De-Chen Lin
Cancer Res (2025)
Review April 21 2025
A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment
Cancer Res (2025)
Research Article April 17 2025
Antigen Cross-Presentation by Type-2 Innate Lymphoid Cells Facilitates the Activation of Anti-Tumor CD8+ T Cells
Jihyun Kim; Seung Geun Song; Suhyun Park; Young Gyun Ko; Jongho Ham; TaeSoo Kim; Sang-Jun Ha; Yong-Soo Bae; Doo Hyun Chung; Hye Young Kim
Cancer Res (2025)
Review April 17 2025
AXL Tyrosine Kinases: A Growing Isoform Family that Promotes Cancer Pathogenesis
Cancer Res (2025)
Research Article April 17 2025
Mannose Enhances Immunotherapy Efficacy in Ovarian Cancer by Modulating Gut Microbial Metabolites
Chen Zhang; Yiying Wang; Mengdi He; Chenyang Wang; Kankan Cao; Yujing Zhong; Xueling Wang; Moran Yang; Guodong Zhang; Jiaqi Lu; Huan Yi; Haiou Liu; Congjian Xu
Cancer Res (2025)
Research Article April 17 2025
Targeting LTBP2 Derived from Cancer-Associated Fibroblasts Sensitizes Esophageal Squamous Cell Carcinoma to Chemotherapy
Jiarong Zhan; Mengqing Li; Lei Li; Ting-Ting Zeng; Jun Liu; Qingyun Chen; Chen Jiang; Xin Wang; Dan Xie; Xin-Yuan Guan; Ying-Hui Zhu
Cancer Res (2025)
Research Article April 14 2025
Immunological Tolerance to Luciferase and Fluorescent Proteins using Tol Mice Enables Development of Improved Tumor Models for Investigating Immunity and Metastasis
Kabir A. Khan; Areeba A. Qureshi; Ping Xu; Hung-Yang Kuo; Ton N. Schumacher; Iacovos P. Michael; Robert S. Kerbel
Cancer Res (2025)
Research Article April 14 2025
Cis-regulatory Alterations in FOXP4 Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure
Siyuan Niu; Jialing Ma; Shasha Liu; Yueping Li; Xinying Yue; Miaoxin Pan; Lina Song; Yutong Wu; Zifei Yang; Yuqian Tan; Linglong Gu; Chaolong Wang; Jiang Chang
Cancer Res (2025)
Cancer Landscapes April 14 2025
Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles
Marco Matejcic; Jamie K. Teer; Hannah J. Hoehn; Diana B. Diaz; Kritika Shankar; Jun Gong; Nathalie T. Nguyen; Nicole C. Loroña; Domenico Coppola; Clifton G. Fulmer; Ozlen Saglam; Kun Jiang; W. Douglas Cress; Teresita Muñoz-Antonia; Idhaliz Flores; Edna R. Gordián; José A. Oliveras Torres; Seth I. Felder; Julian Sanchez; Jason B. Fleming; Erin M. Siegel; Jennifer A. Freedman; Julie Dutil; Mariana C. Stern; Brooke L. Fridley; Jane C. Figueiredo; Stephanie L. Schmit
Cancer Res (2025)
Research Article April 11 2025
Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation
Lingjiao Meng; Haotian Wu; Jiaxiang Wu; Ping'an Ding; Jinchen He; Tongkun Li; Xiaoman Niu; Meixiang Sang; Lihua Liu
Cancer Res (2025)
Research Article April 11 2025
Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties
Joshua Cumming; Parniyan Maneshi; Mitesh Dongre; Tala Alsaed; Mohammad Javad Dehghan-Nayeri; Agnes Ling; Kristian Pietras; Cedric Patthey; Daniel Öhlund
Cancer Res (2025)
Research Article April 9 2025
Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression
Cuilan Liu; Hengwei Du; Guoxing Yu; Jingjing Qi; Hongliang Dong; Ruiqi Hu; Fei Wang; Bingjie Cui; Weiwei Chen; Qian Zhang; Chen Li; Ran Gao; Clemens A. Schmitt; Jiong Deng; Yong Yu; Jing Du
Cancer Res (2025)
In the Spotlight April 8 2025
To EMT or not to EMT: Ablation of mesenchymal tumor cell lineages reveals the essential role of EMT in pancreatic cancer initiation and evolution
Cancer Res (2025)
Research Article April 8 2025
SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma
Utsav Sen; Charles Coleman; Nishant Gandhi; Vrinda Jethalia; Deniz Demircioglu; Andrew Elliott; Ari M. Vanderwalde; Omar Hayatt; Elisa de Stanchina; Balazs Halmos; Patrick C. Ma; Mirela Berisa; Dan Hasson; Triparna Sen
Cancer Res (2025)
Research Article April 2 2025
Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases
Jason Eigenbrood; Nathan Wong; Paul Mallory; Janice S. Pereira; Demond Williams; Douglass W. Morris-II; Jessica A. Beck; James C. Cronk; Carly M. Sayers; Monica Mendez; Linus Kaiser; Julie Galindo; Jatinder Singh; Ashley Cardamone; Milind Pore; Michael Kelly; Amy K. LeBlanc; Jennifer Cotter; Rosandra N. Kaplan; Troy A. McEachron
Cancer Res (2025)
Review April 2 2025
Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment
Lu Liu; Yuheng Zhang; Hanyu Liu; Jian Yang; Qi Tian; Nareekarn Chueakula; Saravana Ramasamy; Navin Kumar Verma; Christine Cheung; Anjali P. Kusumbe
Cancer Res (2025)
In the Spotlight March 31 2025
PROX1: a key regulator of hepatocyte identity and tumorigenesis
Cancer Res (2025)
Research Article March 31 2025
The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wildtype p53 to Exert the Dominant-Negative Effect
Nancy Klemm; Roman R. Schimmer; Nils K. Konrad; Flavian Thelen; Jonas Fullin; Ebru Topçu; Christian Koch; Milena Treacy; Matthew Joseph. Leventhal; Marco M. Bühler; Veronika Lysenko; Alexandre P. A. Theocharides; Kari J. Kurppa; Stefan Balabanov; Tuncay Baubec; Andrei V. Krivtsov; Peter G. Miller; Scott A. Armstrong; Benjamin L. Ebert; Markus G. Manz; Cesar Nombela-Arrieta; Steffen Boettcher
Cancer Res (2025)
Research Article March 31 2025
Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
Joanna Domagala; Tomasz M. Grzywa; Iwona Baranowska; Magdalena Justyniarska; Ryan Tannir; Agnieszka Graczyk-Jarzynka; Aleksandra Kusowska; Maria Lecka; Marcin Poreba; Klaudyna Fidyt; Katsiaryna Marhelava; Zofia Pilch; Lea K. Picard; Tomasz Wegierski; Kamil Jastrzebski; Marta Krawczyk; Marta Klopotowska; Monika Granica; Doris Urlaub; Szymon Hajduk; Alexandra Neeser; Spencer Moros; Pawel Kozlowski; Malgorzata Bobrowicz; Marta Miaczynska; Leyuan Ma; Carsten Watzl; Magdalena Winiarska
Cancer Res (2025)
Research Article March 26 2025
Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer
Tingting Li; Chonghui Hu; Tianhao Huang; Yu Zhou; Qing Tian; Huimou Chen; Rihua He; Yuan Yuan; Yong Jiang; Honghui Jiang; Kaijun Huang; Di Cheng; Rufu Chen; Shangyou Zheng
Cancer Res (2025)
Research Article March 24 2025
Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis
Marzia Scortegagna; Rabi Murad; Parinaz Bina; Yongmei Feng; Rebecca A. Porritt; Alexey V. Terskikh; Xiao Tian; Peter D. Adams; Kristiina Vuori; Ze'ev A. Ronai
Cancer Res (2025)
Research Article March 24 2025
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer
Yanchao Yu; Xincheng Gao; Huayuan Zhao; Jiayin Sun; Miao Wang; Xing Xiong; Junping Li; Chao Huang; Hui Zhang; Guosong Jiang; Xingyuan Xiao
Cancer Res (2025)
In the Spotlight March 24 2025
“Dr. Jekyll and Mr. Hyde”: AT2 Cells in Lung Regeneration and Tumor Development
Cancer Res (2025)
Research Article March 24 2025
An Anti-EGFR Antibody-Drug Radioconjugate Labeled with Actinium-225 Elicits Durable Anti-Tumor Responses in KRAS and BRAF Mutant Colorectal Cancer
Anjong Florence Tikum; Nikita W. Henning; Jessica Pougoue Ketchemen; Alireza Doroudi; Hanan Babeker; Fabrice Ngoh Njotu; Emmanuel Nwangele; Alissar Monzer; Bridget Gray; Emina Torlakovic; Maruti Uppalapati; Humphrey Fonge
Cancer Res (2025)
Research Article March 24 2025
SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T cell Activity in Hepatocellular Carcinoma
Yating Chang; Naizhen Wang; Shaopeng Li; Jiaqi Zhang; Yipeng Rao; Zilong Xu; Lu Li; Hongning Wu; Jun Chen; Yanhua Lin; Xiaoxuan Huang; Pingguo Liu; Jun Zhang; Yueting Liao; Chaolong Lin; Chenghao Huang; Ningshao Xia
Cancer Res (2025)
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