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Review Article June 30 2022
Metabolic reprogramming in hematological malignancies: advances and clinical perspectives
Cancer Res can.22.0917.
Research Article June 30 2022
CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
Haoyan Li; Yin Wang; Kevin Lin; Varadha Balaji Venkadakrishnan; Martin Bakht; Wei Shi; Chenling Meng; Jie Zhang; Kaitlyn Tremble; Xin Liang; Jian H. Song; Xu Feng; Vivien Van; Pingna Deng; Jared K. Burks; Ana Aparicio; Khandan Keyomarsi; Junjie Chen; Yue Lu; Himisha Beltran; Di Zhao
Cancer Res can.22.0631.
Research Article June 29 2022
Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer
Cancer Res canres.3822.2021.
Research Article June 29 2022
Caspase-3-induced activation of SREBP2 drives drug resistance via promotion of cholesterol biosynthesis in hepatocellular carcinoma
Etienne H. Mok; Carmen Oi-Ning Leung; Lei Zhou; Martina Mang Leng Lei; Hoi Wing Leung; Man Tong; Tin Lok Wong; Eunice Y. Lau; Irene Oi-Lin Ng; Jin Ding; Jing-Ping Yun; Jun Yu; Hui Lian Zhu; Chi Ho Lin; Dan Lindholm; Kit Sum Leung; Jonathan D. Cybulski; David M. Baker; Stephanie Ma; Terence K. Lee
Cancer Res canres.2934.2021.
Research Article June 28 2022
RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression
Hong Shan; Tianze Liu; Hairun Gan; Simeng He; Jia Deng; Xinyan Hu; Luting Li; Li Cai; JianZhong He; Haoyu Long; Jianxun Cai; Hanjie Li; Qianqian Zhang; Lijie Wang; Fangbin Chen; Yuming Chen; Haopei Zhang; Jian Li; Lukun Yang; Ye Liu; Jianhua Yang; Dong-Ming Kuang; Pengfei Pang; Huanhuan He
Cancer Res canres.3748.2021.
Review Article June 24 2022
The central role of mTORC1 in amino acid sensing
Cancer Res canres.4403.2021.
Research Article June 24 2022
Cancer-associated fibroblasts suppress CD8+ T cell infiltration and confer resistance to immune checkpoint blockade
Liam Jenkins; Ute Jungwirth; Alexandra Avgustinova; Marjan Iravani; Adam P. Mills; Syed Haider; James Harper; Clare M. Isacke
Cancer Res canres.4141.2021.
Brief Report June 24 2022
The interaction of SWI/SNF with the ribosome regulates translation and confers sensitivity to translation pathway inhibitors in cancers with complex perturbations
Livia Ulicna; Samuel C. Kimmey; Christopher M. Weber; Grace M. Allard; Aihui Wang; Nam Q. Bui; Sean C. Bendall; Gerald R. Crabtree; Gregory R. Bean; Capucine Van Rechem
Cancer Res canres.1360.2021.
Research Article June 24 2022
Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer
Demetra P. Kelenis; Kathia E. Rodarte; Rahul K. Kollipara; Karine Pozo; Shreoshi Pal Choudhuri; Kyle B. Spainhower; Sarah J. Wait; Victor Stastny; Trudy G. Oliver; Jane E. Johnson
Cancer Res canres.3713.2021.
Research Article June 24 2022
Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer
Viswam S. Nair; Angela B. Hui; Jacob J. Chabon; Mohammad Shahrokh Esfahani; Henning Stehr; Barzin Y. Nabet; Li Zhou; Aadel A. Chaudhuri; Jalen A. Benson; Kelsey Ayers; Harmeet Bedi; Meghan C. Ramsey; Ryan Van Wert; Sanja Antic; Natalie Shaubie. Lui; Leah M. Backhus; Mark F. Berry; Arthur W. Sung; Pierre P. Massion; Joseph B. Shrager; Ash A. Alizadeh; Maximilian Diehn
Cancer Res canres.0554.2022.
Research Article June 23 2022
Poziotinib inhibits HER2 mutant-driven therapeutic resistance and multi-organ metastasis in breast cancer
Rashi Kalra; Ching Hui Chen; Junkai Wang; Ahmad Bin Salam; Lacey E. Dobrolecki; Alaina Lewis; Christina Sallas; Clayton C. Yates; Carolina Gutierrez; Balasubramanyam Karanam; Meenakshi Anurag; Bora Lim; Matthew J. Ellis; Shyam M. Kavuri
Cancer Res canres.CAN-21-3106-E.2021-9-13 12:18:38.287.
Review Article June 22 2022
Inactivating amplified HER2: challenges, dilemmas, and future directions
Cancer Res canres.1121.2022.
Research Article June 22 2022
PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma
Cancer Res canres.CAN-21-4313-E.2021.
Research Article June 22 2022
Treatment represents a key driver of metastatic cancer evolution
Ditte Sigaard. Christensen; Johanne Ahrenfeldt; Mateo Sokač; Judit Kisistók; Martin K. Thomsen; Lasse Maretty; Nicholas McGranahan; Nicolai J. Birkbak
Cancer Res canres.CAN-22-0562-E.2022.
Research Article June 22 2022
The prostate cancer androgen receptor cistrome in African American men associates with upregulation of lipid metabolism and immune response
Jacob E. Berchuck; Elio Adib; Sarah Abou Alaiwi; Amit K. Dash; Jin Na Shin; Dallin Lowder; Collin McColl; Patricia Castro; Ryan Carelli; Elisa Benedetti; Jenny Deng; Matthew Robertson; Sylvan C. Baca; Connor Bell; Heather M. McClure; Talal El Zarif; Matthew P. Davidsohn; Gitanjali Lakshminarayanan; Kinza Rizwan; Darlene G. Skapura; Sandra L. Grimm; Christel M. Davis; Erik A. Ehli; Kaitlin M. Kelleher; Ji-Heui Seo; Nicholas Mitsiades; Cristian Coarfa; Mark M. Pomerantz; Massimo Loda; Michael Ittmann; Matthew L. Freedman; Salma Kaochar
Cancer Res canres.3552.2021.
Research Article June 22 2022
DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma
Cancer Res canres.0717.2022.
Research Article June 17 2022
Leveraging therapy-specific polygenic risk scores to predict restrictive lung defects in childhood cancer survivors
Cindy Im; Yan Yuan; Eric D. Austin; Dennis C. Stokes; Matthew J. Krasin; Andrew M. Davidoff; Yadav Sapkota; Zhaoming Wang; Kirsten K. Ness; Carmen L. Wilson; Gregory T. Armstrong; Melissa M. Hudson; Leslie L. Robison; Daniel A. Mulrooney; Yutaka Yasui
Cancer Res canres.0418.2022-2-4 09:20:02.663.
Article Commentary June 16 2022
The Kinetics and (Dys)kinetics of Cancer Chronotherapy
Cancer Res (2022)
Research Article June 16 2022
Therapeutic targeting of macrophage plasticity remodels the tumor-immune microenvironment
Hee-Jin Jang; Hyun-Sung Lee; Wendong Yu; Maheshwari Ramineni; Cynthia Y. Truong; Daniela Ramos; Taylor Splawn; Jong Min Choi; Sung Yun Jung; Ju-Seog Lee; Daniel Y. Wang; Joel M. Sederstrom; Massimo Pietropaolo; Farrah Kheradmand; Christopher I. Amos; Thomas M. Wheeler; R. Taylor. Ripley; Bryan M. Burt
Cancer Res canres.CAN-21-3506-A.2021.
Research Article June 15 2022
Developmental pathways are epigenetically reprogrammed during lung cancer brain metastasis
Jennifer A. Karlow; Siddhartha Devarakonda; Xiaoyun Xing; Hyo Sik Jang; Ramaswamy Govindan; Mark A. Watson; Ting Wang
Cancer Res canres.4160.2021-12-4 00:44:15.000.
Research Article June 15 2022
MAB21L4 deficiency drives squamous cell carcinoma via activation of RET
Ankit Srivastava; Cristina Tommasi; Dane Sessions; Angela Mah; Tomas Bencomo; Jasmine M. Garcia; Tiffany Jiang; Michael Lee; Joseph Y. Shen; Lek Wei Seow; Audrey Nguyen; Kimal Rajapakshe; Cristian Coarfa; Kenneth Y. Tsai; Vanessa Lopez-Pajares; Carolyn S. Lee
Cancer Res canres.CAN-22-0047-E.2022-1-7 09:20:59.670.
Research Article June 14 2022
NELL-1 regulates the matrisome to promote osteosarcoma progression
Qizhi Qin; Mario Gomez-Salazar; Robert J. Tower; Leslie Chang; Carol D. Morris; Edward F. McCarthy; Kang Ting; Xinli Zhang; Aaron W. James
Cancer Res canres.0732.2022-3-1 13:01:34.140.
Research Article June 14 2022
The reversible fourth-generation EGFR tyrosine kinase inhibitor OBX02-011 overcomes C797S-mediated resistance in lung cancer
Yun Jung Choi; Da-Som Kim; Young Hoon Sung; Dong Ha Kim; Kyungtaek Im; Hyeonjeong Lee; Chae Won Lee; Jeongin Cho; Joongkee Min; Dong-Cheol Woo; Sung-Eun Kim; Sunho Lee; Yun Jeong Kong; Hyung Chul Ryu; Jae-Sun Kim; Rajesh Rengasamy; Wonjun Ji; Chang-Min Choi; Jae Cheol Lee; Jin Kyung Rho
Cancer Res canres.0394.2022-2-3 21:03:12.200.
Research Article June 13 2022
Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.
Yuki Makino; Hayato Hikita; Kenji Fukumoto; Ji Hyun Sung; Yoshihiro Sakano; Kazuhiro Murai; Sadatsugu Sakane; Takahiro Kodama; Ryotaro Sakamori; Jumpei Kondo; Shogo Kobayashi; Tomohide Tatsumi; Tetsuo Takehara
Cancer Res canres.4390.2021.
Research Article June 10 2022
An active learning framework improves tumor variant interpretation
Alexandra M. Blee; Bian Li; Turner Pecen; Jens Meiler; Zachary D. Nagel; John A. Capra; Walter J. Chazin
Cancer Res canres.3798.2021-11-8 10:24:42.443.
Research Article June 9 2022
Activity and Resistance of a Brain-Permeable Paradox Breaker BRAF Inhibitor in Melanoma Brain Metastasis
Ester Bonfill-Teixidor; Raffaella Iurlaro; Cornelia Handl; Jürgen Wichmann; Alexandra Arias; Isabel Cuartas; Jasmin Emmenegger; Andrea Romagnani; Luca Mangano; Thomas Lorber; Marco Berrera; Christina Godfried Sie; Fabian Köchl; Jan Eckmann; Romi Feddersen; Martin Kornacker; Gabriel Schnetzler; Marta Cicuendez; Esteban Cordero; Thomaz E. Topczewski; Abel Ferres-Pijoan; Josep González; Francisco Martínez-Ricarte; Eva Muñoz-Couselo; Josep Tabernero; James R. Bischoff; Piergiorgio Pettazzoni; Joan Seoane
Cancer Res (2022)
Research Article June 8 2022
Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression
Rachana Patel; Catriona A. Ford; Lisa Rodgers; Linda K. Rushworth; Janis Fleming; Ernest Mui; Tong Zhang; David Watson; Victoria Lynch; Gillian Mackay; David Sumpton; Owen J. Sansom; Johan Vande Voorde; Hing Y. Leung
Cancer Res canres.1301.2021-5-4 10:59:25.103.
Research Article June 6 2022
A programmable in vivo CRISPR activation model elucidates the oncogenic and immunosuppressive functions of MYC in lung adenocarcinoma
Fredrik I. Thege; Dhwani N. Rupani; Bhargavi Brahmendra Barathi; Sara L. Manning; Anirban Maitra; Andrew D. Rhim; Sonja M. Wörmann
Cancer Res canres.4009.2021.
Research Article June 6 2022
IL-6 and CCL18 mediate crosstalk between VHL-deficient kidney cells and macrophages during development of renal cell carcinoma
Cancer Res canres.3749.2021-11-3 04:32:07.783.
Research Article June 3 2022
A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
Weijia Cai; Mai Q. Nguyen; Nicole A. Wilski; Timothy J. Purwin; Megane Vernon; Manoela Tiago; Andrew E. Aplin
Cancer Res canres.3217.2021-9-22 14:53:05.437.
Research Article June 3 2022
Intratumoral resolution of driver gene mutation heterogeneity in renal cancer using deep learning
Paul Acosta; Vandana Panwar; Vipul Jarmale; Alana Christie; Jay Jasti; Vitaly Margulis; Dinesh Rakheja; John Cheville; Bradley C. Leibovich; Alexander Parker; James Brugarolas; Payal Kapur; Satwik Rajaram
Cancer Res canres.CAN-21-2318-A.2021-7-15 15:52:51.650.
Retraction June 3 2022
Retraction: Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis
Cancer Res (2022)
Correction June 2 2022
Correction: Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis
Cancer Res (2022)
Research Article June 2 2022
Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis
Cancer Res (2022)
Research Article May 31 2022
Reengineering Ponatinib to Minimize Cardiovascular Toxicity
Anna Pavlovna. Hnatiuk; Arne A.N. Bruyneel; Dhanir Tailor; Mallesh Pandrala; Arpit Dheeraj; Wenqi Li; Ricardo Serrano; Dries A.M. Feyen; Michelle M. Vu; Prashila Amatya; Saloni Gupta; Yusuke Nakauchi; Isabel Morgado; Volker Wiebking; Ronglih Liao; Matthew Porteus; Ravindra Majeti; Sanjay V. Malhotra; Mark Mercola
Cancer Res canres.CAN-21-3652-E.2021.
Research Article May 31 2022
SETDB1 restrains endogenous retrovirus expression and antitumor immunity during radiotherapy
Cancer Res canres.3523.2021.
Research Article May 31 2022
Intracellular acetyl CoA potentiates the therapeutic efficacy of anti-tumor CD8+ T cells
Snehanshu Chowdhury; Anwesha Kar; Debaleena Bhowmik; Anupam Gautam; Debashree Basak; Ishita Sarkar; Puspendu Ghosh; Deborpita Sarkar; Alvina Deka; Paramita Chakraborty; Asima Mukhopadhyay; Shikhar Mehrotra; Soumen Basak; Sandip Paul; Shilpak Chatterjee
Cancer Res canres.4052.2021.
Research Article May 27 2022
Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification
Bingteng Xie; Yang Pu; Fan Yang; Wei Chen; Wei Yue; Jihong Ma; Na Zhang; Yuening Jiang; Jiegen Wu; Yihan Lin; Xin Liang; Chu Wang; Peng Zou; Mo Li
Cancer Res canres.0225.2022-1-31 22:36:38.487.
Review Article May 18 2022
Drug-tolerant persister cells in cancer therapy resistance
Cancer Res canres.3844.2021.
Research Article May 18 2022
Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
Dragana Kopanja; Vaibhav Chand; Eilidh Mills. O'Brien; Nishit K. Mukhopadhyay; Maria Paula. Zappia; Abul B.M.M.K. Islam; Maxim Frolov; Bradley J. Merrill; Pradip Raychaudhuri
Cancer Res canres.0410.2022.
Research Article May 18 2022
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
Shawn M. Davidson; Daniel R. Schmidt; Julia E. Heyman; James P. O'Brien; Amy C. Liu; William J. Israelsen; Talya L. Dayton; Raghav Sehgal; Roderick T. Bronson; Elizaveta Freinkman; Howard H. Mak; Giuseppe Nicolo Fanelli; Scott Malstrom; Gary Bellinger; Arkaitz Carracedo; Pier Paolo Pandolfi; Kevin D. Courtney; Abhishek Jha; Ronald A. DePinho; James W. Horner; Craig J. Thomas; Lewis C. Cantley; Massimo Loda; Matthew G. Vander Heiden
Cancer Res canres.CAN-21-2352-E.2021.
Research Article May 18 2022
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Amrita M. Nargund; Chang Xu; Amit Mandoli; Atsushi Okabe; Gao Bin Chen; Kie Kyon Huang; Taotao Sheng; Xiaosai Yao; Jia Ming Nickolas Teo; Raghav Sundar; Yee Jiun Kok; Yi Xiang See; Manjie Xing; Zhimei Li; Chern Han Yong; Aparna Anand; Zul Fazreen A.I.; Lai Fong. Poon; Michelle Shu Wen. Ng; Javier Yu Peng Koh; Wen Fong Ooi; Su Ting Tay; Xuewen Ong; Angie Lay Keng Tan; Heike I. Grabsch; Melissa Jane. Fullwood; Tean Bin Teh; Xuezhi Bi; Atsushi Kaneda; Shang Li; Patrick Tan
Cancer Res canres.CAN-21-2072-E.2021.
Research Article May 17 2022
Claudin-12 deficiency inhibits tumor growth by impairing transendothelial migration of myeloid-derived suppressor cells
Zhihai Qin; Hong Cao; Chen Ni; Le Han; Ruoqi Wang; Rosel Blasig; Reiner Haseloff; Yue Qin; Jie Lan; Xiaohan Lou; Pan Ma; Xiaohan Yao; Linlin Wang; Fei Wang; Linyu Zhu; Ningjing Lei; Ingolf E. Blasig
Cancer Res canres.3896.2021.
Research Article May 11 2022
Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis
Chen Xie; Feng-Yi Wang; Ye Sang; Bin Chen; Jia-Hui Huang; Feng-Jun He; Hui Li; Ying Zhu; Xingguo Liu; Shi-Mei Zhuang; Jian-Hong Fang
Cancer Res canres.3910.2021.
Research Article May 10 2022
Computational identification of preneoplastic cells displaying high stemness and risk of cancer progression
Tianyuan Liu; Xuan Zhao; Yuan Lin; Qi Luo; Shaosen Zhang; Yiyi Xi; Yamei Chen; Lin Lin; Wenyi Fan; Jie Yang; Yuling Ma; Alok K. Maity; Yanyi Huang; Jianbin Wang; Jiang Chang; Dongxin Lin; Andrew E. Teschendorff; Chen Wu
Cancer Res canres.0668.2022.
Research Article May 10 2022
Bimodal gene expression in cancer patients provides interpretable biomarkers for drug sensitivity
Wail Ba-alawi; Sisira Kadambat Nair; Bo Li; Anthony Mammoliti; Petr Smirnov; Arvind Singh. Mer; Linda Z. Penn; Benjamin Haibe-Kains
Cancer Res canres.2395.2021.
Research Article May 10 2022
Hypoxia-reoxygenation couples 3βHSD1 enzyme and cofactor upregulation to facilitate androgen biosynthesis and hormone therapy resistance in prostate cancer
Liang Qin; Yoon-Mi Chung; Michael Berk; Bryan Naelitz; Ziqi Zhu; Eric Klein; Abhishek A. Chakraborty; Nima Sharifi
Cancer Res canres.4256.2021.
Research Article May 4 2022
Anti-HIV drug elvitegravir suppresses cancer metastasis via increased proteasomal degradation of m6A methyltransferase METTL3
Long Liao; Yan He; Shu Jun. Li; Guo Geng. Zhang; Wei Yu; Jing Yang; Zi-Jia Huang; Can-Can Zheng; Qing-Yu He; Yan Li; Bin Li
Cancer Res canres.4124.2021.
Research Article May 3 2022
Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects
Noboru Ishiyama; Matthew O'Connor; Andrei Salomatov; Darlene Romashko; Shalabh Thakur; Ahmet Mentes; Julia F. Hopkins; Garrett M. Frampton; Lee A. Albacker; Anna Kohlmann; Christopher Roberts; Elizabeth Buck
Cancer Res canres.0940.2021.
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